Genetic Control of a Central Pattern Generator: Rhythmic Oromotor Movement in Mice Is Controlled by a Major Locus near Atp1a2
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{"title"=>"Genetic control of a central pattern generator: Rhythmic oromotor movement in mice is controlled by a major locus near atp1a2", "type"=>"journal", "authors"=>[{"first_name"=>"John D.", "last_name"=>"Boughter", "scopus_author_id"=>"6701691280"}, {"first_name"=>"Megan K.", "last_name"=>"Mulligan", "scopus_author_id"=>"7102563323"}, {"first_name"=>"Steven J.", "last_name"=>"St. John", "scopus_author_id"=>"8979881300"}, {"first_name"=>"Kenichi", "last_name"=>"Tokita", "scopus_author_id"=>"7005458397"}, {"first_name"=>"Lu", "last_name"=>"Lu", "scopus_author_id"=>"56457005100"}, {"first_name"=>"Detlef H.", "last_name"=>"Heck", "scopus_author_id"=>"7102735819"}, {"first_name"=>"Robert W.", "last_name"=>"Williams", "scopus_author_id"=>"55674268100"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"22675444", "doi"=>"10.1371/journal.pone.0038169", "pui"=>"364923192", "issn"=>"19326203", "sgr"=>"84861677001", "scopus"=>"2-s2.0-84861677001"}, "id"=>"951a4036-f43b-3c48-b058-4f69bb1a0c81", "abstract"=>"Fluid licking in mice is a rhythmic behavior that is controlled by a central pattern generator (CPG) located in a complex of brainstem nuclei. C57BL/6J (B6) and DBA/2J (D2) strains differ significantly in water-restricted licking, with a highly heritable difference in rates (h(2)≥0.62) and a corresponding 20% difference in interlick interval (mean ± SEM = 116.3±1 vs 95.4±1.1 ms). We systematically quantified motor output in these strains, their F(1) hybrids, and a set of 64 BXD progeny strains. The mean primary interlick interval (MPI) varied continuously among progeny strains. We detected a significant quantitative trait locus (QTL) for a CPG controlling lick rate on Chr 1 (Lick1), and a suggestive locus on Chr 10 (Lick10). Linkage was verified by testing of B6.D2-1D congenic stock in which a segment of Chr 1 of the D2 strain was introgressed onto the B6 parent. The Lick1 interval on distal Chr 1 contains several strong candidate genes. One of these is a sodium/potassium pump subunit (Atp1a2) with widespread expression in astrocytes, as well as in a restricted population of neurons. Both this subunit and the entire Na(+)/K(+)-ATPase molecule have been implicated in rhythmogenesis for respiration and locomotion. Sequence variants in or near Apt1a2 strongly modulate expression of the cognate mRNA in multiple brain regions. This gene region has recently been sequenced exhaustively and we have cataloged over 300 non-coding and synonymous mutations segregating among BXD strains, one or more of which is likely to contribute to differences in central pattern generator tempo.", "link"=>"http://www.mendeley.com/research/genetic-control-central-pattern-generator-rhythmic-oromotor-movement-mice-controlled-major-locus-nea", "reader_count"=>18, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>3, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>3, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>10, "Medicine and Dentistry"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>1, "United Kingdom"=>2, "Portugal"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/629574"], "description"=>"<p>A. In a 20 minute session licks for B6 (red ticks), F<sub>1</sub> (blue ticks), and D2 (green ticks) mice are organized into a number of drinking bouts; in this view, individual licks are not discernable. B. Expanded view of five seconds of licking for each of the mice shown in A. Each tick denotes a single lick contact C. Frequency distributions of ILIs (bin size = 5 ms)<250 ms for each of these mice show primary distributions with peaks in the range of 50–160 ms. The mean ILI duration in this interval for each mouse is calculated as the MPI (mean primary ILI).</p>", "links"=>[], "tags"=>["licking"], "article_id"=>300063, "categories"=>["Neuroscience", "Genetics"], "users"=>["John D. Boughter Jr", "Megan K. Mulligan", "Steven J. St. John", "Kenichi Tokita", "Lu Lu", "Detlef H. Heck", "Robert W. Williams"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0038169.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patterns_of_licking_in_representative_individual_mice_/300063", "title"=>"Patterns of licking in representative individual mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 04:24:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/629701"], "description"=>"<p>A. Water MPI. B. Sucrose MPI. Green, blue and red bars denote values for D2, F<sub>1</sub> and B6, respectively. C. Scatter plot of strain averages for water MPI and sucrose MPI.</p>", "links"=>[], "tags"=>["inter-lick"], "article_id"=>300197, "categories"=>["Neuroscience", "Genetics"], "users"=>["John D. Boughter Jr", "Megan K. Mulligan", "Steven J. St. John", "Kenichi Tokita", "Lu Lu", "Detlef H. Heck", "Robert W. Williams"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0038169.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histograms_for_average_SE_mean_primary_inter_lick_interval_MPI_across_all_BXD_parental_and_F_1_strains_/300197", "title"=>"Histograms for average (± SE) mean primary inter-lick interval (MPI) across all BXD, parental, and F<sub>1</sub> strains.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 04:25:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/629864"], "description"=>"<p>A. Licks to water. B. Licks to sucrose. Green, blue, and red bars denote values for D2, F<sub>1</sub> and B6, respectively. C. Scatter plot of strain averages for water MPI and sucrose MPI.</p>", "links"=>[], "tags"=>["licks"], "article_id"=>300356, "categories"=>["Neuroscience", "Genetics"], "users"=>["John D. Boughter Jr", "Megan K. Mulligan", "Steven J. St. John", "Kenichi Tokita", "Lu Lu", "Detlef H. Heck", "Robert W. Williams"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0038169.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histograms_for_mean_SE_number_of_licks_across_all_BXD_parental_and_F_1_strains_/300356", "title"=>"Histograms for mean (± SE) number of licks across all BXD, parental, and F<sub>1</sub> strains.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 04:26:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/630044"], "description"=>"<p>A. Water VPL. B. Sucrose VPL. Green, blue, and red bars denote values for D2, F<sub>1</sub> and B6, respectively. C. Scatter plot of strain averages for water MPI and sucrose MPI.</p>", "links"=>[], "tags"=>["lick"], "article_id"=>300538, "categories"=>["Neuroscience", "Genetics"], "users"=>["John D. Boughter Jr", "Megan K. Mulligan", "Steven J. St. John", "Kenichi Tokita", "Lu Lu", "Detlef H. Heck", "Robert W. Williams"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0038169.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histograms_for_average_SE_volume_per_lick_VPL_across_all_BXD_parental_and_F_1_strains_/300538", "title"=>"Histograms for average (± SE) volume per lick (VPL) across all BXD, parental, and F<sub>1</sub> strains.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 04:26:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/630309"], "description"=>"<p>A. Water MPI. B. Sucrose MPI. Blue trace denotes likelihood ratio (LRS) statistic. A QTL on chromosome 1 exceeds the significance threshold (pink horizontal line; p<0.05) for either stimulus. A suggestive QTL (gray line; p<0.63) was found on chromosome 10.</p>", "links"=>[], "tags"=>["linkage", "maps"], "article_id"=>300801, "categories"=>["Neuroscience", "Genetics"], "users"=>["John D. Boughter Jr", "Megan K. Mulligan", "Steven J. St. John", "Kenichi Tokita", "Lu Lu", "Detlef H. Heck", "Robert W. Williams"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0038169.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genome_wide_linkage_maps_of_MPI_/300801", "title"=>"Genome-wide linkage maps of MPI.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 04:28:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/630538"], "description"=>"<p>Blue trace denotes LRS score, and red trace shows additive effect of the B6 allele. Values for the additive effect are shown in green at right. The LRS score exceeds the threshold for genome-wide significance (pink horizontal line; p<0.05). The dashed black line indicates the confidence interval of the QTL, defined by a 1.5 LOD drop on either side of the peak. Orange seismograph marks indicate SNP density, and colored ticks at top of plot show positions of known genes. Below plot, haplotype distribution among BXD strains is shown for part of the peak QTL region, between the SNP markers rs8242766 and rs6375522. D2 (<i>D</i>/<i>D</i>) genotype is indicated by green bars and B6 (<i>B</i>/<i>B</i>) by red bars. Strains in this table are ordered according to MPI score, from fast to slow (top to bottom). The D2 genotype is associated with faster lick rates, as reflected in low MPI values in strains possessing this genotype in the QTL region.</p>", "links"=>[], "tags"=>["qtl", "chromosome"], "article_id"=>301029, "categories"=>["Neuroscience", "Genetics"], "users"=>["John D. Boughter Jr", "Megan K. Mulligan", "Steven J. St. John", "Kenichi Tokita", "Lu Lu", "Detlef H. Heck", "Robert W. Williams"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0038169.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Interval_QTL_map_on_part_of_chromosome_1_for_water_MPI_/301029", "title"=>"Interval QTL map on part of chromosome 1 for water MPI.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 04:29:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/630750"], "description"=>"<p>A. Genome-wide Interval map of water MPI, after controlling for the effect of <i>Lick1</i> (composite interval mapping). The blue LRS trace shows a significant QTL (pink horizontal line; p<0.05) on Chr 10. B. Enhanced view of QTL (blue trace) on Chr 10 following composite interval mapping. The dashed black line indicates the confidence interval of the QTL, defined by a 1.5 LOD drop on either side of the peak. The red trace shows additive effects of the B6 allele, and the orange seismograph marks indicate SNP density. Additive values are shown in green on right. Colored ticks at top of map indicate positions of known genes. C. Epistasis plot comparing water MPI among BXD strains (means; <i>n</i> = 13–19 strains per diplotype at <i>Lick1</i> and <i>Lick10</i>). The nearly parallel lines in this plot are most consistent with a strictly additive model. D. Histograms comparing average water MPI in D2, F1, B6.D2.1D, B6.D2.10M, and B6 strains (means of individuals; n = 11–14 per strain). Green stripes superimposed on red bars indicate congenic strains. Groups sharing common letters (a,b,c) do not significantly differ, whereas those with different letters significantly differ. Black bars indicate statistically distinct groups, and asterisks denote significant group differences (p<0.005; Bonferroni-corrected t-test).</p>", "links"=>[], "tags"=>["qtl", "mpi", "chr", "phenotype"], "article_id"=>301235, "categories"=>["Neuroscience", "Genetics"], "users"=>["John D. Boughter Jr", "Megan K. Mulligan", "Steven J. St. John", "Kenichi Tokita", "Lu Lu", "Detlef H. Heck", "Robert W. Williams"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0038169.g007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mapping_of_a_QTL_for_MPI_on_Chr_10_and_examination_of_the_effects_on_phenotype_of_both_Lick1_and_Lick10_/301235", "title"=>"Mapping of a QTL for MPI on Chr 10, and examination of the effects on phenotype of both <i>Lick1</i> and <i>Lick10</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 04:30:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/630943"], "description"=>"<p>A. Licks to water. B. Licks to sucrose. A QTL on chromosome 16 exceeds the suggestive threshold (gray line; p<0.63) for either stimulus.</p>", "links"=>[], "tags"=>["linkage", "qtl", "maps"], "article_id"=>301432, "categories"=>["Neuroscience", "Genetics"], "users"=>["John D. Boughter Jr", "Megan K. Mulligan", "Steven J. St. John", "Kenichi Tokita", "Lu Lu", "Detlef H. Heck", "Robert W. Williams"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0038169.g008"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genome_wide_linkage_QTL_maps_of_total_licks_/301432", "title"=>"Genome-wide linkage QTL maps of total licks.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 04:31:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/631081"], "description"=>"<p>A. Water VPL. B. Sucrose VPL. QTLs on chromosome 1,11 and 16 exceed the suggestive threshold (gray line; p<0.63) for water. QTLs on chromosome 8,13 and 16 exceed the suggestive threshold for sucrose.</p>", "links"=>[], "tags"=>["linkage", "qtl", "maps"], "article_id"=>301574, "categories"=>["Neuroscience", "Genetics"], "users"=>["John D. Boughter Jr", "Megan K. Mulligan", "Steven J. St. John", "Kenichi Tokita", "Lu Lu", "Detlef H. Heck", "Robert W. Williams"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0038169.g009"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genome_wide_linkage_QTL_maps_of_VPL_/301574", "title"=>"Genome-wide linkage QTL maps of VPL.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 04:32:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/631266"], "description"=>"<p>Normalized (RPKM) values in whole brain are shown for the <i>B</i> (N = 20) and <i>D</i> allele (N = 11) for each feature of <i>Atp1a2</i> RefSeq transcript model. “Transcript level” (far right on X-axis) measures expression for the entire <i>Atp1a2</i> transcript based on the NCBI RefSeq transcript model. Asterisks denote the level of significance with single and doublets representing p-values less than 0.05 and 0.01, respectively. There is a trend toward higher expression of all transcript features associated with the <i>D</i> allele and this difference achieves statistical significance for exons 5, 8, 14, 18, 19, 20, 21, and exon 23 and the 3′ UTR. Consequently, the <i>D</i> allele is associated with higher expression of the entire Atp1a2 transcript in whole brain.</p>", "links"=>[], "tags"=>["bxd"], "article_id"=>301759, "categories"=>["Neuroscience", "Genetics"], "users"=>["John D. Boughter Jr", "Megan K. Mulligan", "Steven J. St. John", "Kenichi Tokita", "Lu Lu", "Detlef H. Heck", "Robert W. Williams"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0038169.g010"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Validation_of_strain_variation_in_Atp1a2_expression_in_the_BXD_population_by_RNA_seq_/301759", "title"=>"Validation of strain variation in <i>Atp1a2</i> expression in the BXD population by RNA-seq.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 04:33:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/631375"], "description"=>"<p>Mean = Mean expression in the Hippocampus Consortium M430v2 (Jun06) PDNN; R MPI = Pearson correlation between probe set and MPI (record 12297); Partial R MPI = Partial Pearson correlation between probe set and MPI (record 12297) when controlling for marker rs13476241; Partial P MPI = P-value of partial correlation. The additive effect shows the contribution of genotype on average log2 expression. A negative or positive additive effect indicates that the B6 or D2 allele increases trait values, respectively. Probe sets 14348893_at, 1427465_at, and 1452308_a_at have multiple probes that overlap B6 vs. D2 sequence variants and show higher expression associated with the <i>B</i> allele which is indicative of a probe artifact (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038169#pone.0038169-Ciobanu1\" target=\"_blank\">[78]</a>). However, the use of partial correlation here corrects for these artifacts and any residual covariation is the result of true biological networks. For example, notice the sign change before and after control for these three probe sets to match the sign of the Partial RMPI for the remaining two <i>Atp1a2</i> probe sets not affected by probe artifacts.</p>", "links"=>[], "tags"=>["qtl"], "article_id"=>301867, "categories"=>["Neuroscience", "Genetics"], "users"=>["John D. Boughter Jr", "Megan K. Mulligan", "Steven J. St. John", "Kenichi Tokita", "Lu Lu", "Detlef H. Heck", "Robert W. Williams"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0038169.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Lick1_QTL_candidate_gene_evidence_table_/301867", "title"=>"Lick1 QTL candidate gene evidence table.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 04:33:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/631405"], "description"=>"<p>Estimated broad-sense heritability.</p>", "links"=>[], "tags"=>["broad-sense"], "article_id"=>301895, "categories"=>["Neuroscience", "Genetics"], "users"=>["John D. Boughter Jr", "Megan K. Mulligan", "Steven J. St. John", "Kenichi Tokita", "Lu Lu", "Detlef H. Heck", "Robert W. Williams"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0038169.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Estimated_broad_sense_heritability_/301895", "title"=>"Estimated broad-sense heritability.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 04:34:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/631438"], "description"=>"t<p>n = 455 for water, 451 for sucrose (casewise deletion of missing data).</p>*<p>p value<0.05.</p>", "links"=>[], "tags"=>["cases", "d2", "f1"], "article_id"=>301926, "categories"=>["Neuroscience", "Genetics"], "users"=>["John D. Boughter Jr", "Megan K. Mulligan", "Steven J. St. John", "Kenichi Tokita", "Lu Lu", "Detlef H. Heck", "Robert W. Williams"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0038169.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlations_among_all_individual_cases_BXD_B6_D2_and_F1_mice_t_for_MPI_total_licks_VPL_and_body_weight_/301926", "title"=>"Correlations among all individual cases (BXD, B6, D2 and F1 mice<sup>t</sup>) for MPI, total licks, VPL, and body weight.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 04:34:15"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
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  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
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  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"1", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
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  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
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  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
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