Sources of Pre-Analytical Variations in Yield of DNA Extracted from Blood Samples: Analysis of 50,000 DNA Samples in EPIC
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{"title"=>"Sources of pre-analytical variations in yield of DNA extracted from blood samples: Analysis of 50,000 DNA samples in EPIC", "type"=>"journal", "authors"=>[{"first_name"=>"Elodie", "last_name"=>"Caboux", "scopus_author_id"=>"6505519807"}, {"first_name"=>"Christophe", "last_name"=>"Lallemand", "scopus_author_id"=>"56829235200"}, {"first_name"=>"Gilles", "last_name"=>"Ferro", "scopus_author_id"=>"7102149768"}, {"first_name"=>"Bertrand", "last_name"=>"Hémon", "scopus_author_id"=>"6603001244"}, {"first_name"=>"Maimuna", "last_name"=>"Mendy", "scopus_author_id"=>"6603920700"}, {"first_name"=>"Carine", "last_name"=>"Biessy", "scopus_author_id"=>"6603599299"}, {"first_name"=>"Matt", "last_name"=>"Sims", "scopus_author_id"=>"23486818500"}, {"first_name"=>"Nick", "last_name"=>"Wareham", "scopus_author_id"=>"7006224498"}, {"first_name"=>"Abigail", "last_name"=>"Britten", "scopus_author_id"=>"55311775000"}, {"first_name"=>"Anne", "last_name"=>"Boland", "scopus_author_id"=>"56265429900"}, {"first_name"=>"Amy", "last_name"=>"Hutchinson", "scopus_author_id"=>"35381552100"}, {"first_name"=>"Afshan", "last_name"=>"Siddiq", "scopus_author_id"=>"12786841100"}, {"first_name"=>"Paolo", "last_name"=>"Vineis", "scopus_author_id"=>"7103293037"}, {"first_name"=>"Elio", "last_name"=>"Riboli", "scopus_author_id"=>"57191801446"}, {"first_name"=>"Isabelle", "last_name"=>"Romieu", "scopus_author_id"=>"7006918513"}, {"first_name"=>"Sabina", "last_name"=>"Rinaldi", "scopus_author_id"=>"7102958980"}, {"first_name"=>"Marc J.", "last_name"=>"Gunter", "scopus_author_id"=>"8245299200"}, {"first_name"=>"Petra H.M.", "last_name"=>"Peeters", "scopus_author_id"=>"7102793088"}, {"first_name"=>"Yvonne T.", "last_name"=>"van der Schouw", "scopus_author_id"=>"7006003970"}, {"first_name"=>"Ruth", "last_name"=>"Travis", "scopus_author_id"=>"7006381597"}, {"first_name"=>"H. Bas", "last_name"=>"Bueno-de-Mesquita", "scopus_author_id"=>"7006169903"}, {"first_name"=>"Federico", "last_name"=>"Canzian", "scopus_author_id"=>"56221555400"}, {"first_name"=>"Maria José", "last_name"=>"Sánchez", "scopus_author_id"=>"56424707700"}, {"first_name"=>"Guri", "last_name"=>"Skeie", "scopus_author_id"=>"7004150818"}, {"first_name"=>"Karina Standahl", "last_name"=>"Olsen", "scopus_author_id"=>"7202717264"}, {"first_name"=>"Eiliv", "last_name"=>"Lund", "scopus_author_id"=>"55423514100"}, {"first_name"=>"Roberto", "last_name"=>"Bilbao", "scopus_author_id"=>"7006140751"}, {"first_name"=>"Núria", "last_name"=>"Sala", "scopus_author_id"=>"7005539367"}, {"first_name"=>"Aurelio", "last_name"=>"Barricarte", "scopus_author_id"=>"6604043458"}, {"first_name"=>"Domenico", "last_name"=>"Palli", "scopus_author_id"=>"56448226000"}, {"first_name"=>"Carmen", "last_name"=>"Navarro", "scopus_author_id"=>"55697355400"}, {"first_name"=>"Salvatore", "last_name"=>"Panico", "scopus_author_id"=>"7005295199"}, {"first_name"=>"Maria Luisa", "last_name"=>"Redondo", "scopus_author_id"=>"16043903900"}, {"first_name"=>"Silvia", "last_name"=>"Polidoro", "scopus_author_id"=>"57199507851"}, {"first_name"=>"Laure", "last_name"=>"Dossus", "scopus_author_id"=>"8873084400"}, {"first_name"=>"Marie Christine", "last_name"=>"Boutron-Ruault", "scopus_author_id"=>"7003878660"}, {"first_name"=>"Françoise", "last_name"=>"Clavel-Chapelon", "scopus_author_id"=>"7005617997"}, {"first_name"=>"Antonia", "last_name"=>"Trichopoulou", "scopus_author_id"=>"56448218100"}, {"first_name"=>"Dimitrios", "last_name"=>"Trichopoulos", "scopus_author_id"=>"35372963400"}, {"first_name"=>"Pagona", "last_name"=>"Lagiou", "scopus_author_id"=>"7006861789"}, {"first_name"=>"Heiner", "last_name"=>"Boeing", "scopus_author_id"=>"7004900619"}, {"first_name"=>"Eva", "last_name"=>"Fisher", "scopus_author_id"=>"8913075800"}, {"first_name"=>"Rosario", "last_name"=>"Tumino", "scopus_author_id"=>"7006077607"}, {"first_name"=>"Claudia", "last_name"=>"Agnoli", "scopus_author_id"=>"25959868900"}, {"first_name"=>"Pierre", "last_name"=>"Hainaut", "scopus_author_id"=>"7005014064"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84863764712", "sgr"=>"84863764712", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"22808065", "doi"=>"10.1371/journal.pone.0039821", "pui"=>"365232386"}, "id"=>"2471be0e-83c7-36bd-a450-ad6dea6bd956", "abstract"=>"The European Prospective Investigation into Cancer and nutrition (EPIC) is a long-term, multi-centric prospective study in Europe investigating the relationships between cancer and nutrition. This study has served as a basis for a number of Genome-Wide Association Studies (GWAS) and other types of genetic analyses. Over a period of 5 years, 52,256 EPIC DNA samples have been extracted using an automated DNA extraction platform. Here we have evaluated the pre-analytical factors affecting DNA yield, including anthropometric, epidemiological and technical factors such as center of subject recruitment, age, gender, body-mass index, disease case or control status, tobacco consumption, number of aliquots of buffy coat used for DNA extraction, extraction machine or procedure, DNA quantification method, degree of haemolysis and variations in the timing of sample processing. We show that the largest significant variations in DNA yield were observed with degree of haemolysis and with center of subject recruitment. Age, gender, body-mass index, cancer case or control status and tobacco consumption also significantly impacted DNA yield. Feedback from laboratories which have analyzed DNA with different SNP genotyping technologies demonstrate that the vast majority of samples (approximately 88%) performed adequately in different types of assays. To our knowledge this study is the largest to date to evaluate the sources of pre-analytical variations in DNA extracted from peripheral leucocytes. The results provide a strong evidence-based rationale for standardized recommendations on blood collection and processing protocols for large-scale genetic studies.", "link"=>"http://www.mendeley.com/research/sources-preanalytical-variations-yield-dna-extracted-blood-samples-analysis-50000-dna-samples-epic", "reader_count"=>44, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>19, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>3, "Student > Bachelor"=>8, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>19, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>3, "Student > Bachelor"=>8, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>25, "Medicine and Dentistry"=>7, "Psychology"=>1, "Chemistry"=>1, "Social Sciences"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>25}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>2, "United Kingdom"=>1, "France"=>1, "Germany"=>1, "Spain"=>2}, "group_count"=>3}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/609347"], "description"=>"<p>DNA extraction generated in the course of 12 distinct projects using specimens of the EPIC cohort.</p>", "links"=>[], "tags"=>["extraction", "generated", "12", "projects", "specimens", "epic"], "article_id"=>279744, "categories"=>["Immunology", "Biochemistry", "Biotechnology", "Biological Sciences", "Cell Biology", "Genetics"], "users"=>["Elodie Caboux", "Christophe Lallemand", "Gilles Ferro", "Bertrand Hémon", "Maimuna Mendy", "Carine Biessy", "Matt Sims", "Nick Wareham", "Abigail Britten", "Anne Boland", "Amy Hutchinson", "Afshan Siddiq", "Paolo Vineis", "Elio Riboli", "Isabelle Romieu", "Sabina Rinaldi", "Marc J. Gunter", "Petra H. M. Peeters", "Yvonne T. van der Schouw", "Ruth Travis", "H. Bas Bueno-de-Mesquita", "Federico Canzian", "María-José Sánchez", "Guri Skeie", "Karina Standahl Olsen", "Eiliv Lund", "Roberto Bilbao", "Núria Sala", "Aurelio Barricarte", "Domenico Palli", "Carmen Navarro", "Salvatore Panico", "Maria Luisa Redondo", "Silvia Polidoro", "Laure Dossus", "Marie Christine Boutron-Ruault", "Françoise Clavel-Chapelon", "Antonia Trichopoulou", "Dimitrios Trichopoulos", "Pagona Lagiou", "Heiner Boeing", "Eva Fisher", "Rosario Tumino", "Claudia Agnoli", "Pierre Hainaut"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0039821.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_DNA_extraction_generated_in_the_course_of_12_distinct_projects_using_specimens_of_the_EPIC_cohort_/279744", "title"=>"DNA extraction generated in the course of 12 distinct projects using specimens of the EPIC cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-13 02:42:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/609477"], "description"=>"c<p>The estimated coefficients for effect reflect the increasing (positive value) or decreasing (negative value) concentration response to the lifestyle/exposure factor, adjusted for the other lifestyle/exposure factors.</p>", "links"=>[], "tags"=>["characteristics", "variations", "dna"], "article_id"=>279872, "categories"=>["Immunology", "Biochemistry", "Biotechnology", "Biological Sciences", "Cell Biology", "Genetics"], "users"=>["Elodie Caboux", "Christophe Lallemand", "Gilles Ferro", "Bertrand Hémon", "Maimuna Mendy", "Carine Biessy", "Matt Sims", "Nick Wareham", "Abigail Britten", "Anne Boland", "Amy Hutchinson", "Afshan Siddiq", "Paolo Vineis", "Elio Riboli", "Isabelle Romieu", "Sabina Rinaldi", "Marc J. Gunter", "Petra H. M. Peeters", "Yvonne T. van der Schouw", "Ruth Travis", "H. Bas Bueno-de-Mesquita", "Federico Canzian", "María-José Sánchez", "Guri Skeie", "Karina Standahl Olsen", "Eiliv Lund", "Roberto Bilbao", "Núria Sala", "Aurelio Barricarte", "Domenico Palli", "Carmen Navarro", "Salvatore Panico", "Maria Luisa Redondo", "Silvia Polidoro", "Laure Dossus", "Marie Christine Boutron-Ruault", "Françoise Clavel-Chapelon", "Antonia Trichopoulou", "Dimitrios Trichopoulos", "Pagona Lagiou", "Heiner Boeing", "Eva Fisher", "Rosario Tumino", "Claudia Agnoli", "Pierre Hainaut"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0039821.t003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_individual_characteristics_and_processing_variations_on_DNA_yield_181_g_/279872", "title"=>"Effects of individual characteristics and processing variations on DNA yield (µg).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-13 02:44:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/609605"], "description"=>"a<p>First incident cancer case.</p>b<p>Last prevalent cancer case.</p>", "links"=>[], "tags"=>["epidemiological", "anthropometric", "factors", "dna"], "article_id"=>280008, "categories"=>["Immunology", "Biochemistry", "Biotechnology", "Biological Sciences", "Cell Biology", "Genetics"], "users"=>["Elodie Caboux", "Christophe Lallemand", "Gilles Ferro", "Bertrand Hémon", "Maimuna Mendy", "Carine Biessy", "Matt Sims", "Nick Wareham", "Abigail Britten", "Anne Boland", "Amy Hutchinson", "Afshan Siddiq", "Paolo Vineis", "Elio Riboli", "Isabelle Romieu", "Sabina Rinaldi", "Marc J. Gunter", "Petra H. M. Peeters", "Yvonne T. van der Schouw", "Ruth Travis", "H. Bas Bueno-de-Mesquita", "Federico Canzian", "María-José Sánchez", "Guri Skeie", "Karina Standahl Olsen", "Eiliv Lund", "Roberto Bilbao", "Núria Sala", "Aurelio Barricarte", "Domenico Palli", "Carmen Navarro", "Salvatore Panico", "Maria Luisa Redondo", "Silvia Polidoro", "Laure Dossus", "Marie Christine Boutron-Ruault", "Françoise Clavel-Chapelon", "Antonia Trichopoulou", "Dimitrios Trichopoulos", "Pagona Lagiou", "Heiner Boeing", "Eva Fisher", "Rosario Tumino", "Claudia Agnoli", "Pierre Hainaut"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0039821.t002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Technical_epidemiological_and_anthropometric_factors_analyzed_for_evaluation_of_DNA_yield_variations_/280008", "title"=>"Technical, epidemiological and anthropometric factors analyzed for evaluation of DNA yield variations.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-13 00:00:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/609151"], "description"=>"<p>Representation of DNA yield for DNA extractions performed from 2 buffy coat aliquots. Boxes extend from 25<sup>th</sup> to 75<sup>th</sup> percentiles and are divided by a solid line representing the median of each center. Whiskers extend from lower to upper adjacent values as defined by Tukey. Outliers are denoted by a dot.</p>", "links"=>[], "tags"=>["dna", "samples", "extracted", "aliquots", "buffy"], "article_id"=>279573, "categories"=>["Immunology", "Biochemistry", "Biotechnology", "Biological Sciences", "Cell Biology", "Genetics"], "users"=>["Elodie Caboux", "Christophe Lallemand", "Gilles Ferro", "Bertrand Hémon", "Maimuna Mendy", "Carine Biessy", "Matt Sims", "Nick Wareham", "Abigail Britten", "Anne Boland", "Amy Hutchinson", "Afshan Siddiq", "Paolo Vineis", "Elio Riboli", "Isabelle Romieu", "Sabina Rinaldi", "Marc J. Gunter", "Petra H. M. Peeters", "Yvonne T. van der Schouw", "Ruth Travis", "H. Bas Bueno-de-Mesquita", "Federico Canzian", "María-José Sánchez", "Guri Skeie", "Karina Standahl Olsen", "Eiliv Lund", "Roberto Bilbao", "Núria Sala", "Aurelio Barricarte", "Domenico Palli", "Carmen Navarro", "Salvatore Panico", "Maria Luisa Redondo", "Silvia Polidoro", "Laure Dossus", "Marie Christine Boutron-Ruault", "Françoise Clavel-Chapelon", "Antonia Trichopoulou", "Dimitrios Trichopoulos", "Pagona Lagiou", "Heiner Boeing", "Eva Fisher", "Rosario Tumino", "Claudia Agnoli", "Pierre Hainaut"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0039821.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_yield_181_g_for_DNA_samples_extracted_with_2_aliquots_of_buffy_coat_/279573", "title"=>"Distribution of yield (µg) for DNA samples extracted with 2 aliquots of buffy coat.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-13 02:39:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/609723"], "description"=>"<p>Qualification for different genotyping method.</p>", "links"=>[], "tags"=>["genotyping"], "article_id"=>280134, "categories"=>["Immunology", "Biochemistry", "Biotechnology", "Biological Sciences", "Cell Biology", "Genetics"], "users"=>["Elodie Caboux", "Christophe Lallemand", "Gilles Ferro", "Bertrand Hémon", "Maimuna Mendy", "Carine Biessy", "Matt Sims", "Nick Wareham", "Abigail Britten", "Anne Boland", "Amy Hutchinson", "Afshan Siddiq", "Paolo Vineis", "Elio Riboli", "Isabelle Romieu", "Sabina Rinaldi", "Marc J. Gunter", "Petra H. M. Peeters", "Yvonne T. van der Schouw", "Ruth Travis", "H. Bas Bueno-de-Mesquita", "Federico Canzian", "María-José Sánchez", "Guri Skeie", "Karina Standahl Olsen", "Eiliv Lund", "Roberto Bilbao", "Núria Sala", "Aurelio Barricarte", "Domenico Palli", "Carmen Navarro", "Salvatore Panico", "Maria Luisa Redondo", "Silvia Polidoro", "Laure Dossus", "Marie Christine Boutron-Ruault", "Françoise Clavel-Chapelon", "Antonia Trichopoulou", "Dimitrios Trichopoulos", "Pagona Lagiou", "Heiner Boeing", "Eva Fisher", "Rosario Tumino", "Claudia Agnoli", "Pierre Hainaut"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0039821.t005", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Qualification_for_different_genotyping_method_/280134", "title"=>"Qualification for different genotyping method.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-13 00:02:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/317814", "https://ndownloader.figshare.com/files/317918", "https://ndownloader.figshare.com/files/317963", "https://ndownloader.figshare.com/files/318025"], "description"=>"<div><p>The European Prospective Investigation into Cancer and nutrition (EPIC) is a long-term, multi-centric prospective study in Europe investigating the relationships between cancer and nutrition. This study has served as a basis for a number of Genome-Wide Association Studies (GWAS) and other types of genetic analyses. Over a period of 5 years, 52,256 EPIC DNA samples have been extracted using an automated DNA extraction platform. Here we have evaluated the pre-analytical factors affecting DNA yield, including anthropometric, epidemiological and technical factors such as center of subject recruitment, age, gender, body-mass index, disease case or control status, tobacco consumption, number of aliquots of buffy coat used for DNA extraction, extraction machine or procedure, DNA quantification method, degree of haemolysis and variations in the timing of sample processing. We show that the largest significant variations in DNA yield were observed with degree of haemolysis and with center of subject recruitment. Age, gender, body-mass index, cancer case or control status and tobacco consumption also significantly impacted DNA yield. Feedback from laboratories which have analyzed DNA with different SNP genotyping technologies demonstrate that the vast majority of samples (approximately 88%) performed adequately in different types of assays. To our knowledge this study is the largest to date to evaluate the sources of pre-analytical variations in DNA extracted from peripheral leucocytes. The results provide a strong evidence-based rationale for standardized recommendations on blood collection and processing protocols for large-scale genetic studies.</p> </div>", "links"=>[], "tags"=>["sources", "pre-analytical", "variations", "dna", "extracted", "samples", "epic"], "article_id"=>122722, "categories"=>["Immunology", "Biochemistry", "Biotechnology", "Biological Sciences", "Cell Biology", "Genetics"], "users"=>["Elodie Caboux", "Christophe Lallemand", "Gilles Ferro", "Bertrand Hémon", "Maimuna Mendy", "Carine Biessy", "Matt Sims", "Nick Wareham", "Abigail Britten", "Anne Boland", "Amy Hutchinson", "Afshan Siddiq", "Paolo Vineis", "Elio Riboli", "Isabelle Romieu", "Sabina Rinaldi", "Marc J. Gunter", "Petra H. M. Peeters", "Yvonne T. van der Schouw", "Ruth Travis", "H. Bas Bueno-de-Mesquita", "Federico Canzian", "María-José Sánchez", "Guri Skeie", "Karina Standahl Olsen", "Eiliv Lund", "Roberto Bilbao", "Núria Sala", "Aurelio Barricarte", "Domenico Palli", "Carmen Navarro", "Salvatore Panico", "Maria Luisa Redondo", "Silvia Polidoro", "Laure Dossus", "Marie Christine Boutron-Ruault", "Françoise Clavel-Chapelon", "Antonia Trichopoulou", "Dimitrios Trichopoulos", "Pagona Lagiou", "Heiner Boeing", "Eva Fisher", "Rosario Tumino", "Claudia Agnoli", "Pierre Hainaut"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0039821.s001", "https://dx.doi.org/10.1371/journal.pone.0039821.s002", "https://dx.doi.org/10.1371/journal.pone.0039821.s003", "https://dx.doi.org/10.1371/journal.pone.0039821.s004"], "stats"=>{"downloads"=>14, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Sources_of_Pre_Analytical_Variations_in_Yield_of_DNA_Extracted_from_Blood_Samples_Analysis_of_50_000_DNA_Samples_in_EPIC/122722", "title"=>"Sources of Pre-Analytical Variations in Yield of DNA Extracted from Blood Samples: Analysis of 50,000 DNA Samples in EPIC", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-07-13 00:45:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/609844"], "description"=>"d<p>Samples not having the required amount of DNA (with less than 10 µg of DNA) were sent to the laboratory.</p>", "links"=>[], "tags"=>["genotyping"], "article_id"=>280249, "categories"=>["Immunology", "Biochemistry", "Biotechnology", "Biological Sciences", "Cell Biology", "Genetics"], "users"=>["Elodie Caboux", "Christophe Lallemand", "Gilles Ferro", "Bertrand Hémon", "Maimuna Mendy", "Carine Biessy", "Matt Sims", "Nick Wareham", "Abigail Britten", "Anne Boland", "Amy Hutchinson", "Afshan Siddiq", "Paolo Vineis", "Elio Riboli", "Isabelle Romieu", "Sabina Rinaldi", "Marc J. Gunter", "Petra H. M. Peeters", "Yvonne T. van der Schouw", "Ruth Travis", "H. Bas Bueno-de-Mesquita", "Federico Canzian", "María-José Sánchez", "Guri Skeie", "Karina Standahl Olsen", "Eiliv Lund", "Roberto Bilbao", "Núria Sala", "Aurelio Barricarte", "Domenico Palli", "Carmen Navarro", "Salvatore Panico", "Maria Luisa Redondo", "Silvia Polidoro", "Laure Dossus", "Marie Christine Boutron-Ruault", "Françoise Clavel-Chapelon", "Antonia Trichopoulou", "Dimitrios Trichopoulos", "Pagona Lagiou", "Heiner Boeing", "Eva Fisher", "Rosario Tumino", "Claudia Agnoli", "Pierre Hainaut"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0039821.t004", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Inclusion_criteria_for_genotyping_projects_/280249", "title"=>"Inclusion criteria for genotyping projects.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-13 00:04:09"}

PMC Usage Stats | Further Information

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Relative Metric

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