High Phobic Anxiety Is Related to Lower Leukocyte Telomere Length in Women
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{"title"=>"High phobic anxiety is related to lower leukocyte Telomere length in women", "type"=>"journal", "authors"=>[{"first_name"=>"Olivia I.", "last_name"=>"Okereke", "scopus_author_id"=>"8613630300"}, {"first_name"=>"Jennifer", "last_name"=>"Prescott", "scopus_author_id"=>"9843290100"}, {"first_name"=>"Jason Y.Y.", "last_name"=>"Wong", "scopus_author_id"=>"19336599300"}, {"first_name"=>"Jiali", "last_name"=>"Han", "scopus_author_id"=>"7406442327"}, {"first_name"=>"Kathryn M.", "last_name"=>"Rexrode", "scopus_author_id"=>"7003464052"}, {"first_name"=>"Immaculata", "last_name"=>"de Vivo", "scopus_author_id"=>"7003341293"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"365242159", "doi"=>"10.1371/journal.pone.0040516", "sgr"=>"84863814764", "scopus"=>"2-s2.0-84863814764", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"22808180"}, "id"=>"48458467-3131-3817-9b65-5b0ab54c4d42", "abstract"=>"BACKGROUND: Chronic psychological distress has been linked to shorter telomeres, an indication of accelerated aging. Yet, little is known about relations of anxiety to telomeres. We examined whether a typically chronic form of anxiety--phobic anxiety--is related to telomere length. METHODOLOGY/PRINCIPAL FINDINGS: Relative telomere lengths (RTLs) in peripheral blood leukocytes were measured by quantitative real-time polymerase chain reaction among 5,243 women (aged 42-69 years) who: were participants in the Nurses' Health Study; were controls in prior case-control studies of telomeres and disease, or randomly selected healthy participants in a cognitive function sub-study; had completed the Crown-Crisp phobic index proximal to blood collection. Adjusted least-squares mean RTLs (z-scores) were calculated across phobic categories. Higher phobic anxiety was generally associated with lower RTLs (age-adjusted p-trend = 0.09); this association was similar after adjustment for confounders--paternal age-at-birth, smoking, body mass index (BMI) and physical activity (p-trend = 0.15). Notably, a threshold was identified. Among women with Crown-Crisp<6 points, the multivariable-adjusted least-squares mean RTL z-score = 0.02 standard units; however, among the most phobic women (Crown-Crisp >/= 6), the multivariable-adjusted least-squares mean RTL z-score = -0.09 standard units (mean difference = -0.10 standard units; p = 0.02). The magnitude of this difference was comparable to that for women 6 years apart in age. Finally, effect modification by BMI, smoking and paternal age was observed: associations were stronger among highly phobic women with BMI >/= 25 kg/m(2), without smoking history, or born to fathers aged >/= 40 years. CONCLUSIONS/SIGNIFICANCE: In this large, cross-sectional study high phobic anxiety was associated with shorter telomeres. These results point toward prospective investigations relating anxiety to telomere length change", "link"=>"http://www.mendeley.com/research/high-phobic-anxiety-related-lower-leukocyte-telomere-length-women", "reader_count"=>39, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>4, "Student > Master"=>6, "Other"=>4, "Student > Bachelor"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>4, "Student > Master"=>6, "Other"=>4, "Student > Bachelor"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>10, "Neuroscience"=>2, "Sports and Recreations"=>1, "Psychology"=>8, "Social Sciences"=>3, "Mathematics"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>2}, "Social Sciences"=>{"Social Sciences"=>3}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>8}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>6}}, "reader_count_by_country"=>{"United States"=>1, "Ireland"=>1}, "group_count"=>3}

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  • {"files"=>["https://ndownloader.figshare.com/files/611150"], "description"=>"<p>*, Models were adjusted for age in years (continuous), pack-years of smoking (0, >0 to <20, 20 to <40, ≥40), body mass index (continuous, kg/m<sup>2</sup>) and physical activity (continuous, MET-hrs/wk). Least squares means and 95% confidence intervals are shown. N = 281 excluded due to missing paternal age. <sup>‡</sup>, P-value for test of difference in least-squares means.</p>", "links"=>[], "tags"=>["least-squares", "telomere", "phobic", "stratified", "paternal"], "article_id"=>281632, "categories"=>["Mental Health", "Cell Biology", "Genetics"], "users"=>["Olivia I. Okereke", "Jennifer Prescott", "Jason Y. Y. Wong", "Jiali Han", "Kathryn M. Rexrode", "Immaculata De Vivo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040516.g003", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Adjusted_least_squares_mean_telomere_length_z_scores_by_phobic_anxiety_level_stratified_by_paternal_age_/281632", "title"=>"Adjusted* least-squares mean telomere length <i>z</i>-scores, by phobic anxiety level, stratified by paternal age (<40 or ≥40 years).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-11 00:27:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/611283"], "description"=>"*<p>Due to rounding, percentages may not sum to 100.0.</p>†<p>Combined alpha-linolenic acid and long-chain omega-3 fatty acids (docosahexaenoic and eicosapentaenoic acids).</p>", "links"=>[], "tags"=>["phobic", "categories"], "article_id"=>281772, "categories"=>["Mental Health", "Cell Biology", "Genetics"], "users"=>["Olivia I. Okereke", "Jennifer Prescott", "Jason Y. Y. Wong", "Jiali Han", "Kathryn M. Rexrode", "Immaculata De Vivo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040516.t001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_by_phobic_anxiety_categories_lowest_to_highest_at_blood_draw_n_5_243_/281772", "title"=>"Characteristics by phobic anxiety categories (lowest to highest) at blood draw (n = 5,243)<sup>*</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-11 00:29:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/611376"], "description"=>"*<p>Adjusted for age in years (continuous), paternal age-at-birth (15–24, 25–29, 30–34, 35–39, ≥40 years), pack-years of smoking (0, 0< to <20, 20 to <40, 40+), physical activity (continuous, MET-hrs/wk), body mass index (continuous, kg/m<sup>2</sup>).</p>†<p>Adjusted for model I variables, plus chronic medical conditions/potential intermediates: hypertension (yes/no), dyslipidemia (yes/no), diabetes (yes/no), cardiovascular disease (yes/no).</p>‡<p>P-value for test of difference in least-squares means.</p>", "links"=>[], "tags"=>["leukocyte", "telomere", "z-scores", "phobic"], "article_id"=>281858, "categories"=>["Mental Health", "Cell Biology", "Genetics"], "users"=>["Olivia I. Okereke", "Jennifer Prescott", "Jason Y. Y. Wong", "Jiali Han", "Kathryn M. Rexrode", "Immaculata De Vivo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040516.t003", "stats"=>{"downloads"=>3, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Least_squares_mean_leukocyte_telomere_length_z_scores_standard_errors_by_high_phobic_anxiety_/281858", "title"=>"Least-squares mean leukocyte telomere length z-scores (standard errors), by high phobic anxiety.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-11 00:30:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/610876"], "description"=>"<p>*, Models were adjusted for age in years (continuous), paternal age-at-birth (15–24, 25–29, 30–34, 35–39, ≥40 years), pack-years of smoking (0, >0 to <20, 20 to <40, ≥40), and physical activity (continuous, MET-hrs/wk). Least squares means and 95% confidence intervals are shown. N = 9 excluded due to missing body mass index. <sup>‡</sup>, P-value for test of difference in least-squares means.</p>", "links"=>[], "tags"=>["least-squares", "leukocyte", "telomere", "phobic", "stratified"], "article_id"=>281360, "categories"=>["Mental Health", "Cell Biology", "Genetics"], "users"=>["Olivia I. Okereke", "Jennifer Prescott", "Jason Y. Y. Wong", "Jiali Han", "Kathryn M. Rexrode", "Immaculata De Vivo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040516.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Adjusted_least_squares_mean_leukocyte_telomere_length_z_scores_by_phobic_anxiety_level_stratified_by_body_mass_index_2_or_8805_25_kg_m_2_/281360", "title"=>"Adjusted* least-squares mean leukocyte telomere length <i>z</i>-scores, by phobic anxiety level, stratified by body mass index (<25 kg/m<sup>2</sup> or ≥25 kg/m<sup>2</sup>).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-11 00:22:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/318889"], "description"=>"<div><h3>Background</h3><p>Chronic psychological distress has been linked to shorter telomeres, an indication of accelerated aging. Yet, little is known about relations of anxiety to telomeres. We examined whether a typically chronic form of anxiety – phobic anxiety – is related to telomere length.</p> <h3>Methodology/Principal Findings</h3><p>Relative telomere lengths (RTLs) in peripheral blood leukocytes were measured by quantitative real-time polymerase chain reaction among 5,243 women (aged 42–69 years) who: were participants in the Nurses' Health Study; were controls in prior case-control studies of telomeres and disease, or randomly selected healthy participants in a cognitive function sub-study; had completed the Crown-Crisp phobic index proximal to blood collection. Adjusted least-squares mean RTLs (<em>z</em>-scores) were calculated across phobic categories. Higher phobic anxiety was generally associated with lower RTLs (age-adjusted p-trend = 0.09); this association was similar after adjustment for confounders – paternal age-at-birth, smoking, body mass index (BMI) and physical activity (p-trend = 0.15). Notably, a threshold was identified. Among women with Crown-Crisp<6 points, the multivariable-adjusted least-squares mean RTL <em>z</em>-score = 0.02 standard units; however, among the most phobic women (Crown-Crisp≥6), the multivariable-adjusted least-squares mean RTL <em>z</em>-score = −0.09 standard units (mean difference = −0.10 standard units; p = 0.02). The magnitude of this difference was comparable to that for women 6 years apart in age. Finally, effect modification by BMI, smoking and paternal age was observed: associations were stronger among highly phobic women with BMI≥25 kg/m<sup>2</sup>, without smoking history, or born to fathers aged ≥40 years.</p> <h3>Conclusions/Significance</h3><p>In this large, cross-sectional study high phobic anxiety was associated with shorter telomeres. These results point toward prospective investigations relating anxiety to telomere length change.</p> </div>", "links"=>[], "tags"=>["phobic", "leukocyte", "telomere", "women"], "article_id"=>122937, "categories"=>["Mental Health", "Cell Biology", "Genetics"], "users"=>["Olivia I. Okereke", "Jennifer Prescott", "Jason Y. Y. Wong", "Jiali Han", "Kathryn M. Rexrode", "Immaculata De Vivo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040516", "stats"=>{"downloads"=>2, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/High_Phobic_Anxiety_Is_Related_to_Lower_Leukocyte_Telomere_Length_in_Women/122937", "title"=>"High Phobic Anxiety Is Related to Lower Leukocyte Telomere Length in Women", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-11 00:48:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/611333"], "description"=>"*<p>Adjusted for age in years (continuous), paternal age-at-birth (15–24, 25–29, 30–34, 35–39, ≥40 years), pack-years of smoking (0, 0< to <20, 20 to <40, 40+), physical activity (continuous, MET-hrs/wk), body mass index (continuous, kg/m<sup>2</sup>).</p>†<p>Adjusted for model I variables, plus chronic medical conditions/potential intermediates: hypertension (yes/no), dyslipidemia (yes/no), diabetes (yes/no), cardiovascular disease (yes/no).</p>", "links"=>[], "tags"=>["leukocyte", "telomere", "z-scores", "phobic"], "article_id"=>281811, "categories"=>["Mental Health", "Cell Biology", "Genetics"], "users"=>["Olivia I. Okereke", "Jennifer Prescott", "Jason Y. Y. Wong", "Jiali Han", "Kathryn M. Rexrode", "Immaculata De Vivo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040516.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Least_squares_mean_leukocyte_telomere_length_z_scores_standard_errors_by_phobic_anxiety_categories_/281811", "title"=>"Least-squares mean leukocyte telomere length z-scores (standard errors), by phobic anxiety categories.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-11 00:30:11"}

PMC Usage Stats | Further Information

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Relative Metric

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