Morphological Alterations in Newly Born Dentate Gyrus Granule Cells That Emerge after Status Epilepticus Contribute to Make Them Less Excitable
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{"title"=>"Morphological alterations in newly born dentate gyrus granule cells that emerge after status epilepticus contribute to make them less excitable", "type"=>"journal", "authors"=>[{"first_name"=>"Julián", "last_name"=>"Tejada", "scopus_author_id"=>"7005407195"}, {"first_name"=>"Gabriel M.", "last_name"=>"Arisi", "scopus_author_id"=>"8525718900"}, {"first_name"=>"Norberto", "last_name"=>"García-Cairasco", "scopus_author_id"=>"7003476789"}, {"first_name"=>"Antonio C.", "last_name"=>"Roque", "scopus_author_id"=>"35614678100"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"365242126", "doi"=>"10.1371/journal.pone.0040726", "sgr"=>"84863852556", "scopus"=>"2-s2.0-84863852556", "isbn"=>"1932-6203", "pmid"=>"22811762"}, "id"=>"9cdd689c-5e9c-3641-80b3-417d6ac5cb83", "abstract"=>"Computer simulations of external current stimulations of dentate gyrus granule cells of rats with Status Epilepticus induced by pilocarpine and control rats were used to evaluate whether morphological differences alone between these cells have an impact on their electrophysiological behavior. The cell models were constructed using morphological information from tridimensional reconstructions with Neurolucida software. To evaluate the effect of morphology differences alone, ion channel conductances, densities and distributions over the dendritic trees of dentate gyrus granule cells were the same for all models. External simulated currents were injected in randomly chosen dendrites belonging to one of three different areas of dentate gyrus granule cell molecular layer: inner molecular layer, medial molecular layer and outer molecular layer. Somatic membrane potentials were recorded to determine firing frequencies and inter-spike intervals. The results show that morphologically altered granule cells from pilocarpine-induced epileptic rats are less excitable than control cells, especially when they are stimulated in the inner molecular layer, which is the target area for mossy fibers that sprout after pilocarpine-induced cell degeneration. This suggests that morphological alterations may act as a protective mechanism to allow dentate gyrus granule cells to cope with the increase of stimulation caused by mossy fiber sprouting.", "link"=>"http://www.mendeley.com/research/morphological-alterations-newly-born-dentate-gyrus-granule-cells-emerge-after-status-epilepticus-con", "reader_count"=>30, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>4}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>4}, "reader_count_by_subject_area"=>{"Environmental Science"=>1, "Agricultural and Biological Sciences"=>17, "Medicine and Dentistry"=>5, "Neuroscience"=>4, "Physics and Astronomy"=>1, "Chemistry"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>4}, "Chemistry"=>{"Chemistry"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>17}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Greece"=>1, "Brazil"=>1, "United Kingdom"=>1, "Germany"=>3}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/611770"], "description"=>"<p>Values given are averages ± standard errors. The asterisk represents significant difference (<i>p</i> < 0.05).</p>", "links"=>[], "tags"=>["dendritic", "morphology", "quantified", "l-measure", "belonging", "oml", "pilo"], "article_id"=>282253, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Julián Tejada", "Gabriel M. Arisi", "Norberto Garcia-Cairasco", "Antonio C. Roque"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040726.t002", "stats"=>{"downloads"=>0, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Some_features_of_dendritic_morphology_quantified_using_L_Measure_38_belonging_to_the_OML_control_and_PILO_cells_/282253", "title"=>"Some features of dendritic morphology quantified using L-Measure [38] belonging to the OML control and PILO cells.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 02:43:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/611515"], "description"=>"<p><b>A</b>. Tridimensional reconstruction of an example of cell from our sample (n20-cont02-sl1 cell from the neuromorpho database <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040726#pone.0040726-Arisi1\" target=\"_blank\">[6]</a> showing how the two distances (d1 and d2) used to determine the distribution of biophysical mechanisms were chosen. In the figure the two distances calculated for a dendrite are represented by an orange line. <b>B</b>. Example of classification of one dendrite of the n20-cont02-sl1 cell using the two distances criteria. The dendrite represented in red was classified as a medial dendrite (MD) when using the distance 1 criterion, and as a distal dendrite (DD) when the distance 2 criterion was used. <b>C</b>. Example of utilization of the pruning-shrinking criteria to classify dendrites of the n20-cont02-sl1 and n38-r06-09-sl4 models. The horizontal lines represent the tripartite division of the average maximum values of a given distance measure for the pruned (pink area) and shrank models (orange area). Dendrites of the PILO cell that are classified as DD using the pruning and the shrinking criteria are within the pink and the orange areas respectively. Notice that with the shrinking criterion (orange area) there are more dendrites classified as DD. <b>D</b>. Schematic reconstruction of the n20-cont02-sl1 Control-GC and n38-r06-09-sl4 PILO-GC models in a general localization in the dentate granule cell layer. Laminar distributions of different afferents are shown using arrows. In the figure is shown an example of a set of five electrodes connected to five dendrites belonging to the MML, which simulate the medial entorhinal afferents. <b>E</b>. Configurations of electrode sets used to stimulate the cells. Each cell was stimulated with electrodes connected randomly to one up to five dendrites in each sublayer of the molecular layer. The figure shows an example of the stimulation protocol for current injection in sublayer MML of the Control-GC n16-cont02-sl3 model. The circle size represents the intensity of the injected current (the total intensity was the same for all 5 cases).</p>", "links"=>[], "tags"=>["procedures", "computational"], "article_id"=>282011, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Julián Tejada", "Gabriel M. Arisi", "Norberto Garcia-Cairasco", "Antonio C. Roque"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040726.g004", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Graphical_representation_of_the_procedures_used_to_build_and_stimulate_the_computational_models_/282011", "title"=>"Graphical representation of the procedures used to build and stimulate the computational models.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:42:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/611686"], "description"=>"<p>Values given are averages ± standard errors. The asterisk represents significant difference (<i>p</i> < 0.05).</p>", "links"=>[], "tags"=>["dendritic", "morphology", "quantified", "l-measure", "belonging", "iml", "pilo"], "article_id"=>282156, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Julián Tejada", "Gabriel M. Arisi", "Norberto Garcia-Cairasco", "Antonio C. Roque"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040726.t001", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Some_features_of_dendritic_morphology_quantified_using_L_Measure_38_belonging_to_the_IML_of_control_and_PILO_cells_/282156", "title"=>"Some features of dendritic morphology quantified using L-Measure [38] belonging to the IML of control and PILO cells.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 02:43:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/611027"], "description"=>"<p><b>A</b>. Firing traces for pruned-distance 1 cell models stimulated with three electrodes in the MML. The green curve is for the Control-GC n09-cont02-sl2 and the orange curve is for the PILO-GC n33-r05-01-s14 model. <b>B</b>. Firing traces for the same cell models as in A with the same stimulation protocol but built using the pruned-distance 2 criterion. <b>C</b>. Average input resistance for pruned-distance 1 and distance 2 cell models. <b>D</b>. Average input resistance for shrank-distance 1 and distance 2 cell models. Error bars represent standard error.</p>", "links"=>[], "tags"=>["firing", "traces", "pilo", "cells"], "article_id"=>281506, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Julián Tejada", "Gabriel M. Arisi", "Norberto Garcia-Cairasco", "Antonio C. Roque"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040726.g001", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_firing_traces_of_the_control_and_PILO_model_cells_and_input_resistance_values_measured_in_the_simulations_/281506", "title"=>"Representative firing traces of the control and PILO model cells and input resistance values measured in the simulations.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:39:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/611154"], "description"=>"<p><b>A</b>. F–I curves for pruned-distance 1 cell models stimulated with three electrodes in the MML. The error bars represent standard error. <b>B</b>. F–I curves for pruned-distance 2 cell models stimulated with three electrodes in the MML. Asterisks represent significant differences between Control-GC and PILO-GC models. Error bars represent standard error. <b>C</b>. Number of significant differences between the F–I curves of pruned-distance 1 Control-GC and PILO-GC models for each region of stimulation (IML, MML and OML) and for each number of electrodes (1e = one electrode, 2e = two electrodes, and so on). <b>D</b>. Number of significant differences between the F–I curves of pruned-distance 2 Control-GC and PILO-GC models for each region of stimulation (IML, MML and OML) and for each number of electrodes (1e = one electrode, 2e = two electrodes, and so on). <b>E</b>. Average inter-spike interval for pruned-distance 1 cell models estimated for each region of stimulation (IML, MML and OML) and for each number of electrodes (1e = one electrode, 2e = two electrodes, and so on). <b>F</b>. Average inter-spike interval for pruned-distance 2 cell models estimated for each region of stimulation (IML, MML and OML) and for each number of electrodes (1e = one electrode, 2e = two electrodes, and so on).</p>", "links"=>[], "tags"=>["displayed", "pruned"], "article_id"=>281648, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Julián Tejada", "Gabriel M. Arisi", "Norberto Garcia-Cairasco", "Antonio C. Roque"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040726.g002", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_with_the_main_results_displayed_by_the_pruned_models_/281648", "title"=>"Summary with the main results displayed by the pruned models.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:40:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/611310"], "description"=>"<p><b>A</b>. F–I curves for shrank-distance 1 cell models stimulated with three electrodes in the MML. The error bars represent standard error. <b>B</b>. F–I curves for shrank-distance 2 cell models stimulated with three electrodes in the MML. Asterisks represent significant differences between Control-GC and PILO-GC models. Error bars represent standard error. <b>C</b>. Number of significant differences between the F–I curves of shrank-distance 1 Control-GC and PILO-GC models for each region of stimulation (IML, MML and OML) and for each number of electrodes (1e = one electrode, 2e = two electrodes, and so on). <b>D</b>. Number of significant differences between the F–I curves of shrank-distance 2 Control-GC and PILO-GC models for each region of stimulation (IML, MML and OML) and for each number of electrodes (1e = one electrode, 2e = two electrodes, and so on). <b>E</b>. Average inter-spike interval for shrank-distance 1 cell models estimated for each region of stimulation (IML, MML and OML) and for each number of electrodes (1e = one electrode, 2e = two electrodes, and so on). <b>F</b>. Average inter-spike interval for shrank-distance 2 cell models estimated for each region of stimulation (IML, MML and OML) and for each number of electrodes (1e = one electrode, 2e = two electrodes, and so on).</p>", "links"=>[], "tags"=>["displayed", "shrank"], "article_id"=>281802, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Julián Tejada", "Gabriel M. Arisi", "Norberto Garcia-Cairasco", "Antonio C. Roque"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040726.g003", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_with_the_main_results_displayed_by_the_shrank_models_/281802", "title"=>"Summary with the main results displayed by the shrank models.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:41:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/611722"], "description"=>"*<p>The reversal potential of the calcium conductances, E<sub>ca</sub>, was calculated at each simulation time step following the rate of change of the intracellular calcium concentration with a calcium removal rate of τ = 9 ms, and [Ca<sup>2+</sup>]<sub>0</sub> = 70 was the resting calcium concentration <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040726#pone.0040726-Aradi1\" target=\"_blank\">[18]</a>.</p>", "links"=>[], "tags"=>["membrane", "ionic", "reversal", "potentials", "channels", "neuron", "models"], "article_id"=>282207, "categories"=>["Biological Sciences", "Neuroscience"], "users"=>["Julián Tejada", "Gabriel M. Arisi", "Norberto Garcia-Cairasco", "Antonio C. Roque"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040726.t003", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Passive_membrane_parameters_maximum_ionic_conductances_and_reversal_potentials_of_the_channels_used_in_the_neuron_models_units_are_given_within_brackets_/282207", "title"=>"Passive membrane parameters, maximum ionic conductances, and reversal potentials of the channels used in the neuron models (units are given within brackets).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 02:43:43"}

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Relative Metric

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