Microarray Analysis of Rat Sensory Ganglia after Local Inflammation Implicates Novel Cytokines in Pain
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{"title"=>"Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain", "type"=>"journal", "authors"=>[{"first_name"=>"Judith A.", "last_name"=>"Strong", "scopus_author_id"=>"7203075360"}, {"first_name"=>"Wenrui", "last_name"=>"Xie", "scopus_author_id"=>"8572607300"}, {"first_name"=>"Dennis E.", "last_name"=>"Coyle", "scopus_author_id"=>"7102318843"}, {"first_name"=>"Jun Ming", "last_name"=>"Zhang", "scopus_author_id"=>"57173418100"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"365274139", "issn"=>"19326203", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0040779", "scopus"=>"2-s2.0-84864011434", "pmid"=>"22815815", "sgr"=>"84864011434"}, "id"=>"6b149f97-8319-32c3-8308-5615c2127a4b", "abstract"=>"Inflammation plays a role in neuropathic pain conditions as well as in pain induced solely by an inflammatory stimulus. Robust mechanical hyperalgesia and allodynia can be induced by locally inflaming the L5 dorsal root ganglion (DRG) in rat. This model allows investigation of the contribution of inflammation per se to chronic pain conditions. Most previous microarray studies of DRG gene expression have investigated neuropathic pain models. To examine the role of inflammation, we used microarray methods to examine gene expression 3 days after local inflammation of the L5 DRG in rat. We observed significant regulation in a large number of genes (23% of observed transcripts), and examined 221 (3%) with a fold-change of 1.5-fold or more in more detail. Immune-related genes were the largest category in this group and included members of the complement system as well as several pro-inflammatory cytokines. However, these upregulated cytokines had no prior links to peripheral pain in the literature other than through microarray studies, though most had previously described roles in CNS (especially neuroinflammatory conditions) as well as in immune responses. To confirm an association to pain, qPCR studies examined these cytokines at a later time (day 14), as well as in two different versions of the spinal nerve ligation pain model including a version without any foreign immunogenic material (suture). Cxcl11, Cxcl13, and Cxcl14 were found to be significantly upregulated in all these conditions, while Cxcl9, Cxcl10, and Cxcl16 were upregulated in at least two of these conditions.", "link"=>"http://www.mendeley.com/research/microarray-analysis-rat-sensory-ganglia-after-local-inflammation-implicates-novel-cytokines-pain", "reader_count"=>36, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>11, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>11, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>12, "Medicine and Dentistry"=>14, "Neuroscience"=>3, "Computer Science"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Neuroscience"=>{"Neuroscience"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>12}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Germany"=>1}, "group_count"=>2}

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  • {"files"=>["https://ndownloader.figshare.com/files/609193"], "description"=>"<p>GO processes.</p>", "links"=>[], "tags"=>["immunology", "Computational biology", "neuroscience"], "article_id"=>279682, "categories"=>["Biological Sciences", "Neuroscience", "Immunology"], "users"=>["Judith A. Strong", "Wenrui Xie", "Dennis E. Coyle", "Jun-Ming Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040779.t003", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GO_processes_/279682", "title"=>"GO processes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-16 02:41:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/608677"], "description"=>"<p>All cytokines shown were significantly upregulated by microarray measurement (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040779#pone-0040779-t001\" target=\"_blank\">Table 1</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040779#pone-0040779-t002\" target=\"_blank\">2</a>). The fold change (compared to normal DRG) for each cytokine was measured with qPRC methods in samples taken from DRG 3 days after DRG inflammation (“LID POD3”), 14 days after DRG inflammation (“LID POD 14″), 3 days after conventional spinal nerve ligation (“SNL POD 3″) or 3 days after modified spinal nerve ligation in which no suture was used (“mSNL POD 3″). *, significant upregulation compared to normal DRG. #, significant downregulation compared to normal DRG (note change of scale for Cxcl16 data). The number of symbols indicates the level of significance (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040779#s4\" target=\"_blank\">Methods</a>). n.s., upregulation not significant.</p>", "links"=>[], "tags"=>["cytokines"], "article_id"=>279171, "categories"=>["Biological Sciences", "Neuroscience", "Immunology"], "users"=>["Judith A. Strong", "Wenrui Xie", "Dennis E. Coyle", "Jun-Ming Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040779.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Upregulation_of_selected_cytokines_in_different_pain_models_/279171", "title"=>"Upregulation of selected cytokines in different pain models.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-16 02:32:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/317752", "https://ndownloader.figshare.com/files/317773", "https://ndownloader.figshare.com/files/317832"], "description"=>"<div><p>Inflammation plays a role in neuropathic pain conditions as well as in pain induced solely by an inflammatory stimulus. Robust mechanical hyperalgesia and allodynia can be induced by locally inflaming the L5 dorsal root ganglion (DRG) in rat. This model allows investigation of the contribution of inflammation <em>per se</em> to chronic pain conditions. Most previous microarray studies of DRG gene expression have investigated neuropathic pain models. To examine the role of inflammation, we used microarray methods to examine gene expression 3 days after local inflammation of the L5 DRG in rat. We observed significant regulation in a large number of genes (23% of observed transcripts), and examined 221 (3%) with a fold-change of 1.5-fold or more in more detail. Immune-related genes were the largest category in this group and included members of the complement system as well as several pro-inflammatory cytokines. However, these upregulated cytokines had no prior links to peripheral pain in the literature other than through microarray studies, though most had previously described roles in CNS (especially neuroinflammatory conditions) as well as in immune responses. To confirm an association to pain, qPCR studies examined these cytokines at a later time (day 14), as well as in two different versions of the spinal nerve ligation pain model including a version without any foreign immunogenic material (suture). Cxcl11, Cxcl13, and Cxcl14 were found to be significantly upregulated in all these conditions, while Cxcl9, Cxcl10, and Cxcl16 were upregulated in at least two of these conditions.</p> </div>", "links"=>[], "tags"=>["microarray", "sensory", "ganglia", "inflammation", "implicates", "cytokines"], "article_id"=>122727, "categories"=>["Biological Sciences", "Neuroscience", "Immunology"], "users"=>["Judith A. Strong", "Wenrui Xie", "Dennis E. Coyle", "Jun-Ming Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0040779.s001", "https://dx.doi.org/10.1371/journal.pone.0040779.s002", "https://dx.doi.org/10.1371/journal.pone.0040779.s003"], "stats"=>{"downloads"=>19, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Microarray_Analysis_of_Rat_Sensory_Ganglia_after_Local_Inflammation_Implicates_Novel_Cytokines_in_Pain/122727", "title"=>"Microarray Analysis of Rat Sensory Ganglia after Local Inflammation Implicates Novel Cytokines in Pain", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-07-16 00:45:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/609168"], "description"=>"<p>Negative values for fold change indicate downregulation. Data taken from microarray data.</p>", "links"=>[], "tags"=>["immunology", "Computational biology", "neuroscience"], "article_id"=>279659, "categories"=>["Biological Sciences", "Neuroscience", "Immunology"], "users"=>["Judith A. Strong", "Wenrui Xie", "Dennis E. Coyle", "Jun-Ming Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040779.t001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regulation_of_selected_cytokines_/279659", "title"=>"Regulation of selected cytokines.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-16 02:40:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/609021"], "description"=>"<p>Top panel, in normal DRG; bottom panel, 3 days after DRG inflammation.</p>", "links"=>[], "tags"=>["cxcl14", "staining", "drg"], "article_id"=>279515, "categories"=>["Biological Sciences", "Neuroscience", "Immunology"], "users"=>["Judith A. Strong", "Wenrui Xie", "Dennis E. Coyle", "Jun-Ming Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040779.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Examples_of_Cxcl14_staining_red_in_DRG_sections_/279515", "title"=>"Examples of Cxcl14 staining (red) in DRG sections.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-16 02:38:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/608492"], "description"=>"<p>Data are based on gene-level analysis of core transcripts using GeneSpring 11.5 software as described in the text. “Up”, “down”, transcripts with higher expression in inflamed DRG (POD3) vs. control DRG, respectively.</p>", "links"=>[], "tags"=>["diagram", "genes", "transcript", "microarray"], "article_id"=>278991, "categories"=>["Biological Sciences", "Neuroscience", "Immunology"], "users"=>["Judith A. Strong", "Wenrui Xie", "Dennis E. Coyle", "Jun-Ming Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040779.g001", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Venn_diagram_summary_of_regulation_of_genes_in_the_8220_core_8221_transcript_set_via_microarray_analysis_/278991", "title"=>"Venn diagram summary of regulation of genes in the “core” transcript set via microarray analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-16 02:29:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/609138"], "description"=>"<p>\n <b>Abbreviations:</b></p><p>Affy, Affymetrix. SNL, spinal nerve ligation of L5 or L5+ L6. SNI, spared nerve injury. CCI, chronic constriction injury. CFA, injection of Complete Freund’s Adjuvant into the paw. CSNT, complete sciatic nerve transection.</p><p>Notes</p>1<p>Comparison was to laser capture microdissection data from large and small neurons combined.</p>2<p>Retrovirus model data from this study was not used.</p>3<p>Data from L4 (non ligated) and L5 (ligated) DRG were combined.</p>4<p>The complete list of regulated genes was kindly provided by Dr. F. Amy Zou.</p>5<p>This study did not examine pain behaviors per se.</p>", "links"=>[], "tags"=>["drg", "microarray"], "article_id"=>279636, "categories"=>["Biological Sciences", "Neuroscience", "Immunology"], "users"=>["Judith A. Strong", "Wenrui Xie", "Dennis E. Coyle", "Jun-Ming Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040779.t004", "stats"=>{"downloads"=>3, "page_views"=>29, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_to_other_DRG_microarray_studies_/279636", "title"=>"Comparison to other DRG microarray studies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-16 02:40:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/609212"], "description"=>"*<p>appeared in meta-analysis list in LaCroix-Fralish et al. 2011, regulated in multiple microarray studies.</p>", "links"=>[], "tags"=>["upregulated"], "article_id"=>279707, "categories"=>["Biological Sciences", "Neuroscience", "Immunology"], "users"=>["Judith A. Strong", "Wenrui Xie", "Dennis E. Coyle", "Jun-Ming Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040779.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Selected_upregulated_genes_/279707", "title"=>"Selected upregulated genes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-16 02:41:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/608758"], "description"=>"<p>Top: mechanical sensitivity as measured by von Frey test. Baseline (plotted on POD 0) is the average of 2 measurements taken in the days before the surgery. *, significantly different from baseline (Kruskal-Wallis test with Dunn’s multiple comparison). Bottom: percent of animals responding to the cotton wisp test of mechanical allodynia. No responses were seen at baseline or on POD 1. N = 6 animals, the same animals were used to obtain the DRGs used in the qPCR experiments shown in Fig. 2 “mSNL POD3”.</p>", "links"=>[], "tags"=>["behaviors", "induced", "modified", "snl"], "article_id"=>279255, "categories"=>["Biological Sciences", "Neuroscience", "Immunology"], "users"=>["Judith A. Strong", "Wenrui Xie", "Dennis E. Coyle", "Jun-Ming Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040779.g003", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pain_behaviors_induced_by_modified_SNL_model_/279255", "title"=>"Pain behaviors induced by modified SNL model.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-16 02:34:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/608861"], "description"=>"<p>Top: mechanical sensitivity as measured by von Frey test. Baseline (plotted on POD 0) is the average of 2 measurements taken in the days before the surgery. *, significantly different from baseline (Kruskal-Wallis test with Dunn’s multiple comparison). Bottom: percent of animals responding to the cotton wisp test of mechanical allodynia. No responses were seen at baseline. N = 6 animals, the same animals were used to obtain the DRGs used in the qPCR experiments shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0040779#pone-0040779-g002\" target=\"_blank\">Fig. 2</a> “LID POD14”).</p>", "links"=>[], "tags"=>["behaviors", "observed", "14", "days"], "article_id"=>279355, "categories"=>["Biological Sciences", "Neuroscience", "Immunology"], "users"=>["Judith A. Strong", "Wenrui Xie", "Dennis E. Coyle", "Jun-Ming Zhang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0040779.g004", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pain_behaviors_observed_for_14_days_in_LID_model_/279355", "title"=>"Pain behaviors observed for 14 days in LID model.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-16 02:35:55"}

PMC Usage Stats | Further Information

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Relative Metric

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