Detecting the Immune System Response of a 500 Year-Old Inca Mummy
Publication Date
July 25, 2012
Journal
PLOS ONE
Authors
Angelique Corthals, Antonius Koller, Dwight W. Martin, Robert Rieger, et al
Volume
7
Issue
7
Pages
e41244
DOI
https://dx.plos.org/10.1371/journal.pone.0041244
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0041244
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/22848450
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405130
Europe PMC
http://europepmc.org/abstract/MED/22848450
Web of Science
000306806600046
Scopus
84864375664
Mendeley
http://www.mendeley.com/research/detecting-immune-system-response-500-yearold-inca-mummy
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Mendeley | Further Information

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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/314838", "https://ndownloader.figshare.com/files/314850"], "description"=>"<div><p>Disease detection in historical samples currently relies on DNA extraction and amplification, or immunoassays. These techniques only establish pathogen presence rather than active disease. We report the first use of shotgun proteomics to detect the protein expression profile of buccal swabs and cloth samples from two 500-year-old Andean mummies. The profile of one of the mummies is consistent with immune system response to severe pulmonary bacterial infection at the time of death. Presence of a probably pathogenic <em>Mycobacterium sp</em>. in one buccal swab was confirmed by DNA amplification, sequencing, and phylogenetic analyses. Our study provides positive evidence of active pathogenic infection in an ancient sample for the first time. The protocol introduced here is less susceptible to contamination than DNA-based or immunoassay-based studies. In scarce forensic samples, shotgun proteomics narrows the range of pathogens to detect using DNA assays, reducing cost. This analytical technique can be broadly applied for detecting infection in ancient samples to answer questions on the historical ecology of specific pathogens, as well as in medico-legal cases when active pathogenic infection is suspected.</p> </div>", "links"=>[], "tags"=>["detecting", "500", "year-old", "inca", "mummy"], "article_id"=>122105, "categories"=>["Microbiology", "Cancer", "Biochemistry", "Immunology", "Evolutionary Biology"], "users"=>["Angelique Corthals", "Antonius Koller", "Dwight W. Martin", "Robert Rieger", "Emily I. Chen", "Mario Bernaski", "Gabriella Recagno", "Liliana M. Dávalos"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0041244.s001", "https://dx.doi.org/10.1371/journal.pone.0041244.s002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Detecting_the_Immune_System_Response_of_a_500_Year_Old_Inca_Mummy/122105", "title"=>"Detecting the Immune System Response of a 500 Year-Old Inca Mummy", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-07-25 00:35:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/603283"], "description"=>"<p>a) La Doncella (the Maiden); b) El Niño (the Boy); and c) La Niña (the Girl).</p>", "links"=>[], "tags"=>["children"], "article_id"=>273761, "categories"=>["Microbiology", "Biochemistry", "Immunology", "Infectious Diseases", "Evolutionary Biology"], "users"=>["Angelique Corthals", "Antonius Koller", "Dwight W. Martin", "Robert Rieger", "Emily I. Chen", "Mario Bernaski", "Gabriella Recagno", "Liliana M. Dávalos"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0041244.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_children_of_Llullallaico_/273761", "title"=>"The children of Llullallaico.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-25 01:02:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/603404"], "description"=>"<p>Gel electrophoresis (2%) showing the amplification of the <i>Mycobacterium sp. hsp65</i> gene fragments in the Maiden’s buccal swab samples 6 and 11, both sequenced successfully. The image was inverted to facilitate detection of bands and no other image treatment was performed. Sample 16 did not produce a satisfactory sequence. Samples 3 and 4 were positive for primers described as specific to <i>Mycobacterium avium</i>, but did not produce satisfactory sequences. Sample 1 and 7 were positive for primers described as specific to <i>Mycobacterium tuberculosis</i>, but did not produce satisfactory sequences. The negative controls are in lanes 17, 18, 19 and 20. Ladders are 100-bp Fisher exACTgene.</p>", "links"=>[], "tags"=>["electrophoresis"], "article_id"=>273883, "categories"=>["Microbiology", "Biochemistry", "Immunology", "Infectious Diseases", "Evolutionary Biology"], "users"=>["Angelique Corthals", "Antonius Koller", "Dwight W. Martin", "Robert Rieger", "Emily I. Chen", "Mario Bernaski", "Gabriella Recagno", "Liliana M. Dávalos"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0041244.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gel_electrophoresis_from_the_Maiden_/273883", "title"=>"Gel electrophoresis from the Maiden.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-25 01:04:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/603476"], "description"=>"<p>Gel electrophoresis (2%) showing the products of PCR amplification from samples from the boy. The results were negative: no amplification bands could be detected. The image was inverted, and contrast was increased to facilitate detection of bands. No other image treatment was performed. Lanes 1 and 2 were amplified with <i>M. tuberculosis</i>-specific primers, lanes 3 and 4 with the <i>Mycobacterium</i>-specific primers, and lanes 5, 6 and 7 were negative controls.</p>", "links"=>[], "tags"=>["electrophoresis"], "article_id"=>273960, "categories"=>["Microbiology", "Biochemistry", "Immunology", "Infectious Diseases", "Evolutionary Biology"], "users"=>["Angelique Corthals", "Antonius Koller", "Dwight W. Martin", "Robert Rieger", "Emily I. Chen", "Mario Bernaski", "Gabriella Recagno", "Liliana M. Dávalos"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0041244.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gel_electrophoresis_from_the_boy_/273960", "title"=>"Gel electrophoresis from the boy.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-25 01:06:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/603575"], "description"=>"<p>Maximum likelihood phylogeny and bootstrap support values based on 1000 pseudoreplicates of the alignment of <i>hsp65</i> gene nucleotide sequences. Sequences generated from the Maiden’s swab samples are shown in bold, larger font, and marked with an asterisk.</p>", "links"=>[], "tags"=>["immunology", "Infectious diseases", "microbiology", "Evolutionary biology", "Biochemistry"], "article_id"=>274048, "categories"=>["Microbiology", "Biochemistry", "Immunology", "Infectious Diseases", "Evolutionary Biology"], "users"=>["Angelique Corthals", "Antonius Koller", "Dwight W. Martin", "Robert Rieger", "Emily I. Chen", "Mario Bernaski", "Gabriella Recagno", "Liliana M. Dávalos"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0041244.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Maximum_likelihood_phylogeny_/274048", "title"=>"Maximum likelihood phylogeny.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-25 01:07:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/603769"], "description"=>"<p>Alternative phylogenies compared to the best phylogeny obtained through maximum likelihood analyses of DNA sequence data from the Maiden’s swab samples (fig. 4) using Bayesian posterior probabilities, approximately unbiased, and weighted Shimodaira-Hasegawa tests. See <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041244#pone-0041244-t002\" target=\"_blank\">table 2</a> for description of each alternative and test results.</p>", "links"=>[], "tags"=>["phylogenies", "compared"], "article_id"=>274253, "categories"=>["Microbiology", "Biochemistry", "Immunology", "Infectious Diseases", "Evolutionary Biology"], "users"=>["Angelique Corthals", "Antonius Koller", "Dwight W. Martin", "Robert Rieger", "Emily I. Chen", "Mario Bernaski", "Gabriella Recagno", "Liliana M. Dávalos"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0041244.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Alternative_phylogenies_compared_to_the_best_phylogeny_/274253", "title"=>"Alternative phylogenies compared to the best phylogeny.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-25 01:10:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/603946"], "description"=>"<p>Numbers in the last three columns indicate the number of unique peptides, the number of spectra observed and the sequence coverage for that particular protein (for a full list see supplemental table S1).</p>", "links"=>[], "tags"=>["proteins", "respective", "accession", "numbers", "swab", "maiden"], "article_id"=>274413, "categories"=>["Microbiology", "Biochemistry", "Immunology", "Infectious Diseases", "Evolutionary Biology"], "users"=>["Angelique Corthals", "Antonius Koller", "Dwight W. Martin", "Robert Rieger", "Emily I. Chen", "Mario Bernaski", "Gabriella Recagno", "Liliana M. Dávalos"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0041244.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immune_system_proteins_and_their_respective_accession_numbers_in_the_swab_sample_of_the_Maiden_identified_by_mass_spectrometry_/274413", "title"=>"Immune system proteins and their respective accession numbers in the swab sample of the Maiden identified by mass spectrometry.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-25 01:13:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/604011"], "description"=>"<p>Maximum likelihood, Bayesian posterior probability (BPP), and significance of alternative phylogenies (for numbering, see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041244#pone-0041244-g005\" target=\"_blank\">fig. 5</a>) using the approximately unbiased (AU) and weighted Shimodaira-Hasegawa (WSH) tests.</p>", "links"=>[], "tags"=>["bayesian", "posterior", "probability", "phylogenies", "unbiased", "weighted", "shimodaira-hasegawa"], "article_id"=>274475, "categories"=>["Microbiology", "Biochemistry", "Immunology", "Infectious Diseases", "Evolutionary Biology"], "users"=>["Angelique Corthals", "Antonius Koller", "Dwight W. Martin", "Robert Rieger", "Emily I. Chen", "Mario Bernaski", "Gabriella Recagno", "Liliana M. Dávalos"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0041244.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Maximum_likelihood_Bayesian_posterior_probability_BPP_and_significance_of_alternative_phylogenies_for_numbering_see_fig_5_using_the_approximately_unbiased_AU_and_weighted_Shimodaira_Hasegawa_WSH_tests_/274475", "title"=>"Maximum likelihood, Bayesian posterior probability (BPP), and significance of alternative phylogenies (for numbering, see fig. 5) using the approximately unbiased (AU) and weighted Shimodaira-Hasegawa (WSH) tests.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-25 01:14:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/604066"], "description"=>"<p>Primers used for PCR amplification from DNA extracted from swab samples.</p>", "links"=>[], "tags"=>["pcr", "amplification", "dna", "extracted", "swab"], "article_id"=>274540, "categories"=>["Microbiology", "Biochemistry", "Immunology", "Infectious Diseases", "Evolutionary Biology"], "users"=>["Angelique Corthals", "Antonius Koller", "Dwight W. Martin", "Robert Rieger", "Emily I. Chen", "Mario Bernaski", "Gabriella Recagno", "Liliana M. Dávalos"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0041244.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Primers_used_for_PCR_amplification_from_DNA_extracted_from_swab_samples_/274540", "title"=>"Primers used for PCR amplification from DNA extracted from swab samples.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-25 01:15:40"}

PMC Usage Stats | Further Information

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Relative Metric

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