Early-Onset Ventilator-Associated Pneumonia in Adults Randomized Clinical Trial: Comparison of 8 versus 15 Days of Antibiotic Treatment
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{"title"=>"Early-Onset Ventilator-Associated Pneumonia in Adults Randomized Clinical Trial: Comparison of 8 versus 15 Days of Antibiotic Treatment", "type"=>"journal", "authors"=>[{"first_name"=>"Gilles", "last_name"=>"Capellier", "scopus_author_id"=>"7003663052"}, {"first_name"=>"Hélène", "last_name"=>"Mockly", "scopus_author_id"=>"55349010200"}, {"first_name"=>"Claire", "last_name"=>"Charpentier", "scopus_author_id"=>"7007080957"}, {"first_name"=>"Djillali", "last_name"=>"Annane", "scopus_author_id"=>"7006490729"}, {"first_name"=>"Gilles", "last_name"=>"Blasco", "scopus_author_id"=>"6602554841"}, {"first_name"=>"Thibault", "last_name"=>"Desmettre", "scopus_author_id"=>"9249875600"}, {"first_name"=>"Antoine", "last_name"=>"Roch", "scopus_author_id"=>"7005672486"}, {"first_name"=>"Christophe", "last_name"=>"Faisy", "scopus_author_id"=>"6701380243"}, {"first_name"=>"Joel", "last_name"=>"Cousson", "scopus_author_id"=>"57200426339"}, {"first_name"=>"Samuel", "last_name"=>"Limat", "scopus_author_id"=>"6603668301"}, {"first_name"=>"Mariette", "last_name"=>"Mercier", "scopus_author_id"=>"55810786000"}, {"first_name"=>"Laurent", "last_name"=>"Papazian", "scopus_author_id"=>"7004816541"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"22952580", "doi"=>"10.1371/journal.pone.0041290", "sgr"=>"84865646619", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "scopus"=>"2-s2.0-84865646619", "issn"=>"19326203", "pui"=>"365552208"}, "id"=>"5e1cb929-e4d3-3aec-9761-9b32775ad65a", "abstract"=>"PURPOSE: The optimal treatment duration for ventilator-associated pneumonia is based on one study dealing with late-onset of the condition. Shortening the length of antibiotic treatment remains a major prevention factor for the emergence of multiresistant bacteria.\\n\\nOBJECTIVE: To demonstrate that 2 different antibiotic treatment durations (8 versus 15 days) are equivalent in terms of clinical cure for early-onset ventilator-associated pneumonia.\\n\\nMETHODS: Randomized, prospective, open, multicenter trial carried out from 1998 to 2002.\\n\\nMEASUREMENTS: The primary endpoint was the clinical cure rate at day 21. The mortality rate was evaluated on days 21 and 90.\\n\\nRESULTS: 225 patients were included in 13 centers. 191 (84.9%) patients were cured: 92 out of 109 (84.4%) in the 15 day cohort and 99 out of 116 (85.3%) in the 8 day cohort (difference = 0.9%, odds ratio = 0.929). 95% two-sided confidence intervals for difference and odds ratio were [-8.4% to 10.3%] and [0.448 to 1.928] respectively. Taking into account the limits of equivalence (10% for difference and 2.25 for odds ratio), the objective of demonstrative equivalence between the 2 treatment durations was fulfilled. Although the rate of secondary infection was greater in the 8 day than the 15 day cohort, the number of days of antibiotic treatment remained lower in the 8 day cohort. There was no difference in mortality rate between the 2 groups on days 21 and 90.\\n\\nCONCLUSION: Our results suggest that an 8-day course of antibiotic therapy is safe for early-onset ventilator-associated pneumonia in intubated patients.\\n\\nTRIAL REGISTRATION: ClinicalTrials.gov NCT01559753.", "link"=>"http://www.mendeley.com/research/earlyonset-ventilatorassociated-pneumonia-adults-randomized-clinical-trial-comparison-8-versus-15-da", "reader_count"=>52, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>3, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>6, "Other"=>9, "Student > Master"=>11, "Student > Bachelor"=>7}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>3, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>6, "Other"=>9, "Student > Master"=>11, "Student > Bachelor"=>7}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>36, "Agricultural and Biological Sciences"=>4, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>36}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>7}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Ecuador"=>1, "Brazil"=>2, "France"=>1}, "group_count"=>6}

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  • {"files"=>["https://ndownloader.figshare.com/files/582255"], "description"=>"<p>Abbreviations:</p>*<p>RTA: road traffic accident;</p>†<p>SAPS: simplified acute physiological score;</p>‡<p>ICU: intensive care unit;</p>§<p>BAL: bronchoalveolar lavage;</p>**<p>3GC: third generation cephalosporin.</p>", "links"=>[], "tags"=>["characteristics", "patients", "duration", "antibiotic"], "article_id"=>252739, "categories"=>["Medicine", "Infectious Diseases", "Pharmacology"], "users"=>["Gilles Capellier", "Hélène Mockly", "Claire Charpentier", "Djillali Annane", "Gilles Blasco", "Thibault Desmettre", "Antoine Roch", "Christophe Faisy", "Joel Cousson", "Samuel Limat", "Mariette Mercier", "Laurent Papazian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041290.t007", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Admission_characteristics_of_the_study_patients_according_to_the_duration_of_antibiotic_treatment_/252739", "title"=>"Admission characteristics of the study patients according to the duration of antibiotic treatment.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-08-31 00:45:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/582036"], "description"=>"<p>Data regarding number of patients included, treated according to protocol and followed up at 21 and 90 days.</p>", "links"=>[], "tags"=>["patients", "treated", "followed", "21", "90"], "article_id"=>252518, "categories"=>["Medicine", "Infectious Diseases", "Pharmacology"], "users"=>["Gilles Capellier", "Hélène Mockly", "Claire Charpentier", "Djillali Annane", "Gilles Blasco", "Thibault Desmettre", "Antoine Roch", "Christophe Faisy", "Joel Cousson", "Samuel Limat", "Mariette Mercier", "Laurent Papazian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041290.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Data_regarding_number_of_patients_included_treated_according_to_protocol_and_followed_up_at_21_and_90_days_/252518", "title"=>"Data regarding number of patients included, treated according to protocol and followed up at 21 and 90 days.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-08-31 00:41:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/582330"], "description"=>"<p>Definition of secondary infections requiring the initiation of antibiotic treatment for more than 48 hours.</p>", "links"=>[], "tags"=>["infections", "requiring", "initiation", "antibiotic", "48"], "article_id"=>252817, "categories"=>["Medicine", "Infectious Diseases", "Pharmacology"], "users"=>["Gilles Capellier", "Hélène Mockly", "Claire Charpentier", "Djillali Annane", "Gilles Blasco", "Thibault Desmettre", "Antoine Roch", "Christophe Faisy", "Joel Cousson", "Samuel Limat", "Mariette Mercier", "Laurent Papazian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041290.t005", "stats"=>{"downloads"=>1, "page_views"=>40, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Definition_of_secondary_infections_requiring_the_initiation_of_antibiotic_treatment_for_more_than_48_hours_/252817", "title"=>"Definition of secondary infections requiring the initiation of antibiotic treatment for more than 48 hours.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-08-31 00:46:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/582293"], "description"=>"*<p>Aminoglycosides were administered in a single dose with a loading dose on the first day of treatment. The dose was adapted in the event of renal failure.</p>", "links"=>[], "tags"=>["authorized"], "article_id"=>252778, "categories"=>["Medicine", "Infectious Diseases", "Pharmacology"], "users"=>["Gilles Capellier", "Hélène Mockly", "Claire Charpentier", "Djillali Annane", "Gilles Blasco", "Thibault Desmettre", "Antoine Roch", "Christophe Faisy", "Joel Cousson", "Samuel Limat", "Mariette Mercier", "Laurent Papazian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041290.t004", "stats"=>{"downloads"=>9, "page_views"=>41, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Treatments_authorized_in_the_study_/252778", "title"=>"Treatments authorized in the study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-08-31 00:46:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/306312", "https://ndownloader.figshare.com/files/306326"], "description"=>"<div><h3>Purpose</h3><p>The optimal treatment duration for ventilator-associated pneumonia is based on one study dealing with late-onset of the condition. Shortening the length of antibiotic treatment remains a major prevention factor for the emergence of multiresistant bacteria.</p> <h3>Objective</h3><p>To demonstrate that 2 different antibiotic treatment durations (8 versus 15 days) are equivalent in terms of clinical cure for early-onset ventilator-associated pneumonia.</p> <h3>Methods</h3><p>Randomized, prospective, open, multicenter trial carried out from 1998 to 2002.</p> <h3>Measurements</h3><p>The primary endpoint was the clinical cure rate at day 21. The mortality rate was evaluated on days 21 and 90.</p> <h3>Results</h3><p>225 patients were included in 13 centers. 191 (84.9%) patients were cured: 92 out of 109 (84.4%) in the 15 day cohort and 99 out of 116 (85.3%) in the 8 day cohort (difference = 0.9%, odds ratio = 0.929). 95% two-sided confidence intervals for difference and odds ratio were [−8.4% to 10.3%] and [0.448 to 1.928] respectively. Taking into account the limits of equivalence (10% for difference and 2.25 for odds ratio), the objective of demonstrative equivalence between the 2 treatment durations was fulfilled. Although the rate of secondary infection was greater in the 8 day than the 15 day cohort, the number of days of antibiotic treatment remained lower in the 8 day cohort. There was no difference in mortality rate between the 2 groups on days 21 and 90.</p> <h3>Conclusion</h3><p>Our results suggest that an 8-day course of antibiotic therapy is safe for early-onset ventilator-associated pneumonia in intubated patients.</p> <h3>Trial Registration</h3><p>ClinicalTrials.gov <a href=\"http://www.clinicaltrials.gov/ct2/show/NCT01559753\">NCT01559753</a></p> </div>", "links"=>[], "tags"=>["early-onset", "ventilator-associated", "pneumonia", "adults", "randomized", "15", "days", "antibiotic"], "article_id"=>120433, "categories"=>["Medicine", "Cancer", "Pharmacology"], "users"=>["Gilles Capellier", "Hélène Mockly", "Claire Charpentier", "Djillali Annane", "Gilles Blasco", "Thibault Desmettre", "Antoine Roch", "Christophe Faisy", "Joel Cousson", "Samuel Limat", "Mariette Mercier", "Laurent Papazian"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0041290.s001", "https://dx.doi.org/10.1371/journal.pone.0041290.s002"], "stats"=>{"downloads"=>11, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Early_Onset_Ventilator_Associated_Pneumonia_in_Adults_Randomized_Clinical_Trial_Comparison_of_8_versus_15_Days_of_Antibiotic_Treatment/120433", "title"=>"Early-Onset Ventilator-Associated Pneumonia in Adults Randomized Clinical Trial: Comparison of 8 versus 15 Days of Antibiotic Treatment", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-08-31 00:07:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/582145"], "description"=>"<p>Indications for antibiotic treatment before bacteriology results.</p>", "links"=>[], "tags"=>["antibiotic", "bacteriology"], "article_id"=>252627, "categories"=>["Medicine", "Infectious Diseases", "Pharmacology"], "users"=>["Gilles Capellier", "Hélène Mockly", "Claire Charpentier", "Djillali Annane", "Gilles Blasco", "Thibault Desmettre", "Antoine Roch", "Christophe Faisy", "Joel Cousson", "Samuel Limat", "Mariette Mercier", "Laurent Papazian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041290.t003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Indications_for_antibiotic_treatment_before_bacteriology_results_/252627", "title"=>"Indications for antibiotic treatment before bacteriology results.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-08-31 00:43:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/582362"], "description"=>"<p>Abbreviations:</p>†<p>SAPS: simplified acute physiological score;</p>‡<p>ICU: intensive care unit;</p>§<p>BAL: bronchoalveolar lavage;</p>*<p>3GC: third generation cephalosporin;</p>**<p>all molecules grouped together.</p>", "links"=>[], "tags"=>["patients"], "article_id"=>252852, "categories"=>["Medicine", "Infectious Diseases", "Pharmacology"], "users"=>["Gilles Capellier", "Hélène Mockly", "Claire Charpentier", "Djillali Annane", "Gilles Blasco", "Thibault Desmettre", "Antoine Roch", "Christophe Faisy", "Joel Cousson", "Samuel Limat", "Mariette Mercier", "Laurent Papazian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041290.t010", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparisons_between_patients_with_and_without_secondary_infections_/252852", "title"=>"Comparisons between patients with and without secondary infections.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-08-31 00:47:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/582114"], "description"=>"<p>Exclusion criteria.</p>", "links"=>[], "tags"=>["Infectious diseases", "Critical care and emergency medicine", "pharmacology", "respiratory medicine"], "article_id"=>252600, "categories"=>["Medicine", "Infectious Diseases", "Pharmacology"], "users"=>["Gilles Capellier", "Hélène Mockly", "Claire Charpentier", "Djillali Annane", "Gilles Blasco", "Thibault Desmettre", "Antoine Roch", "Christophe Faisy", "Joel Cousson", "Samuel Limat", "Mariette Mercier", "Laurent Papazian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041290.t002", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Exclusion_criteria_/252600", "title"=>"Exclusion criteria.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-08-31 00:43:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/581952"], "description"=>"<p>Design of the study governing inclusion of a new patient according to BAL bacteriological results and follow up criteria.</p>", "links"=>[], "tags"=>["governing", "inclusion", "bal", "bacteriological"], "article_id"=>252441, "categories"=>["Medicine", "Infectious Diseases", "Pharmacology"], "users"=>["Gilles Capellier", "Hélène Mockly", "Claire Charpentier", "Djillali Annane", "Gilles Blasco", "Thibault Desmettre", "Antoine Roch", "Christophe Faisy", "Joel Cousson", "Samuel Limat", "Mariette Mercier", "Laurent Papazian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041290.g001", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Design_of_the_study_governing_inclusion_of_a_new_patient_according_to_BAL_bacteriological_results_and_follow_up_criteria_/252441", "title"=>"Design of the study governing inclusion of a new patient according to BAL bacteriological results and follow up criteria.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-08-31 00:40:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/582173"], "description"=>"<p>Radiologic score by Weinberg <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041290#pone.0041290-Weinberg1\" target=\"_blank\">[26]</a>.</p>", "links"=>[], "tags"=>["weinberg"], "article_id"=>252666, "categories"=>["Medicine", "Infectious Diseases", "Pharmacology"], "users"=>["Gilles Capellier", "Hélène Mockly", "Claire Charpentier", "Djillali Annane", "Gilles Blasco", "Thibault Desmettre", "Antoine Roch", "Christophe Faisy", "Joel Cousson", "Samuel Limat", "Mariette Mercier", "Laurent Papazian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041290.t001", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Radiologic_score_by_Weinberg_26_/252666", "title"=>"Radiologic score by Weinberg [26].", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-08-31 00:44:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/582407"], "description"=>"*<p>The number of bacteria isolated in the BAL sample is >1 for 59 patients in the 15 days and 44 patients in the 8 days cohorts.</p>", "links"=>[], "tags"=>["pneumonia"], "article_id"=>252891, "categories"=>["Medicine", "Infectious Diseases", "Pharmacology"], "users"=>["Gilles Capellier", "Hélène Mockly", "Claire Charpentier", "Djillali Annane", "Gilles Blasco", "Thibault Desmettre", "Antoine Roch", "Christophe Faisy", "Joel Cousson", "Samuel Limat", "Mariette Mercier", "Laurent Papazian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041290.t008", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Microbiology_of_pneumonia_according_to_the_treatment_group_/252891", "title"=>"Microbiology of pneumonia according to the treatment group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-08-31 00:48:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/582436"], "description"=>"<p>Abbreviations:</p>*<p>sensitive,</p>†<p>resistant,</p>**<p>Fischer exact test.</p>", "links"=>[], "tags"=>["documented"], "article_id"=>252925, "categories"=>["Medicine", "Infectious Diseases", "Pharmacology"], "users"=>["Gilles Capellier", "Hélène Mockly", "Claire Charpentier", "Djillali Annane", "Gilles Blasco", "Thibault Desmettre", "Antoine Roch", "Christophe Faisy", "Joel Cousson", "Samuel Limat", "Mariette Mercier", "Laurent Papazian"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041290.t009", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patients_with_documented_secondary_infections_/252925", "title"=>"Patients with documented secondary infections.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-08-31 00:48:45"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"81", "full-text"=>"86", "pdf"=>"51", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
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  • {"unique-ip"=>"38", "full-text"=>"40", "pdf"=>"27", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"75", "full-text"=>"85", "pdf"=>"58", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
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  • {"unique-ip"=>"62", "full-text"=>"70", "pdf"=>"62", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"52", "full-text"=>"56", "pdf"=>"37", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"68", "full-text"=>"58", "pdf"=>"33", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"56", "full-text"=>"61", "pdf"=>"55", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"41", "full-text"=>"62", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"50", "full-text"=>"57", "pdf"=>"47", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"47", "full-text"=>"45", "pdf"=>"42", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"55", "full-text"=>"67", "pdf"=>"30", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"36", "full-text"=>"42", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
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  • {"unique-ip"=>"28", "full-text"=>"33", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"26", "full-text"=>"30", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"23", "full-text"=>"32", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"33", "full-text"=>"33", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"27", "full-text"=>"32", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"27", "full-text"=>"29", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"30", "full-text"=>"29", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
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Relative Metric

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