Wallerian Degeneration in Central Nervous System: Dynamic Associations between Diffusion Indices and Their Underlying Pathology
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{"title"=>"Wallerian degeneration in central nervous system: Dynamic associations between diffusion indices and their underlying pathology", "type"=>"journal", "authors"=>[{"first_name"=>"Wen", "last_name"=>"Qin", "scopus_author_id"=>"8955000500"}, {"first_name"=>"Min", "last_name"=>"Zhang", "scopus_author_id"=>"56130353400"}, {"first_name"=>"Yueshan", "last_name"=>"Piao", "scopus_author_id"=>"7006148714"}, {"first_name"=>"Deyu", "last_name"=>"Guo", "scopus_author_id"=>"14055737700"}, {"first_name"=>"Zixin", "last_name"=>"Zhu", "scopus_author_id"=>"56163582000"}, {"first_name"=>"Xin", "last_name"=>"Tian", "scopus_author_id"=>"56317595900"}, {"first_name"=>"Kuncheng", "last_name"=>"Li", "scopus_author_id"=>"36066893600"}, {"first_name"=>"Chunshui", "last_name"=>"Yu", "scopus_author_id"=>"12646941900"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"22829950", "sgr"=>"84864048390", "doi"=>"10.1371/journal.pone.0041441", "scopus"=>"2-s2.0-84864048390", "pui"=>"365284969", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203"}, "id"=>"f10b9b55-637c-334f-b3df-a2dac722a91c", "abstract"=>"BACKGROUND: Although diffusion tensor imaging has been used to monitor Wallerian degeneration, the exact relationship between the evolution of diffusion indices and its underlying pathology, especially in central nervous system, remains largely unknown. Here we aimed to address this question using a cat Wallerian degeneration model of corticospinal tract.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: Twenty-five domestic mature Felis catus were included in the present study. The evolution of diffusion indices, including mean diffusivity (MD), fractional anisotropy (FA), primary (λ1) and transverse eigenvalues (λ23) of the degenerated corticospinal tract, were observed at baseline (before modeling) and at 2, 4, 6, 8, 10, 15, 20, 25, 30, 45 and 60 days after modeling in 4 cats. Pathological examinations were performed at eight time points mentioned above. Wallerian degeneration can be detected as early as the 2nd day after modeling by both diffusion tensor imaging and pathology. According to the evolution of diffusion indices, Wallerian degeneration can be classified into 2 stages. During the early stage (within 8 days after modeling), progressive disintegration of axons and myelin sheaths underlies the decreases in FA and λ1 and the increase in λ23. However, during the late stage (after 8 days), the gradual increases in FA, MD and λ1 and the unchanged λ23 seem to be a comprehensive reflection of the pathological processes including microglia activation, myelin clearance, and astrocytosis.\\n\\nCONCLUSIONS/SIGNIFICANCE: Our findings help the understanding of the altered diffusion indices in the context of pathology and suggest that diffusion tensor imaging has the potential to monitor the processes of Wallerian degeneration in the central nervous system in vivo after acute damage.", "link"=>"http://www.mendeley.com/research/wallerian-degeneration-central-nervous-system-dynamic-associations-between-diffusion-indices-underly", "reader_count"=>25, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>5}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>4, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>11, "Neuroscience"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Neuroscience"=>{"Neuroscience"=>3}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1, "China"=>1, "Brazil"=>1, "Mexico"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/606943"], "description"=>"<p>The NF images of the normal side and the degenerated side of pons at 2<sup>nd</sup>, 6<sup>th</sup>, 10<sup>th</sup>, 20<sup>th</sup>, 30<sup>th</sup>, 45<sup>th</sup> and 60<sup>th</sup> day after modeling were displayed. Scale bar, 50 µm.</p>", "links"=>[], "tags"=>["stained", "histological", "images"], "article_id"=>277427, "categories"=>["Cell Biology", "Neuroscience", "Physiology"], "users"=>["Wen Qin", "Min Zhang", "Yueshan Piao", "Deyu Guo", "Zixin Zhu", "Xin Tian", "Kuncheng Li", "Chunshui Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041441.g005", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_NF_stained_histological_images_of_cat_s_pons_/277427", "title"=>"NF stained histological images of cat's pons.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:16:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/607250"], "description"=>"<p>The LFB images of normal and degenerated side of pons at 2<sup>nd</sup>, 6<sup>th</sup>, 10<sup>th</sup>, 20<sup>th</sup>, 30<sup>th</sup>, 45<sup>th</sup> and 60<sup>th</sup> day after modeling were displayed. White arrow heads indicated the activated microglias that phagocytized the axonal debris (purple stained), while black arrow heads labeled the microglias with myelin debris (blue stained). Black arrows indicated the reactive astrocytes. Scale bar, 50 µm.</p>", "links"=>[], "tags"=>["stained", "histological", "images"], "article_id"=>277740, "categories"=>["Cell Biology", "Neuroscience", "Physiology"], "users"=>["Wen Qin", "Min Zhang", "Yueshan Piao", "Deyu Guo", "Zixin Zhu", "Xin Tian", "Kuncheng Li", "Chunshui Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041441.g007", "stats"=>{"downloads"=>1, "page_views"=>88, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_LFB_stained_histological_images_of_cat_s_pons_/277740", "title"=>"LFB stained histological images of cat's pons.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:18:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/606860"], "description"=>"<p>Panel A showed the dynamic changes of the ratios of diffusion indices, and Panel B showed the corresponding axonal counts at the injury side. Note a significant increase of axonal counts at 45<sup>th</sup> and 60<sup>th</sup> day after modeling.</p>", "links"=>[], "tags"=>["ratios", "diffusion", "indices", "axonal"], "article_id"=>277351, "categories"=>["Cell Biology", "Neuroscience", "Physiology"], "users"=>["Wen Qin", "Min Zhang", "Yueshan Piao", "Deyu Guo", "Zixin Zhu", "Xin Tian", "Kuncheng Li", "Chunshui Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041441.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_between_the_ratios_of_diffusion_indices_and_the_axonal_counts_/277351", "title"=>"Correlation between the ratios of diffusion indices and the axonal counts.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:16:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/607454"], "description"=>"<p>Schematic associations between the evolution of diffusion indices and underlying pathology in Wallerian degeneration.</p>", "links"=>[], "tags"=>["associations", "diffusion", "indices", "pathology", "wallerian"], "article_id"=>277941, "categories"=>["Cell Biology", "Neuroscience", "Physiology"], "users"=>["Wen Qin", "Min Zhang", "Yueshan Piao", "Deyu Guo", "Zixin Zhu", "Xin Tian", "Kuncheng Li", "Chunshui Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041441.g009", "stats"=>{"downloads"=>2, "page_views"=>49, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_associations_between_the_evolution_of_diffusion_indices_and_underlying_pathology_in_Wallerian_degeneration_/277941", "title"=>"Schematic associations between the evolution of diffusion indices and underlying pathology in Wallerian degeneration.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:19:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/606707"], "description"=>"<p>Three sections of corticospinal tract were defined on FA maps at 8<sup>th</sup> day after modeling, including the pons (A), cerebral peduncle (B), and internal capsule (C) level, respectively. Note the decreased FA signal at the left CST.</p>", "links"=>[], "tags"=>["corticospinal"], "article_id"=>277201, "categories"=>["Cell Biology", "Neuroscience", "Physiology"], "users"=>["Wen Qin", "Min Zhang", "Yueshan Piao", "Deyu Guo", "Zixin Zhu", "Xin Tian", "Kuncheng Li", "Chunshui Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041441.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ROI_definition_of_corticospinal_tract_/277201", "title"=>"ROI definition of corticospinal tract.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:15:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/606774"], "description"=>"<p>The diffusion indices on the intact side of corticospinal tract (black bar) showed little changes between each time points, which however, evolved dynamically on the injury side (twill bar).</p>", "links"=>[], "tags"=>["changes", "diffusion"], "article_id"=>277264, "categories"=>["Cell Biology", "Neuroscience", "Physiology"], "users"=>["Wen Qin", "Min Zhang", "Yueshan Piao", "Deyu Guo", "Zixin Zhu", "Xin Tian", "Kuncheng Li", "Chunshui Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041441.g003", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dynamic_changes_of_diffusion_indices_/277264", "title"=>"Dynamic changes of diffusion indices.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:15:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/607365"], "description"=>"<p>(A) LFB stained histological images of the pons at 2<sup>nd</sup>, 4<sup>th</sup>, 6<sup>th</sup>, 10<sup>th</sup>, 20<sup>th</sup>, 30<sup>th</sup>, 45<sup>th</sup> and 60<sup>th</sup> day after modeling. Scale bar, 500 µm. (B) Time course of the LFB optical density ratios between the degenerated and normal sides of CST. Progressive decreases of optical density were shown 20 days after modeling, implying the clearance of myelin debris.</p>", "links"=>[], "tags"=>["lfb"], "article_id"=>277849, "categories"=>["Cell Biology", "Neuroscience", "Physiology"], "users"=>["Wen Qin", "Min Zhang", "Yueshan Piao", "Deyu Guo", "Zixin Zhu", "Xin Tian", "Kuncheng Li", "Chunshui Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041441.g008", "stats"=>{"downloads"=>1, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantitative_analysis_of_LFB_stain_/277849", "title"=>"Quantitative analysis of LFB stain.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:19:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/606655"], "description"=>"<p>The cortical origins of left CST including left frontal region, precentral region and postcentral region were removed to establish the Wallerian degeneration model.</p>", "links"=>[], "tags"=>["weighted", "images"], "article_id"=>277139, "categories"=>["Cell Biology", "Neuroscience", "Physiology"], "users"=>["Wen Qin", "Min Zhang", "Yueshan Piao", "Deyu Guo", "Zixin Zhu", "Xin Tian", "Kuncheng Li", "Chunshui Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041441.g001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_T2_weighted_images_of_cat_s_brain_at_8_th_day_after_modeling_/277139", "title"=>"T2 weighted images of cat's brain at 8<sup>th</sup> day after modeling.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:15:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/607099"], "description"=>"<p>The H&E images of normal side and the degenerated side of pons at 2<sup>nd</sup>, 6<sup>th</sup>, 10<sup>th</sup>, 20<sup>th</sup>, 30<sup>th</sup>, 45<sup>th</sup> and 60<sup>th</sup> day after modeling were displayed. Black arrows indicated the activated microglias, and the black arrow heads labeled the reactive astrocytes. Microgliosis emerged at 10<sup>th</sup> day after modeling, while marked astrocytosis started at 45<sup>th</sup> day after modeling. Scale bar, 50 µm.</p>", "links"=>[], "tags"=>["stained", "histological", "images"], "article_id"=>277586, "categories"=>["Cell Biology", "Neuroscience", "Physiology"], "users"=>["Wen Qin", "Min Zhang", "Yueshan Piao", "Deyu Guo", "Zixin Zhu", "Xin Tian", "Kuncheng Li", "Chunshui Yu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041441.g006", "stats"=>{"downloads"=>6, "page_views"=>420, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_H_amp_E_stained_histological_images_of_cat_s_pons_/277586", "title"=>"H&E stained histological images of cat's pons.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:17:48"}

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Relative Metric

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