Antibodies to the α1-Adrenergic Receptor Cause Vascular Impairments in Rat Brain as Demonstrated by Magnetic Resonance Angiography
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{"title"=>"Antibodies to the α1-Adrenergic receptor cause vascular impairments in rat brain as demonstrated by magnetic resonance Angiography", "type"=>"journal", "authors"=>[{"first_name"=>"Peter", "last_name"=>"Karczewski", "scopus_author_id"=>"7004286306"}, {"first_name"=>"Andreas", "last_name"=>"Pohlmann", "scopus_author_id"=>"23390128100"}, {"first_name"=>"Babette", "last_name"=>"Wagenhaus", "scopus_author_id"=>"55325591500"}, {"first_name"=>"Natali", "last_name"=>"Wisbrun", "scopus_author_id"=>"54382725500"}, {"first_name"=>"Petra", "last_name"=>"Hempel", "scopus_author_id"=>"7003994440"}, {"first_name"=>"Bernd", "last_name"=>"Lemke", "scopus_author_id"=>"57197699219"}, {"first_name"=>"Rudolf", "last_name"=>"Kunze", "scopus_author_id"=>"7005079632"}, {"first_name"=>"Thoralf", "last_name"=>"Niendorf", "scopus_author_id"=>"55075555700"}, {"first_name"=>"Marion", "last_name"=>"Bimmler", "scopus_author_id"=>"34874561100"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84864419024", "pui"=>"365350970", "doi"=>"10.1371/journal.pone.0041602", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)", "sgr"=>"84864419024", "pmid"=>"22860001"}, "id"=>"a4a597e6-4303-3eb5-bb50-14ed6aa9d242", "abstract"=>"Circulating agonistic autoantibodies acting at G protein-coupled receptors have been associated with numerous sever pathologies in humans. Antibodies directed predominantly against the α(1)-adrenergig receptor were detected in patients suffering from widespread diseases such as hypertension and type 2 diabetes. Their deleterious action has been demonstrated for peripheral organs. We postulate that antibodies to the α(1)-adrenergig receptor are relevant pathomolecules in diseases of the central nervous system associated with vascular impairments.", "link"=>"http://www.mendeley.com/research/antibodies-%CE%B11adrenergic-receptor-cause-vascular-impairments-rat-brain-demonstrated-magnetic-resonanc", "reader_count"=>15, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>10, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>10, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>4, "Neuroscience"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United States"=>1, "United Kingdom"=>1, "Germany"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/600336"], "description"=>"<p>Antibodies were detected by ELISA. (PEP) rats immunized with the α<sub>1</sub>-AR peptide, (C-PEP) controls treated with vehicle. Blood samples were taken about one month before the final TOF-MRA. The obtained sera were analyzed at a 1∶50 dilution.</p>", "links"=>[], "tags"=>["sera", "antibodies"], "article_id"=>270814, "categories"=>["Neuroscience", "Cell Biology", "Immunology"], "users"=>["Peter Karczewski", "Andreas Pohlmann", "Babette Wagenhaus", "Natali Wisbrun", "Petra Hempel", "Bernd Lemke", "Rudolf Kunze", "Thoralf Niendorf", "Marion Bimmler"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041602.g001", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analysis_of_rat_sera_for_the_presence_of_antibodies_to_the_1_AR_/270814", "title"=>"Analysis of rat sera for the presence of antibodies to the α<sub>1</sub>-AR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:38:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/600605"], "description"=>"<p><b>TOF-MRA of rat brain.</b> Coronal images of rat brains were screened in 3 mm slices. The rat shown in A, B was immunized with the α<sub>1</sub>-AR peptide, the rat shown in C, D obtained vehicle as control. Injections were performed monthly. Angiographs of the same animal were taken at the beginning of the treatment (A, C) and eight months later (B, D). Light contrasts correlate with vascular blood flow. Eight months of treatment with the α<sub>1</sub>-AR peptide led to apparent attenuations of blood flow (B, right part of brain section) compared to the initial situation (A). Control injections did not result in comparable defects in the same time frame (D versus C).</p>", "links"=>[], "tags"=>["maximum-intensity-projections"], "article_id"=>271093, "categories"=>["Neuroscience", "Cell Biology", "Immunology"], "users"=>["Peter Karczewski", "Andreas Pohlmann", "Babette Wagenhaus", "Natali Wisbrun", "Petra Hempel", "Bernd Lemke", "Rudolf Kunze", "Thoralf Niendorf", "Marion Bimmler"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041602.g003", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Two_dimensional_maximum_intensity_projections_of_/271093", "title"=>"Two-dimensional maximum-intensity-projections of", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:40:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/600748"], "description"=>"<p>Three-dimensional coronal views of the frontal brain segment. The rat shown is as in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041602#pone-0041602-g003\" target=\"_blank\">Figure 3</a> which was immunized with the α<sub>1</sub>-AR peptide. Angiographs of the same animal were taken at the beginning of the treatment (A, C) and eight months later (B, C). C, D show the same brain segment as in A, C but vertically rotated by 45°. The defects in blood flow in the right part of the brain as displayed in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041602#pone-0041602-g003\" target=\"_blank\">Figure 3</a> are obvious (B, D) compared to the situation eight months before (A, C).</p>", "links"=>[], "tags"=>["immunology", "neurological disorders", "radiology and medical imaging"], "article_id"=>271235, "categories"=>["Neuroscience", "Cell Biology", "Immunology"], "users"=>["Peter Karczewski", "Andreas Pohlmann", "Babette Wagenhaus", "Natali Wisbrun", "Petra Hempel", "Bernd Lemke", "Rudolf Kunze", "Thoralf Niendorf", "Marion Bimmler"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041602.g004", "stats"=>{"downloads"=>0, "page_views"=>46, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_TOF_MRA_of_rat_brain_/271235", "title"=>"TOF-MRA of rat brain.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:41:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/601141"], "description"=>"<p>Cohorts of rats were treated either with intravenous injections of α<sub>1</sub>-adrenoceptor antibody (AB) or with subcutaneous injections with α<sub>1</sub>-adrenoceptor peptide (PEP). Control animals received unspecific control IgG (C-AB) or albumin (C-PEP). Applications of substances were repeated monthly. The time span between TOF-MRA measurement 1 and measurement 2 was eight months. Relative vascular areas were determined by grayscale analysis of two-dimensional TOF-MRA maximum-intensity-projections. Values are given as means ± standard error of the mean. The number of animals of each group is given in brackets.</p>*<p>significantly different to measurement 1 (p<0.05).</p>", "links"=>[], "tags"=>["vascular"], "article_id"=>271633, "categories"=>["Neuroscience", "Cell Biology", "Immunology"], "users"=>["Peter Karczewski", "Andreas Pohlmann", "Babette Wagenhaus", "Natali Wisbrun", "Petra Hempel", "Bernd Lemke", "Rudolf Kunze", "Thoralf Niendorf", "Marion Bimmler"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041602.t001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_relative_vascular_areas_/271633", "title"=>"Comparison of relative vascular areas.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 01:43:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/600894"], "description"=>"<p>Two-dimensional sections of maximum-intensity-projections (MIP) of TOF-MRA images were processed as described in Materials and Methods. The black and white images were generated using the median plus two standard deviations as threshold value. White areas correspond approximately to the area of vessels with blood flow. Exemplarily shown is one animal treated with intravenous injections of the α<sub>1</sub>-AR antibody (A, B) and one control animal (C, D) at measurement 1 (A, C) and at measurement 2 eight months later (B, D). The reduction of the white areas in B compared to A is evident.</p>", "links"=>[], "tags"=>["immunology", "neurological disorders", "radiology and medical imaging"], "article_id"=>271382, "categories"=>["Neuroscience", "Cell Biology", "Immunology"], "users"=>["Peter Karczewski", "Andreas Pohlmann", "Babette Wagenhaus", "Natali Wisbrun", "Petra Hempel", "Bernd Lemke", "Rudolf Kunze", "Thoralf Niendorf", "Marion Bimmler"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041602.g005", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Black_and_white_threshold_images_/271382", "title"=>"Black and white threshold images.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:41:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/600478"], "description"=>"<p>Maximum-intensity-projections (MIP) of the TOF-MRA image data are shown for a coronal view (B) and axial view (E) together with corresponding 2-dimensional anatomical T<sub>2</sub>-weighted image slices (A, D). C) sagittal MIP view. F) double-oblique MIP view from the left posterior perspective (shown at a smaller scale).</p>", "links"=>[], "tags"=>["images", "tof-mra"], "article_id"=>270963, "categories"=>["Neuroscience", "Cell Biology", "Immunology"], "users"=>["Peter Karczewski", "Andreas Pohlmann", "Babette Wagenhaus", "Natali Wisbrun", "Petra Hempel", "Bernd Lemke", "Rudolf Kunze", "Thoralf Niendorf", "Marion Bimmler"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041602.g002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Anatomical_images_and_TOF_MRA_of_the_rat_brain_/270963", "title"=>"Anatomical images and TOF-MRA of the rat brain.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:39:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/601032"], "description"=>"<p>Vascular area was calculated from two-dimensional section of angiographs of rat brains by grayscale analysis as described in the methods section. Relative vascular circulation of the individual animal is expressed as ratios of vascular areas from the last and the first TOF-MRA. Time between measurements was eight months. Ratios <1 indicate attenuated vascular blood flow. Data are given of animals treated with intravenous injections of the antibody to the α<sub>1</sub>-AR (AB; n = 9), their controls (C-AB); n = 10), and rats injected subcutaneously with the α<sub>1</sub>-AR peptide (PEP; n = 10) and the respective controls (C-PEP; n = 10). Asterisk indicates statistically significant differences with p<0.05.</p>", "links"=>[], "tags"=>["vascular"], "article_id"=>271519, "categories"=>["Neuroscience", "Cell Biology", "Immunology"], "users"=>["Peter Karczewski", "Andreas Pohlmann", "Babette Wagenhaus", "Natali Wisbrun", "Petra Hempel", "Bernd Lemke", "Rudolf Kunze", "Thoralf Niendorf", "Marion Bimmler"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0041602.g006", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Box_plot_of_relative_brain_vascular_blood_flow_/271519", "title"=>"Box plot of relative brain vascular blood flow.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:42:41"}

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Relative Metric

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