Early-Life Stress Is Associated with Gender-Based Vulnerability to Epileptogenesis in Rat Pups
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Mendeley | Further Information

{"title"=>"Early-life stress is associated with gender-based vulnerability to epileptogenesis in rat pups", "type"=>"journal", "authors"=>[{"first_name"=>"Sébastien", "last_name"=>"Desgent", "scopus_author_id"=>"8602937400"}, {"first_name"=>"Sandra", "last_name"=>"Duss", "scopus_author_id"=>"53877000000"}, {"first_name"=>"Nathalie T.", "last_name"=>"Sanon", "scopus_author_id"=>"6507605772"}, {"first_name"=>"Pablo", "last_name"=>"Lema", "scopus_author_id"=>"9737916900"}, {"first_name"=>"Maxime", "last_name"=>"Lévesque", "scopus_author_id"=>"36521194400"}, {"first_name"=>"David", "last_name"=>"Hébert", "scopus_author_id"=>"57196796882"}, {"first_name"=>"Rose Marie", "last_name"=>"Rébillard", "scopus_author_id"=>"37665939800"}, {"first_name"=>"Karine", "last_name"=>"Bibeau", "scopus_author_id"=>"22633528800"}, {"first_name"=>"Michèle", "last_name"=>"Brochu", "scopus_author_id"=>"7006746730"}, {"first_name"=>"Lionel", "last_name"=>"Carmant", "scopus_author_id"=>"7003942561"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84864559753", "pmid"=>"22880055", "doi"=>"10.1371/journal.pone.0042622", "pui"=>"365375517", "isbn"=>"1932-6203", "sgr"=>"84864559753"}, "id"=>"84417d80-b7de-33a6-abd0-4b1233f7bcb4", "abstract"=>"During development, the risk of developing mesial temporal lobe epilepsy (MTLE) increases when the developing brain is exposed to more than one insult in early life. Early life insults include abnormalities of cortical development, hypoxic-ischemic injury and prolonged febrile seizures. To study epileptogenesis, we have developed a two-hit model of MTLE characterized by two early-life insults: a freeze lesion-induced cortical malformation at post-natal day 1 (P1), and a prolonged hyperthermic seizure (HS) at P10. As early life stressors lead to sexual dimorphism in both acute response and long-term outcome, we hypothesized that our model could lead to gender-based differences in acute stress response and long-term risk of developing MTLE. Male and female pups underwent a freeze-lesion induced cortical microgyrus at P1 and were exposed to HS at P10. Animals were monitored by video-EEG from P90 to P120. Pre and post-procedure plasma corticosterone levels were used to measure stress response at P1 and P10. To confirm the role of sex steroids, androgenized female pups received daily testosterone injections to the mother pre-natally and post-natally for nine days while undergoing both insults. We demonstrated that after both insults females did not develop MTLE while all males did. This correlated with a rise in corticosterone levels at P1 following the lesion in males only. Interestingly, all androgenized females showed a similar rise in corticosterone at P1, and also developed MTLE. Moreover, we found that the cortical lesion significantly decreased the latency to generalized convulsion during hyperthermia at P10 in both genders. The cortical dysplasia volumes at adulthood were also similar between male and female individuals. Our data demonstrate sexual dimorphism in long-term vulnerability to develop epilepsy in the lesion + hyperthermia animal model of MTLE and suggest that the response to early-life stress at P1 contributes significantly to epileptogenesis in a gender-specific manner.", "link"=>"http://www.mendeley.com/research/earlylife-stress-associated-genderbased-vulnerability-epileptogenesis-rat-pups", "reader_count"=>27, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>4, "Student > Master"=>3, "Student > Bachelor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>4, "Student > Master"=>3, "Student > Bachelor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>8, "Neuroscience"=>6, "Psychology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Neuroscience"=>{"Neuroscience"=>6}, "Psychology"=>{"Psychology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "Brazil"=>1}, "group_count"=>3}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/596784"], "description"=>"<p><b>A</b>) Histrograms showing changes in PCL before and after the cortical lesion in nmol/ml at P1 in males (top) and in females, bottom). <b>B</b>) Mean PCL variations for all the experimental groups in percentages. Note that the LM and LF+T groups were the only ones that showed an increase of corticosterone levels following cortical dysplasia induction at this age, whereas the others showed diminution. These increases were statistically different from their controls, notably LM compared to NM (*** p<0.001), LF+T compared to NF (* p<0.05) and to LF (** p<0.01).</p>", "links"=>[], "tags"=>["corticosterone", "changes"], "article_id"=>267274, "categories"=>["Physiology", "Neuroscience"], "users"=>["Sébastien Desgent", "Sandra Duss", "Nathalie T. Sanon", "Pablo Lema", "Maxime Lévesque", "David Hébert", "Rose-Marie Rébillard", "Karine Bibeau", "Michèle Brochu", "Lionel Carmant"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0042622.g004", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Plasma_corticosterone_level_PCL_changes_following_treatments_/267274", "title"=>"Plasma corticosterone level (PCL) changes following treatments.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:18:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/596886"], "description"=>"<p><b>M</b>, Male; <b>F</b>, Female; <b>N</b>, naïve rats separated from the dam for a period equivalent to the surgery time in the L group at P1; <b>L</b>, animals simply subjected to cortical freeze lesion at P1; <b>HS</b>, only exposed to hyperthermia-induced febrile seizures at P10; <b>LHS</b>, submitted to the combination of cortical freeze lesion at P1 and hyperthermia seizures at P10; <b>L+T</b>, subjected to perinatal testosterone administration (from E16 to P9) and cortical freeze lesion at P1; <b>LHS+T</b>, perinatal testosterone treatment plus dual postnatal insults at P1 and P10.</p>", "links"=>[], "tags"=>["groups"], "article_id"=>267378, "categories"=>["Physiology", "Neuroscience"], "users"=>["Sébastien Desgent", "Sandra Duss", "Nathalie T. Sanon", "Pablo Lema", "Maxime Lévesque", "David Hébert", "Rose-Marie Rébillard", "Karine Bibeau", "Michèle Brochu", "Lionel Carmant"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0042622.t001", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_table_of_study_design_experimental_groups_and_investigations_/267378", "title"=>"Schematic table of study design, experimental groups and investigations.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 01:19:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/596549"], "description"=>"<p>Histograms showing that in the lesioned pups latency for GC is significantly shorter than in controls. This decrease is independent of gender and testosterone treatment (* = p<0.05, ** = p<0.01, *** = p<0.001).</p>", "links"=>[], "tags"=>["generalized", "convulsion", "hyperthermia"], "article_id"=>267028, "categories"=>["Physiology", "Neuroscience"], "users"=>["Sébastien Desgent", "Sandra Duss", "Nathalie T. Sanon", "Pablo Lema", "Maxime Lévesque", "David Hébert", "Rose-Marie Rébillard", "Karine Bibeau", "Michèle Brochu", "Lionel Carmant"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0042622.g002", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Latencies_to_behavioral_generalized_convulsion_GC_during_hyperthermia_at_P10_/267028", "title"=>"Latencies to behavioral generalized convulsion (GC) during hyperthermia at P10.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:17:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/596629"], "description"=>"<p><b>A</b>) Photographs showing the effects of testosterone treatment on female anatomy at P10. Male rat (NM, left), female rat (NF, middle) and testosterone injected female (F+T, right) are shown. Testosterone exposure during the fetal and perinatal periods altered the development of secondary sex characteristics in female rat (F+T) pups such as the presence of a longer anogenital distance (top) and the lack of breast (bottom). <b>B</b>) EEG in an adult LHSF+T rat showing an example of an electrographic seizure. Seizure activity recorded over a 60-second period from the right primary motor cortex (M1, top trace) and hippocampus (CA1, bottom trace) ipsilateral to the lesion. <b>C</b>) Pre-seizure baseline rhythm was composed of irregular, low amplitude, 6 to 12 Hz frequency activity. In this case, the first behavioral manifestation was characterized by abrupt rearing and hind limb myoclonus associated with the slow wave polyspiking pattern shown by the first arrow. Interictal epileptic spike or spike and wave activity was also recorded frequently throughout this period (arrows 2 and 3). <b>D</b>) Just before the seizure, the epileptic discharges were intermingled with a burst of hippocampal fast activity (1), followed by a slow rhythmic activity at a frequency of 1 to 3 Hz (2) progressing into 6 to 8 Hz rhythmic activity (3). <b>E</b>) During the seizure the EEG trace showed a prolongation of the rhythmic activity characterized by high amplitude oscillations equivalent to two to ten-fold of baseline rhythm at a lower frequency range (5–7 Hz range). <b>F</b>) The end of the seizure (1) is marked by low amplitude fast activity intermingled with periodic epileptic discharges before a progressive return to theta activity (2). The clinical manifestations included freezing followed by myoclonus, and abrupt rearing and falling. Acquisition frequency was 200 Hz, and filtering at 1–35 Hz. Horizontal bar = 1 second; vertical bar = 500 µV.</p>", "links"=>[], "tags"=>["testosterone", "lesioned"], "article_id"=>267113, "categories"=>["Physiology", "Neuroscience"], "users"=>["Sébastien Desgent", "Sandra Duss", "Nathalie T. Sanon", "Pablo Lema", "Maxime Lévesque", "David Hébert", "Rose-Marie Rébillard", "Karine Bibeau", "Michèle Brochu", "Lionel Carmant"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0042622.g003", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_testosterone_on_lesioned_females_/267113", "title"=>"Effect of testosterone on lesioned females.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:17:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/596426"], "description"=>"<p>In <b>A</b>), a confirmation example of the bipolar electrodes placement for EEG recordings in a LHSF+T rat is shown in motor cortex M1 (left panel) and in the <i>cornus ammonis</i> region one (CA1) of the hippocampus (right panel). <b>B</b>) Cresyl violet stained coronal section through the dysplasic lesion in sensorimotor cortex of P120 rat brains, male (left) and female (right), that received a freeze-induced lesion at P1 and hyperthermic seizure at P10 (LHS). Photomicrographs are showing a similar and well-formed, four-layered microgyrus in the middle of each panel for both genders. In <b>C</b>), (Top panel) histograms of the volume estimations in the LHSM versus LHSF groups using the Cavalieri's principle for the focal mycrogyrus (left) and total amount of altered neocortex (right). (Bottom panel) diagrams illustrating the region of interest for sampling in each case highlighted with grid points. All Scale bars = 250 µm.</p>", "links"=>[], "tags"=>["cresyl", "violet", "sections", "cortical", "lesion", "volumes", "estimations"], "article_id"=>266890, "categories"=>["Physiology", "Neuroscience"], "users"=>["Sébastien Desgent", "Sandra Duss", "Nathalie T. Sanon", "Pablo Lema", "Maxime Lévesque", "David Hébert", "Rose-Marie Rébillard", "Karine Bibeau", "Michèle Brochu", "Lionel Carmant"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0042622.g001", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Photomicrographs_of_cresyl_violet_sections_and_Cavalieri_s_cortical_lesion_volumes_estimations_in_the_adult_rats_/266890", "title"=>"Photomicrographs of cresyl violet sections and Cavalieri's cortical lesion volumes estimations in the adult rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:16:10"}

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Relative Metric

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