n-Butyl Benzyl Phthalate Promotes Breast Cancer Progression by Inducing Expression of Lymphoid Enhancer Factor 1
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{"title"=>"N-butyl benzyl phthalate promotes breast cancer progression by inducing expression of lymphoid enhancer factor 1", "type"=>"journal", "authors"=>[{"first_name"=>"Tsung Hua", "last_name"=>"Hsieh", "scopus_author_id"=>"54946691600"}, {"first_name"=>"Cheng Fang", "last_name"=>"Tsai", "scopus_author_id"=>"56409024000"}, {"first_name"=>"Chia Yi", "last_name"=>"Hsu", "scopus_author_id"=>"36838894600"}, {"first_name"=>"Po Lin", "last_name"=>"Kuo", "scopus_author_id"=>"18233917100"}, {"first_name"=>"Edward", "last_name"=>"Hsi", "scopus_author_id"=>"15053395800"}, {"first_name"=>"Jau Ling", "last_name"=>"Suen", "scopus_author_id"=>"7006603101"}, {"first_name"=>"Chih Hsing", "last_name"=>"Hung", "scopus_author_id"=>"57139398300"}, {"first_name"=>"Jau Nan", "last_name"=>"Lee", "scopus_author_id"=>"8980323400"}, {"first_name"=>"Chee Yin", "last_name"=>"Chai", "scopus_author_id"=>"57154892600"}, {"first_name"=>"Shao Chun", "last_name"=>"Wang", "scopus_author_id"=>"35316397400"}, {"first_name"=>"Eing Mei", "last_name"=>"Tsai", "scopus_author_id"=>"55664356700"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"22905168", "sgr"=>"84864697428", "doi"=>"10.1371/journal.pone.0042750", "scopus"=>"2-s2.0-84864697428", "pui"=>"365400263", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "issn"=>"19326203"}, "id"=>"c94bfdd9-75e6-3182-8bf5-696ca802e8ee", "abstract"=>"Environmental hormones play important roles in regulating the expression of genes involved in cell proliferation, drug resistance, and breast cancer risk; however, their precise role in human breast cancer cells during cancer progression remains unclear. To elucidate the effect of the most widely used industrial phthalate, n-butyl benzyl phthalate (BBP), on cancer progression, we evaluated the results of BBP treatment using a whole human genome cDNA microarray and MetaCore software and selected candidate genes whose expression was changed by more than ten-fold by BBP compared with controls to analyze the signaling pathways in human breast cancer initiating cells (R2d). A total of 473 genes were upregulated, and 468 were downregulated. Most of these genes are involved in proliferation, epithelial-mesenchymal transition, and angiogenesis signaling. BBP induced the viability, invasion and migration, and tube formation in vitro, and Matrigel plug angiogenesis in vivo of R2d and MCF-7. Furthermore, the viability and invasion and migration of these cell lines following BBP treatment was reduced by transfection with a small interfering RNA targeting the mRNA for lymphoid enhancer-binding factor 1; notably, the altered expression of this gene consistently differentiated tumors expressing genes involved in proliferation, epithelial-mesenchymal transition, and angiogenesis. These findings contribute to our understanding of the molecular impact of the environmental hormone BBP and suggest possible strategies for preventing and treating human breast cancer.", "link"=>"http://www.mendeley.com/research/nbutyl-benzyl-phthalate-promotes-breast-cancer-progression-inducing-expression-lymphoid-enhancer-fac", "reader_count"=>14, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>2, "Researcher"=>6, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Professor"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>2, "Researcher"=>6, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Professor"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>5, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Chemistry"=>{"Chemistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Hungary"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/594580"], "description"=>"<p>(A) R2d cells were exposed to 10 nM, 100 nM, 1 µM, or 10 µM BBP in serum-free medium for 24 h. Cell viability was determined with the XTT assay. (B) CD44, CD24 surface markers and estrogen receptor was stained by flow cytometry in R2d. (C,D) R2d cells were pretreated with ICI182780 (1 uM), tamoxifen (1 uM) for 1 h, and then treated with 1 µM of BBP for an additional 24 h. Viability of cells and CD44 was measured. These data represent the mean ± SE of three experiments. Each asterisk denotes a significant difference compared to the control (P<0.05; one-tailed Student's t-test). Control-S: control cells grown in serum containing media, Control-SF: control cells grown in serum-free media.</p>", "links"=>[], "tags"=>["bbp", "viability", "cultured", "r2d"], "article_id"=>265035, "categories"=>["Physiology", "Cancer", "Cell Biology", "Genetics", "Developmental Biology"], "users"=>["Tsung-Hua Hsieh", "Cheng-Fang Tsai", "Chia-Yi Hsu", "Po-Lin Kuo", "Edward Hsi", "Jau-Ling Suen", "Chih-Hsing Hung", "Jau-Nan Lee", "Chee-Yin Chai", "Shao-Chun Wang", "Eing-Mei Tsai"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0042750.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_BBP_on_the_viability_of_cultured_R2d_cells_/265035", "title"=>"Effects of BBP on the viability of cultured R2d cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:05:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/594698"], "description"=>"<p>The top ten GeneGO pathway maps (A), cellular processes (B), diseases (C), and metabolic networks (D) in BBP-treated cells are shown. These gene pathways were analyzed with MetaCore software.</p>", "links"=>[], "tags"=>["genes", "was", "altered", "bbp", "compared"], "article_id"=>265157, "categories"=>["Physiology", "Cancer", "Cell Biology", "Genetics", "Developmental Biology"], "users"=>["Tsung-Hua Hsieh", "Cheng-Fang Tsai", "Chia-Yi Hsu", "Po-Lin Kuo", "Edward Hsi", "Jau-Ling Suen", "Chih-Hsing Hung", "Jau-Nan Lee", "Chee-Yin Chai", "Shao-Chun Wang", "Eing-Mei Tsai"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0042750.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pathway_analysis_of_genes_whose_expression_was_significantly_altered_by_BBP_treatment_compared_with_control_/265157", "title"=>"Pathway analysis of genes whose expression was significantly altered by BBP treatment compared with control.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:06:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/594843"], "description"=>"<p>Breast cancer cells were exposed to 10 or 20 µm BBP for 24 h. The viability of R2d (A) and MCF-7 (B) cells was analyzed with the XTT assay. Invasion and migration were assessed with invasion assays (C, D) and the wound healing assay (E, F). The horizontal dashed line in panels E and F indicates the width of the wound. For the in vitro angiogenesis study, HUVECs were seeded into BioCoated plates, and added the medium that was obtained from the MCF-7 replacing medium with or without BBP (10, 20 µM) for 18 h. The capillary-like structures formed by HUVECs were stained with Calcein-AM and imaged by fluorescence microscopy. The tube formation number in different concentrations of HUVECs was calculated by MetaMorph software (Molecular Devices) (G). For the in vivo angiogenesis study, MCF-7 cells were mixed with phenol red–free Matrigel and injected into the flanks of nude mice for 15 days. In vivo angiogenesis was determined by the levels of red blood cells in tissue sections containing Matrigel plugs (H, top). The hemoglobin levels were determined with the Drabkin method (H, bottom). The data represent the mean ± SE of three experiments. Each asterisk denotes a significant difference compared to the control (P<0.05; one-tailed Student's t-test).</p>", "links"=>[], "tags"=>["cancer", "cells", "angiogenesis"], "article_id"=>265307, "categories"=>["Physiology", "Cancer", "Cell Biology", "Genetics", "Developmental Biology"], "users"=>["Tsung-Hua Hsieh", "Cheng-Fang Tsai", "Chia-Yi Hsu", "Po-Lin Kuo", "Edward Hsi", "Jau-Ling Suen", "Chih-Hsing Hung", "Jau-Nan Lee", "Chee-Yin Chai", "Shao-Chun Wang", "Eing-Mei Tsai"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0042750.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_BBP_mediated_cell_viability_invasion_and_migration_of_breast_cancer_cells_and_angiogenesis_in_breast_cancer_/265307", "title"=>"BBP-mediated cell viability, invasion and migration of breast cancer cells and angiogenesis in breast cancer.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:07:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/594971"], "description"=>"<p>The expression of CRITPO, FGF, PKA, EDNRA, LMO1, VEGF-D, LEF-1, PDGFR, PDGFRA, ADCV, and TCF (LEF) was examined in R2d and MCF-7 cells treated with 1 µM BBP using qRT-PCR. The data represent the mean ± SE of three experiments.</p>", "links"=>[], "tags"=>["bbp", "genes", "cancer"], "article_id"=>265441, "categories"=>["Physiology", "Cancer", "Cell Biology", "Genetics", "Developmental Biology"], "users"=>["Tsung-Hua Hsieh", "Cheng-Fang Tsai", "Chia-Yi Hsu", "Po-Lin Kuo", "Edward Hsi", "Jau-Ling Suen", "Chih-Hsing Hung", "Jau-Nan Lee", "Chee-Yin Chai", "Shao-Chun Wang", "Eing-Mei Tsai"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0042750.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_effect_of_BBP_on_expression_of_selected_genes_in_breast_cancer_cells_/265441", "title"=>"The effect of BBP on expression of selected genes in breast cancer cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:08:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/595119"], "description"=>"<p>(A) One identified gene, LEF-1, was found to be in the proliferation pathway group, the EMT pathway group, and the angiogenesis pathway group. (B, C) Silencing of LEF-1 was performed by transfecting LEF-1 siRNA-1 (5 nM) or LEF-1 siRNA-2 (5 nM), and LEF-1 expression was detected with qRT-PCR, western blot and compared to cells transfected with control siRNA. (D, E) Breast cancer cells were pretransfected with control siRNA or siRNA for LEF-1 (siRNA-1/2) and then treated with BBP for 24 h. Cell viability was analyzed with the XXT assay in R2d (D) and MCF-7 (E) cells. Cells treated as in panels D and E were assessed with the invasion assay (F, G) and wound healing assay (H, I). The horizontal dashed line in panels H and I indicates the width of the wound. The data represent the mean ± SE of three experiments. Each asterisk denotes a significant difference compared to the control (P<0.05; one-tailed Student's t-test).</p>", "links"=>[], "tags"=>["lef-1", "cancer", "cells", "treated"], "article_id"=>265585, "categories"=>["Physiology", "Cancer", "Cell Biology", "Genetics", "Developmental Biology"], "users"=>["Tsung-Hua Hsieh", "Cheng-Fang Tsai", "Chia-Yi Hsu", "Po-Lin Kuo", "Edward Hsi", "Jau-Ling Suen", "Chih-Hsing Hung", "Jau-Nan Lee", "Chee-Yin Chai", "Shao-Chun Wang", "Eing-Mei Tsai"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0042750.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Role_of_LEF_1_in_breast_cancer_cells_treated_with_BBP_/265585", "title"=>"Role of LEF-1 in breast cancer cells treated with BBP.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:08:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/595281"], "description"=>"<p>See text for details.</p>", "links"=>[], "tags"=>["pathway", "proteins", "differentially", "bbp"], "article_id"=>265743, "categories"=>["Physiology", "Cancer", "Cell Biology", "Genetics", "Developmental Biology"], "users"=>["Tsung-Hua Hsieh", "Cheng-Fang Tsai", "Chia-Yi Hsu", "Po-Lin Kuo", "Edward Hsi", "Jau-Ling Suen", "Chih-Hsing Hung", "Jau-Nan Lee", "Chee-Yin Chai", "Shao-Chun Wang", "Eing-Mei Tsai"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0042750.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_network_pathway_associated_with_the_proteins_differentially_expressed_in_response_to_BBP_treatment_/265743", "title"=>"The network pathway associated with the proteins differentially expressed in response to BBP treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 01:09:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/595415"], "description"=>"<p>Functional description of the candidate genes whose expression was altered by BBP treatment in R2d cells.</p>", "links"=>[], "tags"=>["genes", "was", "altered", "bbp", "r2d"], "article_id"=>265875, "categories"=>["Physiology", "Cancer", "Cell Biology", "Genetics", "Developmental Biology"], "users"=>["Tsung-Hua Hsieh", "Cheng-Fang Tsai", "Chia-Yi Hsu", "Po-Lin Kuo", "Edward Hsi", "Jau-Ling Suen", "Chih-Hsing Hung", "Jau-Nan Lee", "Chee-Yin Chai", "Shao-Chun Wang", "Eing-Mei Tsai"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0042750.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Functional_description_of_the_candidate_genes_whose_expression_was_altered_by_BBP_treatment_in_R2d_cells_/265875", "title"=>"Functional description of the candidate genes whose expression was altered by BBP treatment in R2d cells.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 01:10:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/595491"], "description"=>"<p>Top 30 genes upregulated by BBP treatment compared with the control.</p>", "links"=>[], "tags"=>["30", "genes", "upregulated", "bbp", "compared"], "article_id"=>265952, "categories"=>["Physiology", "Cancer", "Cell Biology", "Genetics", "Developmental Biology"], "users"=>["Tsung-Hua Hsieh", "Cheng-Fang Tsai", "Chia-Yi Hsu", "Po-Lin Kuo", "Edward Hsi", "Jau-Ling Suen", "Chih-Hsing Hung", "Jau-Nan Lee", "Chee-Yin Chai", "Shao-Chun Wang", "Eing-Mei Tsai"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0042750.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Top_30_genes_upregulated_by_BBP_treatment_compared_with_the_control_/265952", "title"=>"Top 30 genes upregulated by BBP treatment compared with the control.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 01:10:58"}

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Relative Metric

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