Vitamin K-Antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Vitamin K-Antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype", "type"=>"journal", "authors"=>[{"first_name"=>"Leon J.", "last_name"=>"Schurgers", "scopus_author_id"=>"6603547811"}, {"first_name"=>"Ivo A.", "last_name"=>"Joosen", "scopus_author_id"=>"36128619100"}, {"first_name"=>"Eduard M.", "last_name"=>"Laufer", "scopus_author_id"=>"26221182000"}, {"first_name"=>"Martijn L.L.", "last_name"=>"Chatrou", "scopus_author_id"=>"54784026900"}, {"first_name"=>"Marjolein", "last_name"=>"Herfs", "scopus_author_id"=>"25635931800"}, {"first_name"=>"Mark H.M.", "last_name"=>"Winkens", "scopus_author_id"=>"25224994000"}, {"first_name"=>"Ralf", "last_name"=>"Westenfeld", "scopus_author_id"=>"6603228982"}, {"first_name"=>"Verena", "last_name"=>"Veulemans", "scopus_author_id"=>"55347742900"}, {"first_name"=>"Thilo", "last_name"=>"Krueger", "scopus_author_id"=>"26435396700"}, {"first_name"=>"Catherine M.", "last_name"=>"Shanahan", "scopus_author_id"=>"7003716714"}, {"first_name"=>"Willi", "last_name"=>"Jahnen-Dechent", "scopus_author_id"=>"7004596581"}, {"first_name"=>"Erik", "last_name"=>"Biessen", "scopus_author_id"=>"7005399404"}, {"first_name"=>"Jagat", "last_name"=>"Narula", "scopus_author_id"=>"7006139754"}, {"first_name"=>"Cees", "last_name"=>"Vermeer", "scopus_author_id"=>"55358941800"}, {"first_name"=>"Leonard", "last_name"=>"Hofstra", "scopus_author_id"=>"7004868273"}, {"first_name"=>"Chris P.", "last_name"=>"Reutelingsperger", "scopus_author_id"=>"7006626020"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"365542816", "sgr"=>"84865598969", "issn"=>"19326203", "pmid"=>"22952653", "scopus"=>"2-s2.0-84865598969", "doi"=>"10.1371/journal.pone.0043229", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"29af4344-7152-3ffe-bd96-665f8feff05c", "abstract"=>"BACKGROUND: Vitamin K-antagonists (VKA) are treatment of choice and standard care for patients with venous thrombosis and thromboembolic risk. In experimental animal models as well as humans, VKA have been shown to promote medial elastocalcinosis. As vascular calcification is considered an independent risk factor for plaque instability, we here investigated the effect of VKA on coronary calcification in patients and on calcification of atherosclerotic plaques in the ApoE(-/-) model of atherosclerosis.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: A total of 266 patients (133 VKA users and 133 gender and Framingham Risk Score matched non-VKA users) underwent 64-slice MDCT to assess the degree of coronary artery disease (CAD). VKA-users developed significantly more calcified coronary plaques as compared to non-VKA users. ApoE(-/-) mice (10 weeks) received a Western type diet (WTD) for 12 weeks, after which mice were fed a WTD supplemented with vitamin K(1) (VK(1), 1.5 mg/g) or vitamin K(1) and warfarin (VK(1)&W; 1.5 mg/g & 3.0 mg/g) for 1 or 4 weeks, after which mice were sacrificed. Warfarin significantly increased frequency and extent of vascular calcification. Also, plaque calcification comprised microcalcification of the intimal layer. Furthermore, warfarin treatment decreased plaque expression of calcification regulatory protein carboxylated matrix Gla-protein, increased apoptosis and, surprisingly outward plaque remodeling, without affecting overall plaque burden.\\n\\nCONCLUSIONS/SIGNIFICANCE: VKA use is associated with coronary artery plaque calcification in patients with suspected CAD and causes changes in plaque morphology with features of plaque vulnerability in ApoE(-/-) mice. Our findings underscore the need for alternative anticoagulants that do not interfere with the vitamin K cycle.", "link"=>"http://www.mendeley.com/research/vitamin-kantagonists-accelerate-atherosclerotic-calcification-induce-vulnerable-plaque-phenotype", "reader_count"=>66, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>8, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>12, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>8, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>12, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>5, "Medicine and Dentistry"=>37, "Agricultural and Biological Sciences"=>13, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Sports and Recreations"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>37}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}}, "reader_count_by_country"=>{"Netherlands"=>1, "Brazil"=>1, "Israel"=>1, "Germany"=>1}, "group_count"=>10}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84865598969"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84865598969?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84865598969&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84865598969&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84865598969", "dc:identifier"=>"SCOPUS_ID:84865598969", "eid"=>"2-s2.0-84865598969", "dc:title"=>"Vitamin K-Antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype", "dc:creator"=>"Schurgers L.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"7", "prism:issueIdentifier"=>"8", "prism:pageRange"=>nil, "prism:coverDate"=>"2012-08-29", "prism:coverDisplayDate"=>"29 August 2012", "prism:doi"=>"10.1371/journal.pone.0043229", "citedby-count"=>"73", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Cardiovascular Research Institute Maastricht", "affiliation-city"=>"Maastricht", "affiliation-country"=>"Netherlands"}], "pubmed-id"=>"22952653", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e43229", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0043229", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"71", "xml_views"=>"0", "html_views"=>"150"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"40", "xml_views"=>"1", "html_views"=>"94"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"60"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"93"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"116"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"76"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"64"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"30", "xml_views"=>"2", "html_views"=>"108"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"114"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"102"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"23", "xml_views"=>"3", "html_views"=>"78"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"106"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"92"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"3", "html_views"=>"92"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"103"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"68"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"109"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"75"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"3", "html_views"=>"60"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"50"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"140"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"60"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"59"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"42"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"82"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"60"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"4", "html_views"=>"25"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"19"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"38", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"3", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"14"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/585555"], "description"=>"<p>Continuous variables are presented as means ± SD, while categorical variables are expressed as number (percentage). BP, blood pressure; HDL, high-density lipoprotein; LDL, low-density lipoprotein.</p>", "links"=>[], "tags"=>["characteristics", "patients", "vka"], "article_id"=>256035, "categories"=>["Biochemistry"], "users"=>["Leon J. Schurgers", "Ivo A. Joosen", "Eduard M. Laufer", "Martijn L. L. Chatrou", "Marjolein Herfs", "Mark H. M. Winkens", "Ralf Westenfeld", "Verena Veulemans", "Thilo Krueger", "Catherine M. Shanahan", "Willi Jahnen-Dechent", "Erik Biessen", "Jagat Narula", "Cees Vermeer", "Leonard Hofstra", "Chris P. Reutelingsperger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043229.t001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_of_patients_on_VKA_treatment_/256035", "title"=>"Baseline characteristics of patients on VKA treatment.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 00:16:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/585692"], "description"=>"<p>mRNA expression levels of aortic tissue (n = 3) of calcification biomarkers at control and warfarin treatment at 4 weeks time point.</p>", "links"=>[], "tags"=>["levels", "aortic", "calcification", "biomarkers", "warfarin", "weeks"], "article_id"=>256165, "categories"=>["Biochemistry"], "users"=>["Leon J. Schurgers", "Ivo A. Joosen", "Eduard M. Laufer", "Martijn L. L. Chatrou", "Marjolein Herfs", "Mark H. M. Winkens", "Ralf Westenfeld", "Verena Veulemans", "Thilo Krueger", "Catherine M. Shanahan", "Willi Jahnen-Dechent", "Erik Biessen", "Jagat Narula", "Cees Vermeer", "Leonard Hofstra", "Chris P. Reutelingsperger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043229.t004", "stats"=>{"downloads"=>6, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_mRNA_expression_levels_of_aortic_tissue_n_8202_8202_3_of_calcification_biomarkers_at_control_and_warfarin_treatment_at_4_weeks_time_point_/256165", "title"=>"mRNA expression levels of aortic tissue (n = 3) of calcification biomarkers at control and warfarin treatment at 4 weeks time point.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 00:17:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/584791"], "description"=>"<p>To further characterize the calcified lesions we measured (A) and stained for alkaline phosphatase (C). Areas positive for von Kossa (B) often co-stained for ALK (C). Therefore we analyzed the ALK content of the different treatment groups (A). After one week of warfarin treatment a significant increase in ALK was already noticed, which further increased after 4 weeks of warfarin. ALK expression indicates an osteo/chondrogenic differentiation of VSMCs. Statistically significant differences were determined by the Kruskal Wallis test. *P<0.05, **P<0.01. p, plaque.</p>", "links"=>[], "tags"=>["upregulates", "alkaline", "phosphatase", "atherosclerotic"], "article_id"=>255270, "categories"=>["Biochemistry"], "users"=>["Leon J. Schurgers", "Ivo A. Joosen", "Eduard M. Laufer", "Martijn L. L. Chatrou", "Marjolein Herfs", "Mark H. M. Winkens", "Ralf Westenfeld", "Verena Veulemans", "Thilo Krueger", "Catherine M. Shanahan", "Willi Jahnen-Dechent", "Erik Biessen", "Jagat Narula", "Cees Vermeer", "Leonard Hofstra", "Chris P. Reutelingsperger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043229.g005", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Warfarin_upregulates_alkaline_phosphatase_activity_in_atherosclerotic_plaque_/255270", "title"=>"Warfarin upregulates alkaline phosphatase activity in atherosclerotic plaque.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 00:12:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/584048"], "description"=>"<p>A non-enhanced scan was performed to measure the Coronary artery calcification (Agatston score). Panel A shows a significant increase in Agatston score in VKA users (p = 0.029), as patients use VKA for a longer time (T = tertile of VKA use). This increase is not visible in individually matched patients not on VKA (panel B; p = 0.965). Next, CT-angiography was performed. All coronary segments were assessed for plaque presence and plaque morphology. In patients using VKA, a significant trend (p = 0.009) was seen towards a higher percentage of calcified plaques in those patients treated longest with VKA (panel C). In contrast, this was not the case for the non-VKA users (panel D). Coronary plaques were identified and categorized as calcified (closed circles), mixed calcified (diamonds) and non-calcified (open circles). T1, T2 and T3 indicate 1<sup>st</sup>, 2<sup>nd</sup> and 3<sup>rd</sup> tertile respectively.</p>", "links"=>[], "tags"=>["vka", "increases", "coronary", "calcification", "calcified", "stenotic"], "article_id"=>254504, "categories"=>["Biochemistry"], "users"=>["Leon J. Schurgers", "Ivo A. Joosen", "Eduard M. Laufer", "Martijn L. L. Chatrou", "Marjolein Herfs", "Mark H. M. Winkens", "Ralf Westenfeld", "Verena Veulemans", "Thilo Krueger", "Catherine M. Shanahan", "Willi Jahnen-Dechent", "Erik Biessen", "Jagat Narula", "Cees Vermeer", "Leonard Hofstra", "Chris P. Reutelingsperger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043229.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Duration_of_VKA_treatment_significantly_increases_the_amount_of_coronary_calcification_and_number_of_calcified_stenotic_plaques_/254504", "title"=>"Duration of VKA treatment significantly increases the amount of coronary calcification and number of calcified stenotic plaques.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 00:08:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/585598"], "description"=>"<p>Continuous variables are presented as means ± SD, while categorical variables are expressed as number (percentage). BP, blood pressure; HDL, high-density lipoprotein; LDL, low-density lipoprotein.</p>", "links"=>[], "tags"=>["characteristics", "patients", "vka"], "article_id"=>256075, "categories"=>["Biochemistry"], "users"=>["Leon J. Schurgers", "Ivo A. Joosen", "Eduard M. Laufer", "Martijn L. L. Chatrou", "Marjolein Herfs", "Mark H. M. Winkens", "Ralf Westenfeld", "Verena Veulemans", "Thilo Krueger", "Catherine M. Shanahan", "Willi Jahnen-Dechent", "Erik Biessen", "Jagat Narula", "Cees Vermeer", "Leonard Hofstra", "Chris P. Reutelingsperger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043229.t002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_of_patients_not_on_VKA_treatment_/256075", "title"=>"Baseline characteristics of patients not on VKA treatment.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 00:16:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/584984"], "description"=>"<p>To confirm action of warfarin locally in the plaque we stained plaques for ucMGP and cMGP. UcMGP is the result of vitamin K-deficiency. Within one week of warfarin treatment the amount of cMGP (A,E) decreased significantly and decreased even further after 4 weeks of warfarin treatment. The decrease in cMGP was accompanied by an increase in ucMGP (B,F). Immunohistochemistry for cMGP and ucMGP (E,F) showed increased amounts of ucMGP compared with cMGP in apoE<sup>−/−</sup> mice on warfarin, whereas apoE<sup>−/−</sup> mice on control diet had predominantly cMGP (C,D). cMGP indicates carboxylated MGP; ucMGP, uncarboxylated MGP. Statistically significant differences were determined by the Kruskal Wallis test. *P<0.05, **P<0.01. i, intima; m, media; l, lumen.</p>", "links"=>[], "tags"=>["affects", "carboxylation", "mgp", "atherosclerotic"], "article_id"=>255464, "categories"=>["Biochemistry"], "users"=>["Leon J. Schurgers", "Ivo A. Joosen", "Eduard M. Laufer", "Martijn L. L. Chatrou", "Marjolein Herfs", "Mark H. M. Winkens", "Ralf Westenfeld", "Verena Veulemans", "Thilo Krueger", "Catherine M. Shanahan", "Willi Jahnen-Dechent", "Erik Biessen", "Jagat Narula", "Cees Vermeer", "Leonard Hofstra", "Chris P. Reutelingsperger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043229.g006", "stats"=>{"downloads"=>9, "page_views"=>61, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Warfarin_affects_carboxylation_of_MGP_in_atherosclerotic_plaque_/255464", "title"=>"Warfarin affects carboxylation of MGP in atherosclerotic plaque.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 00:13:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/584391"], "description"=>"<p>ApoE−/− mice received WTD for three month (baseline) and subsequently control diet (WTD plus VK<sub>1</sub>) or warfarin (WTD plus VK<sub>1</sub>&W). Von Kossa stained calcified plaques were scored for medial (A,C) and intimal plaque calcification (B,D). In addition calcification was categorized as microcalcification (E, arrow heads) and macrocalcification (F, arrows). Microcalcifications occur either alone or in conjunction with macrocalcification. Statistically significant differences were determined by the Kruskal Wallis test. *P<0.05, **P<0.01, ***P<0.001. i, intima; m, media; l, lumen; a, adventitia.</p>", "links"=>[], "tags"=>["increases", "medial", "intimal", "plaque", "calcification"], "article_id"=>254872, "categories"=>["Biochemistry"], "users"=>["Leon J. Schurgers", "Ivo A. Joosen", "Eduard M. Laufer", "Martijn L. L. Chatrou", "Marjolein Herfs", "Mark H. M. Winkens", "Ralf Westenfeld", "Verena Veulemans", "Thilo Krueger", "Catherine M. Shanahan", "Willi Jahnen-Dechent", "Erik Biessen", "Jagat Narula", "Cees Vermeer", "Leonard Hofstra", "Chris P. Reutelingsperger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043229.g003", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Warfarin_treatment_rapidly_increases_medial_and_intimal_plaque_calcification_in_apoE_8722_8722_mice_/254872", "title"=>"Warfarin treatment rapidly increases medial and intimal plaque calcification in apoE<i><sup>−/−</sup></i> mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 00:10:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/585225"], "description"=>"<p>Vascular calcification is closely linked to apoptosis. Therefore we stained sections for caspase-3. Moreover, all animals were injected with annexin A5-biotin, a protein with high affinity for phosphatidylserine (PS). Both cleaved caspase-3 (A,C) and annexin A5-biotin (B,D) increased in the warfarin treatment, with annexin A5 accumulation significantly increased after 4 weeks of warfarin treatment (B). Annexin A5 staining using AP vector blue confirmed PS externalization at different sites in the atherosclerotic plaques. Activated and apoptotic macrophages are known to express PS on their surface. We found co-localization of macrophages in the shoulder of the atherosclerotic plaque (Mac3; F) and PS (annexin A5 stained with AP vector red; E), indicating activated and apoptotic macrophages. In the inset annexin A5 (blue) localizes with Mac-3 staining (red/brown), indicating activated macrophages. Moreover, at baseline annexin A5 was only incidentally present at the surface of the plaque (G), whereas at the 4 weeks warfarin treatment, annexin A5 stained significantly positive (H). Statistically significant differences were determined by the Kruskal Wallis test. *P<0.05. i, intima; m, media; l, lumen.</p>", "links"=>[], "tags"=>["mice", "increases", "apoptosis", "atherosclerotic"], "article_id"=>255699, "categories"=>["Biochemistry"], "users"=>["Leon J. Schurgers", "Ivo A. Joosen", "Eduard M. Laufer", "Martijn L. L. Chatrou", "Marjolein Herfs", "Mark H. M. Winkens", "Ralf Westenfeld", "Verena Veulemans", "Thilo Krueger", "Catherine M. Shanahan", "Willi Jahnen-Dechent", "Erik Biessen", "Jagat Narula", "Cees Vermeer", "Leonard Hofstra", "Chris P. Reutelingsperger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043229.g007", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Warfarin_treatment_of_apoE_8722_8722_mice_increases_apoptosis_in_atherosclerotic_plaque_/255699", "title"=>"Warfarin treatment of apoE<sup>−/−</sup> mice increases apoptosis in atherosclerotic plaque.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 00:14:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/585433"], "description"=>"<p>An unexpected feature of warfarin treatment was the significantly increased number of outward remodeled plaques (B,D). Outward remodeling is, like plaque calcification, a feature of the instable rupture-prone atherosclerotic plaque. To explain this phenotype induced by warfarin we stained sections for the VSMC marker αSMactin. We found that warfarin treatment was associated with a significant loss of medial VSMCs (A,C). Statistically significant differences were determined by the Kruskal Wallis test. *P<0.05, **P<0.01. i, intima; m, media; l, lumen; o, outward remodeled plaque.</p>", "links"=>[], "tags"=>["induces", "medial", "vsmc", "increases", "outward", "remodeling", "atherosclerotic", "indications", "instable", "plaque"], "article_id"=>255893, "categories"=>["Biochemistry"], "users"=>["Leon J. Schurgers", "Ivo A. Joosen", "Eduard M. Laufer", "Martijn L. L. Chatrou", "Marjolein Herfs", "Mark H. M. Winkens", "Ralf Westenfeld", "Verena Veulemans", "Thilo Krueger", "Catherine M. Shanahan", "Willi Jahnen-Dechent", "Erik Biessen", "Jagat Narula", "Cees Vermeer", "Leonard Hofstra", "Chris P. Reutelingsperger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043229.g008", "stats"=>{"downloads"=>0, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Warfarin_induces_medial_VSMC_loss_and_increases_outward_remodeling_of_atherosclerotic_plaques_both_indications_of_an_instable_plaque_phenotype_/255893", "title"=>"Warfarin induces medial VSMC loss and increases outward remodeling of atherosclerotic plaques, both indications of an instable plaque phenotype.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 00:15:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/584208"], "description"=>"<p>ApoE<sup>−/−</sup> mice developed atherosclerotic lesions in the aortic arch and carotid arteries when maintained on Western type diet (WTD) for 12 weeks (A). From baseline mice were fed with WTD plus vitamin K (VK<sub>1</sub>) or WTD plus vitamin K and warfarin (VK<sub>1</sub>&W) for the duration of one week or four weeks. Growth of intimal area was not significantly affected by warfarin. Vascular calcium was determined by AAS and revealed significant increase in calcium at 1 and 4 weeks warfarin treatment. Statistically significant differences were determined by the Kruskal Wallis test. *P<0.05.</p>", "links"=>[], "tags"=>["apoe", "deficient", "mice", "plaque", "increases", "vascular"], "article_id"=>254681, "categories"=>["Biochemistry"], "users"=>["Leon J. Schurgers", "Ivo A. Joosen", "Eduard M. Laufer", "Martijn L. L. Chatrou", "Marjolein Herfs", "Mark H. M. Winkens", "Ralf Westenfeld", "Verena Veulemans", "Thilo Krueger", "Catherine M. Shanahan", "Willi Jahnen-Dechent", "Erik Biessen", "Jagat Narula", "Cees Vermeer", "Leonard Hofstra", "Chris P. Reutelingsperger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043229.g002", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Warfarin_treatment_of_apoE_deficient_mice_on_Western_Type_Diet_does_not_influence_plaque_size_but_increases_vascular_calcification_/254681", "title"=>"Warfarin treatment of apoE deficient mice on Western Type Diet does not influence plaque size but increases vascular calcification.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 00:09:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/584623"], "description"=>"<p>To characterize cells calcified or adjacent to the calcification area we closely examined stained von Kossa sections (A). Calcified cells in the atherosclerotic plaque displayed chondrocyte features. To confirm the presence of chondrocytes we stained for collagen type-II, a specific marker for chondrocytes. Areas in the plaque with suspected chondrocytes stained positive for collagen type-II (B). Quantification revealed that after 4 weeks of warfarin treatment a significant increase was measured (C). Statistically significant differences were determined by the Kruskal Wallis test. *P<0.05. i, intima; m, media; l, lumen; a, adventitia.</p>", "links"=>[], "tags"=>["induces", "atherosclerotic", "calcification", "chondrogenic", "plaque"], "article_id"=>255096, "categories"=>["Biochemistry"], "users"=>["Leon J. Schurgers", "Ivo A. Joosen", "Eduard M. Laufer", "Martijn L. L. Chatrou", "Marjolein Herfs", "Mark H. M. Winkens", "Ralf Westenfeld", "Verena Veulemans", "Thilo Krueger", "Catherine M. Shanahan", "Willi Jahnen-Dechent", "Erik Biessen", "Jagat Narula", "Cees Vermeer", "Leonard Hofstra", "Chris P. Reutelingsperger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043229.g004", "stats"=>{"downloads"=>0, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Warfarin_induces_atherosclerotic_calcification_which_induces_a_chondrogenic_plaque_phenotype_/255096", "title"=>"Warfarin induces atherosclerotic calcification which induces a chondrogenic plaque phenotype.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 00:11:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/585645"], "description"=>"<p>WTD, Western type diet.</p>", "links"=>[], "tags"=>["characteristics", "mice", "weeks"], "article_id"=>256121, "categories"=>["Biochemistry"], "users"=>["Leon J. Schurgers", "Ivo A. Joosen", "Eduard M. Laufer", "Martijn L. L. Chatrou", "Marjolein Herfs", "Mark H. M. Winkens", "Ralf Westenfeld", "Verena Veulemans", "Thilo Krueger", "Catherine M. Shanahan", "Willi Jahnen-Dechent", "Erik Biessen", "Jagat Narula", "Cees Vermeer", "Leonard Hofstra", "Chris P. Reutelingsperger"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043229.t003", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Weight_and_blood_characteristics_of_apoE_8722_8722_mice_at_baseline_and_after_one_or_four_weeks_of_treatment_/256121", "title"=>"Weight and blood characteristics of apoE<sup>−/−</sup> mice at baseline, and after one or four weeks of treatment.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 00:16:45"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"122", "full-text"=>"138", "pdf"=>"80", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"41", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"119", "full-text"=>"134", "pdf"=>"99", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"52", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"48", "full-text"=>"51", "pdf"=>"27", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"73", "full-text"=>"80", "pdf"=>"26", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"54", "full-text"=>"54", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"47", "full-text"=>"58", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"64", "full-text"=>"76", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"91", "full-text"=>"97", "pdf"=>"74", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"24", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"47", "full-text"=>"62", "pdf"=>"30", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"35", "full-text"=>"32", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"31", "full-text"=>"43", "pdf"=>"36", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"36", "full-text"=>"40", "pdf"=>"34", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"42", "full-text"=>"55", "pdf"=>"39", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"40", "full-text"=>"44", "pdf"=>"23", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"22", "full-text"=>"32", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"32", "full-text"=>"40", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"36", "full-text"=>"33", "pdf"=>"25", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"27", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"28", "full-text"=>"25", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"29", "full-text"=>"40", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"30", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"49", "full-text"=>"51", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"47", "full-text"=>"48", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"49", "full-text"=>"56", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"44", "full-text"=>"51", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"48", "full-text"=>"48", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"49", "full-text"=>"64", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"33", "full-text"=>"34", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"49", "full-text"=>"54", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"35", "full-text"=>"37", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"29", "full-text"=>"25", "pdf"=>"13", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"32", "full-text"=>"36", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"29", "full-text"=>"35", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"54", "full-text"=>"60", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"34", "full-text"=>"40", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"47", "full-text"=>"44", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"41", "full-text"=>"43", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"29", "full-text"=>"31", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"33", "full-text"=>"39", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"45", "full-text"=>"45", "pdf"=>"29", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"43", "full-text"=>"46", "pdf"=>"43", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"32", "full-text"=>"38", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"62", "full-text"=>"69", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"50", "full-text"=>"54", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"45", "full-text"=>"57", "pdf"=>"29", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"51", "full-text"=>"55", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"31", "full-text"=>"39", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"46", "full-text"=>"60", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"37", "full-text"=>"35", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"54", "full-text"=>"63", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"38", "full-text"=>"44", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"71", "full-text"=>"102", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"73", "full-text"=>"81", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"59", "full-text"=>"60", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"58", "full-text"=>"62", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"62", "full-text"=>"72", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"47", "full-text"=>"46", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"82", "full-text"=>"92", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"57", "full-text"=>"66", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"66", "full-text"=>"68", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"68", "full-text"=>"83", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"67", "full-text"=>"75", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"44", "full-text"=>"52", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"48", "full-text"=>"58", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"83", "full-text"=>"109", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"56", "full-text"=>"59", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"58", "full-text"=>"73", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"58", "full-text"=>"72", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"46", "full-text"=>"60", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"56", "full-text"=>"70", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"77", "full-text"=>"76", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"62", "full-text"=>"70", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"45", "full-text"=>"52", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"40", "full-text"=>"53", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"54", "full-text"=>"66", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"39", "full-text"=>"43", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"42", "full-text"=>"40", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"49", "full-text"=>"48", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"59", "full-text"=>"67", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"6", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Nutrition", "average_usage"=>[292, 539, 673, 776, 876, 986, 1099, 1210, 1305, 1390, 1476, 1560, 1633, 1726, 1813, 1903, 1969, 2024, 2082, 2153, 2235, 2301, 2366, 2432, 2495]}, {"subject_area"=>"/Medicine and health sciences/Nutrition", "average_usage"=>[307, 546, 676, 780, 888, 986, 1099, 1202, 1282, 1376, 1468, 1552, 1627, 1713, 1774, 1875, 1944, 2011, 2079, 2133, 2210, 2282, 2358, 2422, 2480]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[308, 535, 653, 754, 847, 930, 1020, 1103, 1188, 1268, 1351, 1420, 1487, 1550, 1614, 1679, 1757, 1830, 1898, 1961, 2024, 2086, 2150, 2216, 2266]}]}
Loading … Spinner
There are currently no alerts