Investigating the Role of FGF18 in the Cultivation and Osteogenic Differentiation of Mesenchymal Stem Cells
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Mendeley | Further Information

{"title"=>"Investigating the Role of FGF18 in the Cultivation and Osteogenic Differentiation of Mesenchymal Stem Cells", "type"=>"journal", "authors"=>[{"first_name"=>"Eunyi", "last_name"=>"Jeon"}, {"first_name"=>"Ye-Rang", "last_name"=>"Yun"}, {"first_name"=>"Wonmo", "last_name"=>"Kang"}, {"first_name"=>"Sujin", "last_name"=>"Lee"}, {"first_name"=>"Young-Hyag", "last_name"=>"Koh"}, {"first_name"=>"Hae-Won", "last_name"=>"Kim"}, {"first_name"=>"Chang Kook", "last_name"=>"Suh"}, {"first_name"=>"Jun-Hyeog", "last_name"=>"Jang"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0043982", "pmid"=>"22937141"}, "id"=>"ec6ca688-b154-309c-bc6a-37b77845b19c", "abstract"=>"Fibroblast growth factor18 (FGF18) belongs to the FGF family and is a pleiotropic protein that stimulates proliferation in several tissues. Bone marrow mesenchymal stem cells (BMSCs) participate in the normal replacement of damaged cells and in disease healing processes within bone and the haematopoietic system. In this study, we constructed FGF18 and investigated its effects on rat BMSCs (rBMSCs). The proliferative effects of FGF18 on rBMSCs were examined using an MTS assay. To validate the osteogenic differentiation effects of FGF18, ALP and mineralization activity were examined as well as osteogenic differentiation-related gene levels. FGF18 significantly enhanced rBMSCs proliferation (p<0.001) and induced the osteogenic differentiation by elevating ALP and mineralization activity of rBMSCs (p<0.001). Furthermore, these osteogenic differentiation effects of FGF18 were confirmed via increasing the mRNA levels of collagen type I (Col I), bone morphogenetic protein 4 (BMP4), and Runt-related transcription factor 2 (Runx2) at 3 and 7 days. These results suggest that FGF18 could be used to improve bone repair and regeneration.", "link"=>"http://www.mendeley.com/research/investigating-role-fgf18-cultivation-osteogenic-differentiation-mesenchymal-stem-cells", "reader_count"=>12, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Materials Science"=>1, "Agricultural and Biological Sciences"=>6, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Materials Science"=>{"Materials Science"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Japan"=>1, "United Kingdom"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/587801"], "description"=>"<p>Cells were seeded at a density of 1×10<sup>4</sup> cells/well on plates coated with or without FGF18 and incubated overnight at 4°C. Non-treated cells were used as a control. Mineralization activity was expressed as absorbance and represent the mean±SD. <sup>a–c</sup>Different letters show statistically significance difference among groups (<i>p</i><0.001).</p>", "links"=>[], "tags"=>["fgf18", "rbmscs", "14"], "article_id"=>258295, "categories"=>["Physiology", "Biotechnology", "Biochemistry"], "users"=>["Eunyi Jeon", "Ye-Rang Yun", "Wonmo Kang", "Sujin Lee", "Young-Hyag Koh", "Hae-Won Kim", "Chang Kook Suh", "Jun-Hyeog Jang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0043982.g004", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mineralization_activity_of_FGF18_500_ng_ml_on_rBMSCs_at_0_7_and_14_days_/258295", "title"=>"Mineralization activity of FGF18 (500 ng/ml) on rBMSCs at 0, 7 and 14 days.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 00:28:42"}
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