Measurements of DNA Methylation at Seven Loci in Various Tissues of CD1 Mice
Publication Date
September 07, 2012
Journal
PLOS ONE
Authors
Laurynas Daugela, Nicole Nüsgen, Maja Walier, Johannes Oldenburg, et al
Volume
7
Issue
9
Pages
e44585
DOI
https://dx.plos.org/10.1371/journal.pone.0044585
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0044585
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/22970256
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436786
Europe PMC
http://europepmc.org/abstract/MED/22970256
Web of Science
000308462000032
Scopus
84866119125
Mendeley
http://www.mendeley.com/research/measurements-dna-methylation-seven-loci-various-tissues-cd1-mice
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Mendeley | Further Information

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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/579675"], "description"=>"<p>Box plots represent both male and female individual methylation data at each loci/tissues. Red boxes represent females and blue boxes represent males. Significant t-test (corrected for multiple testing by Bonferoni method) differences between sexes are indicated by a green bracket and a star (for detailed p values see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044585#pone.0044585.s006\" target=\"_blank\">Table S2</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044585#pone.0044585.s007\" target=\"_blank\">S3</a>).</p>", "links"=>[], "tags"=>["plots", "methylation"], "article_id"=>250170, "categories"=>["Molecular Biology", "Biochemistry", "Physics", "Genetics", "Biophysics"], "users"=>["Laurynas Daugela", "Nicole Nüsgen", "Maja Walier", "Johannes Oldenburg", "Rainer Schwaab", "Osman El-Maarri"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0044585.g002", "stats"=>{"downloads"=>0, "page_views"=>33, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Box_plots_of_methylation_values_/250170", "title"=>"Box plots of methylation values.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-09-07 00:02:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/579751"], "description"=>"<p>Data for two separate CpG sites and their average are shown. Significant p values are in bold.</p>", "links"=>[], "tags"=>["correlations", "inter", "intra-", "mice"], "article_id"=>250242, "categories"=>["Molecular Biology", "Biochemistry", "Physics", "Genetics", "Biophysics"], "users"=>["Laurynas Daugela", "Nicole Nüsgen", "Maja Walier", "Johannes Oldenburg", "Rainer Schwaab", "Osman El-Maarri"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0044585.t001", "stats"=>{"downloads"=>4, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spearman_correlations_of_significant_inter_A_and_intra_tissue_correlations_in_the_first_mice_population_/250242", "title"=>"Spearman correlations of significant inter (A) and intra- tissue correlations in the first mice population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-09-07 00:04:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/579572"], "description"=>"<p>A) Heat map and clustering of average methylation values (based on SIRPH results for the CpG-1 and first population of mice). Using the average linkage and Euclidean distance clustering method the average of all methylation values at a given loci/tissue in males (M) and females (F) (separate) are clustered. B) Heat map of variance of methylation values. The variance at each loci and tissue combination in both male and female mice subpopulations is shown. The levels of variances are noticeably similar in both sexes.</p>", "links"=>[], "tags"=>["maps", "methylation"], "article_id"=>250065, "categories"=>["Molecular Biology", "Biochemistry", "Physics", "Genetics", "Biophysics"], "users"=>["Laurynas Daugela", "Nicole Nüsgen", "Maja Walier", "Johannes Oldenburg", "Rainer Schwaab", "Osman El-Maarri"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0044585.g001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Heat_maps_of_methylation_values_and_variances_/250065", "title"=>"Heat maps of methylation values and variances.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-09-07 00:01:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/305328", "https://ndownloader.figshare.com/files/305342", "https://ndownloader.figshare.com/files/305357", "https://ndownloader.figshare.com/files/305377", "https://ndownloader.figshare.com/files/305393", "https://ndownloader.figshare.com/files/305406", "https://ndownloader.figshare.com/files/305412", "https://ndownloader.figshare.com/files/305426"], "description"=>"<div><p>In humans, considerable variation in methylation at single loci and repetitive elements in various cells and tissues is observed. Recently, several inter- and intra-tissue correlations for DNA methylation have been reported. To investigate the extent and reproducibility of such correlations, we investigated inter- and intra-tissue methylation correlations among seven different loci in 9 different tissues in a population of 100 healthy seven-week-old CD1 outbred mice. We used a highly quantitative approach to measure methylation levels to high accuracy at two single loci in the alpha-actin and myosine light chain promoters, at three differentially methylated regions of the <em>Peg3</em>, <em>Snrpn</em> and <em>Lit1</em> genes associated with imprinted loci, and at two repetitive elements in the <em>Line-1</em> and <em>IAP-LTR</em> genes in the various tissues. In this population of mice, methylation at several loci was sex-associated and intra-tissue correlations among the studied loci were observed for brain and spleen. Inter-tissue correlations were rarely observed. To investigate method-dependent experimental variability, we re-analyzed the same spleen and tongue samples using SIRPH and pyrosequencing methods and reconfirmed intra-tissue correlations for spleen and sex-associated correlations for DNA methylation for tongue. When we repeated DNA methylation measurements for a second mouse population raised under similar conditions three months later, we did not detect sex-associated or intra-tissues correlations. Additional studies that examine large numbers of loci may be required to further understand the factors that influence stability of DNA methylation.</p> </div>", "links"=>[], "tags"=>["measurements", "dna", "methylation", "loci", "tissues", "cd1", "mice"], "article_id"=>120234, "categories"=>["Molecular Biology", "Biochemistry", "Physics", "Genetics", "Biophysics"], "users"=>["Laurynas Daugela", "Nicole Nüsgen", "Maja Walier", "Johannes Oldenburg", "Rainer Schwaab", "Osman El-Maarri"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0044585.s001", "https://dx.doi.org/10.1371/journal.pone.0044585.s002", "https://dx.doi.org/10.1371/journal.pone.0044585.s003", "https://dx.doi.org/10.1371/journal.pone.0044585.s004", "https://dx.doi.org/10.1371/journal.pone.0044585.s005", "https://dx.doi.org/10.1371/journal.pone.0044585.s006", "https://dx.doi.org/10.1371/journal.pone.0044585.s007", "https://dx.doi.org/10.1371/journal.pone.0044585.s008"], "stats"=>{"downloads"=>28, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Measurements_of_DNA_Methylation_at_Seven_Loci_in_Various_Tissues_of_CD1_Mice/120234", "title"=>"Measurements of DNA Methylation at Seven Loci in Various Tissues of CD1 Mice", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-09-07 00:03:54"}

PMC Usage Stats | Further Information

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Relative Metric

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