Increased Renal Versican Expression Is Associated with Progression of Chronic Kidney Disease
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{"title"=>"Increased Renal Versican Expression Is Associated with Progression of Chronic Kidney Disease", "type"=>"journal", "authors"=>[{"first_name"=>"Michael", "last_name"=>"Rudnicki"}, {"first_name"=>"Paul", "last_name"=>"Perco"}, {"first_name"=>"Hannes", "last_name"=>"Neuwirt"}, {"first_name"=>"Susie-Jane", "last_name"=>"Noppert"}, {"first_name"=>"Johannes", "last_name"=>"Leierer"}, {"first_name"=>"Judith", "last_name"=>"Sunzenauer"}, {"first_name"=>"Susanne", "last_name"=>"Eder"}, {"first_name"=>"Carlamaria", "last_name"=>"Zoja"}, {"first_name"=>"Kathrin", "last_name"=>"Eller"}, {"first_name"=>"Alexander R.", "last_name"=>"Rosenkranz"}, {"first_name"=>"Gerhard A.", "last_name"=>"Müller"}, {"first_name"=>"Bernd", "last_name"=>"Mayer"}, {"first_name"=>"Gert", "last_name"=>"Mayer"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"1932-6203", "pmid"=>"23024773", "doi"=>"10.1371/journal.pone.0044891"}, "id"=>"c93fdffa-799f-37eb-aa2d-2a69fda13521", "abstract"=>"Novel prognostic markers for progression of kidney disease are needed to distinguish patients who might benefit from a more aggressive nephroprotective therapy. Expression of the proteoglycan versican was evaluated in renal transcriptomics profiles and in an independent set of 74 renal biopsies. Versican levels were correlated to histologic damage scores and to renal outcome, and versican expression and regulation was evaluated in vitro. In transcriptomics profiles of renal tissue versican was positively correlated with (i) histological parameters in kidney biopsies, (ii) progressive decline of renal function in proteinuric kidney diseases, and (iii) impaired renal function and histology scores in diabetic nephropathy. In an independent cohort of 74 biopsies of glomerular diseases renal RNA levels of versican isoforms V0 and V1, but not V2 and V3 correlated significantly with creatinine after a mean follow up time of 53 months. Versican isoforms V0 and V1 together with serum creatinine at time of biopsy and the degree of glomerulosclerosis predicted 20% and 24% of the variability of creatinine at follow up, which was significantly more than serum creatinine and histological parameters alone (16%). However, when patients with acute kidney failure at time of biopsy (n = 5) were excluded, the additive predictive value of versican V1 was only marginally higher (35%) than creatinine and glomerulosclerosis alone (34%). Versican isoforms V0 and V1 were primarily expressed in vitro in proximal tubule cells and in fibroblasts. The results in humans were confirmed in three rodent models of kidney disease, in which renal versican expression was significantly upregulated as compared to corresponding controls. These data show for the first time an association of renal versican isoform V0 and V1 expression with progressive renal disease.", "link"=>"http://www.mendeley.com/research/increased-renal-versican-expression-associated-progression-chronic-kidney-disease", "reader_count"=>14, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1, "Lecturer"=>2}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1, "Lecturer"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/576435"], "description"=>"<p>Versican is expressed in various renal and non-renal cell lines. HK2 renal proximal tubule cells, SF primary skin fibroblasts, TK173 kidney fibroblasts, A431 epidermoid carcinoma cell line, EP prostate epithelial cells, CACO2 colon carcinoma cells, CMS primary smooth muscle cells, EA.hy926 endothelial cells. The expression values are shown as ratio to PPIA. The mean and the standard deviation from n = 3 experiments is shown. * p<0.05 as compared to HK2 cells measured by a two-tailed t-test. n.e. not expressed.</p>", "links"=>[], "tags"=>["versican", "mrna"], "article_id"=>246912, "categories"=>["Cell Biology", "Biochemistry", "Marine Biology", "Biological Sciences", "Genetics"], "users"=>["Michael Rudnicki", "Paul Perco", "Hannes Neuwirt", "Susie-Jane Noppert", "Johannes Leierer", "Judith Sunzenauer", "Susanne Eder", "Carlamaria Zoja", "Kathrin Eller", "Alexander R. Rosenkranz", "Gerhard A. Müller", "Bernd Mayer", "Gert Mayer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0044891.g003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_versican_mRNA_in_vitro_/246912", "title"=>"Expression of versican mRNA in vitro.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-09-14 01:55:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/576799"], "description"=>"<p>Versican protein expression is induced in two rat models of glomerulonephritis (Adriamycin-induced glomerulonephritis (ADR) and Passive Heymann Nephritis (PHN)) compared to respective controls, Lewis and Ctrl. Versican expression was analyzed in 6 samples of each group. <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044891#pone-0044891-g006\" target=\"_blank\">Figure 6</a> shows one representative sample each.</p>", "links"=>[], "tags"=>["versican"], "article_id"=>247280, "categories"=>["Cell Biology", "Biochemistry", "Marine Biology", "Biological Sciences", "Genetics"], "users"=>["Michael Rudnicki", "Paul Perco", "Hannes Neuwirt", "Susie-Jane Noppert", "Johannes Leierer", "Judith Sunzenauer", "Susanne Eder", "Carlamaria Zoja", "Kathrin Eller", "Alexander R. Rosenkranz", "Gerhard A. Müller", "Bernd Mayer", "Gert Mayer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0044891.g006", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_versican_protein_in_vivo_/247280", "title"=>"Expression of versican protein in vivo.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-09-14 02:01:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/577169"], "description"=>"<p>DN diabetic nephropathy, MCD minimal change disease, LD living donors, CD cadaveric donors, PTECs proximal tubular epithelial cells. <sup>a</sup> Proteinuric glomerular diseases included focal segmental glomerulosclerosis (FSGS), MCD, IgA nephropathy (IGAN), lupus nephritis (LN), rapid-progressive glomerulonephritis (RPGN), membranoproliferative glomerulonephritis (MPGN), ANCA associated vasculitis (AAV) and hypertensive nephropathy (HTN). Mean values and standard deviations are shown. <sup>b</sup> Refer to the text for definition of the histological classes. <sup>c</sup> In (8) samples with low and high histological damage were compared and in (9) stable and progressive samples were compared. A two-tailed t-test was performed. In (10) samples from MCD and DN were compared (two tailed t-test), and also a Pearson correlation of creatinine at biopsy and histology score in DN with versican levels was calculated.</p>", "links"=>[], "tags"=>["sets", "versican", "renal"], "article_id"=>247643, "categories"=>["Cell Biology", "Biochemistry", "Marine Biology", "Biological Sciences", "Genetics"], "users"=>["Michael Rudnicki", "Paul Perco", "Hannes Neuwirt", "Susie-Jane Noppert", "Johannes Leierer", "Judith Sunzenauer", "Susanne Eder", "Carlamaria Zoja", "Kathrin Eller", "Alexander R. Rosenkranz", "Gerhard A. Müller", "Bernd Mayer", "Gert Mayer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0044891.t001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Microarray_data_sets_used_to_evaluate_the_expression_of_versican_in_renal_pathologies_/247643", "title"=>"Microarray data sets used to evaluate the expression of versican in renal pathologies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-09-14 02:07:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/576958"], "description"=>"<p>TAIF tubular atrophy/interstitial fibrosis, II Interstitial inflammation, GS glomerular sclerosis.</p>", "links"=>[], "tags"=>["histological", "correlations", "versican", "isoforms", "v0", "v1", "ckd", "cohort", "excluding", "patients"], "article_id"=>247430, "categories"=>["Cell Biology", "Biochemistry", "Marine Biology", "Biological Sciences", "Genetics"], "users"=>["Michael Rudnicki", "Paul Perco", "Hannes Neuwirt", "Susie-Jane Noppert", "Johannes Leierer", "Judith Sunzenauer", "Susanne Eder", "Carlamaria Zoja", "Kathrin Eller", "Alexander R. Rosenkranz", "Gerhard A. Müller", "Bernd Mayer", "Gert Mayer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0044891.t004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_and_histological_correlations_of_versican_isoforms_V0_and_V1_in_the_CKD_cohort_excluding_patients_with_ARF_/247430", "title"=>"Clinical and histological correlations of versican isoforms V0 and V1 in the CKD cohort excluding patients with ARF.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-09-14 02:03:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/576228"], "description"=>"<p>Representative images are shown. a) negative control 100x, b) isotype control 400x, c) and d) positive control in prostate cancer samples (100x and 400x), e) glomerular (LN4, stable), f) tubular (LN4, stable), g) interstitial (IgAN, stable), h) vascular (IgAN, stable) expression (all 400x) of versican in human biopsy samples of renal disease, and i) healthy kidney tissue from a tumor nephrectomy (100x).</p>", "links"=>[], "tags"=>["staining", "versican", "biopsy", "samples", "iga-nephropathy", "iv", "lupus", "nephritis", "kidney"], "article_id"=>246696, "categories"=>["Cell Biology", "Biochemistry", "Marine Biology", "Biological Sciences", "Genetics"], "users"=>["Michael Rudnicki", "Paul Perco", "Hannes Neuwirt", "Susie-Jane Noppert", "Johannes Leierer", "Judith Sunzenauer", "Susanne Eder", "Carlamaria Zoja", "Kathrin Eller", "Alexander R. Rosenkranz", "Gerhard A. Müller", "Bernd Mayer", "Gert Mayer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0044891.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunohistochemical_staining_of_versican_in_positive_controls_in_human_biopsy_samples_of_IgA_Nephropathy_IgAN_and_WHO_Class_IV_Lupus_Nephritis_LN4_and_in_healthy_kidney_tissue_/246696", "title"=>"Immunohistochemical staining of versican in positive controls, in human biopsy samples of IgA-Nephropathy (IgAN) and WHO Class IV Lupus Nephritis (LN4) and in healthy kidney tissue.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-09-14 01:51:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/577051"], "description"=>"<p>ESRD end-stage renal disease, 2 x creatinine doubling of serum creatinine. Proteinuria was measured as protein/creatinine ratio in g/g. Mean values and standard deviations are shown. Differences between the means were analyzed by a two-tailed t-test. n.s. not significant (p>0.05), NA not applicable. For abbreviation of the histological diagnosis see the <i>Experimental Procedures</i> section. ARF Acute Renal Failure. * <i>all stable vs progressive. ** stable w/o ARF vs progressive.</i></p>", "links"=>[], "tags"=>["included", "versican"], "article_id"=>247531, "categories"=>["Cell Biology", "Biochemistry", "Marine Biology", "Biological Sciences", "Genetics"], "users"=>["Michael Rudnicki", "Paul Perco", "Hannes Neuwirt", "Susie-Jane Noppert", "Johannes Leierer", "Judith Sunzenauer", "Susanne Eder", "Carlamaria Zoja", "Kathrin Eller", "Alexander R. Rosenkranz", "Gerhard A. Müller", "Bernd Mayer", "Gert Mayer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0044891.t002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patients_included_in_the_analysis_of_versican_expression_/247531", "title"=>"Patients included in the analysis of versican expression.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-09-14 02:05:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/576899"], "description"=>"<p>For abbreviations see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044891#pone-0044891-t003\" target=\"_blank\">table 3</a> or 4.</p>", "links"=>[], "tags"=>["isoforms", "factors", "dataset", "arf"], "article_id"=>247374, "categories"=>["Cell Biology", "Biochemistry", "Marine Biology", "Biological Sciences", "Genetics"], "users"=>["Michael Rudnicki", "Paul Perco", "Hannes Neuwirt", "Susie-Jane Noppert", "Johannes Leierer", "Judith Sunzenauer", "Susanne Eder", "Carlamaria Zoja", "Kathrin Eller", "Alexander R. Rosenkranz", "Gerhard A. Müller", "Bernd Mayer", "Gert Mayer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0044891.t006", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Versican_isoforms_predict_the_clinical_course_on_top_of_traditional_risk_factors_8211_analysis_of_the_dataset_without_ARF_patients_/247374", "title"=>"Versican isoforms predict the clinical course on top of traditional risk factors – analysis of the dataset without ARF patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-09-14 02:02:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/303662", "https://ndownloader.figshare.com/files/303705", "https://ndownloader.figshare.com/files/303740", "https://ndownloader.figshare.com/files/303773", "https://ndownloader.figshare.com/files/303826"], "description"=>"<div><p>Novel prognostic markers for progression of kidney disease are needed to distinguish patients who might benefit from a more aggressive nephroprotective therapy. Expression of the proteoglycan versican was evaluated in renal transcriptomics profiles and in an independent set of 74 renal biopsies. Versican levels were correlated to histologic damage scores and to renal outcome, and versican expression and regulation was evaluated <em>in vitro</em>. In transcriptomics profiles of renal tissue versican was positively correlated with (i) histological parameters in kidney biopsies, (ii) progressive decline of renal function in proteinuric kidney diseases, and (iii) impaired renal function and histology scores in diabetic nephropathy. In an independent cohort of 74 biopsies of glomerular diseases renal RNA levels of versican isoforms V0 and V1, but not V2 and V3 correlated significantly with creatinine after a mean follow up time of 53 months. Versican isoforms V0 and V1 together with serum creatinine at time of biopsy and the degree of glomerulosclerosis predicted 20% and 24% of the variability of creatinine at follow up, which was significantly more than serum creatinine and histological parameters alone (16%). However, when patients with acute kidney failure at time of biopsy (n = 5) were excluded, the additive predictive value of versican V1 was only marginally higher (35%) than creatinine and glomerulosclerosis alone (34%). Versican isoforms V0 and V1 were primarily expressed <em>in vitro</em> in proximal tubule cells and in fibroblasts. The results in humans were confirmed in three rodent models of kidney disease, in which renal versican expression was significantly upregulated as compared to corresponding controls. These data show for the first time an association of renal versican isoform V0 and V1 expression with progressive renal disease.</p> </div>", "links"=>[], "tags"=>["renal", "versican", "progression", "kidney"], "article_id"=>119888, "categories"=>["Cell Biology", "Biochemistry", "Marine Biology", "Biological Sciences", "Genetics"], "users"=>["Michael Rudnicki", "Paul Perco", "Hannes Neuwirt", "Susie-Jane Noppert", "Johannes Leierer", "Judith Sunzenauer", "Susanne Eder", "Carlamaria Zoja", "Kathrin Eller", "Alexander R. Rosenkranz", "Gerhard A. Müller", "Bernd Mayer", "Gert Mayer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0044891.s001", "https://dx.doi.org/10.1371/journal.pone.0044891.s002", "https://dx.doi.org/10.1371/journal.pone.0044891.s003", "https://dx.doi.org/10.1371/journal.pone.0044891.s004", "https://dx.doi.org/10.1371/journal.pone.0044891.s005"], "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Increased_Renal_Versican_Expression_Is_Associated_with_Progression_of_Chronic_Kidney_Disease/119888", "title"=>"Increased Renal Versican Expression Is Associated with Progression of Chronic Kidney Disease", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-09-14 02:44:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/576014"], "description"=>"<p>(A) Whole patient cohort, (B) Patients without ARF. Mean values and standard deviation are shown. p-values of a two-tailed t-test are indicated.</p>", "links"=>[], "tags"=>["isoform", "v0", "v1", "correlates", "progression", "kidney"], "article_id"=>246494, "categories"=>["Cell Biology", "Biochemistry", "Marine Biology", "Biological Sciences", "Genetics"], "users"=>["Michael Rudnicki", "Paul Perco", "Hannes Neuwirt", "Susie-Jane Noppert", "Johannes Leierer", "Judith Sunzenauer", "Susanne Eder", "Carlamaria Zoja", "Kathrin Eller", "Alexander R. Rosenkranz", "Gerhard A. Müller", "Bernd Mayer", "Gert Mayer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0044891.g001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Versican_isoform_V0_and_V1_expression_correlates_with_progression_of_chronic_kidney_disease_/246494", "title"=>"Versican isoform V0 and V1 expression correlates with progression of chronic kidney disease.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-09-14 01:48:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/576581"], "description"=>"<p>TK-173 and HK-2 cells were treated with Ang II, PDGF-AB and TGF-ß1 for 24 hours. After RNA isolation all 4 versican isoforms were analyzed by real-time PCR (n = 3 assays per ligand). Results shown are mean ratios to the housekeeper gene PPIA ± standard deviation. *p<0.05 as compared to controls.</p>", "links"=>[], "tags"=>["fibroblasts", "tubule"], "article_id"=>247063, "categories"=>["Cell Biology", "Biochemistry", "Marine Biology", "Biological Sciences", "Genetics"], "users"=>["Michael Rudnicki", "Paul Perco", "Hannes Neuwirt", "Susie-Jane Noppert", "Johannes Leierer", "Judith Sunzenauer", "Susanne Eder", "Carlamaria Zoja", "Kathrin Eller", "Alexander R. Rosenkranz", "Gerhard A. Müller", "Bernd Mayer", "Gert Mayer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0044891.g004", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Versican_regulation_in_fibroblasts_and_tubule_cells_/247063", "title"=>"Versican regulation in fibroblasts and tubule cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-09-14 01:57:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/577106"], "description"=>"<p>TAIF tubular atrophy/interstitial fibrosis, II Interstitial inflammation, GS glomerular sclerosis.</p>", "links"=>[], "tags"=>["histological", "correlations", "versican", "isoforms", "v0", "v1", "ckd"], "article_id"=>247579, "categories"=>["Cell Biology", "Biochemistry", "Marine Biology", "Biological Sciences", "Genetics"], "users"=>["Michael Rudnicki", "Paul Perco", "Hannes Neuwirt", "Susie-Jane Noppert", "Johannes Leierer", "Judith Sunzenauer", "Susanne Eder", "Carlamaria Zoja", "Kathrin Eller", "Alexander R. Rosenkranz", "Gerhard A. Müller", "Bernd Mayer", "Gert Mayer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0044891.t003", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_and_histological_correlations_of_versican_isoforms_V0_and_V1_in_the_whole_CKD_cohort_/247579", "title"=>"Clinical and histological correlations of versican isoforms V0 and V1 in the whole CKD cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-09-14 02:06:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/576688"], "description"=>"<p>Versican is significantly upregulated in various mouse and rat models of glomerulonephritis. Mean values and standard deviations are shown. Two-tailed t-test was performed. * p<0.05, § p<0.001, co controls, gn glomerulonephritis, m mouse, phn Passive Heyman Nephritis, adria Adriamycin rats.</p>", "links"=>[], "tags"=>["rodent", "models", "renal"], "article_id"=>247164, "categories"=>["Cell Biology", "Biochemistry", "Marine Biology", "Biological Sciences", "Genetics"], "users"=>["Michael Rudnicki", "Paul Perco", "Hannes Neuwirt", "Susie-Jane Noppert", "Johannes Leierer", "Judith Sunzenauer", "Susanne Eder", "Carlamaria Zoja", "Kathrin Eller", "Alexander R. Rosenkranz", "Gerhard A. Müller", "Bernd Mayer", "Gert Mayer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0044891.g005", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Versican_expression_in_rodent_models_of_renal_disease_/247164", "title"=>"Versican expression in rodent models of renal disease.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-09-14 01:59:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/577004"], "description"=>"<p>For abbreviations see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044891#pone-0044891-t003\" target=\"_blank\">table 3</a> or 4.</p>", "links"=>[], "tags"=>["isoforms", "factors"], "article_id"=>247486, "categories"=>["Cell Biology", "Biochemistry", "Marine Biology", "Biological Sciences", "Genetics"], "users"=>["Michael Rudnicki", "Paul Perco", "Hannes Neuwirt", "Susie-Jane Noppert", "Johannes Leierer", "Judith Sunzenauer", "Susanne Eder", "Carlamaria Zoja", "Kathrin Eller", "Alexander R. Rosenkranz", "Gerhard A. Müller", "Bernd Mayer", "Gert Mayer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0044891.t005", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Versican_isoforms_predict_the_clinical_course_on_top_of_traditional_risk_factors_8211_analysis_of_the_whole_cohort_/247486", "title"=>"Versican isoforms predict the clinical course on top of traditional risk factors – analysis of the whole cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-09-14 02:04:46"}

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