Multiple Loci Associated with Renal Function in African Americans
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{"title"=>"Multiple Loci Associated with Renal Function in African Americans", "type"=>"journal", "authors"=>[{"first_name"=>"Daniel", "last_name"=>"Shriner", "scopus_author_id"=>"7004202273"}, {"first_name"=>"Alan", "last_name"=>"Herbert", "scopus_author_id"=>"7103273576"}, {"first_name"=>"Ayo P.", "last_name"=>"Doumatey", "scopus_author_id"=>"6507897813"}, {"first_name"=>"Jie", "last_name"=>"Zhou", "scopus_author_id"=>"56889899600"}, {"first_name"=>"Hanxia", "last_name"=>"Huang", "scopus_author_id"=>"14323522200"}, {"first_name"=>"Michael R.", "last_name"=>"Erdos", "scopus_author_id"=>"7003599236"}, {"first_name"=>"Guanjie", "last_name"=>"Chen", "scopus_author_id"=>"8050014800"}, {"first_name"=>"Norman P.", "last_name"=>"Gerry", "scopus_author_id"=>"6602113204"}, {"first_name"=>"Michael F.", "last_name"=>"Christman", "scopus_author_id"=>"56749743500"}, {"first_name"=>"Adebowale", "last_name"=>"Adeyemo", "scopus_author_id"=>"56800223700"}, {"first_name"=>"Charles N.", "last_name"=>"Rotimi", "scopus_author_id"=>"7006238725"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84866415741", "pmid"=>"23028791", "doi"=>"10.1371/journal.pone.0045112", "pui"=>"365666285", "issn"=>"19326203", "scopus"=>"2-s2.0-84866415741"}, "id"=>"fc36b91f-586b-309d-9835-ce8e0266037d", "abstract"=>"The incidence of chronic kidney disease varies by ethnic group in the USA, with African Americans displaying a two-fold higher rate than European Americans. One of the two defining variables underlying staging of chronic kidney disease is the glomerular filtration rate. Meta-analysis in individuals of European ancestry has identified 23 genetic loci associated with the estimated glomerular filtration rate (eGFR). We conducted a follow-up study of these 23 genetic loci using a population-based sample of 1,018 unrelated admixed African Americans. We included in our follow-up study two variants in APOL1 associated with end-stage kidney disease discovered by admixture mapping in admixed African Americans. To address confounding due to admixture, we estimated local ancestry at each marker and global ancestry. We performed regression analysis stratified by local ancestry and combined the resulting regression estimates across ancestry strata using an inverse variance-weighted fixed effects model. We found that 11 of the 24 loci were significantly associated with eGFR in our sample. The effect size estimates were not significantly different between the subgroups of individuals with two copies of African ancestry vs. two copies of European ancestry for any of the 11 loci. In contrast, allele frequencies were significantly different at 10 of the 11 loci. Collectively, the 11 loci, including four secondary signals revealed by conditional analyses, explained 14.2% of the phenotypic variance in eGFR, in contrast to the 1.4% explained by the 24 loci in individuals of European ancestry. Our findings provide insight into the genetic basis of variation in renal function among admixed African Americans.", "link"=>"http://www.mendeley.com/research/multiple-loci-associated-renal-function-african-americans", "reader_count"=>8, "reader_count_by_academic_status"=>{"Librarian"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Librarian"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Mathematics"=>2, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Mathematics"=>{"Mathematics"=>2}}, "group_count"=>1}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/306193", "https://ndownloader.figshare.com/files/314719", "https://ndownloader.figshare.com/files/314728", "https://ndownloader.figshare.com/files/314802", "https://ndownloader.figshare.com/files/314813", "https://ndownloader.figshare.com/files/314822", "https://ndownloader.figshare.com/files/314830", "https://ndownloader.figshare.com/files/314841"], "description"=>"<div><p>The incidence of chronic kidney disease varies by ethnic group in the USA, with African Americans displaying a two-fold higher rate than European Americans. One of the two defining variables underlying staging of chronic kidney disease is the glomerular filtration rate. Meta-analysis in individuals of European ancestry has identified 23 genetic loci associated with the estimated glomerular filtration rate (eGFR). We conducted a follow-up study of these 23 genetic loci using a population-based sample of 1,018 unrelated admixed African Americans. We included in our follow-up study two variants in <em>APOL1</em> associated with end-stage kidney disease discovered by admixture mapping in admixed African Americans. To address confounding due to admixture, we estimated local ancestry at each marker and global ancestry. We performed regression analysis stratified by local ancestry and combined the resulting regression estimates across ancestry strata using an inverse variance-weighted fixed effects model. We found that 11 of the 24 loci were significantly associated with eGFR in our sample. The effect size estimates were not significantly different between the subgroups of individuals with two copies of African ancestry <em>vs</em>. two copies of European ancestry for any of the 11 loci. In contrast, allele frequencies were significantly different at 10 of the 11 loci. Collectively, the 11 loci, including four secondary signals revealed by conditional analyses, explained 14.2% of the phenotypic variance in eGFR, in contrast to the 1.4% explained by the 24 loci in individuals of European ancestry. Our findings provide insight into the genetic basis of variation in renal function among admixed African Americans.</p> </div>", "links"=>[], "tags"=>["loci", "renal", "african", "americans"], "article_id"=>120406, "categories"=>["Physiology", "Mathematics", "Marine Biology", "Genetics"], "users"=>["Daniel Shriner", "Alan Herbert", "Ayo P. Doumatey", "Jie Zhou", "Hanxia Huang", "Michael R. Erdos", "Guanjie Chen", "Norman P. Gerry", "Michael F. Christman", "Adebowale Adeyemo", "Charles N. Rotimi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0045112.s001", "https://dx.doi.org/10.1371/journal.pone.0045112.s002", "https://dx.doi.org/10.1371/journal.pone.0045112.s003", "https://dx.doi.org/10.1371/journal.pone.0045112.s004", "https://dx.doi.org/10.1371/journal.pone.0045112.s005", "https://dx.doi.org/10.1371/journal.pone.0045112.s006", "https://dx.doi.org/10.1371/journal.pone.0045112.s007", "https://dx.doi.org/10.1371/journal.pone.0045112.s008"], "stats"=>{"downloads"=>12, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Multiple_Loci_Associated_with_Renal_Function_in_African_Americans/120406", "title"=>"Multiple Loci Associated with Renal Function in African Americans", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-09-13 00:06:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/576959"], "description"=>"a<p>Ranges are presented as median (first quartile, third quartile).</p>", "links"=>[], "tags"=>["genetics and genomics", "Nephrology", "physiology", "mathematics"], "article_id"=>247441, "categories"=>["Physiology", "Mathematics", "Marine Biology", "Genetics"], "users"=>["Daniel Shriner", "Alan Herbert", "Ayo P. Doumatey", "Jie Zhou", "Hanxia Huang", "Michael R. Erdos", "Guanjie Chen", "Norman P. Gerry", "Michael F. Christman", "Adebowale Adeyemo", "Charles N. Rotimi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0045112.t001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_study_sample_/247441", "title"=>"Characteristics of the study sample.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-09-13 02:04:01"}

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