Iron Supplementation Decreases Severity of Allergic Inflammation in Murine Lung
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{"title"=>"Iron Supplementation Decreases Severity of Allergic Inflammation in Murine Lung", "type"=>"journal", "authors"=>[{"first_name"=>"Laura P.", "last_name"=>"Hale", "scopus_author_id"=>"16165882000"}, {"first_name"=>"Erin Potts", "last_name"=>"Kant", "scopus_author_id"=>"55365279300"}, {"first_name"=>"Paula K.", "last_name"=>"Greer", "scopus_author_id"=>"7004605897"}, {"first_name"=>"W. Michael", "last_name"=>"Foster", "scopus_author_id"=>"7202606594"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84866664384", "sgr"=>"84866664384", "pui"=>"365718524", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"23029172", "doi"=>"10.1371/journal.pone.0045667"}, "id"=>"de27dc76-9cb9-361e-9910-ac14ce05d301", "abstract"=>"The incidence and severity of allergic asthma have increased over the last century, particularly in the United States and other developed countries. This time frame was characterized by marked environmental changes, including enhanced hygiene, decreased pathogen exposure, increased exposure to inhaled pollutants, and changes in diet. Although iron is well-known to participate in critical biologic processes such as oxygen transport, energy generation, and host defense, iron deficiency remains common in the United States and world-wide. The purpose of these studies was to determine how dietary iron supplementation affected the severity of allergic inflammation in the lungs, using a classic model of IgE-mediated allergy in mice. Results showed that mice fed an iron-supplemented diet had markedly decreased allergen-induced airway hyperreactivity, eosinophil infiltration, and production of pro-inflammatory cytokines, compared with control mice on an unsupplemented diet that generated mild iron deficiency but not anemia. In vitro, iron supplementation decreased mast cell granule content, IgE-triggered degranulation, and production of pro-inflammatory cytokines post-degranulation. Taken together, these studies show that iron supplementation can decrease the severity of allergic inflammation in the lung, potentially via multiple mechanisms that affect mast cell activity. Further studies are indicated to determine the potential of iron supplementation to modulate the clinical severity of allergic diseases in humans.", "link"=>"http://www.mendeley.com/research/iron-supplementation-decreases-severity-allergic-inflammation-murine-lung-2", "reader_count"=>10, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>1, "Student > Bachelor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>1, "Student > Bachelor"=>3}, "reader_count_by_subject_area"=>{"Environmental Science"=>1, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>5, "Arts and Humanities"=>1, "Physics and Astronomy"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Environmental Science"=>{"Environmental Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Romania"=>1, "United Kingdom"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/573580"], "description"=>"<p>Periodic acid-Schiff (PAS)-stained formalin-fixed, paraffin-embedded lung sections show allergen-induced goblet cell differentiation in the large airways of mice on both 8 ppm (<b>A</b>  =  saline-challenged, <b>B</b>  =  OVA-challenged) and 200 ppm diets (<b>C</b>  =  saline-challenged, <b>D</b>  =  OVA-challenged). Expression of Muc5AC mRNA in the lungs was similar for both diet groups (<b>E</b>).</p>", "links"=>[], "tags"=>["supplementation", "mucus"], "article_id"=>244075, "categories"=>["Physiology", "Medicine", "Immunology"], "users"=>["Laura P. Hale", "Erin Potts Kant", "Paula K. Greer", "W. Michael Foster"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0045667.g003", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Iron_supplementation_does_not_affect_mucus_production_/244075", "title"=>"Iron supplementation does not affect mucus production.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 23:03:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/573874"], "description"=>"*<p>indicates p≤0.05 for comparisons of unsupplemented vs. iron-supplemented diets.</p>**<p>Data shown are mean ± SEM for 6 mice/diet group for red blood cells (RBC), hemoglobin (Hgb), hematocrit (Hct), and mean cellular volume (MCV). The numbers of mice studied for serum and tissue iron ranged from 10–25 per group. Hepcidin measurements are given as the geometric mean (upper - lower confidence interval) for 10 allergen-sensitized, saline-challenged mice/group.</p>", "links"=>[], "tags"=>["mice"], "article_id"=>244371, "categories"=>["Physiology", "Medicine", "Immunology"], "users"=>["Laura P. Hale", "Erin Potts Kant", "Paula K. Greer", "W. Michael Foster"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0045667.t001", "stats"=>{"downloads"=>2, "page_views"=>39, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Iron_Status_of_Mice_Studied_/244371", "title"=>"Iron Status of Mice Studied.<sup>**</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 23:05:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/573210"], "description"=>"<p>WT and mast cell-deficient <i>Sash</i> mice on the indicated diets were sensitized to OVA then challenged with OVA or saline. <b>A</b>. Airway resistance (measured in units of cm H<sub>2</sub>O/ml/sec) in response to methacholine was significantly decreased following allergen challenge for mice that received iron supplementation (*indicates p≤0.0005). <b>B</b>. Iron supplementation decreased infiltration of eosinophils into bronchoalveolar spaces (decrease of 52%; *indicates p = 0.0007).</p>", "links"=>[], "tags"=>["supplementation", "decreases", "severity", "allergic"], "article_id"=>243699, "categories"=>["Physiology", "Medicine", "Immunology"], "users"=>["Laura P. Hale", "Erin Potts Kant", "Paula K. Greer", "W. Michael Foster"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0045667.g001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Iron_supplementation_decreases_severity_of_allergic_asthma_/243699", "title"=>"Iron supplementation decreases severity of allergic asthma.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 23:01:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/573717"], "description"=>"<p><b>A</b>. Supplementation with iron decreased degranulation of primary BMMC by 30% (*indicates p = 0.01). Data shown is the mean ± SEM of 4 experiments. <b>B, C</b>. In duplicate experiments, iron supplementation decreased mast cell production of TNF, MCP-1, and IL-6 by 94%, 29%, and 27%, respectively. An MTS assay confirmed continued viability of the BMMC (not shown). <b>D, E</b>. RBL-2H3 mast cells showed a dose-dependent reduction in total granule contents per cell with iron supplementation, as indicated by β-hexoseaminidase activity following lysis with Triton X-100 (panel D) and flow cytometric analysis of side scatter (panel E). Data shown represents the mean ± SEM of 3 − 4 independent experiments, each conducted in triplicate. *indicates p≤0.02.</p>", "links"=>[], "tags"=>["supplementation", "ige-mediated", "mast", "cytokine", "granule"], "article_id"=>244212, "categories"=>["Physiology", "Medicine", "Immunology"], "users"=>["Laura P. Hale", "Erin Potts Kant", "Paula K. Greer", "W. Michael Foster"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0045667.g004", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_iron_supplementation_on_IgE_mediated_mast_cell_degranulation_cytokine_production_and_total_granule_content_/244212", "title"=>"Effects of iron supplementation on IgE-mediated mast cell degranulation, cytokine production, and total granule content.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 23:04:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/573372"], "description"=>"<p>Cytokine and chemokines present in bronchoalveolar lavage (BAL) fluid obtained from OVA-sensitized mice 24 hrs following the 3d challenge with aerosolized antigen or saline were markedly increased in unsupplemented compared with iron-supplemented mice (*indicate p<0.01). The percentage increase ranged from 25–35% for IL-1β, IL-5, IL-6, and IL-13 to 170% for IL-17.</p>", "links"=>[], "tags"=>["supplementation", "allergen-induced", "cytokine", "secretion", "bronchoalveolar"], "article_id"=>243863, "categories"=>["Physiology", "Medicine", "Immunology"], "users"=>["Laura P. Hale", "Erin Potts Kant", "Paula K. Greer", "W. Michael Foster"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0045667.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_iron_supplementation_on_allergen_induced_cytokine_secretion_into_bronchoalveolar_spaces_/243863", "title"=>"Effects of iron supplementation on allergen-induced cytokine secretion into bronchoalveolar spaces.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 23:02:36"}

PMC Usage Stats | Further Information

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Relative Metric

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