Cobalamin Related Parameters and Disease Patterns in Patients with Increased Serum Cobalamin Levels
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{"title"=>"Cobalamin Related Parameters and Disease Patterns in Patients with Increased Serum Cobalamin Levels", "type"=>"journal", "authors"=>[{"first_name"=>"Johan F B", "last_name"=>"Arendt", "scopus_author_id"=>"55055871100"}, {"first_name"=>"Ebba", "last_name"=>"Nexo", "scopus_author_id"=>"7103336832"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84866657517", "sgr"=>"84866657517", "pui"=>"365719678", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"23029349", "doi"=>"10.1371/journal.pone.0045979"}, "id"=>"3350faca-967e-3ddc-9420-5cedc1e513e9", "abstract"=>"BACKGROUND Measurement of serum cobalamin levels is routinely used to diagnose cobalamin deficiency. Surprisingly, approximately 15% of patients have high cobalamin levels and no consensus exists regarding the clinical implications. METHODS Hospital-treated patients above 18 years of age referred for serum cobalamin measurement were included in groups of patients [percentage cobalamin supplemented] with low (<200 pmol/L, n = 200 [6%]), normal (200-600, n = 202 [6%]) high (601-1000, n = 217 [27%]) and very high (>1000, n = 199 [53%]) cobalamin levels. Total and cobalamin-saturated (holo) transcobalamin, total haptocorrin, soluble TC receptor, sCD320, and methylmalonic acid were analyzed. Data on diagnoses and medical prescriptions was obtained through medical files and the Aarhus University Prescription Database. RESULTS Among patients not cobalamin supplemented median total haptocorrin and holo transcobalamin levels were markedly higher in the groups with high/very high cobalamin levels compared to groups with low/normal cobalamin levels. Median total transcobalamin and sCD320 levels were similar across the groups. A number of diagnoses were significantly associated to very high Cbl levels (odds ratio (95% confidence interval)): alcoholism (5.74 (2.76-11.96)), liver disease (8.53 (3.59-20.23)), and cancer (5.48 (2.85-10.55)). Elevated haptocorrin levels were seen in patients with alcoholism, cancer, liver-, renal-, autoimmune-, and bronchopulmonary disease. No clinical associations to sCD320 and total and holo transcobalamin levels were found. CONCLUSION In non-supplemented patients, high cobalamin levels were associated to high haptocorrin levels, and several diagnoses, including alcoholism, liver disease and cancer. Our study emphasizes that clinicians should take high serum cobalamin levels into consideration in the diagnostic process.", "link"=>"http://www.mendeley.com/research/cobalamin-related-parameters-disease-patterns-patients-increased-serum-cobalamin-levels-2", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>3, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>4, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>3, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>4, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>2, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>13}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/573221"], "description"=>"<p>Diagnoses related to Cbl levels in groups in patients referred for measurement of serum Cbl levels and not in Cbl supplementation therapy (n = 632). Patients were allowed to have more than one diagnosis. Odds ratios and 95% confidence intervals were obtained by logistic regression analyses.</p>a<p>Patients with Cbl levels ≤200 pmol/L were treated as reference group.</p>b<p>Adjusted for age (reference age 56 years) and gender (female as reference). Abbreviations: Cbl: cobalamin, vitamin B12; OR: OR: Odds ratio; 95% CI: 95% confidence interval.</p>", "links"=>[], "tags"=>["associations", "cobalamin"], "article_id"=>243714, "categories"=>["Cancer", "Chemistry", "Mental Health", "Biotechnology"], "users"=>["Johan F. B. Arendt", "Ebba Nexo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0045979.t003", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Diagnostic_associations_to_cobalamin_levels_/243714", "title"=>"Diagnostic associations to cobalamin levels.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-09-21 01:01:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/573249"], "description"=>"<p>Basic characteristics of patients referred for measurement of serum Cbl levels and included in the study (n = 818). Age is displayed with means and corresponding 95% confidence intervals. Sex is displayed as number and fractions (%) of males.</p>*<p>P-values were obtained by one-way analysis of variance when testing for difference in mean age across Cbl levels groups. Cbl: cobalamin, vitamin B12; 95% CI: 95% confidence interval.</p>", "links"=>[], "tags"=>["public health and epidemiology", "Mental health", "oncology", "Gastroenterology and hepatology"], "article_id"=>243748, "categories"=>["Cancer", "Chemistry", "Mental Health", "Biotechnology"], "users"=>["Johan F. B. Arendt", "Ebba Nexo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0045979.t001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Age_and_gender_distribution_of_study_population_/243748", "title"=>"Age and gender distribution of study population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-09-21 01:02:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/573094"], "description"=>"<p>Black signature: patients not in Cbl therapy; grey signatures patients in Cbl therapy. Please note the split y-axis in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045979#pone-0045979-g001\" target=\"_blank\">figure 1B</a>. NS: not significant (p>0.05), *:p<0.01, **:p<0.005, ***:p<0.0001, by comparing patients not in Cbl therapy to patients in Cbl therapy within same Cbl group using Mann-Whitney U-test. Abbreviations: Cbl: cobalamin, vitamin B12; TC: transcobalamin; holoTC: Cbl-saturated transcobalamin; HC: haptocorrin; sCD320: soluble transcobalamin receptor CD320; MMA: methylmalonic acid.</p>", "links"=>[], "tags"=>["interquartile", "ranges", "serum", "holo", "methylmalonic"], "article_id"=>243589, "categories"=>["Cancer", "Chemistry", "Mental Health", "Biotechnology"], "users"=>["Johan F. B. Arendt", "Ebba Nexo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0045979.g001", "stats"=>{"downloads"=>3, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Medians_and_interquartile_ranges_of_serum_total_transcobalamin_A_holo_transcobalamin_B_total_haptocorrin_C_sCD320_D_and_methylmalonic_acid_E_/243589", "title"=>"Medians and interquartile ranges of serum total transcobalamin(A), holo transcobalamin(B), total haptocorrin(C), sCD320(D), and methylmalonic acid(E).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-09-21 00:59:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/302976"], "description"=>"<div><h3>Background</h3><p>Measurement of serum cobalamin levels is routinely used to diagnose cobalamin deficiency. Surprisingly, approximately 15% of patients have high cobalamin levels and no consensus exists regarding the clinical implications.</p> <h3>Methods</h3><p>Hospital-treated patients above 18 years of age referred for serum cobalamin measurement were included in groups of patients [percentage cobalamin supplemented] with low (<200 pmol/L, n = 200 [6%]), normal (200–600, n = 202 [6%]) high (601–1000, n = 217 [27%]) and very high (>1000, n = 199 [53%]) cobalamin levels. Total and cobalamin-saturated (holo) transcobalamin, total haptocorrin, soluble TC receptor, sCD320, and methylmalonic acid were analyzed. Data on diagnoses and medical prescriptions was obtained through medical files and the Aarhus University Prescription Database.</p> <h3>Results</h3><p>Among patients not cobalamin supplemented median total haptocorrin and holo transcobalamin levels were markedly higher in the groups with high/very high cobalamin levels compared to groups with low/normal cobalamin levels. Median total transcobalamin and sCD320 levels were similar across the groups. A number of diagnoses were significantly associated to very high Cbl levels (odds ratio (95% confidence interval)): alcoholism (5.74 (2.76–11.96)), liver disease (8.53 (3.59–20.23)), and cancer (5.48 (2.85–10.55)). Elevated haptocorrin levels were seen in patients with alcoholism, cancer, liver-, renal-, autoimmune-, and bronchopulmonary disease. No clinical associations to sCD320 and total and holo transcobalamin levels were found.</p> <h3>Conclusion</h3><p>In non-supplemented patients, high cobalamin levels were associated to high haptocorrin levels, and several diagnoses, including alcoholism, liver disease and cancer. Our study emphasizes that clinicians should take high serum cobalamin levels into consideration in the diagnostic process.</p> </div>", "links"=>[], "tags"=>["cobalamin", "parameters", "patterns", "patients", "serum", "levels"], "article_id"=>119751, "categories"=>["Cancer", "Chemistry", "Mental Health", "Biotechnology"], "users"=>["Johan F. B. Arendt", "Ebba Nexo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0045979", "stats"=>{"downloads"=>3, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Cobalamin_Related_Parameters_and_Disease_Patterns_in_Patients_with_Increased_Serum_Cobalamin_Levels/119751", "title"=>"Cobalamin Related Parameters and Disease Patterns in Patients with Increased Serum Cobalamin Levels", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-09-21 02:42:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/573197"], "description"=>"<p>Medians (interquartile ranges) [reference ranges] are shown for Cbl related parameters in patients referred for measurement of serum Cbl divided according to Cbl supplementation (n = 818).</p>a<p>Only non-supplemented patients with normal kidney function (eGFR ≥60 mL/min/1.73 m<sup>2</sup>, n = 503).</p>b<p>Numbers and percentages of non-supplemented patients with normal kidney function and serum Cbl >250 pmol/L <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045979#pone.0045979-Hvas1\" target=\"_blank\">[31]</a> showing biochemical Cbl deficiency, defined as holoTC <40 pmol/L and/or MMA >0.28 µmol/L. P-values were obtained by comparing medians across Cbl groups using Kruskal-Wallis test. Abbreviations: Cbl: cobalamin, vitamin B12; holo transcobalamin: Cbl-saturated transcobalamin; sCD320: soluble transcobalamin receptor CD320; MMA: methylmalonic acid; eGFR: estimated glomerular filtration rate.</p>", "links"=>[], "tags"=>["public health and epidemiology", "Mental health", "oncology", "Gastroenterology and hepatology"], "article_id"=>243690, "categories"=>["Cancer", "Chemistry", "Mental Health", "Biotechnology"], "users"=>["Johan F. B. Arendt", "Ebba Nexo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0045979.t002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cobalamin_related_parameters_/243690", "title"=>"Cobalamin related parameters.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-09-21 01:01:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/573163"], "description"=>"<p>Median (interquartile ranges) [reference ranges] levels of Cbl related parameters divided according to diagnoses in patients referred for measurement of serum Cbl levels and not in Cbl supplementation therapy (n = 632). Abbreviations: Cbl: cobalamin, vitamin B12; TC: transcobalamin; holoTC: Cbl-saturated transcobalamin; HC: haptocorrin; sCD320: soluble transcobalamin receptor CD320.</p>", "links"=>[], "tags"=>["parameters"], "article_id"=>243660, "categories"=>["Cancer", "Chemistry", "Mental Health", "Biotechnology"], "users"=>["Johan F. B. Arendt", "Ebba Nexo"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0045979.t004", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cobalamin_related_parameters_in_diagnoses_/243660", "title"=>"Cobalamin related parameters in diagnoses.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-09-21 01:01:00"}

PMC Usage Stats | Further Information

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Relative Metric

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