Distribution of Y-Receptors in Murine Lingual Epithelia
Publication Date
September 26, 2012
Journal
PLOS ONE
Authors
Maria D. Hurtado, Andres Acosta, Paola P. Riveros, Bruce J. Baum, et al
Volume
7
Issue
9
Pages
e46358
DOI
https://dx.plos.org/10.1371/journal.pone.0046358
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0046358
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23050020
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458857
Europe PMC
http://europepmc.org/abstract/MED/23050020
Web of Science
000309517300110
Scopus
84866862195
Mendeley
http://www.mendeley.com/research/distribution-yreceptors-murine-lingual-epithelia
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Mendeley | Further Information

{"title"=>"Distribution of Y-Receptors in Murine Lingual Epithelia", "type"=>"journal", "authors"=>[{"first_name"=>"Maria D.", "last_name"=>"Hurtado", "scopus_author_id"=>"53986442900"}, {"first_name"=>"Andres", "last_name"=>"Acosta", "scopus_author_id"=>"55844615900"}, {"first_name"=>"Paola P.", "last_name"=>"Riveros", "scopus_author_id"=>"55003635900"}, {"first_name"=>"Bruce J.", "last_name"=>"Baum", "scopus_author_id"=>"36014362000"}, {"first_name"=>"Kirill", "last_name"=>"Ukhanov", "scopus_author_id"=>"55405616200"}, {"first_name"=>"Alicia R.", "last_name"=>"Brown", "scopus_author_id"=>"55369242400"}, {"first_name"=>"Cedrick D.", "last_name"=>"Dotson", "scopus_author_id"=>"9744466800"}, {"first_name"=>"Herbert", "last_name"=>"Herzog", "scopus_author_id"=>"55584141200"}, {"first_name"=>"Sergei", "last_name"=>"Zolotukhin", "scopus_author_id"=>"7005606438"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84866862195", "pui"=>"365742319", "scopus"=>"2-s2.0-84866862195", "issn"=>"19326203", "pmid"=>"23050020", "doi"=>"10.1371/journal.pone.0046358"}, "id"=>"9f0ff3f4-0dc8-3546-bcfa-8a50a8f48c28", "abstract"=>"Peptide hormones and their cognate receptors belonging to neuropeptide Y (NPY) family mediate diverse biological functions in a number of tissues. Recently, we discovered the presence of the gut satiation peptide YY (PYY) in saliva of mice and humans and defined its role in the regulation of food intake and body weight maintenance. Here we report the systematic analysis of expression patterns of all NPY receptors (Rs), Y1R, Y2R, Y4R, and Y5R in lingual epithelia in mice. Using four independent assays, immunohistochemistry, in situ hybridization, immunocytochemistry and RT PCR, we show that the morphologically different layers of the keratinized stratified epithelium of the dorsal layer of the tongue express Y receptors in a very distinctive yet overlapping pattern. In particular, the monolayer of basal progenitor cells expresses both Y1 and Y2 receptors. Y1Rs are present in the parabasal prickle cell layer and the granular layer, while differentiated keratinocytes display abundant Y5Rs. Y4Rs are expressed substantially in the neuronal fibers innervating the lamina propria and mechanoreceptors. Basal epithelial cells positive for Y2Rs respond robustly to PYY(3-36) by increasing intracellular Ca(2+) suggesting their possible functional interaction with salivary PYY. In taste buds of the circumvallate papillae, some taste receptor cells (TRCs) express YRs localized primarily at the apical domain, indicative of their potential role in taste perception. Some of the YR-positive TRCs are co-localized with neuronal cell adhesion molecule (NCAM), suggesting that these TRCs may have synaptic contacts with nerve terminals. In summary, we show that all YRs are abundantly expressed in multiple lingual cell types, including epithelial progenitors, keratinocytes, neuronal dendrites and TRCs. These results suggest that these receptors may be involved in the mediation of a wide variety of functions, including proliferation, differentiation, motility, taste perception and satiation.", "link"=>"http://www.mendeley.com/research/distribution-yreceptors-murine-lingual-epithelia", "reader_count"=>19, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>5, "Student > Master"=>2, "Student > Bachelor"=>1, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>5, "Student > Master"=>2, "Student > Bachelor"=>1, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>12, "Medicine and Dentistry"=>2, "Neuroscience"=>1, "Psychology"=>1, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>12}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/569753"], "description"=>"<p>Mirror section pairs (Panels <b>A</b> and <b>B</b>, <b>C</b> and <b>D</b>, <b>E</b> and <b>F</b>) were hybridized to the respective YR antibody (green), followed by DAPI counterstain (blue), as indicated in the upper left corner of each panel. For better viewing, the confocal images in <b>B</b>, <b>D</b>, and <b>F</b> were reflected horizontally. Representative areas of the epithelium, positive for either YR (dashed rectangles in the left-sided panels), are shown as close-up images on the right next to each respective panel. The irregular columned structures at the epithelial surface are transversely sectioned filiform papillae. <b>G -</b> Y4R-positive neuronal fibers (green) are located in the subepithelial region underlying the basal laminae. <b>H</b> – co-localization of Y4R and NCAM (red) immunoreactivity within mechanoreceptors of Meissner corpuscles (MC). As a morpho-histological reference of the dorsal lingual epithelium structure, an hematoxylin and eosin stained section is shown in panel <b>I</b>. Panel <b>J</b> shows a hypothetical diagram of a lingual dorsal epithelium layer and the differentiation/migration lineage of cell types expressing respective YR subtypes. K5 – cytokeratin-5 <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046358#pone.0046358-Acosta1\" target=\"_blank\">[2]</a>.</p>", "links"=>[], "tags"=>["y5", "receptors", "dorsal", "epithelium", "murine"], "article_id"=>240237, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Maria D. Hurtado", "Andres Acosta", "Paola P. Riveros", "Bruce J. Baum", "Kirill Ukhanov", "Alicia R. Brown", "Cedrick D. Dotson", "Herbert Herzog", "Sergei Zolotukhin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0046358.g006", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunolocalization_of_Y1_Y2_Y4_and_Y5_receptors_Rs_in_the_dorsal_epithelium_of_murine_tongue_/240237", "title"=>"Immunolocalization of Y1, Y2, Y4, and Y5 receptors (Rs) in the dorsal epithelium of murine tongue.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 22:42:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/570124"], "description"=>"<p>NPY family RT-PCR primers.</p>", "links"=>[], "tags"=>["rt-pcr"], "article_id"=>240616, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Maria D. Hurtado", "Andres Acosta", "Paola P. Riveros", "Bruce J. Baum", "Kirill Ukhanov", "Alicia R. Brown", "Cedrick D. Dotson", "Herbert Herzog", "Sergei Zolotukhin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0046358.t002", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_NPY_family_RT_PCR_primers_/240616", "title"=>"NPY family RT-PCR primers.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 22:44:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/569026"], "description"=>"<p><b>A</b> and <b>C</b> – negative control samples, Y1R KO and Y2R KO, respectively; <b>B</b>, <b>D</b>, <b>E</b>, and <b>F</b> – positive control samples, WT C57Bl/6 mice. Representative fields outlined by the dashed rectangles in panels <b>A</b> through <b>F</b> are shown as close-up images either below the respective panels (panels <b>A</b>, <b>B</b>, <b>C</b>, and <b>D</b>), or to the right of the panel (panels <b>E</b> and <b>F</b>). Red dots show fluorescently visualized YR mRNAs. DAPI-stained nuclear DNA is shown in pseudo-colored green hue for better viewing.</p>", "links"=>[], "tags"=>["hybridization", "probe", "sets", "ish", "y-receptor", "dentate", "gyrus"], "article_id"=>239509, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Maria D. Hurtado", "Andres Acosta", "Paola P. Riveros", "Bruce J. Baum", "Kirill Ukhanov", "Alicia R. Brown", "Cedrick D. Dotson", "Herbert Herzog", "Sergei Zolotukhin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0046358.g002", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Validation_of_in_situ_hybridization_ISH_probe_sets_by_ISH_analysis_of_Y_receptor_YR_gene_expression_in_the_dentate_gyrus_of_the_mouse_brain_/239509", "title"=>"Validation of <i>in situ</i> hybridization (ISH) probe sets by ISH analysis of Y-receptor (YR) gene expression in the dentate gyrus of the mouse brain.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 22:38:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/569906"], "description"=>"<p><b>A</b> – differential interference contrast micrograph of the agarose embedded acutely-obtained mouse lingual slice. The basal layer of epithelial Y1R/Y2R/K5-positive cells is outlined by a yellow dashed line. <b>B</b> – The same slice was loaded with a Ca<sup>2+</sup> sensitive indicator dye, fura-2/AM. A static fluorescence image was captured at 380 nm excitation showing strong fura-2 loading in the basal cellular layer. <b>C</b> – Representative traces recorded from 13 individual cells selected in the slice shown in <b>B</b>. PYY<sub>3–36</sub> (40 µg/ml) was applied by a local microperfusion for 30 sec indicated with the shaded box. ATP (20 µM) was used as a positive functional control. The data were collected from 38 representative cells individually analyzed in 3 slice preparations from two different animals.</p>", "links"=>[], "tags"=>["induces", "intracellular", "lingual", "basal", "epithelium"], "article_id"=>240390, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Maria D. Hurtado", "Andres Acosta", "Paola P. Riveros", "Bruce J. Baum", "Kirill Ukhanov", "Alicia R. Brown", "Cedrick D. Dotson", "Herbert Herzog", "Sergei Zolotukhin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0046358.g007", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PYY_3_8211_36_induces_intracellular_Ca_2_in_the_lingual_basal_cell_epithelium_layer_/240390", "title"=>"PYY<sub>3–36</sub> induces intracellular Ca<sup>2+</sup> in the lingual basal cell epithelium layer.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 22:43:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/568920"], "description"=>"<p>The names of the genes and the expected PCR fragments sizes (in bp) are shown above the respective lanes. NC – negative (no cDNA) control.</p>", "links"=>[], "tags"=>["npy", "members", "lingual"], "article_id"=>239395, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Maria D. Hurtado", "Andres Acosta", "Paola P. Riveros", "Bruce J. Baum", "Kirill Ukhanov", "Alicia R. Brown", "Cedrick D. Dotson", "Herbert Herzog", "Sergei Zolotukhin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0046358.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RT_PCR_analysis_of_the_expression_of_NPY_family_members_in_the_lingual_epithelia_/239395", "title"=>"RT-PCR analysis of the expression of NPY family members in the lingual epithelia.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 22:38:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/569558"], "description"=>"<p><b>A</b> - Immunofluorescence (IF) analysis of 293 HEK cells expressing murine YR cDNAs. Columns – cells transfected with Y1R, Y2R, Y4R, Y5R-expressing plasmids, respectively. Rows – cells on cover slips incubated to a-Y1R, a-Y2R, a-Y4R, or a-Y5R antibodies, respectively. Please note peripheral (membrane-associated) localization of YRs. <b>B</b> - IF analysis of YRs in the dentate gyrus (coronal sectioned planes) of mouse brain. The diffuse staining for Y1R reflects the distribution of Y1R positive neuronal fibers rather than cell bodies.</p>", "links"=>[], "tags"=>["y-receptor"], "article_id"=>240047, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Maria D. Hurtado", "Andres Acosta", "Paola P. Riveros", "Bruce J. Baum", "Kirill Ukhanov", "Alicia R. Brown", "Cedrick D. Dotson", "Herbert Herzog", "Sergei Zolotukhin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0046358.g005", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Validation_of_Y_receptor_YR_antibodies_/240047", "title"=>"Validation of Y-receptor (YR) antibodies.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 22:41:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/570009"], "description"=>"<p>Panels <b>A</b>, <b>B, C, and D</b> demonstrate Y1R-, Y2R-, Y4R-, and Y5R-positive TRCs, respectively. Areas within the dashed rectangle are shown as a series of magnified images to the right, stained for YRs (green), NCAM (red), DAPI (blue), respectively, with the merged images shown between YRs and NCAM. Open block arrows in the panels <b>A</b>, <b>B</b>, and <b>D</b> point at the YR-positive epithelial cells; filled arrowheads show apical parts of the YR-positive TRCs; open arrowheads – basolateral parts; VEG – von Ebner's gland. The majority of NCAM-positive intragemmal fibers are also Y4R-immunopositive (Panel <b>8C</b>), but do not appear to express Y1Rs, Y2Rs, or Y5Rs.</p>", "links"=>[], "tags"=>["receptors", "receptor", "cells"], "article_id"=>240496, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Maria D. Hurtado", "Andres Acosta", "Paola P. Riveros", "Bruce J. Baum", "Kirill Ukhanov", "Alicia R. Brown", "Cedrick D. Dotson", "Herbert Herzog", "Sergei Zolotukhin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0046358.g008", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunolocalization_of_Y_receptors_YRs_in_taste_receptor_cells_TRCs_/240496", "title"=>"Immunolocalization of Y receptors (YRs) in taste receptor cells (TRCs).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 22:44:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/569396"], "description"=>"<p><b>A</b> and <b>D</b> – negative control samples, Y1R KO and Y2R KO, respectively; <b>B</b>, <b>E</b>, <b>F</b>, and <b>G</b> - samples from wt C57Bl/6 hybridized to Y1R, Y2R, Y5R, and Y4R probe sets, respectively; <b>C</b>, <b>H</b>, and <b>I</b> – close up images of the representative areas from the respective panels (<b>B</b>, <b>G</b> and <b>F</b>, respectively) outlined by white dashed rectangles. The borders of several taste buds are outlined with yellow dashed lines. Red dots show fluorescently visualized Y-receptor mRNAs. DAPI-stained nuclear DNA is shown in pseudo-colored green hue for better viewing.</p>", "links"=>[], "tags"=>["hybridization", "y-receptor", "circumvallate"], "article_id"=>239883, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Maria D. Hurtado", "Andres Acosta", "Paola P. Riveros", "Bruce J. Baum", "Kirill Ukhanov", "Alicia R. Brown", "Cedrick D. Dotson", "Herbert Herzog", "Sergei Zolotukhin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0046358.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_situ_hybridization_analysis_of_Y_receptor_YR_gene_expression_in_the_circumvallate_papillae_/239883", "title"=>"<i>In situ</i> hybridization analysis of Y-receptor (YR) gene expression in the circumvallate papillae.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 22:41:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/570165"], "description"=>"<p>Antibodies used for immunolocalization studies.</p>", "links"=>[], "tags"=>["immunolocalization"], "article_id"=>240650, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Maria D. Hurtado", "Andres Acosta", "Paola P. Riveros", "Bruce J. Baum", "Kirill Ukhanov", "Alicia R. Brown", "Cedrick D. Dotson", "Herbert Herzog", "Sergei Zolotukhin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0046358.t001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Antibodies_used_for_immunolocalization_studies_/240650", "title"=>"Antibodies used for immunolocalization studies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 22:45:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/569229"], "description"=>"<p><b>A</b> and <b>C</b> - (−) control samples, Y1R KO and Y2R KO, respectively; <b>B, D, E, and F</b> – wt C57Bl/6 samples. Bidirectional arrows indicate dorsal/ventral (D/V) coordinates of the section. One-direction arrows in panel E point at Y4R-positive neuronal fiber/s. Red dots show fluorescently visualized YR mRNAs. DAPI-stained nuclear DNA is shown in pseudo-colored green hue for better viewing.</p>", "links"=>[], "tags"=>["hybridization", "y-receptor", "dorsal", "lingual"], "article_id"=>239717, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Maria D. Hurtado", "Andres Acosta", "Paola P. Riveros", "Bruce J. Baum", "Kirill Ukhanov", "Alicia R. Brown", "Cedrick D. Dotson", "Herbert Herzog", "Sergei Zolotukhin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0046358.g003", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_situ_hybridization_analysis_of_Y_receptor_YR_gene_expression_in_the_dorsal_lingual_epithelium_/239717", "title"=>"<i>In situ</i> hybridization analysis of Y-receptor (YR) gene expression in the dorsal lingual epithelium.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 22:40:03"}

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Relative Metric

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