Improved Working Memory but No Effect on Striatal Vesicular Monoamine Transporter Type 2 after Omega-3 Polyunsaturated Fatty Acid Supplementation
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{"title"=>"Improved Working Memory but No Effect on Striatal Vesicular Monoamine Transporter Type 2 after Omega-3 Polyunsaturated Fatty Acid Supplementation", "type"=>"journal", "authors"=>[{"first_name"=>"Rajesh", "last_name"=>"Narendran", "scopus_author_id"=>"6603381860"}, {"first_name"=>"William G.", "last_name"=>"Frankle", "scopus_author_id"=>"6603545459"}, {"first_name"=>"Neale S.", "last_name"=>"Mason", "scopus_author_id"=>"7101772133"}, {"first_name"=>"Matthew F.", "last_name"=>"Muldoon", "scopus_author_id"=>"7005439739"}, {"first_name"=>"Bita", "last_name"=>"Moghaddam", "scopus_author_id"=>"56236492500"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0046832", "sgr"=>"84867050382", "pui"=>"365779574", "scopus"=>"2-s2.0-84867050382", "issn"=>"19326203", "pmid"=>"23056476", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"ef8bbb09-9cfd-30cd-8b6a-540906b7f86b", "abstract"=>"Studies in rodents indicate that diets deficient in omega-3 polyunsaturated fatty acids (n-3 PUFA) lower dopamine neurotransmission as measured by striatal vesicular monoamine transporter type 2 (VMAT2) density and amphetamine-induced dopamine release. This suggests that dietary supplementation with fish oil might increase VMAT2 availability, enhance dopamine storage and release, and improve dopamine-dependent cognitive functions such as working memory. To investigate this mechanism in humans, positron emission tomography (PET) was used to measure VMAT2 availability pre- and post-supplementation of n-3 PUFA in healthy individuals. Healthy young adult subjects were scanned with PET using [(11)C]-(+)-α-dihydrotetrabenzine (DTBZ) before and after six months of n-3 PUFA supplementation (Lovaza, 2 g/day containing docosahexaenonic acid, DHA 750 mg/d and eicosapentaenoic acid, EPA 930 mg/d). In addition, subjects underwent a working memory task (n-back) and red blood cell membrane (RBC) fatty acid composition analysis pre- and post-supplementation. RBC analysis showed a significant increase in both DHA and EPA post-supplementation. In contrast, no significant change in [(11)C]DTBZ binding potential (BP(ND)) in striatum and its subdivisions were observed after supplementation with n-3 PUFA. No correlation was evident between n-3 PUFA induced change in RBC DHA or EPA levels and change in [(11)C]DTBZ BP(ND) in striatal subdivisions. However, pre-supplementation RBC DHA levels was predictive of baseline performance (i.e., adjusted hit rate, AHR on 3-back) on the n-back task (y = 0.19+0.07, r(2) = 0.55, p = 0.009). In addition, subjects AHR performance improved on 3-back post-supplementation (pre 0.65±0.27, post 0.80±0.15, p = 0.04). The correlation between n-back performance, and DHA levels are consistent with reports in which higher DHA levels is related to improved cognitive performance. However, the lack of change in [(11)C]DBTZ BP(ND) indicates that striatal VMAT2 regulation is not the mechanism of action by which n-3 PUFA improves cognitive performance.", "link"=>"http://www.mendeley.com/research/improved-working-memory-effect-striatal-vesicular-monoamine-transporter-type-2-after-omega3-polyunsa", "reader_count"=>63, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>2, "Researcher"=>11, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>8, "Student > Master"=>11, "Other"=>5, "Student > Bachelor"=>9, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>2, "Researcher"=>11, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>8, "Student > Master"=>11, "Other"=>5, "Student > Bachelor"=>9, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Nursing and Health Professions"=>6, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>16, "Agricultural and Biological Sciences"=>10, "Neuroscience"=>3, "Arts and Humanities"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Physics and Astronomy"=>3, "Psychology"=>12, "Social Sciences"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>16}, "Neuroscience"=>{"Neuroscience"=>3}, "Social Sciences"=>{"Social Sciences"=>3}, "Physics and Astronomy"=>{"Physics and Astronomy"=>3}, "Psychology"=>{"Psychology"=>12}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}, "Arts and Humanities"=>{"Arts and Humanities"=>2}}, "reader_count_by_country"=>{"Czech Republic"=>1, "United States"=>2, "Brazil"=>1, "United Kingdom"=>2, "Spain"=>1}, "group_count"=>6}

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  • {"files"=>["https://ndownloader.figshare.com/files/565173"], "description"=>"<p>Values are mean and standard deviation (SD), n = 11 per condition.</p><p>Associative striatum values are a weighted average of Precommissural dorsal caudate, Postcommissural caudate, and Precommissural anterior putamen; Whole striatum values are a weighted average of the five anatomical subdivisions.</p><p>p-values are from two-tailed, paired t tests; t is t statistic; df is degrees of freedom.</p>", "links"=>[], "tags"=>["binding"], "article_id"=>235670, "categories"=>["Biochemistry", "Neuroscience", "Mental Health", "Pharmacology"], "users"=>["Rajesh Narendran", "William G. Frankle", "Neale S. Mason", "Matthew F. Muldoon", "Bita Moghaddam"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0046832.t004", "stats"=>{"downloads"=>4, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regional_11_C_DTBZ_binding_potential_BP_ND_/235670", "title"=>"Regional [<b><sup>11</sup></b>C]DTBZ binding potential (BP<sub>ND</sub>).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 22:18:23"}
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