Sex Differences in Genetic Architecture of Complex Phenotypes?
Publication Date
December 18, 2012
Journal
PLOS ONE
Authors
Jacqueline M. Vink, Meike Bartels, Toos C. E. M. Van Beijsterveldt, Jenny Van Dongen, et al
Volume
7
Issue
12
Pages
e47371
DOI
https://dx.plos.org/10.1371/journal.pone.0047371
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0047371
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23272036
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525575
Europe PMC
http://europepmc.org/abstract/MED/23272036
Web of Science
000312483300001
Scopus
84871288130
Mendeley
http://www.mendeley.com/research/sex-differences-genetic-architecture-complex-phenotypes
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Mendeley | Further Information

{"title"=>"Sex Differences in Genetic Architecture of Complex Phenotypes?", "type"=>"journal", "authors"=>[{"first_name"=>"Jacqueline M.", "last_name"=>"Vink"}, {"first_name"=>"Meike", "last_name"=>"Bartels"}, {"first_name"=>"Toos C. E. M.", "last_name"=>"van Beijsterveldt"}, {"first_name"=>"Jenny", "last_name"=>"van Dongen"}, {"first_name"=>"Jenny H. D. A.", "last_name"=>"van Beek"}, {"first_name"=>"Marijn A.", "last_name"=>"Distel"}, {"first_name"=>"Marleen H. M.", "last_name"=>"de Moor"}, {"first_name"=>"Dirk J. A.", "last_name"=>"Smit"}, {"first_name"=>"Camelia C.", "last_name"=>"Minica"}, {"first_name"=>"Lannie", "last_name"=>"Ligthart"}, {"first_name"=>"Lot M.", "last_name"=>"Geels"}, {"first_name"=>"Abdel", "last_name"=>"Abdellaoui"}, {"first_name"=>"Christel M.", "last_name"=>"Middeldorp"}, {"first_name"=>"Jouke Jan", "last_name"=>"Hottenga"}, {"first_name"=>"Gonneke", "last_name"=>"Willemsen"}, {"first_name"=>"Eco J. C.", "last_name"=>"de Geus"}, {"first_name"=>"Dorret I.", "last_name"=>"Boomsma"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0047371", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "pmid"=>"23272036"}, "id"=>"0b8d379f-7c6d-3c16-9def-bb09adbcec1d", "abstract"=>"We examined sex differences in familial resemblance for a broad range of behavioral, psychiatric and health related phenotypes (122 complex traits) in children and adults. There is a renewed interest in the importance of genotype by sex interaction in, for example, genome-wide association (GWA) studies of complex phenotypes. If different genes play a role across sex, GWA studies should consider the effect of genetic variants separately in men and women, which affects statistical power. Twin and family studies offer an opportunity to compare resemblance between opposite-sex family members to the resemblance between same-sex relatives, thereby presenting a test of quantitative and qualitative sex differences in the genetic architecture of complex traits. We analyzed data on lifestyle, personality, psychiatric disorder, health, growth, development and metabolic traits in dizygotic (DZ) same-sex and opposite-sex twins, as these siblings are perfectly matched for age and prenatal exposures. Sample size varied from slightly over 300 subjects for measures of brain function such as EEG power to over 30,000 subjects for childhood psychopathology and birth weight. For most phenotypes, sample sizes were large, with an average sample size of 9027 individuals. By testing whether the resemblance in DZ opposite-sex pairs is the same as in DZ same-sex pairs, we obtain evidence for genetic qualitative sex-differences in the genetic architecture of complex traits for 4% of phenotypes. We conclude that for most traits that were examined, the current evidence is that same the genes are operating in men and women.", "link"=>"http://www.mendeley.com/research/sex-differences-genetic-architecture-complex-phenotypes", "reader_count"=>43, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>8, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>5, "Student > Master"=>7, "Other"=>2, "Student > Bachelor"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>8, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>5, "Student > Master"=>7, "Other"=>2, "Student > Bachelor"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>6, "Nursing and Health Professions"=>2, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>4, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Business, Management and Accounting"=>1, "Sports and Recreations"=>1, "Psychology"=>10, "Social Sciences"=>5, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>5}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>10}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Sweden"=>1, "Hong Kong"=>1, "United States"=>1, "United Kingdom"=>1, "Spain"=>1}, "group_count"=>0}

CrossRef

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/522876"], "description"=>"<p>(y-axis) for all 122 phenotypes included in the present paper.</p>", "links"=>[], "tags"=>["observed", "correlations", "opposite-sex", "same-sex", "dizygotic"], "article_id"=>193347, "categories"=>["Medicine", "Genetics"], "users"=>["Jacqueline M. Vink", "Meike Bartels", "Toos C. E. M. van Beijsterveldt", "Jenny van Dongen", "Jenny H. D. A. van Beek", "Marijn A. Distel", "Marleen H. M. de Moor", "Dirk J. A. Smit", "Camelia C. Minica", "Lannie Ligthart", "Lot M. Geels", "Abdel Abdellaoui", "Christel M. Middeldorp", "Jouke Jan Hottenga", "Gonneke Willemsen", "Eco J. C. de Geus", "Dorret I. Boomsma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047371.g006", "stats"=>{"downloads"=>1, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_all_observed_correlations_in_opposite_sex_twin_x_axis_pairs_versus_expected_correlations_correlations_based_on_same_sex_dizygotic_twin_correlations_pairs_/193347", "title"=>"Summary of all observed correlations in opposite-sex twin (x-axis)pairs versus expected correlations correlations based on same-sex dizygotic twin correlations pairs", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-18 00:55:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/522493"], "description"=>"<p>1A: adult psychiatry, 1B: adult psychology, 1C Internalizing behavior in children, 1D Externalizing behavior in children, 1E other scales in children. The green bars represent correlations in Monozygotic Male (MZM) twin pairs (light green) and Monozygotic Female (MZF) twin pairs. The blue bars represent correlations in Dizygotic Male (DZM) twin pairs, Dizygotic Female (DZF) twin pairs and Dizygotic Opposite Sex (DOS) twin pairs. The green and blue bars reflect the correlations in a full model, while the orange bars reflect twin correlations for Dizygotic (DZ) twin pairs in the most parsimonious model, with: DZM (light orange), MZF (normal orange), DOS (dark orange).</p>", "links"=>[], "tags"=>["correlations"], "article_id"=>192975, "categories"=>["Medicine", "Genetics"], "users"=>["Jacqueline M. Vink", "Meike Bartels", "Toos C. E. M. van Beijsterveldt", "Jenny van Dongen", "Jenny H. D. A. van Beek", "Marijn A. Distel", "Marleen H. M. de Moor", "Dirk J. A. Smit", "Camelia C. Minica", "Lannie Ligthart", "Lot M. Geels", "Abdel Abdellaoui", "Christel M. Middeldorp", "Jouke Jan Hottenga", "Gonneke Willemsen", "Eco J. C. de Geus", "Dorret I. Boomsma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047371.g002", "stats"=>{"downloads"=>6, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Twin_correlations_for_Behavioral_and_Emotional_Problems_/192975", "title"=>"Twin correlations for Behavioral and Emotional Problems.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-18 00:49:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/522703"], "description"=>"<p>1A: adult twins and 1B: adolescent twins. The green bars represent correlations in Monozygotic Male (MZM) twin pairs (light green) and Monozygotic Female (MZF) twin pairs. The blue bars represent correlations in Dizygotic Male (DZM) twin pairs, Dizygotic Female (DZF) twin pairs and Dizygotic Opposite Sex (DOS) twin pairs. The green and blue bars reflect the correlations in a full model, while the orange bars reflect twin correlations for Dizygotic (DZ) twin pairs in the most parsimonious model, with: DZM (light orange), MZF (normal orange), DOS (dark orange).</p>", "links"=>[], "tags"=>["correlations", "bmi"], "article_id"=>193177, "categories"=>["Medicine", "Genetics"], "users"=>["Jacqueline M. Vink", "Meike Bartels", "Toos C. E. M. van Beijsterveldt", "Jenny van Dongen", "Jenny H. D. A. van Beek", "Marijn A. Distel", "Marleen H. M. de Moor", "Dirk J. A. Smit", "Camelia C. Minica", "Lannie Ligthart", "Lot M. Geels", "Abdel Abdellaoui", "Christel M. Middeldorp", "Jouke Jan Hottenga", "Gonneke Willemsen", "Eco J. C. de Geus", "Dorret I. Boomsma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047371.g004", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Twin_correlations_for_BMI_and_Height_/193177", "title"=>"Twin correlations for BMI and Height.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-18 00:52:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/522398"], "description"=>"<p>1A: adult twins and 1B: adolescent twins. The green bars represent correlations in Monozygotic Male (MZM) twin pairs (light green) and Monozygotic Female (MZF) twin pairs. The blue bars represent correlations in Dizygotic Male (DZM) twin pairs, Dizygotic Female (DZF) twin pairs and Dizygotic Opposite Sex (DOS) twin pairs. The green and blue bars reflect the correlations in a full model, while the orange bars reflect twin correlations for Dizygotic (DZ) twin pairs in the most parsimonious model, with: DZM (light orange), MZF (normal orange), DOS (dark orange).</p>", "links"=>[], "tags"=>["correlations"], "article_id"=>192874, "categories"=>["Medicine", "Genetics"], "users"=>["Jacqueline M. Vink", "Meike Bartels", "Toos C. E. M. van Beijsterveldt", "Jenny van Dongen", "Jenny H. D. A. van Beek", "Marijn A. Distel", "Marleen H. M. de Moor", "Dirk J. A. Smit", "Camelia C. Minica", "Lannie Ligthart", "Lot M. Geels", "Abdel Abdellaoui", "Christel M. Middeldorp", "Jouke Jan Hottenga", "Gonneke Willemsen", "Eco J. C. de Geus", "Dorret I. Boomsma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047371.g001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Twin_correlations_for_Lifestyle_variables_/192874", "title"=>"Twin correlations for Lifestyle variables.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-18 00:47:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/522600"], "description"=>"<p>The green bars represent correlations in Monozygotic Male (MZM) twin pairs (light green) and Monozygotic Female (MZF) twin pairs. The blue bars represent correlations in Dizygotic Male (DZM) twin pairs, Dizygotic Female (DZF) twin pairs and Dizygotic Opposite Sex (DOS) twin pairs. The green and blue bars reflect the correlations in a full model, while the orange bars reflect twin correlations for Dizygotic (DZ) twin pairs in the most parsimonious model, with: DZM (light orange), MZF (normal orange), DOS (dark orange).</p>", "links"=>[], "tags"=>["correlations", "cognition"], "article_id"=>193079, "categories"=>["Medicine", "Genetics"], "users"=>["Jacqueline M. Vink", "Meike Bartels", "Toos C. E. M. van Beijsterveldt", "Jenny van Dongen", "Jenny H. D. A. van Beek", "Marijn A. Distel", "Marleen H. M. de Moor", "Dirk J. A. Smit", "Camelia C. Minica", "Lannie Ligthart", "Lot M. Geels", "Abdel Abdellaoui", "Christel M. Middeldorp", "Jouke Jan Hottenga", "Gonneke Willemsen", "Eco J. C. de Geus", "Dorret I. Boomsma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047371.g003", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Twin_correlations_for_Brain_and_Cognition_variables_/193079", "title"=>"Twin correlations for Brain and Cognition variables.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-18 00:51:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/283300", "https://ndownloader.figshare.com/files/283499", "https://ndownloader.figshare.com/files/283554", "https://ndownloader.figshare.com/files/283692", "https://ndownloader.figshare.com/files/283753", "https://ndownloader.figshare.com/files/283816", "https://ndownloader.figshare.com/files/283882", "https://ndownloader.figshare.com/files/283943", "https://ndownloader.figshare.com/files/284008"], "description"=>"<div><p>We examined sex differences in familial resemblance for a broad range of behavioral, psychiatric and health related phenotypes (122 complex traits) in children and adults. There is a renewed interest in the importance of genotype by sex interaction in, for example, genome-wide association (GWA) studies of complex phenotypes. If different genes play a role across sex, GWA studies should consider the effect of genetic variants separately in men and women, which affects statistical power. Twin and family studies offer an opportunity to compare resemblance between opposite-sex family members to the resemblance between same-sex relatives, thereby presenting a test of quantitative and qualitative sex differences in the genetic architecture of complex traits. We analyzed data on lifestyle, personality, psychiatric disorder, health, growth, development and metabolic traits in dizygotic (DZ) same-sex and opposite-sex twins, as these siblings are perfectly matched for age and prenatal exposures. Sample size varied from slightly over 300 subjects for measures of brain function such as EEG power to over 30,000 subjects for childhood psychopathology and birth weight. For most phenotypes, sample sizes were large, with an average sample size of 9027 individuals. By testing whether the resemblance in DZ opposite-sex pairs is the same as in DZ same-sex pairs, we obtain evidence for genetic qualitative sex-differences in the genetic architecture of complex traits for 4% of phenotypes. We conclude that for most traits that were examined, the current evidence is that same the genes are operating in men and women.</p> </div>", "links"=>[], "tags"=>["differences"], "article_id"=>115858, "categories"=>["Medicine", "Genetics"], "users"=>["Jacqueline M. Vink", "Meike Bartels", "Toos C. E. M. van Beijsterveldt", "Jenny van Dongen", "Jenny H. D. A. van Beek", "Marijn A. Distel", "Marleen H. M. de Moor", "Dirk J. A. Smit", "Camelia C. Minica", "Lannie Ligthart", "Lot M. Geels", "Abdel Abdellaoui", "Christel M. Middeldorp", "Jouke Jan Hottenga", "Gonneke Willemsen", "Eco J. C. de Geus", "Dorret I. Boomsma"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0047371.s001", "https://dx.doi.org/10.1371/journal.pone.0047371.s002", "https://dx.doi.org/10.1371/journal.pone.0047371.s003", "https://dx.doi.org/10.1371/journal.pone.0047371.s004", "https://dx.doi.org/10.1371/journal.pone.0047371.s005", "https://dx.doi.org/10.1371/journal.pone.0047371.s006", "https://dx.doi.org/10.1371/journal.pone.0047371.s007", "https://dx.doi.org/10.1371/journal.pone.0047371.s008", "https://dx.doi.org/10.1371/journal.pone.0047371.s009"], "stats"=>{"downloads"=>31, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Sex_Differences_in_Genetic_Architecture_of_Complex_Phenotypes__/115858", "title"=>"Sex Differences in Genetic Architecture of Complex Phenotypes?", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-12-18 01:37:38"}

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Relative Metric

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