Renal IL-18 Production Is Macrophage Independent During Obstructive Injury
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{"title"=>"Renal IL-18 Production Is Macrophage Independent During Obstructive Injury", "type"=>"journal", "authors"=>[{"first_name"=>"Ethan I.", "last_name"=>"Franke", "scopus_author_id"=>"24448112000"}, {"first_name"=>"Brian A.", "last_name"=>"Vanderbrink", "scopus_author_id"=>"6602901863"}, {"first_name"=>"Karen L.", "last_name"=>"Hile", "scopus_author_id"=>"6506647453"}, {"first_name"=>"Hongji", "last_name"=>"Zhang", "scopus_author_id"=>"7409193497"}, {"first_name"=>"Alexandra", "last_name"=>"Cain", "scopus_author_id"=>"55388852700"}, {"first_name"=>"Futoshi", "last_name"=>"Matsui", "scopus_author_id"=>"55112245100"}, {"first_name"=>"Kirstan K.", "last_name"=>"Meldrum", "scopus_author_id"=>"7004177174"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"365840972", "doi"=>"10.1371/journal.pone.0047417", "sgr"=>"84867423244", "scopus"=>"2-s2.0-84867423244", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "pmid"=>"23077611"}, "id"=>"a488088e-3d91-32dc-abcd-0ae945291899", "abstract"=>"BACKGROUND: Interleukin 18 (IL-18) is a pro-inflammatory cytokine that mediates fibrotic renal injury during obstruction. Macrophages are a well-known source of IL-18; however, renal tubular epithelial cells are also a potential source of this cytokine. We hypothesized that IL-18 is predominantly a renal tubular cell product and is produced during renal obstruction independent of macrophage infiltration.\\n\\nMETHODS: To study this, male C57BL6 mice were subjected to unilateral ureteral obstruction (UUO) vs. sham operation in the presence or absence of macrophage depletion (liposomal clodronate (1 ml/100 g body weight i.v.)). The animals were sacrificed 1 week after surgery and renal cortical tissue harvested. Tissue levels of active IL-18 (ELISA), IL-18 receptor mRNA expression (real time PCR), and active caspase-1 expression (western blot) were measured. The cellular localization of IL-18 and IL-18R was assessed using dual labeling immunofluorescent staining (IFS).\\n\\nRESULTS: Immunohistochemical staining of renal tissue sections confirmed macrophage depletion by liposomal clodronate. IL-18 production, IL-18R expression, and active caspase 1 expression were elevated in response to renal obstruction and did not decline to a significant degree in the presence of macrophage depletion. Obstruction-induced IL-18 and IL-18R production localized predominantly to tubular epithelial cells (TEC) during obstruction despite macrophage depletion.\\n\\nCONCLUSION: These results demonstrate that renal tubular epithelial cells are the primary source of IL-18 production during obstructive injury, and that tubular cell production of IL-18 occurs independent of macrophage infiltration.", "link"=>"http://www.mendeley.com/research/renal-il18-production-macrophage-independent-during-obstructive-injury", "reader_count"=>6, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Postgraduate"=>1, "Student > Bachelor"=>1, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Postgraduate"=>1, "Student > Bachelor"=>1, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>4, "Computer Science"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Computer Science"=>{"Computer Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"China"=>1}, "group_count"=>0}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/559947"], "description"=>"<p><b>A.</b> Photographs (magnification 400X) depicting renal cortical IL-18R production (red) and distal tubular staining (Peanut Agglutinin; green) in vehicle treated and macrophage depleted mice exposed to sham operation or one week of UUO. White arrows indicate IL-18R staining overlying tubules. T = Tubules.</p>", "links"=>[], "tags"=>["cortical", "dual", "labeled", "immunofluorescent", "staining", "il-18r", "tubular", "epithelial", "cells"], "article_id"=>230423, "categories"=>["Physiology", "Cancer", "Marine Biology", "Immunology"], "users"=>["Ethan I. Franke", "Brian A. Vanderbrink", "Karen L. Hile", "Hongji Zhang", "Alexandra Cain", "Futoshi Matsui", "Kirstan K. Meldrum"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047417.g006", "stats"=>{"downloads"=>1, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Renal_cortical_dual_labeled_immunofluorescent_staining_for_IL_18R_and_tubular_epithelial_cells_following_UUO_/230423", "title"=>"Renal cortical dual labeled immunofluorescent staining for IL-18R and tubular epithelial cells following UUO.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:49:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/559709"], "description"=>"<p><b>A.</b> Photographs (magnification 400X) depicting renal cortical IL-18 production (red) and distal tubular staining (Peanut Agglutinin; green) in vehicle treated and macrophage depleted mice exposed to sham operation or one week of UUO. White arrows indicate IL-18 staining overlying tubules. T = Tubules.</p>", "links"=>[], "tags"=>["cortical", "dual", "labeled", "immunofluorescent", "staining", "il-18", "tubular", "epithelial", "cells"], "article_id"=>230188, "categories"=>["Physiology", "Cancer", "Marine Biology", "Immunology"], "users"=>["Ethan I. Franke", "Brian A. Vanderbrink", "Karen L. Hile", "Hongji Zhang", "Alexandra Cain", "Futoshi Matsui", "Kirstan K. Meldrum"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047417.g005", "stats"=>{"downloads"=>1, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Renal_cortical_dual_labeled_immunofluorescent_staining_for_IL_18_and_tubular_epithelial_cells_following_UUO_/230188", "title"=>"Renal cortical dual labeled immunofluorescent staining for IL-18 and tubular epithelial cells following UUO.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:48:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/559275"], "description"=>"<p>Photographs (magnification 400X) depicting macrophage (brown stain; arrows) in vehicle treated and macrophage depleted mice exposed to sham operation or one week of UUO. T = tubule; G = glomerulus.</p>", "links"=>[], "tags"=>["cortical", "macrophage", "accumulation"], "article_id"=>229757, "categories"=>["Physiology", "Cancer", "Marine Biology", "Immunology"], "users"=>["Ethan I. Franke", "Brian A. Vanderbrink", "Karen L. Hile", "Hongji Zhang", "Alexandra Cain", "Futoshi Matsui", "Kirstan K. Meldrum"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047417.g001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Renal_cortical_macrophage_accumulation_following_UUO_/229757", "title"=>"Renal cortical macrophage accumulation following UUO.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:46:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/559395"], "description"=>"<p>Renal cortical active IL-18 protein levels in vehicle treated and macrophage depleted mice exposed to sham operation or one week of UUO.</p>", "links"=>[], "tags"=>["cortical", "il-18"], "article_id"=>229887, "categories"=>["Physiology", "Cancer", "Marine Biology", "Immunology"], "users"=>["Ethan I. Franke", "Brian A. Vanderbrink", "Karen L. Hile", "Hongji Zhang", "Alexandra Cain", "Futoshi Matsui", "Kirstan K. Meldrum"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047417.g002", "stats"=>{"downloads"=>2, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Renal_cortical_active_IL_18_production_following_UUO_/229887", "title"=>"Renal cortical active IL-18 production following UUO.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:47:03"}

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  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
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  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
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  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
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  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
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  • {"unique-ip"=>"6", "full-text"=>"2", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
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Relative Metric

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