Cardiac Atrial Circadian Rhythms in PERIOD2::LUCIFERASE and per1:luc Mice: Amplitude and Phase Responses to Glucocorticoid Signaling and Medium Treatment
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{"title"=>"Cardiac Atrial Circadian Rhythms in PERIOD2::LUCIFERASE and per1:luc Mice: Amplitude and Phase Responses to Glucocorticoid Signaling and Medium Treatment", "type"=>"journal", "authors"=>[{"first_name"=>"Daan R.", "last_name"=>"van der Veen", "scopus_author_id"=>"8954977600"}, {"first_name"=>"Jinping", "last_name"=>"Shao", "scopus_author_id"=>"55028799100"}, {"first_name"=>"Yang", "last_name"=>"Xi", "scopus_author_id"=>"55425560400"}, {"first_name"=>"Lei", "last_name"=>"Li", "scopus_author_id"=>"56927313300"}, {"first_name"=>"Giles E.", "last_name"=>"Duffield", "scopus_author_id"=>"6701530908"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84867889565", "doi"=>"10.1371/journal.pone.0047692", "sgr"=>"84867889565", "arxiv"=>"231", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"23110090", "issn"=>"19326203", "pui"=>"365919065"}, "id"=>"4c916ebf-97f1-31ff-8dbb-d9a20eb44484", "abstract"=>"Circadian rhythms in cardiac function are apparent in e.g., blood pressure, heart rate, and acute adverse cardiac events. A circadian clock in heart tissue has been identified, but entrainment pathways of this clock are still unclear. We cultured tissues of mice carrying bioluminescence reporters of the core clock genes, period 1 or 2 (per1(luc) or PER2(LUC)) and compared in vitro responses of atrium to treatment with medium and a synthetic glucocorticoid (dexamethasone [DEX]) to that of the suprachiasmatic nucleus (SCN) and liver. We observed that PER2(LUC), but not per1(luc) is rhythmic in atrial tissue, while both per1(luc) and PER2(LUC) exhibit rhythmicity in other cultured tissues. In contrast to the SCN and liver, both per1(luc) and PER2(LUC) bioluminescence amplitudes were increased in response to DEX treatment, and the PER2(LUC) amplitude response was dependent on the time of treatment. Large phase-shift responses to both medium and DEX treatments were observed in the atrium, and phase responses to medium treatment were not attributed to serum content but the treatment procedure itself. The phase-response curves of atrium to both DEX and medium treatments were found to be different to the liver. Moreover, the time of day of the culturing procedure itself influenced the phase of the circadian clock in each of the cultured tissues, but the magnitude of this response was uniquely large in atrial tissue. The current data describe novel entrainment signals for the atrial circadian clock and specifically highlight entrainment by mechanical treatment, an intriguing observation considering the mechanical nature of cardiac tissue.", "link"=>"http://www.mendeley.com/research/cardiac-atrial-circadian-rhythms-period2luciferase-per1luc-mice-amplitude-phase-responses-glucocorti", "reader_count"=>32, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>5, "Student > Doctoral Student"=>4, "Researcher"=>4, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>2, "Student > Master"=>5, "Other"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>5, "Student > Doctoral Student"=>4, "Researcher"=>4, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>2, "Student > Master"=>5, "Other"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>7, "Agricultural and Biological Sciences"=>14, "Medicine and Dentistry"=>8, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>14}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>1, "United Kingdom"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/555183"], "description"=>"<p>Data are phase responses of cultures of atrial tissue of PER2<sup>LUC</sup> mice to treatment with gas exchange only (tissue culture lid opened), medium exchange with different serum concentrations (0, 1 and 5%) or removal and reapplication of own medium. Treatment time was at 3.75±0.28 hours after the last peak of bioluminescence (mean ± SEM; range 1.0–5.0 hours). Group means ± SEM values are indicated by filled bars, and individual data points contributing to these averages are shown as circles. **P≤0.01.</p>", "links"=>[], "tags"=>["shifts", "atrial"], "article_id"=>225677, "categories"=>["Physiology", "Molecular Biology", "Chemistry", "Genetics"], "users"=>["Daan R. van der Veen", "Jinping Shao", "Yang Xi", "Lei Li", "Giles E. Duffield"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047692.g005", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_medium_exchange_procedure_on_the_magnitude_of_phase_shifts_of_atrial_explants_/225677", "title"=>"Effect of medium exchange procedure on the magnitude of phase shifts of atrial explants.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-10-23 01:34:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/554850"], "description"=>"<p>(A) Data are plotted as phase shifts to treatment given at different times after the last peak in bioluminescence. For statistical analysis the data were grouped in 3 hour bins (B) and there is a significant effect of treatment, where DEX treated cultures always showed a larger phase shift than medium treated cultures. Panel C shows a DEX-only PRC, as calculated by subtracting the medium response from the DEX response as binned in panel B.</p>", "links"=>[], "tags"=>["responses", "dex", "cultures", "atrial", "taken"], "article_id"=>225342, "categories"=>["Physiology", "Molecular Biology", "Chemistry", "Genetics"], "users"=>["Daan R. van der Veen", "Jinping Shao", "Yang Xi", "Lei Li", "Giles E. Duffield"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047692.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phase_shift_responses_to_medium_and_DEX_treatment_of_cultures_of_atrial_tissue_taken_from_PER2_LUC_mice_/225342", "title"=>"Phase shift responses to medium and DEX treatment of cultures of atrial tissue taken from PER2<sup>LUC</sup> mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-10-23 01:29:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/555319"], "description"=>"<p>The phases for individual cultures and mean ± SEM are shown. The phase is plotted as Zeitgeber time (ZT), based on the preceding light-dark cycle, where ZT0 = lights on and ZT12 = lights off.</p>", "links"=>[], "tags"=>["bioluminescence", "cultures", "atrium"], "article_id"=>225813, "categories"=>["Physiology", "Molecular Biology", "Chemistry", "Genetics"], "users"=>["Daan R. van der Veen", "Jinping Shao", "Yang Xi", "Lei Li", "Giles E. Duffield"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047692.g006", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Timing_of_the_first_peak_in_the_bioluminescence_rhythm_in_cultures_of_left_and_right_atrium_of_PER2_LUC_mice_/225813", "title"=>"Timing of the first peak in the bioluminescence rhythm in cultures of left and right atrium of PER2<sup>LUC</sup> mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-10-23 01:36:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/554717"], "description"=>"<p>Data are explants derived from (A) <i>per1<sup>luc</sup></i> and (B) PER2<sup>LUC</sup> mice. Data are plotted as smoothed data (3 hours running average, colored lines) on top of a background of the unsmoothed data in gray tone. Grey blocks indicate time of treatment for the medium and DEX treated cultured. Amplitude responses to medium and DEX treatment for cultures of PER2<sup>LUC</sup> mice are shown in panel C. The amplitude changes in cultures of atria are further plotted in panel D, showing the responses at different times of day. ***P<0.001. Note the different scale on the atrial traces of <i>per1</i> bioluminescence due to absence of pre-treatment rhythmicity.</p>", "links"=>[], "tags"=>["baseline", "detrended", "bioluminescence", "recordings", "mice", "cultures", "atrial"], "article_id"=>225204, "categories"=>["Physiology", "Molecular Biology", "Chemistry", "Genetics"], "users"=>["Daan R. van der Veen", "Jinping Shao", "Yang Xi", "Lei Li", "Giles E. Duffield"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047692.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Individual_baseline_detrended_bioluminescence_recordings_of_per1_luc_and_PER2_LUC_mice_in_cultures_of_SCN_liver_and_atrial_tissue_/225204", "title"=>"Individual baseline detrended bioluminescence recordings of <i>per1<sup>luc</sup></i> and PER2<sup>LUC</sup> mice in cultures of SCN, liver and atrial tissue.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-10-23 01:26:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/554551"], "description"=>"<p>Time of culturing is denoted as Zeitgeber time (ZT), where ZT0 = lights on and ZT12 = lights off, and the first peak as extrapolated CT (similar as ZT, but based on the preceding light-dark cycle). Explants were cultured at ZT3.5, ZT5, ZT7 and ZT13, and all tissues examined showed an effect of time of culturing on the subsequent <i>in vitro</i> phase, where culturing atrial tissue showed the strongest influence of time of culturing, with all times of culturing resulting in a different phase <i>in vitro</i>. **P<0.01, ***P<0.001.</p>", "links"=>[], "tags"=>["bioluminescence", "cultures", "atrial", "mice"], "article_id"=>225041, "categories"=>["Physiology", "Molecular Biology", "Chemistry", "Genetics"], "users"=>["Daan R. van der Veen", "Jinping Shao", "Yang Xi", "Lei Li", "Giles E. Duffield"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047692.g001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_First_peak_in_the_bioluminescence_rhythm_in_cultures_of_SCN_liver_and_atrial_tissue_of_PER2_LUC_mice_as_a_function_if_time_of_culturing_/225041", "title"=>"First peak in the bioluminescence rhythm in cultures of SCN, liver and atrial tissue of PER2<sup>LUC</sup> mice as a function if time of culturing.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-10-23 01:24:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/555061"], "description"=>"<p>(A) Data are binned in 6 hour bins centered on 6, 12, 18 and 24 hours after the last peak in bioluminescence and responses differ between medium and DEX treated tissue, specifically for the phase responses after treatment centering around 6 and 24 hours after the last peak in the bioluminescence rhythm. For reasons of comparison, atrial phase responses to medium and DEX treatment are re-plotted on the same time scale as the liver in panel B. The liver and atrium show markedly different responses to treatment, and a statistical comparison between treatment and tissue is summarized in panel C. NS = not significant, **P<0.01, ***P<0.001.</p>", "links"=>[], "tags"=>["responses", "dex", "cultures", "derived"], "article_id"=>225553, "categories"=>["Physiology", "Molecular Biology", "Chemistry", "Genetics"], "users"=>["Daan R. van der Veen", "Jinping Shao", "Yang Xi", "Lei Li", "Giles E. Duffield"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047692.g004", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phase_shift_responses_to_medium_and_DEX_treatment_of_cultures_of_liver_tissue_derived_from_PER2_LUC_mice_/225553", "title"=>"Phase shift responses to medium and DEX treatment of cultures of liver tissue derived from PER2<sup>LUC</sup> mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-10-23 01:32:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/295645", "https://ndownloader.figshare.com/files/295716", "https://ndownloader.figshare.com/files/295770"], "description"=>"<div><p>Circadian rhythms in cardiac function are apparent in e.g., blood pressure, heart rate, and acute adverse cardiac events. A circadian clock in heart tissue has been identified, but entrainment pathways of this clock are still unclear. We cultured tissues of mice carrying bioluminescence reporters of the core clock genes, <em>period 1</em> or <em>2</em> (<em>per1<sup>luc</sup></em> or PER2<sup>LUC</sup>) and compared <em>in vitro</em> responses of atrium to treatment with medium and a synthetic glucocorticoid (dexamethasone [DEX]) to that of the suprachiasmatic nucleus (SCN) and liver. We observed that PER2<sup>LUC</sup>, but not <em>per1<sup>luc</sup></em> is rhythmic in atrial tissue, while both <em>per1<sup>luc</sup></em> and PER2<sup>LUC</sup> exhibit rhythmicity in other cultured tissues. In contrast to the SCN and liver, both <em>per1<sup>luc</sup></em> and PER2<sup>LUC</sup> bioluminescence amplitudes were increased in response to DEX treatment, and the PER2<sup>LUC</sup> amplitude response was dependent on the time of treatment. Large phase-shift responses to both medium and DEX treatments were observed in the atrium, and phase responses to medium treatment were not attributed to serum content but the treatment procedure itself. The phase-response curves of atrium to both DEX and medium treatments were found to be different to the liver. Moreover, the time of day of the culturing procedure itself influenced the phase of the circadian clock in each of the cultured tissues, but the magnitude of this response was uniquely large in atrial tissue. The current data describe novel entrainment signals for the atrial circadian clock and specifically highlight entrainment by mechanical treatment, an intriguing observation considering the mechanical nature of cardiac tissue.</p> </div>", "links"=>[], "tags"=>["cardiac", "atrial", "circadian", "rhythms", "amplitude", "responses", "glucocorticoid", "signaling"], "article_id"=>118232, "categories"=>["Physiology", "Molecular Biology", "Chemistry", "Genetics"], "users"=>["Daan R. van der Veen", "Jinping Shao", "Yang Xi", "Lei Li", "Giles E. Duffield"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0047692.s001", "https://dx.doi.org/10.1371/journal.pone.0047692.s002", "https://dx.doi.org/10.1371/journal.pone.0047692.s003"], "stats"=>{"downloads"=>8, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Cardiac_Atrial_Circadian_Rhythms_in_PERIOD2_LUCIFERASE_and_per1_luc_Mice_Amplitude_and_Phase_Responses_to_Glucocorticoid_Signaling_and_Medium_Treatment/118232", "title"=>"Cardiac Atrial Circadian Rhythms in PERIOD2::LUCIFERASE and <em>per1:luc</em> Mice: Amplitude and Phase Responses to Glucocorticoid Signaling and Medium Treatment", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-10-23 02:17:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/555418"], "description"=>"<p>The proportion and percentage occurrence of rhythms of <i>per1<sup>luc</sup></i> or PER2<sup>LUC</sup> bioluminescence observed in cultures of SCN, liver and atrium.</p>", "links"=>[], "tags"=>["occurrence", "rhythms", "bioluminescence", "observed", "cultures"], "article_id"=>225910, "categories"=>["Physiology", "Molecular Biology", "Chemistry", "Genetics"], "users"=>["Daan R. van der Veen", "Jinping Shao", "Yang Xi", "Lei Li", "Giles E. Duffield"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0047692.t001", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_proportion_and_percentage_occurrence_of_rhythms_of_per1_luc_or_PER2_LUC_bioluminescence_observed_in_cultures_of_SCN_liver_and_atrium_/225910", "title"=>"The proportion and percentage occurrence of rhythms of <i>per1<sup>luc</sup></i> or PER2<sup>LUC</sup> bioluminescence observed in cultures of SCN, liver and atrium.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-10-23 01:38:30"}

PMC Usage Stats | Further Information

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