Selenite Stimulates Mitochondrial Biogenesis Signaling and Enhances Mitochondrial Functional Performance in Murine Hippocampal Neuronal Cells
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{"title"=>"Selenite Stimulates Mitochondrial Biogenesis Signaling and Enhances Mitochondrial Functional Performance in Murine Hippocampal Neuronal Cells", "type"=>"journal", "authors"=>[{"first_name"=>"Natalia", "last_name"=>"Mendelev", "scopus_author_id"=>"8532596100"}, {"first_name"=>"Suresh L.", "last_name"=>"Mehta", "scopus_author_id"=>"16069055800"}, {"first_name"=>"Haza", "last_name"=>"Idris", "scopus_author_id"=>"55419673800"}, {"first_name"=>"Santosh", "last_name"=>"Kumari", "scopus_author_id"=>"57197190052"}, {"first_name"=>"P. Andy", "last_name"=>"Li", "scopus_author_id"=>"36063234600"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203", "pui"=>"365892002", "pmid"=>"23110128", "doi"=>"10.1371/journal.pone.0047910", "sgr"=>"84867700140", "scopus"=>"2-s2.0-84867700140"}, "id"=>"a9044434-99a0-3fe3-942d-508776390ae2", "abstract"=>"Supplementation of selenium has been shown to protect cells against free radical mediated cell damage. The objectives of this study are to examine whether supplementation of selenium stimulates mitochondrial biogenesis signaling pathways and whether selenium enhances mitochondrial functional performance. Murine hippocampal neuronal HT22 cells were treated with sodium selenite for 24 hours. Mitochondrial biogenesis markers, mitochondrial respiratory rate and activities of mitochondrial electron transport chain complexes were measured and compared to non-treated cells. The results revealed that treatment of selenium to the HT22 cells elevated the levels of nuclear mitochondrial biogenesis regulators PGC-1α and NRF1, as well as mitochondrial proteins cytochrome c and cytochrome c oxidase IV (COX IV). These effects are associated with phosphorylation of Akt and cAMP response element-binding (CREB). Supplementation of selenium significantly increased mitochondrial respiration and improved the activities of mitochondrial respiratory complexes. We conclude that selenium activates mitochondrial biogenesis signaling pathway and improves mitochondrial function. These effects may be associated with modulation of AKT-CREB pathway.", "link"=>"http://www.mendeley.com/research/selenite-stimulates-mitochondrial-biogenesis-signaling-enhances-mitochondrial-functional-performance", "reader_count"=>11, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>4, "Neuroscience"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/555390"], "description"=>"<p><i>Upper panel</i>, representative Western blot bands. <i>Lower panel</i>, summarized bar graphs show band intensity presented as ratio of targeting protein over actin. Values are means±s.d. * p<0.05 and **p<0.01 by <i>t</i>-test.</p>", "links"=>[], "tags"=>["selenium", "enhances", "levels", "mitochondrial", "biogenesis"], "article_id"=>225873, "categories"=>["Biochemistry", "Neuroscience", "Cell Biology"], "users"=>["Natalia Mendelev", "Suresh L. Mehta", "Haza Idris", "Santosh Kumari", "P. Andy Li"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0047910.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Supplementation_of_selenium_enhances_protein_levels_of_mitochondrial_biogenesis_markers_PGC_1_945_and_NRF1_in_the_nuclear_fractions_/225873", "title"=>"Supplementation of selenium enhances protein levels of mitochondrial biogenesis markers, PGC-1α and NRF1, in the nuclear fractions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:25:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/555448"], "description"=>"<p><b>A</b>, Western blotting bands of Cytochrome <i>c</i> and COX IV in the mitochondrial fractions. <b>B</b>, Summarized bar graphs shows band intensity presented as ratio of targeting protein over actin. Values are means±s.d. * p<0.05 and **p<0.01 by <i>t</i>-test.</p>", "links"=>[], "tags"=>["increases", "mitochondrial"], "article_id"=>225944, "categories"=>["Biochemistry", "Neuroscience", "Cell Biology"], "users"=>["Natalia Mendelev", "Suresh L. Mehta", "Haza Idris", "Santosh Kumari", "P. Andy Li"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0047910.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Selenite_increases_mitochondrial_proteins_/225944", "title"=>"Selenite increases mitochondrial proteins.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:26:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/555511"], "description"=>"<p><i>Upper panel</i>, representative Western blots for phospho-Akt (pAKT), total Akt, phospho-CREB (pCREB) and total CREB. <i>Lower panel</i>, summarized bar graphs presented as ratio of targeting protein over actin. Values are means±s.d. * p<0.05 and **p<0.01 by <i>t</i>-test.</p>", "links"=>[], "tags"=>["increases", "phospho-akt", "cytosolic", "fractions", "phospho-creb"], "article_id"=>225998, "categories"=>["Biochemistry", "Neuroscience", "Cell Biology"], "users"=>["Natalia Mendelev", "Suresh L. Mehta", "Haza Idris", "Santosh Kumari", "P. Andy Li"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0047910.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Selenite_increases_phospho_Akt_in_both_the_cytosolic_and_nuclear_fractions_and_phospho_CREB_in_the_nuclear_fraction_/225998", "title"=>"Selenite increases phospho-Akt in both the cytosolic and nuclear fractions and phospho-CREB in the nuclear fraction.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:26:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/555597"], "description"=>"<p>Cells were treated with 100 nM Se. PKA inhibitor 14–22 amide or AKT inhibitor X (AKTX, 5 µM) were added to medium in the presence of Se. Western blotting was performed after 5 h of incubation. <i>Upper panel</i>, representative Western blot bands. <i>Lower panel</i>, summarized bar graphs show band intensity presented as ratio of targeting protein over Histone H3. Values are means±s.d. * p<0.05 and **p<0.01 by ANOVA followed by Tukey's test.</p>", "links"=>[], "tags"=>["pki", "aktx", "se-induced", "phospho-creb"], "article_id"=>226088, "categories"=>["Biochemistry", "Neuroscience", "Cell Biology"], "users"=>["Natalia Mendelev", "Suresh L. Mehta", "Haza Idris", "Santosh Kumari", "P. Andy Li"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0047910.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_PKI_and_AKTX_on_Se_induced_phospho_CREB_and_PGC_1_945_/226088", "title"=>"Effects of PKI and AKTX on Se-induced phospho-CREB and PGC-1α.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:26:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/555707"], "description"=>"<p><b>A</b>, a typical recording of oxygen content reduction in non-selenium- (red curve) and selenium-treated (green curve) cells ; <b>B</b>, a respiration rate in non-treated (red) and selenium-treated (green) HT22 cells; <b><i>C</i></b>, summarized mitochondrial respiratory rate obtained from 3 independent experiments in non-selenium treated (Se<sup>−ve</sup>) and selenium treated (Se<sup>+ve</sup>) cells. Values are means±s.d. *** p<0.001 by <i>t</i>-test.</p>", "links"=>[], "tags"=>["enhances", "mitochondrial", "respiration", "ht22"], "article_id"=>226197, "categories"=>["Biochemistry", "Neuroscience", "Cell Biology"], "users"=>["Natalia Mendelev", "Suresh L. Mehta", "Haza Idris", "Santosh Kumari", "P. Andy Li"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0047910.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Selenite_enhances_mitochondrial_respiration_in_HT22_cells_/226197", "title"=>"Selenite enhances mitochondrial respiration in HT22 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:27:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/555779"], "description"=>"<p>Oxygen consumption in digitonin permeabilized cells was measured using O2K oxygraph with addition of multiple substrates and inhibitors. The activities of each complex were calculated from the difference in reduction in oxygen content in the presence of specific substrates and inhibitors. Top panel is a polarograph recording showing mitochondrial respiratory activities of complex I, II+III and IV in control (red curve) and Se-treated (green curve) neurons. The mitochondrial enzyme activities were increased by selenite when counted both as oxygen flow rate per million cells (bar graph on left) and per milligram protein (bar graph on right). Values are means±s.d. **<i>P</i><0.01, ***<i>P</i><0.001 vs. non-se controls. AA, antimycin A; As, ascorbate; G+M, glutamate and malate; KCN, potassium cyanide; Rot, rotenone; Sc, succinate; TMPD, N,N,N',N'-tetramethyl-p-phenylenediamine dihydrochloride.</p>", "links"=>[], "tags"=>["increases", "activities", "mitochondrial", "respiratory", "complexes"], "article_id"=>226268, "categories"=>["Biochemistry", "Neuroscience", "Cell Biology"], "users"=>["Natalia Mendelev", "Suresh L. Mehta", "Haza Idris", "Santosh Kumari", "P. Andy Li"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0047910.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Selenite_increases_the_activities_of_mitochondrial_respiratory_complexes_I_II_III_and_IV_/226268", "title"=>"Selenite increases the activities of mitochondrial respiratory complexes I, II+III and IV.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:27:59"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[322, 550, 671, 773, 864, 955, 1048, 1135, 1223, 1308, 1387, 1465, 1534, 1602, 1673, 1744, 1813, 1885, 1955, 2026, 2093, 2160, 2228, 2290, 2349]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[316, 541, 663, 766, 856, 950, 1041, 1128, 1218, 1302, 1382, 1456, 1526, 1593, 1657, 1729, 1796, 1862, 1930, 1999, 2065, 2132, 2202, 2261, 2319]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[304, 506, 616, 712, 799, 879, 968, 1052, 1134, 1212, 1284, 1357, 1427, 1494, 1557, 1621, 1689, 1756, 1823, 1883, 1944, 1997, 2056, 2118, 2171]}, {"subject_area"=>"/Physical sciences/Chemistry", "average_usage"=>[302, 508, 622, 720, 804, 888, 973, 1054, 1141, 1219, 1299, 1370, 1442, 1511, 1574, 1644, 1711, 1782, 1846, 1911, 1971, 2030, 2097, 2155, 2217]}]}
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