Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome
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{"title"=>"Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome", "type"=>"journal", "authors"=>[{"first_name"=>"Kathryn T.", "last_name"=>"Hall", "scopus_author_id"=>"55430243000"}, {"first_name"=>"Anthony J.", "last_name"=>"Lembo", "scopus_author_id"=>"26426421700"}, {"first_name"=>"Irving", "last_name"=>"Kirsch", "scopus_author_id"=>"7102863523"}, {"first_name"=>"Dimitrios C.", "last_name"=>"Ziogas", "scopus_author_id"=>"34972465100"}, {"first_name"=>"Jeffrey", "last_name"=>"Douaiher", "scopus_author_id"=>"55430434600"}, {"first_name"=>"Karin B.", "last_name"=>"Jensen", "scopus_author_id"=>"26537528100"}, {"first_name"=>"Lisa A.", "last_name"=>"Conboy", "scopus_author_id"=>"11840475200"}, {"first_name"=>"John M.", "last_name"=>"Kelley", "scopus_author_id"=>"26642973000"}, {"first_name"=>"Efi", "last_name"=>"Kokkotou", "scopus_author_id"=>"6603579594"}, {"first_name"=>"Ted J.", "last_name"=>"Kaptchuk", "scopus_author_id"=>"26643513100"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84867862609", "sgr"=>"84867862609", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0048135", "pmid"=>"23110189", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "pui"=>"365919090"}, "id"=>"055b7676-9cb2-3629-b4c7-a8bf93a3ddba", "abstract"=>"Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in processes associated with the placebo effect such as reward, pain, memory and learning. We hypothesized that the COMT functional val158met polymorphism, was a predictor of placebo effects and tested our hypothesis in a subset of 104 patients from a previously reported randomized controlled trial in irritable bowel syndrome (IBS). The three treatment arms from this study were: no-treatment (\"waitlist\"), placebo treatment alone (\"limited\") and, placebo treatment \"augmented\" with a supportive patient-health care provider interaction. The primary outcome measure was change from baseline in IBS-Symptom Severity Scale (IBS-SSS) after three weeks of treatment. In a regression model, the number of methionine alleles in COMT val158met was linearly related to placebo response as measured by changes in IBS-SSS (p = .035). The strongest placebo response occurred in met/met homozygotes treated in the augmented placebo arm. A smaller met/met associated effect was observed with limited placebo treatment and there was no effect in the waitlist control. These data support our hypothesis that the COMT val158met polymorphism is a potential biomarker of placebo response.", "link"=>"http://www.mendeley.com/research/catecholomethyltransferase-val158met-polymorphism-predicts-placebo-effect-irritable-bowel-syndrome", "reader_count"=>120, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>10, "Librarian"=>1, "Researcher"=>25, "Student > Doctoral Student"=>9, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>5, "Other"=>14, "Student > Master"=>13, "Student > Bachelor"=>10, "Lecturer"=>1, "Professor"=>6}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>10, "Librarian"=>1, "Researcher"=>25, "Student > Doctoral Student"=>9, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>5, "Other"=>14, "Student > Master"=>13, "Student > Bachelor"=>10, "Lecturer"=>1, "Professor"=>6}, "reader_count_by_subject_area"=>{"Unspecified"=>11, "Agricultural and Biological Sciences"=>25, "Philosophy"=>3, "Arts and Humanities"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Chemistry"=>1, "Computer Science"=>1, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>35, "Neuroscience"=>4, "Sports and Recreations"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>5, "Psychology"=>24, "Social Sciences"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>35}, "Social Sciences"=>{"Social Sciences"=>3}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Psychology"=>{"Psychology"=>24}, "Unspecified"=>{"Unspecified"=>11}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>5}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Neuroscience"=>{"Neuroscience"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>25}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Philosophy"=>{"Philosophy"=>3}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Sweden"=>1, "United States"=>7, "Brazil"=>1, "United Kingdom"=>1, "Italy"=>1, "Australia"=>2, "Germany"=>3, "Russia"=>1}, "group_count"=>8}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/554794"], "description"=>"<p>The interaction (COMT genotype x treatment arm) was statistically significant (beta = 0.25; p = .009), but not COMT genotype (beta = 0.01; p = .954). Adequate Relief was assessed by a single dichotomous categorization at three weeks, which asked patients: “Over the past week have you had adequate relief of your IBS symptoms?” Regression model parameters included: COMT genotype (number of met alleles), treatment arm and their interaction (COMT genotype x treatment arm). Error bars are standard error of the mean. N = 102.</p>", "links"=>[], "tags"=>["comt", "genotype"], "article_id"=>225285, "categories"=>["Cell Biology", "Chemistry", "Genetics"], "users"=>["Kathryn T. Hall", "Anthony J. Lembo", "Irving Kirsch", "Dimitrios C. Ziogas", "Jeffrey Douaiher", "Karin B. Jensen", "Lisa A. Conboy", "John M. Kelley", "Efi Kokkotou", "Ted J. Kaptchuk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048135.g003", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Interaction_effect_of_COMT_genotype_and_treatment_arm_on_Adequate_Relief_/225285", "title"=>"Interaction effect of COMT genotype and treatment arm on Adequate Relief.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:22:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/554689"], "description"=>"<p>Number of val158met met alleles showed a significant linear effect on IBS-SSS (beta = 0.17; p = .032). IBS-SSS includes abdominal pain severity, abdominal pain frequency, abdominal distention severity, dissatisfaction with bowel habits, and disruption of quality of life. Change in IBS-SSS  =  (IBS-SSS at baseline – IBS-SSS at 3-weeks). Regression model included COMT genotype (number of met alleles) and baseline IBS-SSS. Error bars indicate the standard error of the mean. N = 104.</p>", "links"=>[], "tags"=>["comt", "genotype"], "article_id"=>225171, "categories"=>["Cell Biology", "Chemistry", "Genetics"], "users"=>["Kathryn T. Hall", "Anthony J. Lembo", "Irving Kirsch", "Dimitrios C. Ziogas", "Jeffrey Douaiher", "Karin B. Jensen", "Lisa A. Conboy", "John M. Kelley", "Efi Kokkotou", "Ted J. Kaptchuk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048135.g001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_COMT_genotype_on_change_in_IBS_SSS_/225171", "title"=>"Effect of COMT genotype on change in IBS-SSS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:21:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/554848"], "description"=>"*<p>Participants in parent clinical trial previously reported <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048135#pone.0048135-Kaptchuk1\" target=\"_blank\">[30]</a>.</p>", "links"=>[], "tags"=>["characteristics", "genotyped", "ibs", "patients", "compared", "randomized"], "article_id"=>225332, "categories"=>["Cell Biology", "Chemistry", "Genetics"], "users"=>["Kathryn T. Hall", "Anthony J. Lembo", "Irving Kirsch", "Dimitrios C. Ziogas", "Jeffrey Douaiher", "Karin B. Jensen", "Lisa A. Conboy", "John M. Kelley", "Efi Kokkotou", "Ted J. Kaptchuk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048135.t001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_of_genotyped_IBS_patients_compared_to_participants_in_the_parent_randomized_clinical_trial_/225332", "title"=>"Baseline characteristics of genotyped IBS patients compared to participants in the parent randomized clinical trial.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 21:22:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/554756"], "description"=>"<p>The interaction between COMT genotype (number of met alleles) and treatment arm was statistically significant (beta = 0.17; p = .035). Regression model included the following parameters: COMT genotype (number of met alleles), treatment arm, baseline IBS-SSS and their interaction (COMT genotype x treatment arm). Error bars indicate the standard error of the mean. N = 104.</p>", "links"=>[], "tags"=>["comt", "genotype"], "article_id"=>225242, "categories"=>["Cell Biology", "Chemistry", "Genetics"], "users"=>["Kathryn T. Hall", "Anthony J. Lembo", "Irving Kirsch", "Dimitrios C. Ziogas", "Jeffrey Douaiher", "Karin B. Jensen", "Lisa A. Conboy", "John M. Kelley", "Efi Kokkotou", "Ted J. Kaptchuk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048135.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Interaction_effect_of_COMT_genotype_and_treatment_arm_on_change_in_IBS_SSS_/225242", "title"=>"Interaction effect of COMT genotype and treatment arm on change in IBS-SSS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:21:58"}

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  • {"unique-ip"=>"37", "full-text"=>"43", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
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  • {"unique-ip"=>"20", "full-text"=>"32", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
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  • {"unique-ip"=>"24", "full-text"=>"26", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

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