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{"title"=>"Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome", "type"=>"journal", "authors"=>[{"first_name"=>"Kathryn T.", "last_name"=>"Hall", "scopus_author_id"=>"55430243000"}, {"first_name"=>"Anthony J.", "last_name"=>"Lembo", "scopus_author_id"=>"26426421700"}, {"first_name"=>"Irving", "last_name"=>"Kirsch", "scopus_author_id"=>"7102863523"}, {"first_name"=>"Dimitrios C.", "last_name"=>"Ziogas", "scopus_author_id"=>"34972465100"}, {"first_name"=>"Jeffrey", "last_name"=>"Douaiher", "scopus_author_id"=>"55430434600"}, {"first_name"=>"Karin B.", "last_name"=>"Jensen", "scopus_author_id"=>"26537528100"}, {"first_name"=>"Lisa A.", "last_name"=>"Conboy", "scopus_author_id"=>"11840475200"}, {"first_name"=>"John M.", "last_name"=>"Kelley", "scopus_author_id"=>"26642973000"}, {"first_name"=>"Efi", "last_name"=>"Kokkotou", "scopus_author_id"=>"6603579594"}, {"first_name"=>"Ted J.", "last_name"=>"Kaptchuk", "scopus_author_id"=>"26643513100"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84867862609", "sgr"=>"84867862609", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0048135", "pmid"=>"23110189", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "pui"=>"365919090"}, "id"=>"055b7676-9cb2-3629-b4c7-a8bf93a3ddba", "abstract"=>"Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in processes associated with the placebo effect such as reward, pain, memory and learning. We hypothesized that the COMT functional val158met polymorphism, was a predictor of placebo effects and tested our hypothesis in a subset of 104 patients from a previously reported randomized controlled trial in irritable bowel syndrome (IBS). The three treatment arms from this study were: no-treatment (\"waitlist\"), placebo treatment alone (\"limited\") and, placebo treatment \"augmented\" with a supportive patient-health care provider interaction. The primary outcome measure was change from baseline in IBS-Symptom Severity Scale (IBS-SSS) after three weeks of treatment. In a regression model, the number of methionine alleles in COMT val158met was linearly related to placebo response as measured by changes in IBS-SSS (p = .035). The strongest placebo response occurred in met/met homozygotes treated in the augmented placebo arm. A smaller met/met associated effect was observed with limited placebo treatment and there was no effect in the waitlist control. These data support our hypothesis that the COMT val158met polymorphism is a potential biomarker of placebo response.", "link"=>"http://www.mendeley.com/research/catecholomethyltransferase-val158met-polymorphism-predicts-placebo-effect-irritable-bowel-syndrome", "reader_count"=>120, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>10, "Librarian"=>1, "Researcher"=>25, "Student > Doctoral Student"=>9, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>5, "Other"=>14, "Student > Master"=>13, "Student > Bachelor"=>10, "Lecturer"=>1, "Professor"=>6}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>10, "Librarian"=>1, "Researcher"=>25, "Student > Doctoral Student"=>9, "Student > Ph. 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• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/cdb5a36b-1c5c-44c9-af1a-b535009c546a", "title"=>"Media Coverage of this Article", "body"=>"The following article represents some of the media coverage that has occurred for this paper:\n\nPublication: BBC News \nTitle: “BBC News - Placebo effect may be 'down to genes'”\nhttp://www.bbc.co.uk/news/health-20042128\n\nPublication: Bloomberg Business Week \nTitle: “Genetics May Help Explain Placebo Effect, Researchers Say - Businessweek”\nhttp://www.businessweek.com/news/2012-10-23/genetics-may-help-explain-placebo-effect-researchers-say\n\nPublication: Europapress.es \nTitle: “Más cerca de conocer el porqué del 'efecto placebo'”\nhttp://www.europapress.es/salud/noticia-efecto-placebo-depende-factores-geneticos-20121024112635.html\n\nPublication: GEN Genetic Engineering and Biotechnology News \nTitle: “GEN | News Highlights:Placebo Effect Linked to Dopamine-Clearing Enzyme”\nhttp://www.genengnews.com/gen-news-highlights/placebo-effect-linked-to-dopamine-clearing-enzyme/81247530/\n\nPublication: Genome Web \nTitle: “Study Finds Dopamine Gene Variant Predictive of Placebo Response in IBS Patients | Pharmacogenomics Reporter | Clinical Genomics | GenomeWeb”\nhttp://www.genomeweb.com/clinical-genomics/study-finds-dopamine-gene-variant-predictive-placebo-response-ibs-patients\n\nPublication: Gizmodo \nTitle: “The Placebo Effect May Be Genetic”\nhttp://gizmodo.com/5954430/the-placebo-effect-may-be-genetic?utm_medium=twitter&utm_source=twitterfeed\n\nPublication: Health Canal \nTitle: “Researchers Identify Genetic Marker for Placebo Response in IBS Patients”\nhttp://www.healthcanal.com/genetics-birth-defects/33329-Researchers-Identify-Genetic-Marker-for-Placebo-Response-IBS-Patients.html\n\nPublication: Mail Online \nTitle: “The placebo effect may be down to genes | Mail Online”\nhttp://www.dailymail.co.uk/health/article-2222349/The-placebo-effect-genes.html\n\nPublication: Medical Daily \nTitle: “Placebo Effect's Roots May Lie in Genes : Science/Tech : Medical Daily”\nhttp://www.medicaldaily.com/articles/12862/20121024/placebo-effects-roots-lie.htm\n\nPublication: Medical News Today \nTitle: “Placebo Effect Could Be Genetic”\nhttp://www.medicalnewstoday.com/articles/251955.php\n\nPublication: Outsourcing Pharma \nTitle: “Team discovers genetic basis for placebo response”\nhttp://www.outsourcing-pharma.com/Clinical-Development/Genetic-placebo-response-marker-has-trial-design-implications-say-researchers\n\nPublication: Science Based Medicine \nTitle: “The Placebo Gene?”\nhttp://www.sciencebasedmedicine.org/index.php/the-placebo-gene/\n\nPublication: Tiempoenlinea.com.mx \nTitle: “Efecto placebo, producto de genes”\nhttp://www.tiempoenlinea.com.mx/index.php?option=com_content&view=article&id=12767:efecto-placebo-producto-de-genes&catid=94:ciencia-a-tecnologia\n\nPublication: Top News New Zealand \nTitle: “Researchers Find Secret to Placebo Effect in Some Only | TopNews New Zealand”\nhttp://topnews.net.nz/content/224829-researchers-find-secret-placebo-effect-some-only\n\nIf you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article. \n", "isRemoved"=>false, "created"=>"2012-10-26T22:54:21Z", "lastModified"=>"2012-10-26T22:54:21Z", "creator"=>{"userId"=>"80539"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"PLOS ONE STAFF"}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0048135", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>2, "mostRecentActivity"=>"2013-10-29T19:39:14Z", "replies"=>[{"type"=>"REPLY", "parentID"=>56407, "annotationUri"=>"info:doi/10.1371/reply/3a7ba84e-0796-42b9-b466-40506802e4b6", "title"=>"RE: Media Coverage of this Article", "body"=>"The following article represents some of the media coverage that has occurred for this paper:\n\nPublication: NHS Choices \nTitle: “Gene link to placebo effect - Health News - NHS Choices”\nhttp://www.nhs.uk/news/2012/10October/Pages/Gene-link-to-placebo-effect.aspx\n\nIf you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article. \n", "isRemoved"=>false, "created"=>"2012-11-02T18:56:11Z", "lastModified"=>"2012-11-02T18:56:11Z", "creator"=>{"userId"=>"80539"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"PLOS ONE Staff"}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0048135", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>1, "mostRecentActivity"=>"2013-10-29T19:39:14Z", "replies"=>[{"type"=>"REPLY", "parentID"=>57519, "annotationUri"=>"info:doi/10.1371/reply/8c79243a-cbe6-476c-807c-ead5534fa324", "title"=>"RE: RE: Media Coverage of this Article", "body"=>"Publication: Quiris Healthcare Germany\n\"develops and markets innovative ... premium products from natural sources ... offered exclusively in pharmacies.\"\nTitle: “Ursache für Placebo-Effekt entdeckt”\nhttp://www.quiris.de/newsletter/Placebo-Effekt", "isRemoved"=>false, "created"=>"2013-10-29T19:39:14Z", "lastModified"=>"2013-10-29T19:39:14Z", "creator"=>{"userId"=>"379439"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0048135", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2013-10-29T19:39:14Z", "replies"=>[]}]}]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/411be557-965c-4e39-9b2c-4d1bf584eee9", "title"=>"A change in the disease process or a change in questionnaire answering behaviour?", "body"=>"The results of studies like this one may be confounded due to the fact that self-report questionnaires are used in the place of objective measures of the disease process.\n\nThus, the measured effects of the treatment may simply be due to short term changes in questionnaire answering behaviour. Based on a number of biases, including simple human optimism. \n\nThe genetic marker observed in this study may simply be associated with such change in behaviour, rather than an underlying change in the disease process.\n\nI strongly that a long term trial (years) of such placebo treatments would see the treatment effect size reverting towards the mean, as the behavioural biases on symptom reporting diminish.", "isRemoved"=>false, "created"=>"2012-11-08T14:27:15Z", "lastModified"=>"2012-11-08T14:27:15Z", "creator"=>{"userId"=>"276321"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0048135", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2012-11-08T14:27:15Z", "replies"=>[]}

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• {"id"=>"1006812536182837248", "text"=>"RT @Awesomics: COMT gene variant predicts placebo effect in IBS (@PLOSONE) http://t.co/wJM5JsL8 - (BBC) http://t.co/9yPr62Yu", "created_at"=>"2018-06-13T08:16:28Z", "user"=>"PhotoLawn", "user_name"=>"??EU keeps us safe & rich ??", "user_profile_image"=>"http://pbs.twimg.com/profile_images/938864941150466049/4Rl0G-Cq_normal.jpg"}
• {"id"=>"260858329474166784", "text"=>"Placebo's effect may depend on your genes http://t.co/0qJKPzil re: http://t.co/BoDdoaSf", "created_at"=>"2012-10-23T21:40:46Z", "user"=>"PLOSONE", "user_name"=>"PLOS ONE", "user_profile_image"=>"http://a0.twimg.com/profile_images/2429958559/mzjl6as5u2m09r2erof6_normal.jpeg"}
• {"id"=>"260861906833776640", "text"=>"RT @PLOSONE: Placebo's effect may depend on your genes http://t.co/0qJKPzil re: http://t.co/BoDdoaSf", "created_at"=>"2012-10-23T21:54:59Z", "user"=>"zarinahagnew", "user_name"=>"Zarinah Agnew", "user_profile_image"=>"http://a0.twimg.com/profile_images/1208428103/154117_10150307132540261_784370260_15789311_5469198_n_normal.jpg"}
• {"id"=>"260868280519122944", "text"=>"I'm glad they haven't called it placebogenomics or placebomics :\nhttp://t.co/OYAzBSsM\nI hope I'm not giving anybody ideas!\ncc:@phylogenomics", "created_at"=>"2012-10-23T22:20:19Z", "user"=>"azizrk", "user_name"=>"Ramy Karam Aziz", "user_profile_image"=>"http://a0.twimg.com/profile_images/640127985/Ramy_Bioquest_normal.jpg"}
• {"id"=>"260872870664740864", "text"=>"RT @PLOSONE: Placebo's effect may depend on your genes http://t.co/0qJKPzil re: http://t.co/BoDdoaSf", "created_at"=>"2012-10-23T22:38:33Z", "user"=>"keepstherainoff", "user_name"=>"Craig B", "user_profile_image"=>"http://a0.twimg.com/profile_images/1636910667/mariaharmonica_normal.jpg"}
• {"id"=>"260873731222671360", "text"=>"RT @PLOSONE Placebo's effect may depend on your genes http://t.co/ZpsnItRM re: http://t.co/ne08R5Lm", "created_at"=>"2012-10-23T22:41:58Z", "user"=>"BeckiePort", "user_name"=>"Beckie Port", "user_profile_image"=>"http://a0.twimg.com/profile_images/2709889104/54de419d0af6bfa52798c3a337bb785e_normal.jpeg"}
• {"id"=>"260883622800801792", "text"=>"RT @PLOSONE: Placebo's effect may depend on your genes http://t.co/0qJKPzil re: http://t.co/BoDdoaSf", "created_at"=>"2012-10-23T23:21:17Z", "user"=>"ialuddington", "user_name"=>"Ian Luddington", "user_profile_image"=>"http://a0.twimg.com/profile_images/1626466771/fgfgfgf_normal.jpg"}
• {"id"=>"260904001770500096", "text"=>"RT @BeckiePort: RT @PLOSONE Placebo's effect may depend on your genes http://t.co/ZpsnItRM re: http://t.co/ne08R5Lm", "created_at"=>"2012-10-24T00:42:16Z", "user"=>"chrisberdik", "user_name"=>"Chris Berdik", "user_profile_image"=>"http://a0.twimg.com/profile_images/872909191/Ecu5_normal.jpg"}
• {"id"=>"260920583548702721", "text"=>"RT @PLOSONE: Placebo's effect may depend on your genes http://t.co/0qJKPzil re: http://t.co/BoDdoaSf", "created_at"=>"2012-10-24T01:48:09Z", "user"=>"3_adriap", "user_name"=>"Adriana Pliego ", "user_profile_image"=>"http://a0.twimg.com/profile_images/2103655236/huevorosa_normal.png"}
• {"id"=>"260985577485262848", "text"=>"COMT gene variant predicts placebo effect in IBS (@PLOSONE) http://t.co/wJM5JsL8 - (BBC) http://t.co/9yPr62Yu", "created_at"=>"2012-10-24T06:06:25Z", "user"=>"Awesomics", "user_name"=>"Awesomics", "user_profile_image"=>"http://a0.twimg.com/profile_images/1106335072/dna_helix_horizontal_square_inv_normal.png"}
• {"id"=>"261018903801651200", "text"=>"RT @PLOSONE: Placebo's effect may depend on your genes http://t.co/0qJKPzil re: http://t.co/BoDdoaSf", "created_at"=>"2012-10-24T08:18:50Z", "user"=>"Mirjam_vZuiden", "user_name"=>"Mirjam van Zuiden", "user_profile_image"=>"http://a0.twimg.com/profile_images/2366774965/xnx3d8h07veszwq6zl77_normal.jpeg"}
• {"id"=>"261019272329957376", "text"=>"過敏性腸症候群におけるプラセボ効果はCOMT遺伝子多型で予測可能。 Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in... http://t.co/36rdIsHe", "created_at"=>"2012-10-24T08:20:18Z", "user"=>"uranus_2", "user_name"=>"マーキュリー２世", "user_profile_image"=>"http://a0.twimg.com/sticky/default_profile_images/default_profile_5_normal.png"}
• {"id"=>"261020947086180352", "text"=>"Here is the placebo-COMT variant paper http://t.co/DZbWuYCP Free from the kind PlosOne people", "created_at"=>"2012-10-24T08:26:57Z", "user"=>"Keith_Laws", "user_name"=>"Keith R Laws", "user_profile_image"=>"http://a0.twimg.com/profile_images/2754241250/f2e968d3499315b19fa534bde722c5a6_normal.jpeg"}
• {"id"=>"261021327941586944", "text"=>"Oh good grief. More likely false positive candidate gene stuff: http://t.co/la5GSTSn HT @Keith_Laws", "created_at"=>"2012-10-24T08:28:28Z", "user"=>"MarcusMunafo", "user_name"=>"Marcus Munafo", "user_profile_image"=>"http://a0.twimg.com/profile_images/2698615277/08f5f3cbeb1aea37b0b8950a4c54bd8a_normal.jpeg"}
• {"id"=>"261021541121282048", "text"=>"RT @MarcusMunafo: Oh good grief. More likely false positive candidate gene stuff: http://t.co/la5GSTSn HT @Keith_Laws", "created_at"=>"2012-10-24T08:29:19Z", "user"=>"Keith_Laws", "user_name"=>"Keith R Laws", "user_profile_image"=>"http://a0.twimg.com/profile_images/2754241250/f2e968d3499315b19fa534bde722c5a6_normal.jpeg"}
• {"id"=>"261024869993545729", "text"=>"RT @Keith_Laws: Here is the placebo-COMT variant paper http://t.co/DZbWuYCP Free from the kind PlosOne people", "created_at"=>"2012-10-24T08:42:33Z", "user"=>"CBM_UCLSoP", "user_name"=>"CBM", "user_profile_image"=>"http://a0.twimg.com/profile_images/1993212588/twitter_logo_normal.JPG"}
• {"id"=>"261029336243650561", "text"=>"Fascinating: is the placebo response genetically determined? http://t.co/FMfdgC5g Small study, preliminary results, but thought-provoking", "created_at"=>"2012-10-24T09:00:18Z", "user"=>"dianthusmed", "user_name"=>"Dianthus Medical", "user_profile_image"=>"http://a0.twimg.com/profile_images/1197140974/Square_Green_carnation_normal.jpg"}
• {"id"=>"261029346817499136", "text"=>"Headline gist: ‘Placebo effect may be down to genetics’\nExample news report: http://t.co/8rttl68b\nResearch: http://t.co/P5ru6pBI", "created_at"=>"2012-10-24T09:00:20Z", "user"=>"ThePapersBehind", "user_name"=>"The Papers Behind…", "user_profile_image"=>"http://a0.twimg.com/profile_images/2585898049/image_normal.jpg"}
• {"id"=>"261029893448540160", "text"=>"Genes predict placebo effect in IBS? @bengoldacre http://t.co/79UfsrjH", "created_at"=>"2012-10-24T09:02:30Z", "user"=>"BenjaminCBrown", "user_name"=>"Ben Brown", "user_profile_image"=>"http://a0.twimg.com/profile_images/2370492397/eiihz2yoz3g67zlrv3zc_normal.jpeg"}
• {"id"=>"261050106453819392", "text"=>"Potentially interesting insight into genetic basis for placebo effect. http://t.co/w2wKXDyl", "created_at"=>"2012-10-24T10:22:50Z", "user"=>"jflier", "user_name"=>"Jeffrey Flier", "user_profile_image"=>"http://a0.twimg.com/profile_images/2594512994/image_normal.jpg"}
• {"id"=>"261050398897471488", "text"=>"RT @dianthusmed: Fascinating: is the placebo response genetically determined? http://t.co/FMfdgC5g Small study, preliminary results, but thought-provoking", "created_at"=>"2012-10-24T10:23:59Z", "user"=>"Dr_Aust_PhD", "user_name"=>"Dr Aust", "user_profile_image"=>"http://a0.twimg.com/profile_images/1180017231/ca19ebe9-af7e-4177-a910-2746d92b2f16_normal.png"}
• {"id"=>"261058533880123392", "text"=>"@lecanardnoir I agree there. Paper's here: http://t.co/XnMgWY5C Looks like response to support is affected more.", "created_at"=>"2012-10-24T10:56:19Z", "user"=>"BobOHara", "user_name"=>"Bob O'Hara", "user_profile_image"=>"http://a0.twimg.com/profile_images/624292977/twitterProfilePhoto_normal.jpg"}
• {"id"=>"261070411188551680", "text"=>"RT @Awesomics: COMT gene variant predicts placebo effect in IBS (@PLOSONE) http://t.co/wJM5JsL8 - (BBC) http://t.co/9yPr62Yu", "created_at"=>"2012-10-24T11:43:31Z", "user"=>"cathy_kerr", "user_name"=>"Catherine Kerr", "user_profile_image"=>"http://a0.twimg.com/profile_images/366438041/IMG_0437_normal.JPG"}
• {"id"=>"261072531975458817", "text"=>"@cathy_kerr @dgmacarthur @pathogenomenick here is the link to the original paper: http://t.co/KE8b9CzM", "created_at"=>"2012-10-24T11:51:56Z", "user"=>"WvSchaik", "user_name"=>"WvSchaik", "user_profile_image"=>"http://a0.twimg.com/profile_images/1898324242/P1000411-2_normal.jpg"}
• {"id"=>"261077361628442625", "text"=>"Dopamine catabolism, reward etc:Catechol-O-methyltransferase polymorphism pred's placebo effect in irrit.bowel syndrome http://t.co/v3CjzxZj", "created_at"=>"2012-10-24T12:11:08Z", "user"=>"BiomedRevon", "user_name"=>"mvelst@gmail.com", "user_profile_image"=>"http://a0.twimg.com/profile_images/1518893315/Arcimboldo_Librarian_Stokholm_normal.jpg"}
• {"id"=>"261086039488200704", "text"=>"RT @Awesomics: COMT gene variant predicts placebo effect in IBS (@PLOSONE) http://t.co/wJM5JsL8 - (BBC) http://t.co/9yPr62Yu", "created_at"=>"2012-10-24T12:45:37Z", "user"=>"HALLinTheCity", "user_name"=>"dominiquetayo", "user_profile_image"=>"http://a0.twimg.com/profile_images/2443670208/ilaed8l9foqyzntatwdh_normal.jpeg"}
• {"id"=>"261090697128574977", "text"=>"RT @PLOSONE Placebo's effect may depend on your genes http://t.co/BT4eYISA re: http://t.co/bF4CuKgc", "created_at"=>"2012-10-24T13:04:07Z", "user"=>"mgto_org", "user_name"=>"Gilad Fili Feldman", "user_profile_image"=>"http://a0.twimg.com/profile_images/2642027598/eb7ce515cf20e26f3e23fa77884808a8_normal.jpeg"}
• {"id"=>"261096336651337729", "text"=>"#PLOSONE: Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in... http://t.co/IUl5kYJb", "created_at"=>"2012-10-24T13:26:32Z", "user"=>"RxJayOD", "user_name"=>"Jay O'Dwyer", "user_profile_image"=>"http://a0.twimg.com/sticky/default_profile_images/default_profile_0_normal.png"}
• {"id"=>"261107192931958785", "text"=>"A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T14:09:40Z", "user"=>"michaelfbarry", "user_name"=>"Mike Barry", "user_profile_image"=>"http://a0.twimg.com/profile_images/838462411/DSCF0017small_normal.jpg"}
• {"id"=>"261111973771612162", "text"=>"Can we harness *benefits* of the \"placebo effect\"? RT @PLOSONE: Placebo effect may depend on genes http://t.co/8HuWJgJ1 http://t.co/5LUfmtsj", "created_at"=>"2012-10-24T14:28:40Z", "user"=>"KaylanBaban", "user_name"=>"Kaylan Baban MD MPH", "user_profile_image"=>"http://a0.twimg.com/profile_images/1851311279/madmen_bobeyes_head_normal"}
• {"id"=>"261138944454975488", "text"=>"PLOS ONE: Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable B http://t.co/gyLGcYON", "created_at"=>"2012-10-24T16:15:50Z", "user"=>"michaelscally", "user_name"=>"Michael Scally", "user_profile_image"=>"http://a0.twimg.com/profile_images/1408389009/scally_image_normal.png"}
• {"id"=>"261153477139525632", "text"=>"Does the Placebo effect have a genetic component? Interesting small trial on IBS patients, see #PLOS http://t.co/r8ll6O6A", "created_at"=>"2012-10-24T17:13:35Z", "user"=>"zenchaos", "user_name"=>"Jerry", "user_profile_image"=>"http://a0.twimg.com/profile_images/1766630877/IMG_0207_normal.JPG"}
• {"id"=>"261195838414548992", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T20:01:55Z", "user"=>"PLOS", "user_name"=>"PLOS", "user_profile_image"=>"http://a0.twimg.com/profile_images/2424363764/2etoq0zjwxicokm1woge_normal.jpeg"}
• {"id"=>"261195935034511360", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T20:02:18Z", "user"=>"Greenrat", "user_name"=>"Victor Tatarskii", "user_profile_image"=>"http://a0.twimg.com/profile_images/295984818/_____normal.jpg"}
• {"id"=>"261196322886021120", "text"=>"RT @Awesomics: COMT gene variant predicts placebo effect in IBS (@PLOSONE) http://t.co/wJM5JsL8 - (BBC) http://t.co/9yPr62Yu", "created_at"=>"2012-10-24T20:03:50Z", "user"=>"PLOS", "user_name"=>"PLOS", "user_profile_image"=>"http://a0.twimg.com/profile_images/2424363764/2etoq0zjwxicokm1woge_normal.jpeg"}
• {"id"=>"261196325914279936", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T20:03:51Z", "user"=>"kmkubo", "user_name"=>"Ken Kubo", "user_profile_image"=>"http://a0.twimg.com/profile_images/2490300180/f1nx1pjt6cotng7encnj_normal.jpeg"}
• {"id"=>"261196635084824576", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T20:05:05Z", "user"=>"Clin_Trials", "user_name"=>"AppliedClinicalTrial", "user_profile_image"=>"http://a0.twimg.com/profile_images/2623543218/c10vc4a1w181u0qd1bx4_normal.png"}
• {"id"=>"261196905374167041", "text"=>"Please @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/yaglpeOx @PLOS", "created_at"=>"2012-10-24T20:06:09Z", "user"=>"MTomasson", "user_name"=>"Michael Tomasson", "user_profile_image"=>"http://a0.twimg.com/profile_images/1856696263/Erik_normal.jpg"}
• {"id"=>"261197390428643328", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T20:08:05Z", "user"=>"FabianSweeney", "user_name"=>"Fabian Sweeney", "user_profile_image"=>"http://a0.twimg.com/profile_images/2419491672/image_normal.jpg"}
• {"id"=>"261197605344772096", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T20:08:56Z", "user"=>"ferranbrianso", "user_name"=>"Ferran Briansó", "user_profile_image"=>"http://a0.twimg.com/profile_images/2735770716/01aaa513d20866ef255abcebf7a24a76_normal.jpeg"}
• {"id"=>"261197879794868224", "text"=>"Cool! A way to predict placebo responders in drug trials: \nhttp://t.co/E4Yh6aKN", "created_at"=>"2012-10-24T20:10:02Z", "user"=>"NickySlawny", "user_name"=>"Nicky Slawny", "user_profile_image"=>"http://a0.twimg.com/profile_images/2582474383/48g4e87rksdj84t71qa2_normal.jpeg"}
• {"id"=>"261199019366297600", "text"=>"#PLOS RT: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/3oC7Y2yP Nice @michaelfbarry", "created_at"=>"2012-10-24T20:14:33Z", "user"=>"jSimonfortin", "user_name"=>"Jean-Simon Fortin", "user_profile_image"=>"http://a0.twimg.com/profile_images/2734021513/f860a72d4df226bf13d15b83c6ac80bd_normal.png"}
• {"id"=>"261199261872570368", "text"=>"RT @Awesomics: COMT gene variant predicts placebo effect in IBS (@PLOSONE) http://t.co/wJM5JsL8 - (BBC) http://t.co/9yPr62Yu", "created_at"=>"2012-10-24T20:15:31Z", "user"=>"trishgreenhalgh", "user_name"=>"Trisha Greenhalgh", "user_profile_image"=>"http://a0.twimg.com/profile_images/1749978296/TRISH_2010_cropped_normal.jpg"}
• {"id"=>"261199290741956608", "text"=>"#PLOS RT: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/3oC7Y2yP Nice @michaelfbarry", "created_at"=>"2012-10-24T20:15:38Z", "user"=>"jSimonfortin", "user_name"=>"Jean-Simon Fortin", "user_profile_image"=>"http://a0.twimg.com/profile_images/2734021513/f860a72d4df226bf13d15b83c6ac80bd_normal.png"}
• {"id"=>"261199596984872961", "text"=>"RT @Awesomics: COMT gene variant predicts placebo effect in IBS (@PLOSONE) http://t.co/wJM5JsL8 - (BBC) http://t.co/9yPr62Yu", "created_at"=>"2012-10-24T20:16:51Z", "user"=>"legalaware", "user_name"=>"legal aware ", "user_profile_image"=>"http://a0.twimg.com/profile_images/2737639860/a303c8c886786339f510336b477cb47f_normal.jpeg"}
• {"id"=>"261201619109171200", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T20:24:53Z", "user"=>"Technixer", "user_name"=>"Technixer", "user_profile_image"=>"http://a0.twimg.com/profile_images/2674702458/b7a1a51427f0023e051329881bed2583_normal.jpeg"}
• {"id"=>"261202668423372800", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T20:29:03Z", "user"=>"belle_bluebird", "user_name"=>"Michelle Taylor", "user_profile_image"=>"http://a0.twimg.com/profile_images/2302841884/image_normal.jpg"}
• {"id"=>"261202805690347520", "text"=>"Oh wow, a molecular mechanism for the placebo effect? http://t.co/f1Dp0f4H", "created_at"=>"2012-10-24T20:29:36Z", "user"=>"popupcamptrout", "user_name"=>"sam mugford", "user_profile_image"=>"http://a0.twimg.com/profile_images/1249099307/profile_normal.jpg"}
• {"id"=>"261202832051564544", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T20:29:42Z", "user"=>"allitau", "user_name"=>"Allis Tauri", "user_profile_image"=>"http://a0.twimg.com/profile_images/836159402/x_7cfa7dd1_normal.jpg"}
• {"id"=>"261203763384180737", "text"=>"RT @Awesomics: COMT gene variant predicts placebo effect in IBS (@PLOSONE) http://t.co/wJM5JsL8 - (BBC) http://t.co/9yPr62Yu", "created_at"=>"2012-10-24T20:33:24Z", "user"=>"rubiopino", "user_name"=>"Angel", "user_profile_image"=>"http://a0.twimg.com/profile_images/2606828579/J9C986Sr_normal"}
• {"id"=>"261204737989439488", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T20:37:17Z", "user"=>"castarco", "user_name"=>"castarco", "user_profile_image"=>"http://a0.twimg.com/profile_images/1666288099/wc1_normal.png"}
• {"id"=>"261205980069654529", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T20:42:13Z", "user"=>"alexbioinfo", "user_name"=>"Alex Gómez Garrido", "user_profile_image"=>"http://a0.twimg.com/profile_images/1385804800/axAndSigma4_normal.png"}
• {"id"=>"261205986444992513", "text"=>".@Dr_Derek_Jones The original article uses the term 'predicts', which suggests (simple) causality. http://t.co/jTJ7igD1", "created_at"=>"2012-10-24T20:42:14Z", "user"=>"markhawker", "user_name"=>"Mark Hawker", "user_profile_image"=>"http://a0.twimg.com/profile_images/1213952698/markhawker_normal.jpg"}
• {"id"=>"261208695982153728", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T20:53:00Z", "user"=>"jvonneumann", "user_name"=>"jvonneumann", "user_profile_image"=>"http://a0.twimg.com/profile_images/1769482691/image1327098871_normal.png"}
• {"id"=>"261210228148826113", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T20:59:06Z", "user"=>"LillyLyle", "user_name"=>"Lilly Hunter", "user_profile_image"=>"http://a0.twimg.com/profile_images/2296223867/8v6r0z0fdlfh4xlvas81_normal.jpeg"}
• {"id"=>"261216687347617792", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T21:24:46Z", "user"=>"thechadologist", "user_name"=>"Tom Chad", "user_profile_image"=>"http://a0.twimg.com/profile_images/1691584862/image_normal.jpg"}
• {"id"=>"261220605532180481", "text"=>"very significant RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/HIdOX488", "created_at"=>"2012-10-24T21:40:20Z", "user"=>"philipcrobinson", "user_name"=>"Philip Robinson", "user_profile_image"=>"http://a0.twimg.com/profile_images/2693743246/cae87d7bbc6eeb0cde404cc68da5b3f0_normal.jpeg"}
• {"id"=>"261222650557390849", "text"=>"Interesting ... “@michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/PcBp3g7g”", "created_at"=>"2012-10-24T21:48:27Z", "user"=>"fellowsra", "user_name"=>"Richard Fellows", "user_profile_image"=>"http://a0.twimg.com/profile_images/2337271233/image_normal.jpg"}
• {"id"=>"261225702840492034", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T22:00:35Z", "user"=>"YmeBerg", "user_name"=>"Yme van den Berg", "user_profile_image"=>"http://a0.twimg.com/profile_images/1677877676/image_normal.jpg"}
• {"id"=>"261227901784039425", "text"=>"RT @Awesomics: COMT gene variant predicts placebo effect in IBS (@PLOSONE) http://t.co/wJM5JsL8 - (BBC) http://t.co/9yPr62Yu", "created_at"=>"2012-10-24T22:09:19Z", "user"=>"cd_burton", "user_name"=>"Chris Burton", "user_profile_image"=>"http://a0.twimg.com/profile_images/2142623844/CBurton.35x45_normal.jpg"}
• {"id"=>"261237913323462656", "text"=>"woah. DNA predicting placebo response. http://t.co/5CKdaCCk", "created_at"=>"2012-10-24T22:49:06Z", "user"=>"drmarkc7", "user_name"=>"mark", "user_profile_image"=>"http://a0.twimg.com/profile_images/2583028278/fL23Gxge_normal"}
• {"id"=>"261238304819773440", "text"=>"woah. DNA (genes relating to the dopaminergic system) predicts placebo response. http://t.co/fKjcCcaA", "created_at"=>"2012-10-24T22:50:40Z", "user"=>"ProfCoates", "user_name"=>"Mark Coates", "user_profile_image"=>"http://a0.twimg.com/profile_images/2175232722/2011-04-22-vivienne-mark-0315a_normal.jpg"}
• {"id"=>"261244146336010241", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-24T23:13:52Z", "user"=>"laxmivg", "user_name"=>"Laxmi Ghimire", "user_profile_image"=>"http://a0.twimg.com/profile_images/1657937103/Laxmi_normal.jpg"}
• {"id"=>"261249594183278592", "text"=>"Placebo effect \"down to genes\" http://t.co/Qkkse1ws > full paper http://t.co/v7HIPL2H @cebmblog @bengoldacre @ATurner0 Any thoughts?", "created_at"=>"2012-10-24T23:35:31Z", "user"=>"gregjirving", "user_name"=>"Greg Irving ", "user_profile_image"=>"http://a0.twimg.com/profile_images/1005640592/IMG_7108a_normal.jpg"}
• {"id"=>"261258048541163520", "text"=>"RT @gregjirving: Placebo effect \"down to genes\" http://t.co/Qkkse1ws > full paper http://t.co/v7HIPL2H @cebmblog @bengoldacre @ATurner0 Any thoughts?", "created_at"=>"2012-10-25T00:09:07Z", "user"=>"akashkarki", "user_name"=>"Akash Karki", "user_profile_image"=>"http://a0.twimg.com/profile_images/1318572909/40179_10150241095630151_741915150_14436012_1370741_n-1_normal.jpg"}
• {"id"=>"261331112637374464", "text"=>"RT @michaelfbarry: A genetic predictor for the placebo effect that could change clinical trial designs http://t.co/0YBJz94E", "created_at"=>"2012-10-25T04:59:27Z", "user"=>"TheGoldRoot", "user_name"=>"Renée A.D.", "user_profile_image"=>"http://a0.twimg.com/profile_images/2578398530/nzkfrbkmcx543szmpwyh_normal.jpeg"}
• {"id"=>"261346747585032192", "text"=>"Placebo response may be purely genetic? http://t.co/kMdQqWdJ", "created_at"=>"2012-10-25T06:01:34Z", "user"=>"drharishp", "user_name"=>"Dr Harish P", "user_profile_image"=>"http://a0.twimg.com/profile_images/2682836080/8074095fec9391829247bf2453837254_normal.jpeg"}
• {"id"=>"261347581152600064", "text"=>"RT @Awesomics: COMT gene variant predicts placebo effect in IBS (@PLOSONE) http://t.co/wJM5JsL8 - (BBC) http://t.co/9yPr62Yu", "created_at"=>"2012-10-25T06:04:53Z", "user"=>"p_ansell", "user_name"=>"Peter Ansell", "user_profile_image"=>"http://a0.twimg.com/sticky/default_profile_images/default_profile_0_normal.png"}
• {"id"=>"261365740509229056", "text"=>"PLACEBO: Le mystère de l’effet enfin élucidé?\nhttp://t.co/iHRISkHw", "created_at"=>"2012-10-25T07:17:03Z", "user"=>"ClRoOdAl", "user_name"=>"Muriel Gosnat", "user_profile_image"=>"http://a0.twimg.com/sticky/default_profile_images/default_profile_1_normal.png"}
• {"id"=>"261367142778294272", "text"=>"Et si l'effet placebo était, lui aussi, réservé à certains ? #PLOSONE: COMT Polymorphism Predicts Placebo Effect in... http://t.co/mg1dRfW7", "created_at"=>"2012-10-25T07:22:37Z", "user"=>"ThierryO57", "user_name"=>"Thierry Oster", "user_profile_image"=>"http://a0.twimg.com/profile_images/2128634571/h4y7ag82_normal.jpg"}
• {"id"=>"261420527825072128", "text"=>"RT @Awesomics: COMT gene variant predicts placebo effect in IBS (@PLOSONE) http://t.co/iPP8hf1K - (BBC) http://t.co/5fXEmwtK", "created_at"=>"2012-10-25T10:54:45Z", "user"=>"drricky", "user_name"=>"Doc Ricky", "user_profile_image"=>"http://a0.twimg.com/profile_images/1478944508/waffledtost_normal.jpg"}
• {"id"=>"261435422671003650", "text"=>"Strength of placebo response could be encoded in our genes, leading some to be more disposed to a placebo effect. http://t.co/qDNTqnLJ", "created_at"=>"2012-10-25T11:53:56Z", "user"=>"fanaticcook", "user_name"=>"Bix Weber", "user_profile_image"=>"http://a0.twimg.com/profile_images/639359970/BeansTwitterPic2_normal.jpg"}
• {"id"=>"261435976314925056", "text"=>"A stronger placebo response may be a result of slow clearing of dopamine from synapse (caused by gene variant). http://t.co/qDNTqnLJ", "created_at"=>"2012-10-25T11:56:08Z", "user"=>"fanaticcook", "user_name"=>"Bix Weber", "user_profile_image"=>"http://a0.twimg.com/profile_images/639359970/BeansTwitterPic2_normal.jpg"}
• {"id"=>"261456616019337216", "text"=>"Genes that predict your placebo response http://t.co/1jcuRdtx but here again it is the nice supportive doctor that réally does the trick.", "created_at"=>"2012-10-25T13:18:09Z", "user"=>"MaureenVoesterm", "user_name"=>"Maureen Voestermans", "user_profile_image"=>"http://a0.twimg.com/profile_images/2339798117/vzatpxdv8nzbym3yn4ur_normal.jpeg"}
• {"id"=>"261463223780376576", "text"=>"The placebo effect decoded... http://t.co/z40quhLU", "created_at"=>"2012-10-25T13:44:24Z", "user"=>"Tocris", "user_name"=>"Tocris Bioscience", "user_profile_image"=>"http://a0.twimg.com/profile_images/2222872005/tocrisO_normal.jpg"}
• {"id"=>"261471588384403456", "text"=>"Interesting new paper on one of the enzymes involved in #dopamine catabolism http://t.co/1AtAFp8p #pharmacology", "created_at"=>"2012-10-25T14:17:39Z", "user"=>"GuidetoPHARM", "user_name"=>"GuidetoPHARMACOLOGY", "user_profile_image"=>"http://a0.twimg.com/profile_images/2304500899/ztujxydb6viap6og048v_normal.png"}
• {"id"=>"261471589995003904", "text"=>"Interesting new paper on one of the enzymes involved in #dopamine catabolism http://t.co/t5dvMA9o #pharmacology", "created_at"=>"2012-10-25T14:17:39Z", "user"=>"IUPHARDB", "user_name"=>"IUPHAR Database", "user_profile_image"=>"http://a0.twimg.com/profile_images/2322130575/l2k49ct55skzpseyxnqt_normal.png"}
• {"id"=>"261479062827044864", "text"=>"RT @GuidetoPHARM: Interesting new paper on one of the enzymes involved in #dopamine catabolism http://t.co/1AtAFp8p #pharmacology", "created_at"=>"2012-10-25T14:47:21Z", "user"=>"PHCL3700", "user_name"=>"William Messer", "user_profile_image"=>"http://a0.twimg.com/profile_images/2524894359/lk1z9ngpu14546imwq1c_normal.jpeg"}
• {"id"=>"261531889653923840", "text"=>"Am I a believer? I don't know ... let me check my COMT genotype. http://t.co/HNZVs55M original paper http://t.co/lwxLB5Sb", "created_at"=>"2012-10-25T18:17:16Z", "user"=>"genes2brains2me", "user_name"=>"genes2brains2mind2me", "user_profile_image"=>"http://a0.twimg.com/profile_images/1503465862/Picture_1_normal.png"}
• {"id"=>"261570401333817345", "text"=>"No tots responem igual davant un placebo: http://t.co/F7XM4GD6", "created_at"=>"2012-10-25T20:50:18Z", "user"=>"albanutricio", "user_name"=>"ALBA PUIGPIQUE", "user_profile_image"=>"http://a0.twimg.com/profile_images/1346753226/Foto_Alba_normal.jpg"}
• {"id"=>"261874637636530176", "text"=>"\"Catechol-O-Methyltransferase val158met Polymorphism Predicts #Placebo Effect in Irritable Bowel Syndrome\" ( http://t.co/JsGITuIu )#medicine", "created_at"=>"2012-10-26T16:59:13Z", "user"=>"uhmammamia", "user_name"=>"il barone Arian®", "user_profile_image"=>"http://a0.twimg.com/profile_images/2284334781/tpl666jfx7xvhryp70sw_normal.jpeg"}
• {"id"=>"261948260787318785", "text"=>"#PLOSONE: Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in... http://t.co/VhEOvb5O", "created_at"=>"2012-10-26T21:51:46Z", "user"=>"Alhashem_yn", "user_name"=>"Y.Alhashem", "user_profile_image"=>"http://a0.twimg.com/profile_images/1690006228/tMl48cNL_normal"}
• {"id"=>"261976060734881794", "text"=>"From @PLOSONE: Catechol-O-Methyltransferase Polymorphism Predicts Placebo Effect in IBS http://t.co/HcIncNEx via Michael A. Thompson MD #dox", "created_at"=>"2012-10-26T23:42:14Z", "user"=>"CountryKidsDoc", "user_name"=>"Matt Weidman", "user_profile_image"=>"http://a0.twimg.com/profile_images/1817880860/MJW_2_normal.jpg"}
• {"id"=>"262336082358706177", "text"=>"#SNPs in COMT gene to be linked to differences in reward-seeking and pain perception. #PlaceboEffect #IBD #genetics http://t.co/i2KZgVB3", "created_at"=>"2012-10-27T23:32:50Z", "user"=>"Nod_of_Science", "user_name"=>"Fouad B.", "user_profile_image"=>"http://a0.twimg.com/profile_images/1968689136/me_in_Lanzarote_normal.jpg"}
• {"id"=>"262341387108892672", "text"=>"RT @Nod_of_Science: #SNPs in COMT gene to be linked to differences in reward-seeking and pain perception. #PlaceboEffect #IBD #genetics http://t.co/i2KZgVB3", "created_at"=>"2012-10-27T23:53:55Z", "user"=>"JChrisPires", "user_name"=>"J. Chris Pires", "user_profile_image"=>"http://a0.twimg.com/profile_images/1416048607/jcp_2011_normal.jpg"}
• {"id"=>"262347692167016448", "text"=>"RT @PLOSONE: Placebo's effect may depend on your genes http://t.co/0qJKPzil re: http://t.co/BoDdoaSf", "created_at"=>"2012-10-28T00:18:58Z", "user"=>"RKelwick", "user_name"=>"Richard Kelwick", "user_profile_image"=>"http://a0.twimg.com/profile_images/2745465593/7f300c2213b72688f489fee342981da8_normal.jpeg"}
• {"id"=>"262640793720877057", "text"=>"Lumevaikutus on osaltaan kiinni perimästä. Ainakin dopamiinin hajoamiseen liittyvä geenimuoto vaikuttaa. http://t.co/v0Wb5G9N", "created_at"=>"2012-10-28T19:43:39Z", "user"=>"hankalapotilas", "user_name"=>"Maija Haavisto", "user_profile_image"=>"http://a0.twimg.com/profile_images/1582991357/maija_4_300sq_normal.jpg"}
• {"id"=>"262910649468862464", "text"=>"More work is needed to support this => COMT val158met SNP = potential genetic marker of #placebo response ? http://t.co/9CYYuxxp", "created_at"=>"2012-10-29T13:35:58Z", "user"=>"nutrigenomics", "user_name"=>"Michael Müller", "user_profile_image"=>"http://a0.twimg.com/profile_images/2602427754/1dz2su80xk1ve5vg90jd_normal.jpeg"}
• {"id"=>"264779651493265408", "text"=>"I bet I’m val/val. Maybe more skeptics are? http://t.co/98sGBq6M Genetic basis for placebo? @MrMMarsh @mikehall314", "created_at"=>"2012-11-03T17:22:42Z", "user"=>"Ellkjell", "user_name"=>"Ellen Kjellman", "user_profile_image"=>"http://a0.twimg.com/profile_images/2275307478/B4D85BE2-1B50-4FD3-A162-0A928BEA0245_normal"}
• {"id"=>"265203478752808960", "text"=>"а чоб не кинуть просто ссылкой http://t.co/xyJktVuU", "created_at"=>"2012-11-04T21:26:51Z", "user"=>"tru_pablo", "user_name"=>"pablo trukhanov", "user_profile_image"=>"http://a0.twimg.com/profile_images/2228580797/y_4cd23c5f_normal.jpg"}
• {"id"=>"265699294990966784", "text"=>"Нашли ген отвечающий за подверженность части людей эффекту плацебо.\n#PLOSONE: http://t.co/yzdrDrEa", "created_at"=>"2012-11-06T06:17:03Z", "user"=>"Portweinson", "user_name"=>"S. B. Portweinson", "user_profile_image"=>"http://a0.twimg.com/profile_images/1250786337/15200014_normal.jpeg"}
• {"id"=>"266590753428475904", "text"=>"\"@PLOSONE: Placebo's effect may depend on your genes http://t.co/aJGth49W re: http://t.co/Y3w7eJgY\"", "created_at"=>"2012-11-08T17:19:23Z", "user"=>"annemostafa", "user_name"=>"Bahrainpsychologist", "user_profile_image"=>"http://a0.twimg.com/profile_images/2593946511/p7BtvQ75_normal"}
• {"id"=>"267228727388303360", "text"=>"http://t.co/X50R55I6 \nlos genes determinan tantas cosas.... @AlbertoGlezCdo", "created_at"=>"2012-11-10T11:34:28Z", "user"=>"M_C_L_", "user_name"=>"Maria Castillo Lara", "user_profile_image"=>"http://a0.twimg.com/profile_images/1713892124/pinguino_mama_normal.jpg"}
• {"id"=>"267760327175839745", "text"=>"@DerrenBrown should've screened #fearandfaith participants for val158met polymorphism!\nhttp://t.co/TRQ0HfSb", "created_at"=>"2012-11-11T22:46:51Z", "user"=>"thechadologist", "user_name"=>"Tom Chad", "user_profile_image"=>"http://a0.twimg.com/profile_images/1691584862/image_normal.jpg"}
• {"id"=>"268018421185249281", "text"=>"¿Bases genéticas para el \"efecto placebo\"? Tal vez: http://t.co/jq1hldPc", "created_at"=>"2012-11-12T15:52:25Z", "user"=>"GaboTuitero", "user_name"=>"Gabriel León", "user_profile_image"=>"http://a0.twimg.com/profile_images/2243373611/gabo5_normal.jpg"}
• {"id"=>"268170303279071232", "text"=>"Placebo gene not in everybody http://t.co/L1mL8nGe Chiropractic care exceeds placebo http://t.co/Ethnz4mX Will your health provider have...", "created_at"=>"2012-11-13T01:55:57Z", "user"=>"GotitDoc", "user_name"=>"Donald McDowall", "user_profile_image"=>"http://a0.twimg.com/profile_images/2443407905/Image_normal.jpg"}
• {"id"=>"285317870114729986", "text"=>"exciting! genetics of placebo effects: #PLOSONE: COMT..Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome http://t.co/oQMHB1Hw", "created_at"=>"2012-12-30T09:34:15Z", "user"=>"CarstenLincke", "user_name"=>"Carsten Lincke", "user_profile_image"=>"http://a0.twimg.com/profile_images/1953631647/DSCF0180_normal.jpg"}
• {"id"=>"289920800033751040", "text"=>"逆に考えるんだ。これを利用してだまされやすい人をスクリーニングして・・・。 http://t.co/gXLF9sLd", "created_at"=>"2013-01-12T02:24:39Z", "user"=>"556980", "user_name"=>"556980", "user_profile_image"=>"http://a0.twimg.com/sticky/default_profile_images/default_profile_2_normal.png"}
• {"id"=>"291073491917209601", "text"=>"@PaulBrandZwolle ken je deze? genetics of placebo effects: #PLOSONE: COMT..Polymorphism Predicts Placebo Effect in Irri http://t.co/oQMHB1Hw", "created_at"=>"2013-01-15T06:45:03Z", "user"=>"CarstenLincke", "user_name"=>"Carsten Lincke", "user_profile_image"=>"http://a0.twimg.com/profile_images/1953631647/DSCF0180_normal.jpg"}
• {"id"=>"291425527737249792", "text"=>"@martinoffringa @pauldelaat85 @paulbrandzwolle ...#PLOSONE: COMT..Polymorphism Predicts Placebo Effect in Irri http://t.co/oQMHB1Hw", "created_at"=>"2013-01-16T06:03:54Z", "user"=>"CarstenLincke", "user_name"=>"Carsten Lincke", "user_profile_image"=>"http://a0.twimg.com/profile_images/1953631647/DSCF0180_normal.jpg"}
• {"id"=>"291476339825975296", "text"=>"PLOS ONE: Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome http://t.co/Piq2zTUW", "created_at"=>"2013-01-16T09:25:49Z", "user"=>"honeymanya", "user_name"=>"maria vasilenko", "user_profile_image"=>"http://a0.twimg.com/profile_images/2209886121/z_0dc89d9b_normal.jpg"}
• {"id"=>"314005982906834944", "text"=>"過敏性腸症候群におけるプラセボ効果はCOMT遺伝子多型で予測可能。 Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in... http://t.co/JmJKAKw3Wg”", "created_at"=>"2013-03-19T13:30:34Z", "user"=>"TtIi22", "user_name"=>"Tt Ii", "user_profile_image"=>"http://a0.twimg.com/sticky/default_profile_images/default_profile_5_normal.png"}
• {"id"=>"419454468615176192", "text"=>"Polymorphisms in gene for COMT enzyme can predict our placebo response: http://t.co/cLBsut04T2 (thanks to @andre_boorsma!)", "created_at"=>"2014-01-04T13:05:13Z", "user"=>"barbaravreede", "user_name"=>"Barbara Vreede", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000564094228/ddc7ffda3cac8a983076647ad6300ae0_normal.png"}
• {"id"=>"432961515222626304", "text"=>"@MartinShkreli actually the link I posted was not the full article, this is. \nhttp://t.co/pbUFpl7xid", "created_at"=>"2014-02-10T19:37:23Z", "user"=>"vigkap", "user_name"=>"vincent grattan", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2610806418/y1lswgjeejtffki9pei7_normal.jpeg"}
• {"id"=>"596002378341560320", "text"=>"Zaz! Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome http://t.co/A7Pfvh4w3a", "created_at"=>"2015-05-06T17:23:34Z", "user"=>"GaboTuitero", "user_name"=>"Gabriel León", "user_profile_image"=>"http://pbs.twimg.com/profile_images/592893681272774658/qDLHHZ4p_normal.jpg"}
• {"id"=>"716940483122044928", "text"=>"@cmcgovern something to chew on till I get home later. Gene variant predicts placebo response... https://t.co/iFjDfJLzJu @cathyby", "created_at"=>"2016-04-04T10:48:25Z", "user"=>"AuntieDote", "user_name"=>"Auntie Dote", "user_profile_image"=>"http://pbs.twimg.com/profile_images/678216306135588864/Cnh7A5FG_normal.jpg"}
• {"id"=>"754037493159329792", "text"=>"La gen?tica podr?a modificar la respuesta al placebo https://t.co/ZALBJ4ZKT8", "created_at"=>"2016-07-15T19:38:42Z", "user"=>"PabloRichly", "user_name"=>"Pablo Richly", "user_profile_image"=>"http://pbs.twimg.com/profile_images/619571875375632384/Ty9kPecu_normal.jpg"}
• {"id"=>"828270784237940740", "text"=>"The #genetics of #placebo #effects https://t.co/hZP2pmhyCy", "created_at"=>"2017-02-05T15:55:18Z", "user"=>"DrLoBisco", "user_name"=>"Dr. LoBisco", "user_profile_image"=>"http://pbs.twimg.com/profile_images/692540891131691008/q39jpOXM_normal.jpg"}

Wikipedia | Further Information

• {"title"=>"Striatum", "url"=>"http://fr.wikipedia.org/wiki/Striatum", "timestamp"=>"2019-03-16T08:32:31Z"}
• {"title"=>"Douleur psychogène", "url"=>"http://fr.wikipedia.org/wiki/Douleur_psychogène", "timestamp"=>"2018-03-24T00:14:03Z"}
• {"title"=>"Dopamine", "url"=>"http://fr.wikipedia.org/wiki/Dopamine", "timestamp"=>"2019-02-27T22:19:54Z"}
• {"title"=>"Effet placebo", "url"=>"http://fr.wikipedia.org/wiki/Effet_placebo", "timestamp"=>"2019-02-17T08:57:51Z"}

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Figshare

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• {"files"=>["https://ndownloader.figshare.com/files/554689"], "description"=>"<p>Number of val158met met alleles showed a significant linear effect on IBS-SSS (beta = 0.17; p = .032). IBS-SSS includes abdominal pain severity, abdominal pain frequency, abdominal distention severity, dissatisfaction with bowel habits, and disruption of quality of life. Change in IBS-SSS  =  (IBS-SSS at baseline – IBS-SSS at 3-weeks). Regression model included COMT genotype (number of met alleles) and baseline IBS-SSS. Error bars indicate the standard error of the mean. N = 104.</p>", "links"=>[], "tags"=>["comt", "genotype"], "article_id"=>225171, "categories"=>["Cell Biology", "Chemistry", "Genetics"], "users"=>["Kathryn T. Hall", "Anthony J. Lembo", "Irving Kirsch", "Dimitrios C. Ziogas", "Jeffrey Douaiher", "Karin B. Jensen", "Lisa A. Conboy", "John M. Kelley", "Efi Kokkotou", "Ted J. Kaptchuk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048135.g001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_COMT_genotype_on_change_in_IBS_SSS_/225171", "title"=>"Effect of COMT genotype on change in IBS-SSS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:21:34"}
• {"files"=>["https://ndownloader.figshare.com/files/554848"], "description"=>"*<p>Participants in parent clinical trial previously reported <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048135#pone.0048135-Kaptchuk1\" target=\"_blank\">[30]</a>.</p>", "links"=>[], "tags"=>["characteristics", "genotyped", "ibs", "patients", "compared", "randomized"], "article_id"=>225332, "categories"=>["Cell Biology", "Chemistry", "Genetics"], "users"=>["Kathryn T. Hall", "Anthony J. Lembo", "Irving Kirsch", "Dimitrios C. Ziogas", "Jeffrey Douaiher", "Karin B. Jensen", "Lisa A. Conboy", "John M. Kelley", "Efi Kokkotou", "Ted J. Kaptchuk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048135.t001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_of_genotyped_IBS_patients_compared_to_participants_in_the_parent_randomized_clinical_trial_/225332", "title"=>"Baseline characteristics of genotyped IBS patients compared to participants in the parent randomized clinical trial.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 21:22:32"}
• {"files"=>["https://ndownloader.figshare.com/files/554756"], "description"=>"<p>The interaction between COMT genotype (number of met alleles) and treatment arm was statistically significant (beta = 0.17; p = .035). Regression model included the following parameters: COMT genotype (number of met alleles), treatment arm, baseline IBS-SSS and their interaction (COMT genotype x treatment arm). Error bars indicate the standard error of the mean. N = 104.</p>", "links"=>[], "tags"=>["comt", "genotype"], "article_id"=>225242, "categories"=>["Cell Biology", "Chemistry", "Genetics"], "users"=>["Kathryn T. Hall", "Anthony J. Lembo", "Irving Kirsch", "Dimitrios C. Ziogas", "Jeffrey Douaiher", "Karin B. Jensen", "Lisa A. Conboy", "John M. Kelley", "Efi Kokkotou", "Ted J. Kaptchuk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048135.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Interaction_effect_of_COMT_genotype_and_treatment_arm_on_change_in_IBS_SSS_/225242", "title"=>"Interaction effect of COMT genotype and treatment arm on change in IBS-SSS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:21:58"}

PMC Usage Stats | Further Information

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Relative Metric

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F1000Prime