Regional Homogeneity within the Default Mode Network in Bipolar Depression: A Resting-State Functional Magnetic Resonance Imaging Study
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{"title"=>"Regional Homogeneity within the Default Mode Network in Bipolar Depression: A Resting-State Functional Magnetic Resonance Imaging Study", "type"=>"journal", "authors"=>[{"first_name"=>"Chun-Hong", "last_name"=>"Liu"}, {"first_name"=>"Xin", "last_name"=>"Ma"}, {"first_name"=>"Feng", "last_name"=>"Li"}, {"first_name"=>"Yong-Jun", "last_name"=>"Wang"}, {"first_name"=>"Chang-Le", "last_name"=>"Tie"}, {"first_name"=>"Su-Fang", "last_name"=>"Li"}, {"first_name"=>"Tao-Lin", "last_name"=>"Chen"}, {"first_name"=>"Ting-ting", "last_name"=>"Fan"}, {"first_name"=>"Yu", "last_name"=>"Zhang"}, {"first_name"=>"Jie", "last_name"=>"Dong"}, {"first_name"=>"Li", "last_name"=>"Yao"}, {"first_name"=>"Xia", "last_name"=>"Wu"}, {"first_name"=>"Chuan-Yue", "last_name"=>"Wang"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0048181", "pmid"=>"23133615", "issn"=>"1932-6203", "isbn"=>"1011070478100"}, "id"=>"21215f93-f75e-3233-a091-44743fffe779", "abstract"=>"AIM: We sought to use a regional homogeneity (ReHo) approach as an index in resting-state functional magnetic resonance imaging (fMRI) to investigate the features of spontaneous brain activity within the default mode network (DMN) in patients suffering from bipolar depression (BD).\\n\\nMETHODS: Twenty-six patients with BD and 26 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans. We compared the differences in ReHo between the two groups within the DMN and investigated the relationships between sex, age, years of education, disease duration, the Hamilton Rating Scale for Depression (HAMD) total score, and ReHo in regions with significant group differences.\\n\\nRESULTS: Our results revealed that bipolar depressed patients had increased ReHo in the left medial frontal gyrus and left inferior parietal lobe compared to healthy controls. No correlations were found between regional ReHo values and sex, age, and clinical features within the BD group.\\n\\nCONCLUSIONS: Our findings indicate that abnormal brain activity is mainly distributed within prefrontal-limbic circuits, which are believed to be involved in the pathophysiological mechanisms underlying bipolar depression.", "link"=>"http://www.mendeley.com/research/regional-homogeneity-within-default-mode-network-bipolar-depression-restingstate-functional-magnetic-3", "reader_count"=>56, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>5, "Researcher"=>13, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>5, "Student > Master"=>15, "Other"=>3, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>5, "Researcher"=>13, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>5, "Student > Master"=>15, "Other"=>3, "Professor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>1, "Environmental Science"=>1, "Medicine and Dentistry"=>22, "Agricultural and Biological Sciences"=>4, "Neuroscience"=>6, "Psychology"=>20, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>22}, "Neuroscience"=>{"Neuroscience"=>6}, "Psychology"=>{"Psychology"=>20}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Computer Science"=>{"Computer Science"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Netherlands"=>1, "United States"=>3, "Japan"=>2, "United Kingdom"=>1, "Chile"=>1}, "group_count"=>4}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/549057"], "description"=>"<p>Abbreviations: HAMD, Hamilton Depression Rating Scale. The values in the table are Pearson’s Correlation Coefficients.</p>", "links"=>[], "tags"=>["areas", "between-group", "reho", "differences", "dmn"], "article_id"=>219530, "categories"=>["Physics", "Neuroscience", "Mental Health", "Cell Biology"], "users"=>["Chun-Hong Liu", "Xin Ma", "Feng Li", "Yong-Jun Wang", "Chang-Le Tie", "Su-Fang Li", "Tao-Lin Chen", "Ting-ting Fan", "Yu Zhang", "Jie Dong", "Li Yao", "Xia Wu", "Chuan-Yue Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048181.t002", "stats"=>{"downloads"=>0, "page_views"=>37, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Brain_areas_with_significant_between_group_ReHo_differences_within_the_DMN_and_various_clinical_measures_/219530", "title"=>"Brain areas with significant between-group ReHo differences within the DMN and various clinical measures.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 20:51:54"}
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PMC Usage Stats | Further Information

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Relative Metric

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