Chronic Activation of the G Protein-Coupled Receptor 30 with Agonist G-1 Attenuates Heart Failure
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{"title"=>"Chronic Activation of the G Protein-Coupled Receptor 30 with Agonist G-1 Attenuates Heart Failure", "type"=>"journal", "authors"=>[{"first_name"=>"Shoulei", "last_name"=>"Kang", "scopus_author_id"=>"54684191500"}, {"first_name"=>"Ying", "last_name"=>"Liu", "scopus_author_id"=>"56245563200"}, {"first_name"=>"Di", "last_name"=>"Sun", "scopus_author_id"=>"55440977500"}, {"first_name"=>"Chunle", "last_name"=>"Zhou", "scopus_author_id"=>"55441105000"}, {"first_name"=>"Aiying", "last_name"=>"Liu", "scopus_author_id"=>"36673443500"}, {"first_name"=>"Chuanying", "last_name"=>"Xu", "scopus_author_id"=>"35313221100"}, {"first_name"=>"Yanling", "last_name"=>"Hao", "scopus_author_id"=>"55551378200"}, {"first_name"=>"Dongye", "last_name"=>"Li", "scopus_author_id"=>"36067299600"}, {"first_name"=>"Changdong", "last_name"=>"Yan", "scopus_author_id"=>"8833013200"}, {"first_name"=>"Hong", "last_name"=>"Sun", "scopus_author_id"=>"55729330000"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"365952327", "sgr"=>"84868088791", "issn"=>"19326203", "pmid"=>"23110207", "scopus"=>"2-s2.0-84868088791", "doi"=>"10.1371/journal.pone.0048185"}, "id"=>"c0daeebb-de51-385b-a878-1eb77fe5caea", "abstract"=>"G protein-coupled receptor (GPR) 30 is a novel estrogen receptor. Recent studies suggest that activation of the GPR30 confers rapid cardioprotection in isolated rat heart. It is unknown whether chronic activation of GPR30 is beneficial or not for heart failure. In this study we investigated the cardiac effect of sustained activation or inhibition of GPR30. Female Sprague-Dawley rats were divided into 7 groups #2Q1: sham surgery (Sham), bilateral ovariectomy (OVX), OVX+estrogen (E(2)), OVX+isoproterenol (ISO), OVX+ISO+G-1, OVX+ISO+E(2)+G15, OVX+ISO+E(2). ISO (85 mg/kg×17 day, sc) was given to make the heart failure models. G-1(120 µg/kg·d×14 day) was used to activate GPR30 and G15 (190 µg/kg·d×14 day) was used to inhibit GPR30. Concentration of brain natriuretic peptide in serum, masson staining in isolated heart, contractile function and the expression of β(1) and β(2)- adrenergic receptor (AR) of ventricular myocytes were also determined. Our data showed that ISO treatment led to heart failure in OVX rats. G-1 or E(2) treatment decreased concentration of brain natriuretic peptide, reduced cardiac fibrosis, and enhanced contraction of the heart. Combined treatment with β(1) (CGP20712A) and β(2)-AR (ICI118551) antagonist abolished the improvement of myocardial function induced by G-1. We also found that chronic treatment with G-1 normalized the expression of β(1)-AR and increased the expression of β(2)-AR. Our results indicate that chronic activation of the GPR30 with its agonist G-1 attenuates heart failure by normalizing the expression of β(1)-AR and increasing the expression of β(2)-AR.", "link"=>"http://www.mendeley.com/research/chronic-activation-g-proteincoupled-receptor-30-agonist-g1-attenuates-heart-failure", "reader_count"=>16, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>5, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>6, "Sports and Recreations"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"India"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/552279"], "description"=>"<p>The relative arbitrary unit for sham group was assigned as figure (A). Figure (B) showed the expression of p-AKT. Each value represents the mean±S.E.M. n = 10 hearts in each group, *P<0.05 versus Sham, #P<i><</i>0.05 versus OVX+ISO, $p<0.05 versus OVX.</p>", "links"=>[], "tags"=>["diabetes and endocrinology"], "article_id"=>222760, "categories"=>["Chemistry"], "users"=>["Shoulei Kang", "Ying Liu", "Di Sun", "Chunle Zhou", "Aiying Liu", "Chuanying Xu", "Yanling Hao", "Dongye Li", "Changdong Yan", "Hong Sun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048185.g001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_p_AKT_/222760", "title"=>"Expression of p-AKT.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:08:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/552925"], "description"=>"<p>Each value represents the mean±S.E.M. n = 10,</p>*<p>P<0.05 versus Sham.</p>#<p>P<0.05 versus OVX+ISO, and $p<0.05 versus OVX group.</p>", "links"=>[], "tags"=>["diabetes and endocrinology"], "article_id"=>223415, "categories"=>["Chemistry"], "users"=>["Shoulei Kang", "Ying Liu", "Di Sun", "Chunle Zhou", "Aiying Liu", "Chuanying Xu", "Yanling Hao", "Dongye Li", "Changdong Yan", "Hong Sun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048185.t002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cardiac_function_of_each_group_/223415", "title"=>"Cardiac function of each group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 21:12:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/552484"], "description"=>"<p>Each value represents the mean±S.E.M.; n = 10 hearts in each group. *P<0.05 versus Sham, #P<0.05 versus OVX+ISO, $p<0.05 versus OVX.</p>", "links"=>[], "tags"=>["diabetes and endocrinology"], "article_id"=>222969, "categories"=>["Chemistry"], "users"=>["Shoulei Kang", "Ying Liu", "Di Sun", "Chunle Zhou", "Aiying Liu", "Chuanying Xu", "Yanling Hao", "Dongye Li", "Changdong Yan", "Hong Sun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048185.g002", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_BNP_activity_of_each_group_in_serum_/222969", "title"=>"BNP activity of each group in serum.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:10:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/552572"], "description"=>"<p>3A: The fibrotic areas were stained green, and the normal cardiac myocytes were stained red and normal nuclei were stained blue. Representation of each group as following: a: Sham group; b: OVX group; c: OVX+ISO group; d: OVX+ISO+G-1 group; e: OVX+ISO+E<sub>2</sub>+G15 group; f: OVX+ISO+E<sub>2</sub> group 3B: Each value represents the mean±S.E.M. n = 6, *P<0.05 versus Sham, #P<0.05 versus OVX+ISO, and $p<0.05 versus OVX group.</p>", "links"=>[], "tags"=>["staining"], "article_id"=>223063, "categories"=>["Chemistry"], "users"=>["Shoulei Kang", "Ying Liu", "Di Sun", "Chunle Zhou", "Aiying Liu", "Chuanying Xu", "Yanling Hao", "Dongye Li", "Changdong Yan", "Hong Sun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048185.g003", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Masson_staining_of_the_heart_/223063", "title"=>"Masson staining of the heart.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:10:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/552704"], "description"=>"<p>Myocytes of the six groups incubated in veh medium, shortening amplitude, TTP and R90 are shown as figure (A), (B) and (C) respectively. Data shown are mean± S.E.M. n = 10 hearts. *p<0.05 versus Sham, #p<0.05 versus OVX+ISO and $p<0.05 versus OVX. OVX+ISO and OVX+ISO+G-1 groups were incubated in veh, CGP or ICI medium. Shortening amplitude, TTP and R90 are shown as figure (D), (E) and (F) respectively. Data shown are mean±S.E.M. n = 10 hearts. #p<0.05 versus OVX+ISO of each subgroup.</p>", "links"=>[], "tags"=>["cardiac"], "article_id"=>223192, "categories"=>["Chemistry"], "users"=>["Shoulei Kang", "Ying Liu", "Di Sun", "Chunle Zhou", "Aiying Liu", "Chuanying Xu", "Yanling Hao", "Dongye Li", "Changdong Yan", "Hong Sun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048185.g004", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Function_determination_of_the_single_cardiac_cell_/223192", "title"=>"Function determination of the single cardiac cell.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:11:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/552786"], "description"=>"<p>The expression of β-actin was detected as an internal standard. The relative arbitrary unit for sham group was assigned as (A). Figure (B) and (C) showed the expression of β<sub>1</sub>-AR and β<sub>2</sub>-AR. Each value represents the mean±S.E.M. n = 10 hearts in each group, *P<0.05 versus Sham, #P<i><</i>0.05 versus OVX+ISO, $p<0.05 versus OVX.</p>", "links"=>[], "tags"=>["diabetes and endocrinology"], "article_id"=>223283, "categories"=>["Chemistry"], "users"=>["Shoulei Kang", "Ying Liu", "Di Sun", "Chunle Zhou", "Aiying Liu", "Chuanying Xu", "Yanling Hao", "Dongye Li", "Changdong Yan", "Hong Sun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048185.g005", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_expression_of_beta_AR_/223283", "title"=>"The expression of beta-AR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:11:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/552885"], "description"=>"<p>Each value represents the mean±S.E.M. n = 10,</p>*<p>P<0.05 versus Sham</p>#<p>P<0.05 versus OVX+ISO and $p<0.05 versus OVX group.</p>", "links"=>[], "tags"=>["diabetes and endocrinology"], "article_id"=>223378, "categories"=>["Chemistry"], "users"=>["Shoulei Kang", "Ying Liu", "Di Sun", "Chunle Zhou", "Aiying Liu", "Chuanying Xu", "Yanling Hao", "Dongye Li", "Changdong Yan", "Hong Sun"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048185.t001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_General_features_/223378", "title"=>"General features.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 21:12:10"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}

Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[322, 550, 671, 773, 864, 955, 1048, 1135, 1223, 1308, 1387, 1465, 1534, 1602, 1673, 1744, 1813, 1885, 1955, 2026, 2093, 2160, 2228, 2290, 2349]}, {"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[308, 530, 649, 751, 844, 933, 1021, 1107, 1194, 1277, 1357, 1426, 1501, 1572, 1634, 1702, 1768, 1838, 1910, 1976, 2046, 2114, 2181, 2241, 2298]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[307, 540, 660, 756, 847, 936, 1025, 1111, 1199, 1282, 1361, 1432]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[316, 541, 663, 766, 856, 950, 1041, 1128, 1218, 1302, 1382, 1456, 1526, 1593, 1657, 1729, 1796, 1862, 1930, 1999, 2065, 2132, 2202, 2261, 2319]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[313, 562, 690, 796, 893, 986, 1079, 1173, 1257, 1349, 1429, 1506, 1586, 1661, 1730, 1803, 1876, 1945, 2017, 2091, 2163, 2225, 2294, 2362, 2430]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[307, 529, 649, 751, 845, 936, 1025, 1113, 1197, 1284, 1360, 1432, 1501, 1570, 1632, 1697, 1765, 1834, 1904, 1972, 2041, 2107, 2170, 2231, 2292]}, {"subject_area"=>"/Medicine and health sciences/Cardiology", "average_usage"=>[262, 473, 578, 664, 746, 826, 913, 992, 1078, 1143, 1201, 1272, 1338, 1385, 1442, 1507, 1565, 1618, 1680, 1741, 1816, 1871, 1903, 1952, 2009]}, {"subject_area"=>"/Medicine and health sciences/Surgical and invasive medical procedures", "average_usage"=>[286, 511, 637, 736, 826, 907, 995, 1071, 1150, 1221, 1293, 1366, 1437, 1507, 1560, 1637, 1698, 1755, 1815, 1860, 1939, 2007, 2062, 2121, 2162]}]}
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