Maternal Vitamin C Deficiency during Pregnancy Persistently Impairs Hippocampal Neurogenesis in Offspring of Guinea Pigs
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{"title"=>"Maternal Vitamin C Deficiency during Pregnancy Persistently Impairs Hippocampal Neurogenesis in Offspring of Guinea Pigs", "type"=>"journal", "authors"=>[{"first_name"=>"Pernille", "last_name"=>"Tveden-Nyborg", "scopus_author_id"=>"6507356666"}, {"first_name"=>"Lucile", "last_name"=>"Vogt", "scopus_author_id"=>"55446116200"}, {"first_name"=>"Janne G.", "last_name"=>"Schjoldager", "scopus_author_id"=>"55446812600"}, {"first_name"=>"Natalie", "last_name"=>"Jeannet", "scopus_author_id"=>"55446142800"}, {"first_name"=>"Stine", "last_name"=>"Hasselholt", "scopus_author_id"=>"54901765600"}, {"first_name"=>"Maya D.", "last_name"=>"Paidi", "scopus_author_id"=>"55446869500"}, {"first_name"=>"Stephan", "last_name"=>"Christen", "scopus_author_id"=>"7004673119"}, {"first_name"=>"Jens", "last_name"=>"Lykkesfeldt", "scopus_author_id"=>"7004035026"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84868333197", "pui"=>"365978936", "doi"=>"10.1371/journal.pone.0048488", "isbn"=>"1932-6203", "sgr"=>"84868333197", "pmid"=>"23119033"}, "id"=>"5302b160-563d-3b28-85f2-af3cb1b9a4a1", "abstract"=>"While having the highest vitamin C (VitC) concentrations in the body, specific functions of VitC in the brain have only recently been acknowledged. We have shown that postnatal VitC deficiency in guinea pigs causes impairment of hippocampal memory function and leads to 30% less neurons. This study investigates how prenatal VitC deficiency affects postnatal hippocampal development and if any such effect can be reversed by postnatal VitC repletion. Eighty pregnant Dunkin Hartley guinea pig dams were randomized into weight stratified groups receiving High (900 mg) or Low (100 mg) VitC per kg diet. Newborn pups (n = 157) were randomized into a total of four postnatal feeding regimens: High/High (Control); High/Low (Depleted), Low/Low (Deficient); and Low/High (Repleted). Proliferation and migration of newborn cells in the dentate gyrus was assessed by BrdU labeling and hippocampal volumes were determined by stereology. Prenatal VitC deficiency resulted in a significant reduction in postnatal hippocampal volume (P<0.001) which was not reversed by postnatal repletion. There was no difference in postnatal cellular proliferation and survival rates in the hippocampus between dietary groups, however, migration of newborn cells into the granular layer of the hippocampus dentate gyrus was significantly reduced in prenatally deficient animals (P<0.01). We conclude that a prenatal VitC deficiency in guinea pigs leads to persistent impairment of postnatal hippocampal development which is not alleviated by postnatal repletion. Our findings place attention on a yet unrecognized consequence of marginal VitC deficiency during pregnancy.", "link"=>"http://www.mendeley.com/research/maternal-vitamin-c-deficiency-during-pregnancy-persistently-impairs-hippocampal-neurogenesis-offspri-1", "reader_count"=>24, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Master"=>2, "Other"=>2, "Student > Bachelor"=>7, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Master"=>2, "Other"=>2, "Student > Bachelor"=>7, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>7, "Neuroscience"=>1, "Chemistry"=>1, "Psychology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"South Korea"=>1, "United States"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/550851"], "description"=>"<p>Data is presented as mean±SD and were analyzed by two-way ANOVA using postnatal age and dietary regimen as factors followed by Tukey’s test for posthoc comparisons in case of statistical significance.</p>*<p>p<0.05;</p>**<p>p<0.01;</p>***<p>p<0.001 compared to CTRL animals. ns: not significant. Within each time point, one-way ANOVA was used. Effect of the MWM trial on biochemical markers were tested by two-way ANOVA using MWM and dietary regimen as factors.</p>", "links"=>[], "tags"=>["guinea", "pigs", "postnatal"], "article_id"=>221339, "categories"=>["Developmental Biology", "Neuroscience", "Medicine"], "users"=>["Pernille Tveden-Nyborg", "Lucile Vogt", "Janne G. Schjoldager", "Natalie Jeannet", "Stine Hasselholt", "Maya D. Paidi", "Stephan Christen", "Jens Lykkesfeldt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048488.t002", "stats"=>{"downloads"=>0, "page_views"=>35, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Vitamin_C_status_in_guinea_pigs_at_the_different_postnatal_time_points_/221339", "title"=>"Vitamin C status in guinea pigs at the different postnatal time points.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 21:01:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/550454"], "description"=>"<p>Results are presented as the grand mean for each prenatal treatment (i.e., either low or high). Closed circles (•) represent high and open circles (○) represent low postnatal vitamin C. At P10 and P27 there is a significant difference between prenatal diet group by two-way ANOVA, and by Student’s t-test at P70. N = 7–10 for each group.</p>", "links"=>[], "tags"=>["hippocampal", "corrected", "prenatally", "c-depleted"], "article_id"=>220940, "categories"=>["Developmental Biology", "Neuroscience", "Medicine"], "users"=>["Pernille Tveden-Nyborg", "Lucile Vogt", "Janne G. Schjoldager", "Natalie Jeannet", "Stine Hasselholt", "Maya D. Paidi", "Stephan Christen", "Jens Lykkesfeldt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048488.g002", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Persistently_lower_hippocampal_volume_corrected_for_brain_weight_in_prenatally_vitamin_C_depleted_animals_/220940", "title"=>"Persistently lower hippocampal volume corrected for brain weight in prenatally vitamin C-depleted animals.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:59:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/550347"], "description"=>"<p>Eighty pregnant guinea pigs were weight-stratified into two groups at gestational day 18. Group High (n = 30) was assigned to a diet containing 900 mg of vitamin C per kg diet and group Low (n = 50) received a diet containing 100 mg of vitamin C per kg. Otherwise, diets were identical. Newborn pups were assigned to either of four dietary groups (CTRL, DEF, DEPL or REPL) by weight stratification. Weaned male pups (n = 83) received a daily BrdU injection (100 mg/kg body weight) between post-natal day (P) 5 and P9 and were sacrificed either at P10 or P27. Female animals (n = 77) did not receive BrdU. A subset (n = 36) were submitted to two consecutive tests in the non-cued Morris water maze (MWM) initiated at P24 and P52. A cued test (c-MWM) was performed on age-matched pups from both CTRL and DEF groups (n = 5 and n = 6, respectively) at P35. All female pups were sacrificed at approximately two months of age (P70). Biochemical and histochemical analyses were performed as indicated on the scheme.</p>", "links"=>[], "tags"=>["neuroscience", "developmental biology", "pediatrics and child health", "neurological disorders"], "article_id"=>220821, "categories"=>["Developmental Biology", "Neuroscience", "Medicine"], "users"=>["Pernille Tveden-Nyborg", "Lucile Vogt", "Janne G. Schjoldager", "Natalie Jeannet", "Stine Hasselholt", "Maya D. Paidi", "Stephan Christen", "Jens Lykkesfeldt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048488.g001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overview_of_In_Vivo_Study_/220821", "title"=>"Overview of <i>In Vivo</i> Study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:58:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/550589"], "description"=>"<p>Representative dentate gyrus area of immunofluorescence-labeled sections used for assessing the location and phenotype of cells born between P5 and P9. Sections of animals sacrificed at either P10 or P27 were analyzed for BrdU-positive cells (red; arrowheads) together with the mature neuronal marker NeuN (Panels A to C) or the astrocyte marker GFAP (D; arrows) (both in green). DAPI (blue) was used to stain cell nuclei. Hatched lines denominate the border zones between hilus, SGZ and GL. <b>B:</b> Graphical data from evaluation of immunofluorescence images, example shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048488#pone-0048488-g002\" target=\"_blank\">Figure 2b</a>. Results are presented as the mean number of BrdU-positive cells in the different areas of the dentate gyrus for 4–5 regions per animal ± SD for total cell number. N = 7–10 animals per treatment group. We found no difference in the total number of BrdU-positive cells between the different treatment groups analyzed at either P10 or P27 by One-way ANOVA.</p>", "links"=>[], "tags"=>["precursor", "cells", "dentate"], "article_id"=>221072, "categories"=>["Developmental Biology", "Neuroscience", "Medicine"], "users"=>["Pernille Tveden-Nyborg", "Lucile Vogt", "Janne G. Schjoldager", "Natalie Jeannet", "Stine Hasselholt", "Maya D. Paidi", "Stephan Christen", "Jens Lykkesfeldt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048488.g003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Evaluation_of_proliferation_survival_and_migration_of_precursor_cells_in_the_dentate_gyrus_A_/221072", "title"=>"Evaluation of proliferation, survival and migration of precursor cells in the dentate gyrus. A:", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:59:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/550702"], "description"=>"<p>Evaluation of migration pattern of newborn cells according to their location in the different parts of the dentate gyrus at P10 and P27. Results are presented as the percentage of BrdU-positive cells counted in each region. Prenatally-deficient animals were compared to prenatally-sufficient animals by Two-way ANOVA. Closed circles (•) represent high and open circles (○) represent low postnatal vitamin C. N = 7–11 per treatment group. Significantly different mean values are indicated by their respective P-values in the graph; ns indicates no significant difference.</p>", "links"=>[], "tags"=>["deficiency", "causes", "sustained", "postnatal", "newborn", "cells", "granule"], "article_id"=>221181, "categories"=>["Developmental Biology", "Neuroscience", "Medicine"], "users"=>["Pernille Tveden-Nyborg", "Lucile Vogt", "Janne G. Schjoldager", "Natalie Jeannet", "Stine Hasselholt", "Maya D. Paidi", "Stephan Christen", "Jens Lykkesfeldt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048488.g004", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Prenatal_vitamin_C_deficiency_causes_sustained_reduction_in_postnatal_migration_of_newborn_cells_into_the_granule_layer_/221181", "title"=>"Prenatal vitamin C deficiency causes sustained reduction in postnatal migration of newborn cells into the granule layer.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 21:00:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/550814"], "description"=>"<p>Data is presented as mean±SD and were analyzed by two-way ANOVA using postnatal age and dietary regimen as factors followed by Tukey’s test for posthoc comparisons in case of statistical significance.</p>*<p>p<0.05;</p>**<p>p<0.01;</p>***<p>p<0.001 compared to CTRL animals. ‘ns’: not significant. Within each time point, one-way ANOVA was used.</p>", "links"=>[], "tags"=>["histological"], "article_id"=>221304, "categories"=>["Developmental Biology", "Neuroscience", "Medicine"], "users"=>["Pernille Tveden-Nyborg", "Lucile Vogt", "Janne G. Schjoldager", "Natalie Jeannet", "Stine Hasselholt", "Maya D. Paidi", "Stephan Christen", "Jens Lykkesfeldt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048488.t001", "stats"=>{"downloads"=>1, "page_views"=>37, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Brain_weight_and_histological_data_from_the_different_time_points_/221304", "title"=>"Brain weight and histological data from the different time-points.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 21:01:13"}

PMC Usage Stats | Further Information

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Relative Metric

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