Segmentation and Visual Analysis of Whole-Body Mouse Skeleton microSPECT
Publication Date
November 12, 2012
Journal
PLOS ONE
Authors
Artem Khmelinskii, Harald C. Groen, Martin Baiker, Marion De Jong, et al
Volume
7
Issue
11
Pages
e48976
DOI
https://dx.plos.org/10.1371/journal.pone.0048976
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0048976
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23152834
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495855
Europe PMC
http://europepmc.org/abstract/MED/23152834
Web of Science
000311234000042
Scopus
84869015277
Mendeley
http://www.mendeley.com/research/segmentation-visual-analysis-wholebody-mouse-skeleton-microspect
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Segmentation and Visual Analysis of Whole-Body Mouse Skeleton microSPECT", "type"=>"journal", "authors"=>[{"first_name"=>"Artem", "last_name"=>"Khmelinskii", "scopus_author_id"=>"24766174600"}, {"first_name"=>"Harald C.", "last_name"=>"Groen", "scopus_author_id"=>"20433328400"}, {"first_name"=>"Martin", "last_name"=>"Baiker", "scopus_author_id"=>"23007774700"}, {"first_name"=>"Marion", "last_name"=>"de Jong", "scopus_author_id"=>"7201366576"}, {"first_name"=>"Boudewijn P.F.", "last_name"=>"Lelieveldt", "scopus_author_id"=>"7003267462"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84869015277", "pmid"=>"23152834", "scopus"=>"2-s2.0-84869015277", "pui"=>"366043191", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0048976"}, "id"=>"eddf856f-97c2-38af-a0c4-05dd50494123", "abstract"=>"Whole-body SPECT small animal imaging is used to study cancer, and plays an important role in the development of new drugs. Comparing and exploring whole-body datasets can be a difficult and time-consuming task due to the inherent heterogeneity of the data (high volume/throughput, multi-modality, postural and positioning variability). The goal of this study was to provide a method to align and compare side-by-side multiple whole-body skeleton SPECT datasets in a common reference, thus eliminating acquisition variability that exists between the subjects in cross-sectional and multi-modal studies. Six whole-body SPECT/CT datasets of BALB/c mice injected with bone targeting tracers (99m)Tc-methylene diphosphonate ((99m)Tc-MDP) and (99m)Tc-hydroxymethane diphosphonate ((99m)Tc-HDP) were used to evaluate the proposed method. An articulated version of the MOBY whole-body mouse atlas was used as a common reference. Its individual bones were registered one-by-one to the skeleton extracted from the acquired SPECT data following an anatomical hierarchical tree. Sequential registration was used while constraining the local degrees of freedom (DoFs) of each bone in accordance to the type of joint and its range of motion. The Articulated Planar Reformation (APR) algorithm was applied to the segmented data for side-by-side change visualization and comparison of data. To quantitatively evaluate the proposed algorithm, bone segmentations of extracted skeletons from the correspondent CT datasets were used. Euclidean point to surface distances between each dataset and the MOBY atlas were calculated. The obtained results indicate that after registration, the mean Euclidean distance decreased from 11.5±12.1 to 2.6±2.1 voxels. The proposed approach yielded satisfactory segmentation results with minimal user intervention. It proved to be robust for \"incomplete\" data (large chunks of skeleton missing) and for an intuitive exploration and comparison of multi-modal SPECT/CT cross-sectional mouse data.", "link"=>"http://www.mendeley.com/research/segmentation-visual-analysis-wholebody-mouse-skeleton-microspect", "reader_count"=>15, "reader_count_by_academic_status"=>{"Researcher"=>7, "Student > Ph. D. Student"=>3, "Student > Master"=>3, "Other"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>7, "Student > Ph. D. Student"=>3, "Student > Master"=>3, "Other"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>1, "Materials Science"=>1, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>1, "Physics and Astronomy"=>1, "Social Sciences"=>1, "Computer Science"=>5, "Engineering"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>5}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}}, "reader_count_by_country"=>{"Norway"=>1, "Germany"=>1}, "group_count"=>1}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84869015277"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84869015277?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84869015277&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84869015277&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84869015277", "dc:identifier"=>"SCOPUS_ID:84869015277", "eid"=>"2-s2.0-84869015277", "dc:title"=>"Segmentation and Visual Analysis of Whole-Body Mouse Skeleton microSPECT", "dc:creator"=>"Khmelinskii A.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"7", "prism:issueIdentifier"=>"11", "prism:pageRange"=>nil, "prism:coverDate"=>"2012-11-12", "prism:coverDisplayDate"=>"12 November 2012", "prism:doi"=>"10.1371/journal.pone.0048976", "citedby-count"=>"6", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Leiden University Medical Center - LUMC", "affiliation-city"=>"Leiden", "affiliation-country"=>"Netherlands"}], "pubmed-id"=>"23152834", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e48976", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0048976", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"37", "xml_views"=>"8", "html_views"=>"223"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"56"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"48"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"4", "html_views"=>"59"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"63"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"38"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"79"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"70"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"2", "html_views"=>"33"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"75"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"82"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"78"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"40"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"3", "html_views"=>"34"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"19"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"3", "html_views"=>"15"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"2"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/545066"], "description"=>"<p>Mean Euclidian point to surface distance between the SPECT and CT skeletons after the pre-processing step.</p>", "links"=>[], "tags"=>["euclidian", "spect", "ct", "skeletons", "pre-processing"], "article_id"=>215554, "categories"=>["Physiology", "Cell Biology"], "users"=>["Artem Khmelinskii", "Harald C. Groen", "Martin Baiker", "Marion de Jong", "Boudewijn P. F. Lelieveldt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048976.t002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_Euclidian_point_to_surface_distance_between_the_SPECT_and_CT_skeletons_after_the_pre_processing_step_/215554", "title"=>"Mean Euclidian point to surface distance between the SPECT and CT skeletons after the pre-processing step.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-11-12 01:32:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/545092"], "description"=>"<p>Quantitative results of the MOBY atlas-to-skeleton registration for 6 mouse SPECT datasets and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048976#pone.0048976-Baiker1\" target=\"_blank\">[1]</a>.</p>", "links"=>[], "tags"=>["moby", "atlas-to-skeleton", "registration", "spect", "datasets"], "article_id"=>215587, "categories"=>["Physiology", "Cell Biology"], "users"=>["Artem Khmelinskii", "Harald C. Groen", "Martin Baiker", "Marion de Jong", "Boudewijn P. F. Lelieveldt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048976.t003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantitative_results_of_the_MOBY_atlas_to_skeleton_registration_for_6_mouse_SPECT_datasets_and_1_/215587", "title"=>"Quantitative results of the MOBY atlas-to-skeleton registration for 6 mouse SPECT datasets and [1].", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-11-12 01:33:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/545126"], "description"=>"<p>Resolution of each SPECT and correspondent CT dataset.</p>", "links"=>[], "tags"=>["spect", "ct"], "article_id"=>215624, "categories"=>["Physiology", "Cell Biology"], "users"=>["Artem Khmelinskii", "Harald C. Groen", "Martin Baiker", "Marion de Jong", "Boudewijn P. F. Lelieveldt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048976.t001", "stats"=>{"downloads"=>1, "page_views"=>43, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Resolution_of_each_SPECT_and_correspondent_CT_dataset_/215624", "title"=>"Resolution of each SPECT and correspondent CT dataset.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-11-12 01:33:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/544748"], "description"=>"<p>* indicates where user input is necessary: to pin-point the spine location where the vertebra connects the spine to the pelvis.</p>", "links"=>[], "tags"=>["anatomical", "followed", "registration"], "article_id"=>215241, "categories"=>["Physiology", "Cell Biology"], "users"=>["Artem Khmelinskii", "Harald C. Groen", "Martin Baiker", "Marion de Jong", "Boudewijn P. F. Lelieveldt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048976.g004", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hierarchical_anatomical_tree_followed_during_the_registration_process_/215241", "title"=>"Hierarchical anatomical tree followed during the registration process.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-12 01:27:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/544299"], "description"=>"<p>Given a SPECT dataset (a), the skeleton is extracted from the SPECT dataset (b). Next, the atlas skeleton (c) and the extracted skeleton (b) are registered to each other (d, e) using an anatomically realistic kinematic model. After the registration, the segmented data is reformatted into segments corresponding to the mouse atlas and thus mapping the data to a standardized atlas space (f, g). The data is now ready for an easy, fast and intuitive side-by-side exploration (multi-modal, follow-up or cross-sectional data) (h).</p>", "links"=>[], "tags"=>["segmentation"], "article_id"=>214796, "categories"=>["Physiology", "Cell Biology"], "users"=>["Artem Khmelinskii", "Harald C. Groen", "Martin Baiker", "Marion de Jong", "Boudewijn P. F. Lelieveldt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048976.g001", "stats"=>{"downloads"=>3, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overview_of_the_proposed_segmentation_method_/214796", "title"=>"Overview of the proposed segmentation method.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-12 01:19:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/291863", "https://ndownloader.figshare.com/files/291910", "https://ndownloader.figshare.com/files/291980", "https://ndownloader.figshare.com/files/292122"], "description"=>"<div><p>Whole-body SPECT small animal imaging is used to study cancer, and plays an important role in the development of new drugs. Comparing and exploring whole-body datasets can be a difficult and time-consuming task due to the inherent heterogeneity of the data (high volume/throughput, multi-modality, postural and positioning variability). The goal of this study was to provide a method to align and compare side-by-side multiple whole-body skeleton SPECT datasets in a common reference, thus eliminating acquisition variability that exists between the subjects in cross-sectional and multi-modal studies. Six whole-body SPECT/CT datasets of <em>BALB/c</em> mice injected with bone targeting tracers <sup>99m</sup>Tc-methylene diphosphonate (<sup>99m</sup>Tc-MDP) and <sup>99m</sup>Tc-hydroxymethane diphosphonate (<sup>99m</sup>Tc-HDP) were used to evaluate the proposed method. An articulated version of the MOBY whole-body mouse atlas was used as a common reference. Its individual bones were registered one-by-one to the skeleton extracted from the acquired SPECT data following an anatomical hierarchical tree. Sequential registration was used while constraining the local degrees of freedom (DoFs) of each bone in accordance to the type of joint and its range of motion. The Articulated Planar Reformation (APR) algorithm was applied to the segmented data for side-by-side change visualization and comparison of data. To quantitatively evaluate the proposed algorithm, bone segmentations of extracted skeletons from the correspondent CT datasets were used. Euclidean point to surface distances between each dataset and the MOBY atlas were calculated. The obtained results indicate that after registration, the mean Euclidean distance decreased from 11.5±12.1 to 2.6±2.1 voxels. The proposed approach yielded satisfactory segmentation results with minimal user intervention. It proved to be robust for “incomplete” data (large chunks of skeleton missing) and for an intuitive exploration and comparison of multi-modal SPECT/CT cross-sectional mouse data.</p> </div>", "links"=>[], "tags"=>["segmentation", "whole-body", "skeleton", "microspect"], "article_id"=>117456, "categories"=>["Physiology", "Cell Biology"], "users"=>["Artem Khmelinskii", "Harald C. Groen", "Martin Baiker", "Marion de Jong", "Boudewijn P. F. Lelieveldt"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0048976.s001", "https://dx.doi.org/10.1371/journal.pone.0048976.s002", "https://dx.doi.org/10.1371/journal.pone.0048976.s003", "https://dx.doi.org/10.1371/journal.pone.0048976.s004"], "stats"=>{"downloads"=>11, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Segmentation_and_Visual_Analysis_of_Whole_Body_Mouse_Skeleton_microSPECT__/117456", "title"=>"Segmentation and Visual Analysis of Whole-Body Mouse Skeleton microSPECT", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-11-12 02:04:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/544845"], "description"=>"<p>(a) - global articulated planar reformatted visualization of the atlas. (b), (c), (d) and (e) show the different data visualization options after applying the proposed approach. One can choose to visualize simultaneously and side-by-side a particular region of interest in cross-sectional studies for CT, SPECT or the combination of both. (b) - side-by-side visualization of the CT femur bone of 3 subjects, (c) - side-by-side visualization of the SPECT pelvic bone of 3 subjects, (d) - side-by-side visualization of the CT skull data fused with the correspondent SPECT data for 3 subjects, (e) - side-by-side visualization of the skull data of one particular subject: CT, SPECT and a combination of both. Follow-up data visualization was demonstrated in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048976#pone.0048976-Mth1\" target=\"_blank\">[10]</a> for longitudinal CT mouse data.</p>", "links"=>[], "tags"=>["layout", "segmented"], "article_id"=>215345, "categories"=>["Physiology", "Cell Biology"], "users"=>["Artem Khmelinskii", "Harald C. Groen", "Martin Baiker", "Marion de Jong", "Boudewijn P. F. Lelieveldt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048976.g005", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_APR_layout_of_the_segmented_mouse_data_/215345", "title"=>"APR layout of the segmented mouse data.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-12 01:29:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/544637"], "description"=>"<p>The figure shows the positioning differences of the mouse in the scanner, SPECT (left) and the correspondent CT (right). The SPECT skeletons are incomplete, with several parts missing: especially in the case of front, hind limbs and the skull with large holes (blue arrows); also remnants of non-relevant objects such as lungs, kidneys and bladder are present (red arrows). In the bottom dataset the right femur and part of the spine are missing (green arrows) due to incomplete acquisition. The CT skeletons are complete and clean after the pre-processing step and are used in the validation of the proposed approach to calculate the Euclidean point to surface distance between the registered atlas and the skeleton surface. Black arrows indicate examples of regions where over and underestimation of the bone thickness occurred during the skeleton estimation in the data pre-processing step.</p>", "links"=>[], "tags"=>["spect", "skeleton", "isosurfaces", "corresponding", "ct", "pre-processing"], "article_id"=>215125, "categories"=>["Physiology", "Cell Biology"], "users"=>["Artem Khmelinskii", "Harald C. Groen", "Martin Baiker", "Marion de Jong", "Boudewijn P. F. Lelieveldt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048976.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Examples_of_SPECT_skeleton_isosurfaces_with_the_corresponding_CT_skeleton_isosurfaces_after_the_pre_processing_step_/215125", "title"=>"Examples of SPECT skeleton isosurfaces with the corresponding CT skeleton isosurfaces after the pre-processing step.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-12 01:25:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/544460"], "description"=>"<p>As originally included in the atlas (top), after segmenting the individual bones (middle), and a detail of the kinematic constraints and the DoFs of the femur/tibia-fibula bone complex (bottom). The colors indicate the different labels of each bone.</p>", "links"=>[], "tags"=>["moby", "atlas"], "article_id"=>214953, "categories"=>["Physiology", "Cell Biology"], "users"=>["Artem Khmelinskii", "Harald C. Groen", "Martin Baiker", "Marion de Jong", "Boudewijn P. F. Lelieveldt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048976.g002", "stats"=>{"downloads"=>4, "page_views"=>55, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_MOBY_mouse_atlas_skeleton_/214953", "title"=>"The MOBY mouse atlas skeleton.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-12 01:22:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/544992"], "description"=>"<p>The registered MOBY atlas is represented in green.</p>", "links"=>[], "tags"=>["views", "segmented", "spect", "skeleton", "presented"], "article_id"=>215483, "categories"=>["Physiology", "Cell Biology"], "users"=>["Artem Khmelinskii", "Harald C. Groen", "Martin Baiker", "Marion de Jong", "Boudewijn P. F. Lelieveldt"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0048976.g006", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Top_and_side_views_of_the_segmented_SPECT_skeleton_initially_presented_in_Figure_1a_/215483", "title"=>"Top and side views of the segmented SPECT skeleton initially presented in Figure 1a).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-12 01:31:23"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"21", "full-text"=>"14", "pdf"=>"12", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"6", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"19", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"3", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[308, 530, 649, 751, 844, 933, 1021, 1107, 1194, 1277, 1357, 1426, 1501, 1572, 1634, 1702, 1768, 1838, 1910, 1976, 2046, 2114, 2181, 2241, 2298]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[307, 540, 660, 756, 847, 936, 1025, 1111, 1199, 1282, 1361, 1432]}, {"subject_area"=>"/Biology and life sciences/Neuroscience", "average_usage"=>[325, 542, 658, 757, 836, 925, 1015, 1095, 1177, 1263, 1338, 1411, 1477, 1537, 1599, 1663, 1726, 1795, 1857, 1921, 1979, 2041, 2099, 2150, 2205]}, {"subject_area"=>"/Biology and life sciences/Veterinary science", "average_usage"=>[368, 635, 753, 861, 975, 1103, 1205, 1302, 1411, 1512, 1630, 1714, 1767, 1840, 1918, 1992, 2095, 2196, 2254, 2308, 2385, 2438, 2520, 2604, 2682]}, {"subject_area"=>"/Biology and life sciences/Zoology", "average_usage"=>[360, 554, 661, 756, 829, 913, 992, 1072, 1144, 1228, 1306, 1378, 1439, 1500, 1558, 1627, 1689, 1754, 1826, 1892, 1951, 2009, 2067, 2130, 2200]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[312, 547, 668, 769, 861, 953, 1046, 1135, 1224, 1307, 1388, 1464, 1536, 1606, 1676, 1744, 1812, 1882, 1954, 2020, 2089, 2155, 2218, 2282, 2344]}, {"subject_area"=>"/Medicine and health sciences/Diagnostic medicine", "average_usage"=>[303, 515, 631, 731, 816, 904, 995, 1087, 1171, 1251, 1334, 1405, 1474, 1539, 1615, 1679, 1745, 1806, 1874, 1943, 2006, 2070, 2141, 2199, 2263]}]}
Loading … Spinner
There are currently no alerts