Fetal Alcohol Exposure and IQ at Age 8: Evidence from a Population-Based Birth-Cohort Study
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{"title"=>"Fetal Alcohol Exposure and IQ at Age 8: Evidence from a Population-Based Birth-Cohort Study", "type"=>"journal", "authors"=>[{"first_name"=>"Sarah J.", "last_name"=>"Lewis", "scopus_author_id"=>"35478819000"}, {"first_name"=>"Luisa", "last_name"=>"Zuccolo", "scopus_author_id"=>"22636516900"}, {"first_name"=>"George", "last_name"=>"Davey Smith", "scopus_author_id"=>"35354080500"}, {"first_name"=>"John", "last_name"=>"Macleod", "scopus_author_id"=>"7102828944"}, {"first_name"=>"Santiago", "last_name"=>"Rodriguez", "scopus_author_id"=>"35345766800"}, {"first_name"=>"Elizabeth S.", "last_name"=>"Draper", "scopus_author_id"=>"20733798900"}, {"first_name"=>"Margaret", "last_name"=>"Barrow", "scopus_author_id"=>"57201567223"}, {"first_name"=>"Rosa", "last_name"=>"Alati", "scopus_author_id"=>"9739176600"}, {"first_name"=>"Kapil", "last_name"=>"Sayal", "scopus_author_id"=>"6701748666"}, {"first_name"=>"Susan", "last_name"=>"Ring", "scopus_author_id"=>"7005469522"}, {"first_name"=>"Jean", "last_name"=>"Golding", "scopus_author_id"=>"35233306100"}, {"first_name"=>"Ron", "last_name"=>"Gray", "scopus_author_id"=>"9735923900"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"366053766", "sgr"=>"84869147280", "issn"=>"19326203", "pmid"=>"23166662", "scopus"=>"2-s2.0-84869147280", "doi"=>"10.1371/journal.pone.0049407", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"fd131c52-17e0-326e-875a-bc2e107b2a16", "abstract"=>"Background: Observational studies have generated conflicting evidence on the effects of moderate maternal alcohol consumption during pregnancy on offspring cognition mainly reflecting problems of confounding. Among mothers who drink during pregnancy fetal alcohol exposure is influenced not only by mother’s intake but also by genetic variants carried by both the mother and the fetus. Associations between children’s cognitive function and both maternal and child genotype at these loci can shed light on the effects of maternal alcohol consumption on offspring cognitive development. We used a large population based study of women recruited during pregnancy to determine whether genetic variants in alcohol metabolising genes in this cohort of women and their children were related to the child’s cognitive score Findings: Methods: (measured by the Weschler Intelligence Scale) at age 8. We found that four genetic variants in alcohol metabolising genes in 4167 children were strongly related to lower IQ at age 8, as was a risk allele score based on these 4 variants. This effect was only seen amongst the offspring of mothers who were moderate drinkers (1–6 units alcohol per week during pregnancy (per allele effect estimates were 21.80 (95% CI=22.63 to 20.97) p=0.00002, with no effect among children whose mothers abstained during pregnancy (0.16 (95%CI=21.05 to 1.36) p=0.80), p-value for interaction =0.009). A further genetic variant associated with alcohol metabolism in mothers was associated with their child’s IQ, but again only among mothers who drank during pregnancy.", "link"=>"http://www.mendeley.com/research/fetal-alcohol-exposure-iq-age-8-evidence-populationbased-birthcohort-study", "reader_count"=>98, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Librarian"=>1, "Researcher"=>20, "Student > Doctoral Student"=>4, "Student > Ph. D. 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Student"=>23, "Student > Postgraduate"=>5, "Student > Master"=>17, "Other"=>5, "Student > Bachelor"=>11, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Agricultural and Biological Sciences"=>13, "Chemistry"=>2, "Energy"=>1, "Environmental Science"=>1, "Nursing and Health Professions"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Mathematics"=>3, "Medicine and Dentistry"=>33, "Neuroscience"=>3, "Physics and Astronomy"=>1, "Psychology"=>24, "Social Sciences"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>33}, "Social Sciences"=>{"Social Sciences"=>5}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>24}, "Mathematics"=>{"Mathematics"=>3}, "Unspecified"=>{"Unspecified"=>7}, "Environmental Science"=>{"Environmental Science"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Neuroscience"=>{"Neuroscience"=>3}, "Energy"=>{"Energy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "reader_count_by_country"=>{"Canada"=>1, "Argentina"=>1, "Hong Kong"=>1, "United States"=>2, "South Africa"=>1, "United Kingdom"=>2, "Australia"=>1}, "group_count"=>3}

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  • {"files"=>["https://ndownloader.figshare.com/files/543307"], "description"=>"<p>Mothers age, educational level and socio-economic group by genotype score and drinking behaviour during pregnancy.</p>", "links"=>[], "tags"=>["socio-economic", "genotype", "behaviour"], "article_id"=>213789, "categories"=>["Biotechnology", "Neuroscience", "Medicine"], "users"=>["Sarah J. Lewis", "Luisa Zuccolo", "George Davey Smith", "John Macleod", "Santiago Rodriguez", "Elizabeth S. Draper", "Margaret Barrow", "Rosa Alati", "Kapil Sayal", "Susan Ring", "Jean Golding", "Ron Gray"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049407.t004", "stats"=>{"downloads"=>7, "page_views"=>36, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mothers_age_educational_level_and_socio_economic_group_by_genotype_score_and_drinking_behaviour_during_pregnancy_/213789", "title"=>"Mothers age, educational level and socio-economic group by genotype score and drinking behaviour during pregnancy.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-11-14 01:03:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/543259"], "description"=>"<p>P- value for interaction between number of risk alleles and drinking during pregnancy  = 0.009</p>*<p>Total number of risk alleles in <i>ADH1A</i> rs2866151 rs975833, <i>ADH1B</i> rs4147536 and ADH7 rs284779.</p>", "links"=>[], "tags"=>["alleles", "stratified", "maternal", "intake"], "article_id"=>213734, "categories"=>["Biotechnology", "Neuroscience", "Medicine"], "users"=>["Sarah J. Lewis", "Luisa Zuccolo", "George Davey Smith", "John Macleod", "Santiago Rodriguez", "Elizabeth S. Draper", "Margaret Barrow", "Rosa Alati", "Kapil Sayal", "Susan Ring", "Jean Golding", "Ron Gray"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049407.t003", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_IQ_score_by_number_of_risk_alleles_stratified_by_maternal_alcohol_intake_during_pregnancy_/213734", "title"=>"IQ score by number of risk alleles stratified by maternal alcohol intake during pregnancy.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-11-14 01:02:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/291409"], "description"=>"<div><h3>Background</h3><p>Observational studies have generated conflicting evidence on the effects of moderate maternal alcohol consumption during pregnancy on offspring cognition mainly reflecting problems of confounding. Among mothers who drink during pregnancy fetal alcohol exposure is influenced not only by mother’s intake but also by genetic variants carried by both the mother and the fetus. Associations between children’s cognitive function and both maternal and child genotype at these loci can shed light on the effects of maternal alcohol consumption on offspring cognitive development.</p> <h3>Methods</h3><p>We used a large population based study of women recruited during pregnancy to determine whether genetic variants in alcohol metabolising genes in this cohort of women and their children were related to the child’s cognitive score (measured by the Weschler Intelligence Scale) at age 8.</p> <h3>Findings</h3><p>We found that four genetic variants in alcohol metabolising genes in 4167 children were strongly related to lower IQ at age 8, as was a risk allele score based on these 4 variants. This effect was only seen amongst the offspring of mothers who were moderate drinkers (1–6 units alcohol per week during pregnancy (per allele effect estimates were −1.80 (95% CI = −2.63 to −0.97) p = 0.00002, with no effect among children whose mothers abstained during pregnancy (0.16 (95%CI = −1.05 to 1.36) p = 0.80), p-value for interaction  = 0.009). A further genetic variant associated with alcohol metabolism in mothers was associated with their child’s IQ, but again only among mothers who drank during pregnancy.</p> </div>", "links"=>[], "tags"=>["fetal", "iq", "population-based", "birth-cohort", "study"], "article_id"=>117367, "categories"=>["Biotechnology", "Neuroscience", "Medicine"], "users"=>["Sarah J. Lewis", "Luisa Zuccolo", "George Davey Smith", "John Macleod", "Santiago Rodriguez", "Elizabeth S. Draper", "Margaret Barrow", "Rosa Alati", "Kapil Sayal", "Susan Ring", "Jean Golding", "Ron Gray"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049407", "stats"=>{"downloads"=>3, "page_views"=>43, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Fetal_Alcohol_Exposure_and_IQ_at_Age_8_Evidence_from_a_Population_Based_Birth_Cohort_Study__/117367", "title"=>"Fetal Alcohol Exposure and IQ at Age 8: Evidence from a Population-Based Birth-Cohort Study", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-11-14 02:02:47"}

PMC Usage Stats | Further Information

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Relative Metric

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