High CCR5 Density on Central Memory CD4+ T Cells in Acute HIV-1 Infection Is Mostly Associated with Rapid Disease Progression
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{"title"=>"High CCR5 density on central memory CD4+ T cells in acute HIV-1 infection is mostly associated with rapid disease progression.", "type"=>"journal", "authors"=>[{"first_name"=>"Xue", "last_name"=>"Yang"}, {"first_name"=>"Yan-mei", "last_name"=>"Jiao"}, {"first_name"=>"Rui", "last_name"=>"Wang"}, {"first_name"=>"Yun-xia", "last_name"=>"Ji"}, {"first_name"=>"Hong-wei", "last_name"=>"Zhang"}, {"first_name"=>"Yong-hong", "last_name"=>"Zhang"}, {"first_name"=>"De-xi", "last_name"=>"Chen"}, {"first_name"=>"Tong", "last_name"=>"Zhang"}, {"first_name"=>"Hao", "last_name"=>"Wu"}], "year"=>2012, "source"=>"PloS one", "identifiers"=>{"issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0049526", "isbn"=>"1932-6203", "pmid"=>"23185351"}, "keywords"=>["Adult", "Antibodies, Monoclonal", "Antibodies, Monoclonal: chemistry", "CD4 Lymphocyte Count", "CD4-Positive T-Lymphocytes", "CD4-Positive T-Lymphocytes: cytology", "Cell Separation", "Cohort Studies", "Disease Progression", "Flow Cytometry", "HIV Antigens", "HIV Antigens: chemistry", "HIV Antigens: metabolism", "HIV-1", "HIV-1: metabolism", "Humans", "Male", "Middle Aged", "Real-Time Polymerase Chain Reaction", "Real-Time Polymerase Chain Reaction: methods", "Receptors, CCR5", "Receptors, CCR5: chemistry", "Receptors, CCR5: metabolism"], "id"=>"ba245d08-3cb0-3baa-a5d2-ddd8293ebdca", "abstract"=>"CD4+ central memory T cells play a critical role in the pathogenesis of simian immunodeficiency virus disease, and the CCR5 density on the surface of CD4 T cells is an important factor in human immunodeficiency virus (HIV)-1 disease progression. We hypothesized that quantifying central memory cells and CCR5 expression in the early stages of HIV-infection could provide useful prognostic information. We enrolled two different groups of acute HIV-infected subjects. One group progressed to CD4 T cell numbers below 250 cells/µl within 2 years (CD4 Low group), while the other group maintained CD4 cell counts above 450 cells/µl over 2 years (CD4 High group). We compared the CCR5 levels and percentage of CD4 subsets between the two groups during the 1st year of HIV infection. We found no differences between the two groups regarding the percentage of naïve, central memory and effector memory subsets of CD4 cells during the 1st year of HIV-1 infection. CCR5 levels on CD4+ CM subset was higher in the CD4 Low group compared with the CD4 High group during the 1st year of HIV-1 infection. High CCR5 levels on CD4 central memory cells in acute HIV infection are mostly associated with rapid disease progression. Our data suggest that low CCR5 expression on CD4 central memory cells protects CD4 cells from direct virus infection and favors the preservation of CD4(+) T cell homeostasis.", "link"=>"http://www.mendeley.com/research/high-ccr5-density-central-memory-cd4-t-cells-acute-hiv1-infection-mostly-associated-rapid-disease-pr", "reader_count"=>20, "reader_count_by_academic_status"=>{"Librarian"=>1, "Researcher"=>5, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>3, "Student > Master"=>3, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Librarian"=>1, "Researcher"=>5, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>3, "Student > Master"=>3, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Environmental Science"=>1, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>6, "Chemistry"=>1, "Immunology and Microbiology"=>2, "Decision Sciences"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Chemistry"=>{"Chemistry"=>1}, "Decision Sciences"=>{"Decision Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Argentina"=>1, "United States"=>1, "Denmark"=>1, "South Africa"=>1}, "group_count"=>3}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/538390"], "description"=>"<p>Initial CCR5 expression on CD4(A), naïve(B) and CM(C) were associated with the time taken for the study participants’ CD4 counts to fall below 250 cells/µl. There was no obvious association between initial CCR5 expression on EM with the time taken for the study participants’ CD4 counts to fall below 250 cells/µl.</p>", "links"=>[], "tags"=>["ccr5", "cd4", "subsets"], "article_id"=>208876, "categories"=>["Biotechnology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Xue Yang", "Yan-mei Jiao", "Rui Wang", "Yun-xia Ji", "Hong-wei Zhang", "Yong-Hong Zhang", "De-xi Chen", "Tong Zhang", "Hao Wu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049526.g004", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analysis_the_association_between_initial_CCR5_expression_on_CD4_subsets_and_the_time_for_CD4_lt_250_cells_ul_/208876", "title"=>"Analysis the association between initial CCR5 expression on CD4 subsets and the time for CD4<250 cells/ul.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 19:53:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/538019"], "description"=>"<p>(A)Based on the expression of CD45RA and CCR7, CD4 T cells were subdivided into naive(CD45RA+CCR7+), central memory(CM; CD45RA–CCR7+) and effect memory (EM; CD45RA–CCR7–) cell subsets. (B–C)Comparison of the percentage of CD4 subsets between the CD4 High and CD4 Low groups during the first year of HIV infection.</p>", "links"=>[], "tags"=>["cd4", "subsets"], "article_id"=>208500, "categories"=>["Biotechnology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Xue Yang", "Yan-mei Jiao", "Rui Wang", "Yun-xia Ji", "Hong-wei Zhang", "Yong-Hong Zhang", "De-xi Chen", "Tong Zhang", "Hao Wu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049526.g001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_the_percentage_of_CD4_subsets_between_the_CD4_High_and_CD4_Low_groups_/208500", "title"=>"Comparison of the percentage of CD4 subsets between the CD4 High and CD4 Low groups.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 19:51:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/538488"], "description"=>"<p>NA: not applicable; HC: healthy control; VL: viral load.</p>", "links"=>[], "tags"=>["subjects"], "article_id"=>208980, "categories"=>["Biotechnology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Xue Yang", "Yan-mei Jiao", "Rui Wang", "Yun-xia Ji", "Hong-wei Zhang", "Yong-Hong Zhang", "De-xi Chen", "Tong Zhang", "Hao Wu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049526.t001", "stats"=>{"downloads"=>6, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_subjects_in_this_study_/208980", "title"=>"Characteristics of subjects in this study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 19:53:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/538166"], "description"=>"<p>Comparison of the median fluorescence intensity (MFI) of CCR5 on CD4 subsets between the CD4 High and CD4 Low groups among estimated infection 30day(A), 30–90 day(B), 90–180day(C), 180–360day(D). **p<0.01, *p<0.05.</p>", "links"=>[], "tags"=>["median", "fluorescence", "ccr5", "cd4", "subsets"], "article_id"=>208654, "categories"=>["Biotechnology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Xue Yang", "Yan-mei Jiao", "Rui Wang", "Yun-xia Ji", "Hong-wei Zhang", "Yong-Hong Zhang", "De-xi Chen", "Tong Zhang", "Hao Wu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049526.g002", "stats"=>{"downloads"=>1, "page_views"=>157, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_the_median_fluorescence_intensity_MFI_of_CCR5_on_CD4_subsets_between_the_CD4_High_and_CD4_Low_groups_/208654", "title"=>"Comparison of the median fluorescence intensity (MFI) of CCR5 on CD4 subsets between the CD4 High and CD4 Low groups.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 19:52:10"}

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