Comprehensive Phenotype/Genotype Analyses of the Norepinephrine Transporter Gene (SLC6A2) in ADHD: Relation to Maternal Smoking during Pregnancy
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{"title"=>"Comprehensive Phenotype/Genotype Analyses of the Norepinephrine Transporter Gene (SLC6A2) in ADHD: Relation to Maternal Smoking during Pregnancy", "type"=>"journal", "authors"=>[{"first_name"=>"Geeta A.", "last_name"=>"Thakur", "scopus_author_id"=>"33568359700"}, {"first_name"=>"Sarojini M.", "last_name"=>"Sengupta", "scopus_author_id"=>"9235826500"}, {"first_name"=>"Natalie", "last_name"=>"Grizenko", "scopus_author_id"=>"6603793999"}, {"first_name"=>"Zia", "last_name"=>"Choudhry", "scopus_author_id"=>"55034506800"}, {"first_name"=>"Ridha", "last_name"=>"Joober", "scopus_author_id"=>"7003301677"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"366105340", "sgr"=>"84869855996", "issn"=>"19326203", "pmid"=>"23185385", "scopus"=>"2-s2.0-84869855996", "doi"=>"10.1371/journal.pone.0049616", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"216a12b7-6fa1-38b2-a7f7-2f1e1661d91d", "abstract"=>"OBJECTIVE: Despite strong pharmacological evidence implicating the norepinephrine transporter in ADHD, genetic studies have yielded largely insignificant results. We tested the association between 30 tag SNPs within the SLC6A2 gene and ADHD, with stratification based on maternal smoking during pregnancy, an environmental factor strongly associated with ADHD.\\n\\nMETHODS: Children (6-12 years old) diagnosed with ADHD according to DSM-IV criteria were comprehensively evaluated with regard to several behavioral and cognitive dimensions of ADHD as well as response to a fixed dose of methylphenidate (MPH) using a double-blind placebo controlled crossover trial. Family-based association tests (FBAT), including categorical and quantitative trait analyses, were conducted in 377 nuclear families.\\n\\nRESULTS: A highly significant association was observed with rs36021 (and linked SNPs) in the group where mothers smoked during pregnancy. Association was noted with categorical DSM-IV ADHD diagnosis (Z=3.74, P=0.0002), behavioral assessments by parents (CBCL, P=0.00008), as well as restless-impulsive subscale scores on Conners'-teachers (P=0.006) and parents (P=0.006). In this subgroup, significant association was also observed with cognitive deficits, more specifically sustained attention, spatial working memory, planning, and response inhibition. The risk allele was associated with significant improvement of behavior as measured by research staff (Z=3.28, P=0.001), parents (Z=2.62, P=0.009), as well as evaluation in the simulated academic environment (Z=3.58, P=0.0003).\\n\\nCONCLUSIONS: By using maternal smoking during pregnancy to index a putatively more homogeneous group of ADHD, highly significant associations were observed between tag SNPs within SLC6A2 and ADHD diagnosis, behavioral and cognitive measures relevant to ADHD and response to MPH. This comprehensive phenotype/genotype analysis may help to further understand this complex disorder and improve its treatment. Clinical trial registration information - Clinical and Pharmacogenetic Study of Attention Deficit with Hyperactivity Disorder (ADHD); www.clinicaltrials.gov; NCT00483106.", "link"=>"http://www.mendeley.com/research/comprehensive-phenotypegenotype-analyses-norepinephrine-transporter-gene-slc6a2-adhd-relation-matern", "reader_count"=>56, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Librarian"=>2, "Researcher"=>6, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>3, "Student > Master"=>11, "Other"=>4, "Student > Bachelor"=>8}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Librarian"=>2, "Researcher"=>6, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>3, "Student > Master"=>11, "Other"=>4, "Student > Bachelor"=>8}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>5, "Nursing and Health Professions"=>2, "Medicine and Dentistry"=>12, "Agricultural and Biological Sciences"=>6, "Neuroscience"=>2, "Arts and Humanities"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>23, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Neuroscience"=>{"Neuroscience"=>2}, "Psychology"=>{"Psychology"=>23}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Netherlands"=>1, "Sweden"=>1, "Brazil"=>1}, "group_count"=>8}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/539682"], "description"=>"<p>CGI = Clinical Global Impression, PBO = placebo, Conners’ P = Conners’ Parents, Conners’ T = Conners’ Teachers, RI = Restless-Impulsive, EL = Emotional Lability, RASS = Restricted Academic Situation Scale.</p><p>Three major haplotype blocks in <i>SLC6A2</i> are depicted above: Block 1 (rs1362621, rs2397771, rs168924, rs2242446, rs3785143, rs192303, rs41154); Block 2 (rs36017, rs10521329, rs3785155, rs5564, rs11568324, rs2279805, rs8047672, rs5569, rs998424, rs36009); and Block 3 (rs1800887, rs2242447, rs15534).</p><p>Significance (p) value ranges are depicted as follows: For OVER-TRANSMISSION of alleles = <b>+4</b> (≤0.00001), <b>+3</b> (0.0001–0.0009), <b>+2</b> (0.001–0.009), and <b>+1</b> (0.01–0.049).</p><p>For UNDER-TRANSMISSION of alleles = −<b>4</b> (≤0.00001), −<b>3</b> (0.0001–0.0009), −<b>2</b> (0.001–0.009) and −<b>1</b> (0.01–0.049).</p>", "links"=>[], "tags"=>["snps", "msdp"], "article_id"=>210176, "categories"=>["Medicine", "Cell Biology", "Mental Health", "Biotechnology", "Pharmacology", "Neuroscience", "Genetics"], "users"=>["Geeta A. Thakur", "Sarojini M. Sengupta", "Natalie Grizenko", "Zia Choudhry", "Ridha Joober"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049616.t006", "stats"=>{"downloads"=>5, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_SLC6A2_SNPs_and_treatment_response_in_the_MSDP_group_/210176", "title"=>"Association between <i>SLC6A2</i> SNPs and treatment response in the MSDP group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 20:00:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/539403"], "description"=>"<p>ADHD = Attention-Deficit/Hyperactivity Disorder, DISC = Diagnostic Interview Schedule for Children, ODD = Oppositional Defiant Disorder, CD = Conduct Disorder, CBCL = Child Behaviour Checklist, Conners’ P = Conners’ Parents, Conners’ T = Conners’ Teachers, RI = Restless-Impulsive, EL = Emotional Lability.</p><p>Three major haplotype blocks in <i>SLC6A2</i> are depicted above: Block 1 (rs1362621, rs2397771, rs168924, rs2242446, rs3785143, rs192303, rs41154); Block 2 (rs36017, rs10521329, rs3785155, rs5564, rs11568324, rs2279805, rs8047672, rs5569, rs998424, rs36009); and Block 3 (rs1800887, rs2242447, rs15534).</p><p>Significance (p) value ranges are depicted as follows: For OVER-TRANSMISSION of alleles = <b>+4</b> (≤0.00001), <b>+3</b> (0.0001–0.0009), <b>+2</b> (0.001–0.009), and <b>+1</b> (0.01–0.049).</p><p>For UNDER-TRANSMISSION of alleles = −<b>4</b> (≤0.00001), −<b>3</b> (0.0001–0.0009), −<b>2</b> (0.001–0.009) and −<b>1</b> (0.01–0.049).</p>", "links"=>[], "tags"=>["snps", "adhd", "behavioural", "dimensions", "mothers", "did"], "article_id"=>209889, "categories"=>["Medicine", "Cell Biology", "Mental Health", "Biotechnology", "Pharmacology", "Neuroscience", "Genetics"], "users"=>["Geeta A. Thakur", "Sarojini M. Sengupta", "Natalie Grizenko", "Zia Choudhry", "Ridha Joober"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049616.t008", "stats"=>{"downloads"=>1, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_SLC6A2_SNPs_and_ADHD_behavioural_dimensions_in_the_sample_where_mothers_did_not_smoke_during_pregnancy_/209889", "title"=>"Association between <i>SLC6A2</i> SNPs and ADHD behavioural dimensions in the sample where mothers did not smoke during pregnancy.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 19:58:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/539714"], "description"=>"<p>Five SNPs towards the 5′end of <i>SLC6A2</i> (rs41154, rs187714, rs4783899, rs2397771, rs192303) are in strong linkage disequilibrium (LD) with rs36021. LD = linkage disequilibrium</p>", "links"=>[], "tags"=>["disequilibrium"], "article_id"=>210210, "categories"=>["Medicine", "Cell Biology", "Mental Health", "Biotechnology", "Pharmacology", "Neuroscience", "Genetics"], "users"=>["Geeta A. Thakur", "Sarojini M. Sengupta", "Natalie Grizenko", "Zia Choudhry", "Ridha Joober"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049616.t007", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Linkage_disequilibrium_between_SLC6A2_markers_/210210", "title"=>"Linkage disequilibrium between <i>SLC6A2</i> markers.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 20:00:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/539438"], "description"=>"<p>WISC = Wechsler Intelligence Scale, SOPT = Self-Ordered Pointing Task, FW = Finger Windows, CPT = Continuous Performance Test, SE = standard error, RT = reaction time, ISI = inter-stimulus interval, WCST = Wisconsin Card Sorting Test, TOL = Tower of London.</p><p>Standard scores were used for all WCST and TOL measures, and T-scores were used for CPT measures (excl. overall index).</p><p>Three major haplotype blocks in <i>SLC6A2</i> are depicted above: Block 1 (rs1362621, rs2397771, rs168924, rs2242446, rs3785143, rs192303, rs41154); Block 2 (rs36017, rs10521329, rs3785155, rs5564, rs11568324, rs2279805, rs8047672, rs5569, rs998424, rs36009); and Block 3 (rs1800887, rs2242447, rs15534).</p><p>Significance (p) value ranges are depicted as follows: For OVER-TRANSMISSION of alleles = <b>+4</b> (≤0.00001), <b>+3</b> (0.0001–0.0009), <b>+2</b> (0.001–0.009), and <b>+1</b> (0.01–0.049).</p><p>For UNDER-TRANSMISSION of alleles = −<b>4</b> (≤0.00001), −<b>3</b> (0.0001–0.0009), −<b>2</b> (0.001–0.009) and −<b>1</b> (0.01–0.049).</p>", "links"=>[], "tags"=>["snps", "adhd", "dimensions", "mothers", "did"], "article_id"=>209928, "categories"=>["Medicine", "Cell Biology", "Mental Health", "Biotechnology", "Pharmacology", "Neuroscience", "Genetics"], "users"=>["Geeta A. Thakur", "Sarojini M. Sengupta", "Natalie Grizenko", "Zia Choudhry", "Ridha Joober"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049616.t009", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_SLC6A2_SNPs_and_ADHD_cognitive_dimensions_in_the_sample_where_mothers_did_not_smoke_during_pregnancy_/209928", "title"=>"Association between <i>SLC6A2</i> SNPs and ADHD cognitive dimensions in the sample where mothers did not smoke during pregnancy.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 19:59:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/539476"], "description"=>"<p>CGI = Clinical Global Impression, PBO = placebo, Conners’ P = Conners’ Parents, Conners’ T = Conners’ Teachers, RI = Restless-Impulsive, EL = Emotional Lability, RASS = Restricted Academic Situation Scale.</p><p>Three major haplotype blocks in <i>SLC6A2</i> are depicted above: Block 1 (rs1362621, rs2397771, rs168924, rs2242446, rs3785143, rs192303, rs41154); Block 2 (rs36017, rs10521329, rs3785155, rs5564, rs11568324, rs2279805, rs8047672, rs5569, rs998424, rs36009); and Block 3 (rs1800887, rs2242447, rs15534).</p><p>Significance (p) value ranges are depicted as follows: For OVER-TRANSMISSION of alleles = <b>+4</b> (≤0.00001), <b>+3</b> (0.0001–0.0009), <b>+2</b> (0.001–0.009), and <b>+1</b> (0.01–0.049).</p><p>For UNDER-TRANSMISSION of alleles = −<b>4</b> (≤0.00001), −<b>3</b> (0.0001–0.0009), −<b>2</b> (0.001–0.009) and −<b>1</b> (0.01–0.049).</p>", "links"=>[], "tags"=>["snps", "mothers", "did"], "article_id"=>209970, "categories"=>["Medicine", "Cell Biology", "Mental Health", "Biotechnology", "Pharmacology", "Neuroscience", "Genetics"], "users"=>["Geeta A. Thakur", "Sarojini M. Sengupta", "Natalie Grizenko", "Zia Choudhry", "Ridha Joober"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049616.t010", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_SLC6A2_SNPs_and_treatment_response_in_the_sample_where_mothers_did_not_smoke_during_pregnancy_/209970", "title"=>"Association between <i>SLC6A2</i> SNPs and treatment response in the sample where mothers did not smoke during pregnancy.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 19:59:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/539513"], "description"=>"<p>ADHD = Attention-Deficit/Hyperactivity Disorder, DISC = Diagnostic Interview Schedule for Children, ODD = Oppositional Defiant Disorder, CD = Conduct Disorder, CBCL = Child Behaviour Checklist, Conners’ P = Conners’ Parents, Conners’ T = Conners’ Teachers, RI = Restless-Impulsive, EL = Emotional Lability.</p><p>Three major haplotype blocks in <i>SLC6A2</i> are depicted above: Block 1 (rs1362621, rs2397771, rs168924, rs2242446, rs3785143, rs192303, rs41154); Block 2 (rs36017, rs10521329, rs3785155, rs5564, rs11568324, rs2279805, rs8047672, rs5569, rs998424, rs36009); and Block 3 (rs1800887, rs2242447, rs15534).</p><p>Significance (p) value ranges are depicted as follows: For OVER-TRANSMISSION of alleles = <b>+4</b> (≤0.00001), <b>+3</b> (0.0001–0.0009), <b>+2</b> (0.001–0.009), and <b>+1</b> (0.01–0.049).</p><p>For UNDER-TRANSMISSION of alleles = −<b>4</b> (≤0.00001), −<b>3</b> (0.0001–0.0009), −<b>2</b> (0.001–0.009) and −<b>1</b> (0.01–0.049).</p>", "links"=>[], "tags"=>["snps", "adhd", "behavioural", "dimensions"], "article_id"=>210006, "categories"=>["Medicine", "Cell Biology", "Mental Health", "Biotechnology", "Pharmacology", "Neuroscience", "Genetics"], "users"=>["Geeta A. Thakur", "Sarojini M. Sengupta", "Natalie Grizenko", "Zia Choudhry", "Ridha Joober"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049616.t001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_SLC6A2_SNPs_and_ADHD_behavioural_dimensions_in_the_total_sample_/210006", "title"=>"Association between <i>SLC6A2</i> SNPs and ADHD behavioural dimensions in the total sample.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 19:59:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/539549"], "description"=>"<p>WISC = Wechsler Intelligence Scale, SOPT = Self-Ordered Pointing Task, FW = Finger Windows, CPT = Continuous Performance Test, SE = standard error, RT = reaction time, ISI = inter-stimulus interval, WCST = Wisconsin Card Sorting Test, TOL = Tower of London.</p><p>Standard scores were used for all WCST and TOL measures, and T-scores were used for CPT measures (excl. overall index).</p><p>Three major haplotype blocks in <i>SLC6A2</i> are depicted above: Block 1 (rs1362621, rs2397771, rs168924, rs2242446, rs3785143, rs192303, rs41154); Block 2 (rs36017, rs10521329, rs3785155, rs5564, rs11568324, rs2279805, rs8047672, rs5569, rs998424, rs36009); and Block 3 (rs1800887, rs2242447, rs15534).</p><p>Significance (p) value ranges are depicted as follows: For OVER-TRANSMISSION of alleles = <b>+4</b> (≤0.00001), <b>+3</b> (0.0001–0.0009), <b>+2</b> (0.001–0.009), and <b>+1</b> (0.01–0.049).</p><p>For UNDER-TRANSMISSION of alleles = −<b>4</b> (≤0.00001), −<b>3</b> (0.0001–0.0009), −<b>2</b> (0.001–0.009) and −<b>1</b> (0.01–0.049).</p>", "links"=>[], "tags"=>["snps", "adhd", "dimensions"], "article_id"=>210039, "categories"=>["Medicine", "Cell Biology", "Mental Health", "Biotechnology", "Pharmacology", "Neuroscience", "Genetics"], "users"=>["Geeta A. Thakur", "Sarojini M. Sengupta", "Natalie Grizenko", "Zia Choudhry", "Ridha Joober"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049616.t002", "stats"=>{"downloads"=>2, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_SLC6A2_SNPs_and_ADHD_cognitive_dimensions_in_the_total_sample_/210039", "title"=>"Association between <i>SLC6A2</i> SNPs and ADHD cognitive dimensions in the total sample.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 19:59:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/539580"], "description"=>"<p>CGI = Clinical Global Impression, PBO = placebo, Conners’ P = Conners’ Parents, Conners’ T = Conners’ Teachers, RI = Restless-Impulsive, EL = Emotional Lability, RASS = Restricted Academic Situation Scale.</p><p>Three major haplotype blocks in <i>SLC6A2</i> are depicted above: Block 1 (rs1362621, rs2397771, rs168924, rs2242446, rs3785143, rs192303, rs41154); Block 2 (rs36017, rs10521329, rs3785155, rs5564, rs11568324, rs2279805, rs8047672, rs5569, rs998424, rs36009); and Block 3 (rs1800887, rs2242447, rs15534).</p><p>Significance (p) value ranges are depicted as follows: For OVER-TRANSMISSION of alleles = <b>+4</b> (≤0.00001), <b>+3</b> (0.0001–0.0009), <b>+2</b> (0.001–0.009), and <b>+1</b> (0.01–0.049).</p><p>For UNDER-TRANSMISSION of alleles = −<b>4</b> (≤0.00001), −<b>3</b> (0.0001–0.0009), −<b>2</b> (0.001–0.009) and −<b>1</b> (0.01–0.049).</p>", "links"=>[], "tags"=>["snps"], "article_id"=>210072, "categories"=>["Medicine", "Cell Biology", "Mental Health", "Biotechnology", "Pharmacology", "Neuroscience", "Genetics"], "users"=>["Geeta A. Thakur", "Sarojini M. Sengupta", "Natalie Grizenko", "Zia Choudhry", "Ridha Joober"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049616.t003", "stats"=>{"downloads"=>0, "page_views"=>35, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_SLC6A2_SNPs_and_treatment_response_in_the_total_sample_/210072", "title"=>"Association between <i>SLC6A2</i> SNPs and treatment response in the total sample.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 19:59:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/539620"], "description"=>"<p>ADHD = Attention-Deficit/Hyperactivity Disorder, DISC = Diagnostic Interview Schedule for Children, ODD = Oppositional Defiant Disorder, CD = Conduct Disorder, CBCL = Child Behaviour Checklist, Conners’ P = Conners’ Parents, Conners’ T = Conners’ Teachers, RI = Restless-Impulsive, EL = Emotional Lability.</p><p>Three major haplotype blocks in <i>SLC6A2</i> are depicted above: Block 1 (rs1362621, rs2397771, rs168924, rs2242446, rs3785143, rs192303, rs41154); Block 2 (rs36017, rs10521329, rs3785155, rs5564, rs11568324, rs2279805, rs8047672, rs5569, rs998424, rs36009); and Block 3 (rs1800887, rs2242447, rs15534).</p><p>Significance (p) value ranges are depicted as follows: For OVER-TRANSMISSION of alleles = <b>+4</b> (≤0.00001), <b>+3</b> (0.0001–0.0009), <b>+2</b> (0.001–0.009), and <b>+1</b> (0.01–0.049).</p><p>For UNDER-TRANSMISSION of alleles = −<b>4</b> (≤0.00001), −<b>3</b> (0.0001–0.0009), −<b>2</b> (0.001–0.009) and −<b>1</b> (0.01–0.049).</p>", "links"=>[], "tags"=>["snps", "adhd", "behavioural", "dimensions", "mothers", "smoked"], "article_id"=>210106, "categories"=>["Medicine", "Cell Biology", "Mental Health", "Biotechnology", "Pharmacology", "Neuroscience", "Genetics"], "users"=>["Geeta A. Thakur", "Sarojini M. Sengupta", "Natalie Grizenko", "Zia Choudhry", "Ridha Joober"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049616.t004", "stats"=>{"downloads"=>4, "page_views"=>85, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_SLC6A2_SNPs_and_ADHD_behavioural_dimensions_in_the_group_where_mothers_smoked_during_pregnancy_MSDP_/210106", "title"=>"Association between <i>SLC6A2</i> SNPs and ADHD behavioural dimensions in the group where mothers smoked during pregnancy (MSDP).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 20:00:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/539652"], "description"=>"<p>WISC = Wechsler Intelligence Scale, SOPT = Self-Ordered Pointing Task, FW = Finger Windows, CPT = Continuous Performance Test, SE = standard error, RT = reaction time, ISI = inter-stimulus interval, WCST = Wisconsin Card Sorting Test, TOL = Tower of London.</p><p>Standard scores were used for all WCST and TOL measures, and T-scores were used for CPT measures (excl. overall index).</p><p>Three major haplotype blocks in <i>SLC6A2</i> are depicted above: Block 1 (rs1362621, rs2397771, rs168924, rs2242446, rs3785143, rs192303, rs41154); Block 2 (rs36017, rs10521329, rs3785155, rs5564, rs11568324, rs2279805, rs8047672, rs5569, rs998424, rs36009); and Block 3 (rs1800887, rs2242447, rs15534).</p><p>Significance (p) value ranges are depicted as follows: For OVER-TRANSMISSION of alleles = <b>+4</b> (≤0.00001), <b>+3</b> (0.0001–0.0009), <b>+2</b> (0.001–0.009), and <b>+1</b> (0.01–0.049).</p><p>For UNDER-TRANSMISSION of alleles = −<b>4</b> (≤0.00001), −<b>3</b> (0.0001–0.0009), −<b>2</b> (0.001–0.009) and −<b>1</b> (0.01–0.049).</p>", "links"=>[], "tags"=>["snps", "adhd", "dimensions", "msdp"], "article_id"=>210143, "categories"=>["Medicine", "Cell Biology", "Mental Health", "Biotechnology", "Pharmacology", "Neuroscience", "Genetics"], "users"=>["Geeta A. Thakur", "Sarojini M. Sengupta", "Natalie Grizenko", "Zia Choudhry", "Ridha Joober"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049616.t005", "stats"=>{"downloads"=>1, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_SLC6A2_SNPs_and_ADHD_cognitive_dimensions_in_the_MSDP_group_/210143", "title"=>"Association between <i>SLC6A2</i> SNPs and ADHD cognitive dimensions in the MSDP group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 20:00:16"}

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