Activated Human T Cells Secrete Exosomes That Participate in IL-2 Mediated Immune Response Signaling
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{"title"=>"Activated Human T Cells Secrete Exosomes That Participate in IL-2 Mediated Immune Response Signaling", "type"=>"journal", "authors"=>[{"first_name"=>"Jessica", "last_name"=>"Wahlgren", "scopus_author_id"=>"55371499100"}, {"first_name"=>"Tanya De L", "last_name"=>"Karlson", "scopus_author_id"=>"55371636200"}, {"first_name"=>"Pernilla", "last_name"=>"Glader", "scopus_author_id"=>"8725061000"}, {"first_name"=>"Esbjörn", "last_name"=>"Telemo", "scopus_author_id"=>"7004164223"}, {"first_name"=>"Hadi", "last_name"=>"Valadi", "scopus_author_id"=>"6507545281"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84869224916", "sgr"=>"84869224916", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0049723", "pmid"=>"23166755", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"366057756"}, "id"=>"87d5b7b0-2a54-3201-80e2-12d0b1018c9c", "abstract"=>"It has previously been shown that nano-meter sized vesicles (30-100 nm), exosomes, secreted by antigen presenting cells can induce T cell responses thus showing the potential of exosomes to be used as immunological tools. Additionally, activated CD3⁺ T cells can secrete exosomes that have the ability to modulate different immunological responses. Here, we investigated what effects exosomes originating from activated CD3⁺ T cells have on resting CD3⁺ T cells by studying T cell proliferation, cytokine production and by performing T cell and exosome phenotype characterization. Human exosomes were generated in vitro following CD3⁺ T cell stimulation with anti-CD28, anti-CD3 and IL-2. Our results show that exosomes purified from stimulated CD3⁺ T cells together with IL-2 were able to generate proliferation in autologous resting CD3⁺ T cells. The CD3⁺ T cells stimulated with exosomes together with IL-2 had a higher proportion of CD8⁺ T cells and had a different cytokine profile compared to controls. These results indicate that activated CD3⁺ T cells communicate with resting autologous T cells via exosomes.", "link"=>"http://www.mendeley.com/research/activated-human-t-cells-secrete-exosomes-participate-il2-mediated-immune-response-signaling-3", "reader_count"=>59, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>19, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>1, "Student > Master"=>9, "Other"=>1, "Student > Bachelor"=>4, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>19, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>1, "Student > Master"=>9, "Other"=>1, "Student > Bachelor"=>4, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>3, "Biochemistry, Genetics and Molecular Biology"=>11, "Agricultural and Biological Sciences"=>28, "Medicine and Dentistry"=>6, "Physics and Astronomy"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>6}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Chemistry"=>{"Chemistry"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>28}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>11}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Netherlands"=>1, "United States"=>1, "Brazil"=>1, "Portugal"=>1}, "group_count"=>3}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/540937"], "description"=>"<p>Fold changes in the production of cytokines, chemokines and other proteins after five days. T cells stimulated with IL-2 or exosomes had different expression of cytokines and chemokines. Samples stimulated with “exosomes+IL-2″ generated secretion of more cytokines and chemokines compared to samples stimulated with either IL-2 or exosomes alone. A significant decrease could be noticed for CCL5 in cultures stimulated with exosomes only.</p>", "links"=>[], "tags"=>["cytokines", "chemokines", "supernatant", "cells", "pulsed", "exosomes"], "article_id"=>211427, "categories"=>["Cell Biology", "Immunology"], "users"=>["Jessica Wahlgren", "Tanya De L. Karlson", "Pernilla Glader", "Esbjörn Telemo", "Hadi Valadi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049723.g004", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_comparison_of_cytokines_and_chemokines_present_in_the_supernatant_of_CD3_T_cells_pulsed_with_IL_2_exosomes_or_IL_2_exosomes_/211427", "title"=>"A comparison of cytokines and chemokines present in the supernatant of CD3<sup>+</sup> T cells pulsed with IL-2, exosomes or IL-2+exosomes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:07:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/541177"], "description"=>"<p>Relative quantification of spot intensities was performed using Quantity One software (Bio-Rad). Each bar represents an average of the intensity from two protein spots. White bars represent 0 h and grey bars represent 120 h (day 5). The cytokines IL-5, IL-13 and GM-CSF as well as the chemokines CCL3 and CCL4 were present at higher levels at day five.</p>", "links"=>[], "tags"=>["stimulated", "cells", "zero"], "article_id"=>211668, "categories"=>["Cell Biology", "Immunology"], "users"=>["Jessica Wahlgren", "Tanya De L. Karlson", "Pernilla Glader", "Esbjörn Telemo", "Hadi Valadi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049723.g006", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cytokine_production_from_exosome_IL_2_stimulated_CD3_T_cells_at_day_zero_0_h_and_day_five_120_h_/211668", "title"=>"Cytokine production from exosome+IL-2 stimulated CD3<sup>+</sup> T cells at day zero (0 h) and day five (120 h).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:08:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/540866"], "description"=>"<p>Relative quantification of spot intensities was performed using Quantity One software (Bio-Rad). Each bar represents an average of the intensity from two protein spots. White bars represent 0 h and grey bars represent 120 h (day 5). The exosomes appeared to contain significant amounts of CCL5 (RANTES) immediately after the addition of exosomes (at 0 h) since the supernatants showed relatively large amounts of RANTES. These levels were decreased at day five.</p>", "links"=>[], "tags"=>["autologous", "exosome", "stimulated", "cells", "zero"], "article_id"=>211357, "categories"=>["Cell Biology", "Immunology"], "users"=>["Jessica Wahlgren", "Tanya De L. Karlson", "Pernilla Glader", "Esbjörn Telemo", "Hadi Valadi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049723.g003", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cytokine_production_from_autologous_exosome_stimulated_CD3_T_cells_at_day_zero_0_h_and_day_five_120_h_/211357", "title"=>"Cytokine production from autologous exosome stimulated CD3<sup>+</sup> T cells at day zero (0 h) and day five (120 h).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:06:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/541322"], "description"=>"<p>Fold changes (increase/decrease) in production of <b>cytokines</b> after 5 days in CD3<sup>+</sup> T cells incubated with IL-2, Exosomes, or IL-2+Exosomes.</p>", "links"=>[], "tags"=>["cytokine"], "article_id"=>211819, "categories"=>["Cell Biology", "Immunology"], "users"=>["Jessica Wahlgren", "Tanya De L. Karlson", "Pernilla Glader", "Esbjörn Telemo", "Hadi Valadi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049723.t001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Human_cytokine_array_Cytokines_/211819", "title"=>"Human cytokine array (Cytokines).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 20:09:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/540712"], "description"=>"<p>(A) Particle sizes in ultracentrifuge pellet consistent with size range of exosomes. Average exosome size was 54 nm. Measured with dynamic light scattering (B) Exosomes bound to latex beads and stained with antibodies against exosome associated proteins (CD9, CD63 andCD81) and T cell associated proteins (CD3, CD4, CD25, CD40, CD80, CD86, MHC-I, MHC-II and ICAM-1) measured with flow cytometry. Dotted line represents isotype control.</p>", "links"=>[], "tags"=>["exosomes", "cells", "stimulated", "anti-cd3"], "article_id"=>211196, "categories"=>["Cell Biology", "Immunology"], "users"=>["Jessica Wahlgren", "Tanya De L. Karlson", "Pernilla Glader", "Esbjörn Telemo", "Hadi Valadi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049723.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characterization_of_exosomes_from_CD3_T_cells_stimulated_with_IL_2_anti_CD3_and_anti_CD28_/211196", "title"=>"Characterization of exosomes from CD3<sup>+</sup> T cells stimulated with IL-2, anti-CD3 and anti-CD28.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:05:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/541085"], "description"=>"<p>Relative quantification of spot intensities was performed using Quantity One software (Bio-Rad). Each bar represents an average of the intensity from two protein spots. White bars represent 0 h and grey bars represent 120 h (day 5). Cytokines IL-5, MIF, and GM-CSF (CSF2) were present at a high level in the supernatant after five days.</p>", "links"=>[], "tags"=>["il-2", "stimulated", "cells", "zero"], "article_id"=>211577, "categories"=>["Cell Biology", "Immunology"], "users"=>["Jessica Wahlgren", "Tanya De L. Karlson", "Pernilla Glader", "Esbjörn Telemo", "Hadi Valadi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049723.g005", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cytokine_production_from_IL_2_stimulated_CD3_T_cells_at_day_zero_0_h_and_day_five_120_h_/211577", "title"=>"Cytokine production from IL-2 stimulated CD3<sup>+</sup> T cells at day zero (0 h) and day five (120 h).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:08:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/541269"], "description"=>"<p>Fold changes (increase/decrease) in production of other proteins after 5 days in CD3<sup>+</sup> T cells incubated with IL-2, Exosomes, or IL-2+Exosomes.</p>", "links"=>[], "tags"=>["cytokine"], "article_id"=>211763, "categories"=>["Cell Biology", "Immunology"], "users"=>["Jessica Wahlgren", "Tanya De L. Karlson", "Pernilla Glader", "Esbjörn Telemo", "Hadi Valadi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049723.t003", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Human_cytokine_array_Other_proteins_/211763", "title"=>"Human cytokine array (Other proteins).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 20:09:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/540790"], "description"=>"<p>(A) Number of CD3<sup>+</sup> T cells measured with automatic cell counting (Sysmex) at different time points. Cells stimulated with IL-2+exosomes are increasing in numbers. (B) Proliferation of CD3<sup>+</sup> T cells measured with MTT assay at day five. Cells stimulated with IL-2+exosomes showed increased proliferation. (C) Distribution of CD4<sup>+</sup> and CD8<sup>+</sup> cells in CD3<sup>+</sup> T cells stimulated with IL-2, autologous exosomes or IL-2+exosomes measures with flow cytometry.</p>", "links"=>[], "tags"=>["cells", "pulsed", "autologous"], "article_id"=>211282, "categories"=>["Cell Biology", "Immunology"], "users"=>["Jessica Wahlgren", "Tanya De L. Karlson", "Pernilla Glader", "Esbjörn Telemo", "Hadi Valadi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049723.g002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Proliferation_of_CD3_T_cells_pulsed_with_autologous_exosomes_/211282", "title"=>"Proliferation of CD3<sup>+</sup> T cells pulsed with autologous exosomes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:06:25"}

PMC Usage Stats | Further Information

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Relative Metric

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