Drug-Eluting Fibers for HIV-1 Inhibition and Contraception
Publication Date
November 28, 2012
Journal
PLOS ONE
Authors
Cameron Ball, Emily Krogstad, Thanyanan Chaowanachan & Kim A. Woodrow
Volume
7
Issue
11
Pages
e49792
DOI
https://dx.plos.org/10.1371/journal.pone.0049792
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0049792
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23209601
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509119
Europe PMC
http://europepmc.org/abstract/MED/23209601
Web of Science
000312601700019
Scopus
84870318366
Mendeley
http://www.mendeley.com/research/drugeluting-fibers-hiv1-inhibition-contraception
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{"title"=>"Drug-Eluting Fibers for HIV-1 Inhibition and Contraception", "type"=>"journal", "authors"=>[{"first_name"=>"Cameron", "last_name"=>"Ball", "scopus_author_id"=>"55095013600"}, {"first_name"=>"Emily", "last_name"=>"Krogstad", "scopus_author_id"=>"36523216500"}, {"first_name"=>"Thanyanan", "last_name"=>"Chaowanachan", "scopus_author_id"=>"6602608548"}, {"first_name"=>"Kim A.", "last_name"=>"Woodrow", "scopus_author_id"=>"36974291400"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"366164748", "doi"=>"10.1371/journal.pone.0049792", "sgr"=>"84870318366", "scopus"=>"2-s2.0-84870318366", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"23209601"}, "id"=>"e8029ba4-74b1-3507-b914-76e18dd2e026", "abstract"=>"Multipurpose prevention technologies (MPTs) that simultaneously prevent sexually transmitted infections (STIs) and unintended pregnancy are a global health priority. Combining chemical and physical barriers offers the greatest potential to design effective MPTs, but integrating both functional modalities into a single device has been challenging. Here we show that drug-eluting fiber meshes designed for topical drug delivery can function as a combination chemical and physical barrier MPT. Using FDA-approved polymers, we fabricated nanofiber meshes with tunable fiber size and controlled degradation kinetics that facilitate simultaneous release of multiple agents against HIV-1, HSV-2, and sperm. We observed that drug-loaded meshes inhibited HIV-1 infection in vitro and physically obstructed sperm penetration. Furthermore, we report on a previously unknown activity of glycerol monolaurate (GML) to potently inhibit sperm motility and viability. The application of drug-eluting nanofibers for HIV-1 prevention and sperm inhibition may serve as an innovative platform technology for drug delivery to the lower female reproductive tract.", "link"=>"http://www.mendeley.com/research/drugeluting-fibers-hiv1-inhibition-contraception", "reader_count"=>50, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>4, "Student > Master"=>9, "Other"=>1, "Student > Bachelor"=>7, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>15, "Student > Postgraduate"=>4, "Student > Master"=>9, "Other"=>1, "Student > Bachelor"=>7, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Agricultural and Biological Sciences"=>7, "Business, Management and Accounting"=>1, "Chemical Engineering"=>2, "Chemistry"=>6, "Earth and Planetary Sciences"=>1, "Engineering"=>10, "Nursing and Health Professions"=>1, "Materials Science"=>7, "Medicine and Dentistry"=>5, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Physics and Astronomy"=>2, "Psychology"=>1, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>7}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Social Sciences"=>{"Social Sciences"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Chemical Engineering"=>{"Chemical Engineering"=>2}, "Engineering"=>{"Engineering"=>10}, "Chemistry"=>{"Chemistry"=>6}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Ireland"=>1, "France"=>2, "Portugal"=>1}, "group_count"=>3}

CrossRef

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/535609"], "description"=>"<p>(<b>a</b>) Cumulative drug release in VFS was measured for 30∶70 PLLA/PEO (blue) and 70∶30 PLLA/PEO (red). AZT (dashed line) and MVC (solid line) showed rapid burst release from blended fibers within 1 h. (<b>b</b>) Varying fiber diameter resulted in MVC burst release from PCL fibers (black) and 70∶30 PLLA/PEO fibers (red). PCL meshes with two fiber diameters ( •  = 370 nm and <sup>⊥</sup>  = 1.3 μm) and 70∶30 PLLA/PEO fibers with three fiber diameters ( •  = 560 nm, ○  = 1.5 μm, <sup>⊥</sup>  = 3.4 μm) were tested. (<b>c</b>) Sustained release of MVC is achieved from PDLLA/PLLA blends and from 99∶1 PLLA/PEO, but not from PLLA fibers. 50∶50 PDLLA/PLLA (□), 25∶75 PDLLA/PLLA (▪), 99∶1 PLLA/PEO (•), and 100% PLLA (<sup>⊥</sup>). (<b>d</b>) Insertion of fibers into mouse vagina and subsequent fluorescent imaging reveal release of dye within 30 minutes for ICG-loaded fibers (right) compared with blank fibers (left). Fiber meshes are shown next to excised reproductive tracts.</p>", "links"=>[], "tags"=>["antiretroviral"], "article_id"=>206110, "categories"=>["Biotechnology", "Chemistry", "Infectious Diseases", "Pharmacology"], "users"=>["Cameron Ball", "Emily Krogstad", "Thanyanan Chaowanachan", "Kim A. Woodrow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049792.g003", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fibers_release_active_antiretroviral_agents_/206110", "title"=>"Fibers release active antiretroviral agents.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-28 01:41:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/535766"], "description"=>"<p>(<b>a</b>) Motility of human swim-out sperm was completely inhibited within 5 min for 0.05 and 0.5% GML. Data show counts of motile and immotile sperm at 2 min (gray line) and 5 min (black line). Baseline sperm motility (∼89%) was measured at the beginning and end of experiment using a PBS control (dotted line). (<b>b</b>) Sperm viability is reduced in whole semen incubated with GML compared with media control. (<b>c</b>) GML release from fiber meshes was qualitatively measured using TLC. (<b>d, e</b>) A transwell assay was used to test the physical barrier properties of the fiber meshes by replacing Millicell cell culture insert membranes (3 μm pore diameter) with a blank fiber mesh (n = 3). (<b>f, g</b>) SEM micrographs of the upper (<b>f</b>) and lower (<b>g</b>) side of Millicell control membrane. (<b>h, i</b>) SEM micrographs of upper (<b>h</b>) and lower side (<b>i</b>) of fiber mesh show that no sperm penetrate through the fiber mesh.</p>", "links"=>[], "tags"=>["meshes"], "article_id"=>206269, "categories"=>["Biotechnology", "Chemistry", "Infectious Diseases", "Pharmacology"], "users"=>["Cameron Ball", "Emily Krogstad", "Thanyanan Chaowanachan", "Kim A. Woodrow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049792.g005", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fiber_meshes_are_a_physical_and_chemical_barrier_against_sperm_/206269", "title"=>"Fiber meshes are a physical and chemical barrier against sperm.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-28 01:44:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/535699"], "description"=>"<p>(<b>a</b>) Dose-response assay indicates that AZT and MVC released from fibers have similar potency to unformulated drugs (drug eluates, black and unformulated drug, gray). (<b>b</b>) Drug loaded fiber blends (30∶70 PLLA/PEO (blue) and 70∶30 PLLA/PEO (red)), but not blank fiber controls, show equivalent inhibition of HIV infection. (<b>c</b>) Histology indicates that 30∶70 PLLA/PEO, 70∶30 PLLA/PEO, and 30∶70 PLLA/PEO fibers with 10% (wt/wt) GML are nontoxic to macaque cervical tissue explants compared to nonoxynol-9 control. (<b>d</b>) MTT assay confirms fibers, including those containing 10% (wt/wt) GML, are nontoxic to tissue explants. Note that for media controls n = 4, and for all other groups n = 1.</p>", "links"=>[], "tags"=>["meshes", "inhibit", "hiv", "nontoxic", "macaque", "cervical"], "article_id"=>206191, "categories"=>["Biotechnology", "Chemistry", "Infectious Diseases", "Pharmacology"], "users"=>["Cameron Ball", "Emily Krogstad", "Thanyanan Chaowanachan", "Kim A. Woodrow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049792.g004", "stats"=>{"downloads"=>3, "page_views"=>31, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fiber_meshes_inhibit_HIV_in_vitro_and_are_nontoxic_to_macaque_cervical_tissue_explants_/206191", "title"=>"Fiber meshes inhibit HIV <i>in vitro</i> and are nontoxic to macaque cervical tissue explants.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-28 01:43:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/535546"], "description"=>"<p>(<b>a</b>) SEM micrographs show that fiber and mesh morphology changes markedly over 15 d in VFS. (<b>b</b>) Mass loss of fibers over time is controlled by PEO content in fibers. (<b>c</b>) Fiber diameters, displayed as geometric mean with 95% confidence interval, and decrease significantly over three days of degradation in VFS (p<0.0001 for 30∶70 and 70∶30 PLLA/PEO fibers). 30∶70 PLLA/PEO (blue) and 70∶30 PLLA/PEO (red) for (<b>b</b>) and (<b>c</b>).</p>", "links"=>[], "tags"=>["influences", "degradation"], "article_id"=>206040, "categories"=>["Biotechnology", "Chemistry", "Infectious Diseases", "Pharmacology"], "users"=>["Cameron Ball", "Emily Krogstad", "Thanyanan Chaowanachan", "Kim A. Woodrow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049792.g002", "stats"=>{"downloads"=>1, "page_views"=>41, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fiber_composition_influences_degradation_properties_/206040", "title"=>"Fiber composition influences degradation properties.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-28 01:40:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/535421"], "description"=>"<p>(<b>a</b>) Two-axis mandrel electrospinning rig for fiber collection. (<b>b</b>) Controlled fiber deposition along a grounded aluminum collector produces a geometry that may be suitable for vaginal drug delivery. (<b>c</b>) Mesh abstracted from mandrel has a hollow interior. (<b>d</b>) Fiber meshes have porous microstructure. (<b>e</b>) Combining fiber meshes produces a multifunctional material. (<b>f</b>) Diverse agents with action against HIV, HSV-2, or sperm are incorporated into blends of PLLA and PEO. PLLA/PEO (30∶70, blue) and PLLA/PEO (70∶30, red); AZT  = 1 wt% 3′-azido-3′-deoxythymidine, MVC  = 1 wt% maraviroc, ACV  = 1 wt% acycloguanosine, GML  = 10 wt% glycerol monolaurate, MBCD  = 10 wt% methyl-β-cyclodextrin, Fe/Asc  = 10 wt% iron (II) D-gluconate with 10 wt% ascorbic acid.</p>", "links"=>[], "tags"=>["fibers", "drugs", "multipurpose"], "article_id"=>205912, "categories"=>["Biotechnology", "Chemistry", "Infectious Diseases", "Pharmacology"], "users"=>["Cameron Ball", "Emily Krogstad", "Thanyanan Chaowanachan", "Kim A. Woodrow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0049792.g001", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Electrospun_fibers_incorporate_drugs_for_multipurpose_prevention_/205912", "title"=>"Electrospun fibers incorporate drugs for multipurpose prevention.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-28 01:38:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/288702", "https://ndownloader.figshare.com/files/288753", "https://ndownloader.figshare.com/files/288784", "https://ndownloader.figshare.com/files/288899", "https://ndownloader.figshare.com/files/288938", "https://ndownloader.figshare.com/files/288975", "https://ndownloader.figshare.com/files/289013", "https://ndownloader.figshare.com/files/289086", "https://ndownloader.figshare.com/files/289142", "https://ndownloader.figshare.com/files/289175", "https://ndownloader.figshare.com/files/289238", "https://ndownloader.figshare.com/files/289278", "https://ndownloader.figshare.com/files/289306", "https://ndownloader.figshare.com/files/289354", "https://ndownloader.figshare.com/files/289413", "https://ndownloader.figshare.com/files/289457", "https://ndownloader.figshare.com/files/289498", "https://ndownloader.figshare.com/files/289574"], "description"=>"<div><p>Multipurpose prevention technologies (MPTs) that simultaneously prevent sexually transmitted infections (STIs) and unintended pregnancy are a global health priority. Combining chemical and physical barriers offers the greatest potential to design effective MPTs, but integrating both functional modalities into a single device has been challenging. Here we show that drug-eluting fiber meshes designed for topical drug delivery can function as a combination chemical and physical barrier MPT. Using FDA-approved polymers, we fabricated nanofiber meshes with tunable fiber size and controlled degradation kinetics that facilitate simultaneous release of multiple agents against HIV-1, HSV-2, and sperm. We observed that drug-loaded meshes inhibited HIV-1 infection <em>in vitro</em> and physically obstructed sperm penetration. Furthermore, we report on a previously unknown activity of glycerol monolaurate (GML) to potently inhibit sperm motility and viability. The application of drug-eluting nanofibers for HIV-1 prevention and sperm inhibition may serve as an innovative platform technology for drug delivery to the lower female reproductive tract.</p> </div>", "links"=>[], "tags"=>["drug-eluting", "fibers", "hiv-1", "inhibition", "contraception"], "article_id"=>116865, "categories"=>["Cancer", "Biotechnology", "Chemistry", "Pharmacology"], "users"=>["Cameron Ball", "Emily Krogstad", "Thanyanan Chaowanachan", "Kim A. Woodrow"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0049792.s001", "https://dx.doi.org/10.1371/journal.pone.0049792.s002", "https://dx.doi.org/10.1371/journal.pone.0049792.s003", "https://dx.doi.org/10.1371/journal.pone.0049792.s004", "https://dx.doi.org/10.1371/journal.pone.0049792.s005", "https://dx.doi.org/10.1371/journal.pone.0049792.s006", "https://dx.doi.org/10.1371/journal.pone.0049792.s007", "https://dx.doi.org/10.1371/journal.pone.0049792.s008", "https://dx.doi.org/10.1371/journal.pone.0049792.s009", "https://dx.doi.org/10.1371/journal.pone.0049792.s010", "https://dx.doi.org/10.1371/journal.pone.0049792.s011", "https://dx.doi.org/10.1371/journal.pone.0049792.s012", "https://dx.doi.org/10.1371/journal.pone.0049792.s013", "https://dx.doi.org/10.1371/journal.pone.0049792.s014", "https://dx.doi.org/10.1371/journal.pone.0049792.s015", "https://dx.doi.org/10.1371/journal.pone.0049792.s016", "https://dx.doi.org/10.1371/journal.pone.0049792.s017", "https://dx.doi.org/10.1371/journal.pone.0049792.s018"], "stats"=>{"downloads"=>0, "page_views"=>41, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Drug_Eluting_Fibers_for_HIV_1_Inhibition_and_Contraception__/116865", "title"=>"Drug-Eluting Fibers for HIV-1 Inhibition and Contraception", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-11-28 01:54:25"}

PMC Usage Stats | Further Information

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Relative Metric

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