Altered Gene Expression Pattern in Peripheral Blood Mononuclear Cells in Patients with Acute Myocardial Infarction
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{"title"=>"Altered Gene Expression Pattern in Peripheral Blood Mononuclear Cells in Patients with Acute Myocardial Infarction", "type"=>"journal", "authors"=>[{"first_name"=>"Marek", "last_name"=>"Kiliszek", "scopus_author_id"=>"24332191600"}, {"first_name"=>"Beata", "last_name"=>"Burzynska", "scopus_author_id"=>"6602770312"}, {"first_name"=>"Marcin", "last_name"=>"Michalak", "scopus_author_id"=>"55204150100"}, {"first_name"=>"Monika", "last_name"=>"Gora", "scopus_author_id"=>"7003462758"}, {"first_name"=>"Aleksandra", "last_name"=>"Winkler", "scopus_author_id"=>"52864796100"}, {"first_name"=>"Agata", "last_name"=>"Maciejak", "scopus_author_id"=>"55497124000"}, {"first_name"=>"Agata", "last_name"=>"Leszczynska", "scopus_author_id"=>"35748771600"}, {"first_name"=>"Ewa", "last_name"=>"Gajda", "scopus_author_id"=>"36615093700"}, {"first_name"=>"Janusz", "last_name"=>"Kochanowski", "scopus_author_id"=>"7003422600"}, {"first_name"=>"Grzegorz", "last_name"=>"Opolski", "scopus_author_id"=>"55711952200"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"23185530", "doi"=>"10.1371/journal.pone.0050054", "sgr"=>"84869859093", "scopus"=>"2-s2.0-84869859093", "issn"=>"19326203", "pui"=>"366113376"}, "id"=>"c7ddd0db-baab-334a-b0e1-770c6a74e705", "abstract"=>"BACKGROUND: Despite a substantial progress in diagnosis and therapy, acute myocardial infarction (MI) is a major cause of mortality in the general population. A novel insight into the pathophysiology of myocardial infarction obtained by studying gene expression should help to discover novel biomarkers of MI and to suggest novel strategies of therapy. The aim of our study was to establish gene expression patterns in leukocytes from acute myocardial infarction patients.\\n\\nMETHODS AND RESULTS: Twenty-eight patients with ST-segment elevation myocardial infarction (STEMI) were included. The blood was collected on the 1(st) day of myocardial infarction, after 4-6 days, and after 6 months. Control group comprised 14 patients with stable coronary artery disease, without history of myocardial infarction. Gene expression analysis was performed with Affymetrix Human Gene 1.0 ST microarrays and GCS3000 TG system. Lists of genes showing altered expression levels (fold change >1.5, p<0.05) were submitted to Ingenuity Pathway Analysis. Gene lists from each group were examined for canonical pathways and molecular and cellular functions. Comparing acute phase of MI with the same patients after 6 months (stable phase) and with control group we found 24 genes with changed expression. In canonical analysis three pathways were highlighted: signaling of PPAR (peroxisome proliferator-activated receptor), IL-10 and IL-6 (interleukin 10 and 6).\\n\\nCONCLUSIONS: In the acute phase of STEMI, dozens of genes from several pathways linked with lipid/glucose metabolism, platelet function and atherosclerotic plaque stability show altered expression. Up-regulation of SOCS3 and FAM20 genes in the first days of myocardial infarction is observed in the vast majority of patients.", "link"=>"http://www.mendeley.com/research/altered-gene-expression-pattern-peripheral-blood-mononuclear-cells-patients-acute-myocardial-infarct-2", "reader_count"=>16, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>5, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/538839"], "description"=>"<p>Differentially expressed genes common to both analyses: admission versus 6 months after MI and admission versus control.</p>", "links"=>[], "tags"=>["genes", "months", "mi"], "article_id"=>209324, "categories"=>["Biological Sciences", "Hematology", "Immunology", "Physiology", "Molecular Biology", "Cell Biology", "Genetics"], "users"=>["Marek Kiliszek", "Beata Burzynska", "Marcin Michalak", "Monika Gora", "Aleksandra Winkler", "Agata Maciejak", "Agata Leszczynska", "Ewa Gajda", "Janusz Kochanowski", "Grzegorz Opolski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050054.t002", "stats"=>{"downloads"=>3, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differentially_expressed_genes_common_to_both_analyses_admission_versus_6_months_after_MI_and_admission_versus_control_/209324", "title"=>"Differentially expressed genes common to both analyses: admission versus 6 months after MI and admission versus control.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-11-21 02:35:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/538914"], "description"=>"*<p>Mean ± Standard Deviation.</p>**<p>number (%);</p><p>NA – not applicable.</p>", "links"=>[], "tags"=>["characteristics"], "article_id"=>209405, "categories"=>["Biological Sciences", "Hematology", "Immunology", "Physiology", "Molecular Biology", "Cell Biology", "Genetics"], "users"=>["Marek Kiliszek", "Beata Burzynska", "Marcin Michalak", "Monika Gora", "Aleksandra Winkler", "Agata Maciejak", "Agata Leszczynska", "Ewa Gajda", "Janusz Kochanowski", "Grzegorz Opolski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050054.t001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Major_characteristics_of_the_study_and_control_groups_/209405", "title"=>"Major characteristics of the study and control groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-11-21 02:36:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/538661"], "description"=>"<p>The y-axis represents the log2 normalized intensity of the gene and the x-axis represents analyzed groups. The line inside the box and whiskers represents the median of the samples in a group. Points present relative expression levels in individual patients at admission (blue), at discharge (green), 6 month after MI (violet) and from control group (red). Numbers indicate the coded identity of a particular patient. SOCS3– suppressor of cytokine signaling 3; ST14– MT-SP1/matriptase; AQP 9– aquaporin 9; MYBL1– v-myb myeloblastosis viral oncogene homolog (avian)-like 1; STAB1– stabilin 1; ASGR2– asialoglycoprotein receptor 2.</p>", "links"=>[], "tags"=>["microarray", "experiments", "chosen"], "article_id"=>209141, "categories"=>["Biological Sciences", "Hematology", "Immunology", "Physiology", "Molecular Biology", "Cell Biology", "Genetics"], "users"=>["Marek Kiliszek", "Beata Burzynska", "Marcin Michalak", "Monika Gora", "Aleksandra Winkler", "Agata Maciejak", "Agata Leszczynska", "Ewa Gajda", "Janusz Kochanowski", "Grzegorz Opolski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050054.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_data_from_microarray_experiments_for_chosen_genes_/209141", "title"=>"Expression data from microarray experiments for chosen genes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-21 02:32:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/538874"], "description"=>"***<p>p<0.001; **p<0.01; *p<0.05; <sup>NS</sup> – not significant.</p><p>All genes abbreviations are explained in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050054#pone-0050054-t002\" target=\"_blank\">Table 2</a>.</p>", "links"=>[], "tags"=>["microarray"], "article_id"=>209364, "categories"=>["Biological Sciences", "Hematology", "Immunology", "Physiology", "Molecular Biology", "Cell Biology", "Genetics"], "users"=>["Marek Kiliszek", "Beata Burzynska", "Marcin Michalak", "Monika Gora", "Aleksandra Winkler", "Agata Maciejak", "Agata Leszczynska", "Ewa Gajda", "Janusz Kochanowski", "Grzegorz Opolski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050054.t003", "stats"=>{"downloads"=>3, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Validation_of_microarray_data_using_qRT_PCR_/209364", "title"=>"Validation of microarray data using qRT-PCR.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-11-21 02:36:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/538489"], "description"=>"<p>Ingenuity Pathway Analysis of gene sets differentially expressed on the first day of myocardial infarction versus 6 months after MI or versus control group was performed. Functional categories are represented on the x-axis. The significance is expressed as the negative exponent on the p-value calculated for each function on the y-axis of the diagram, increasing with bar height.</p>", "links"=>[], "tags"=>["canonical", "pathways", "acute"], "article_id"=>208976, "categories"=>["Biological Sciences", "Hematology", "Immunology", "Physiology", "Molecular Biology", "Cell Biology", "Genetics"], "users"=>["Marek Kiliszek", "Beata Burzynska", "Marcin Michalak", "Monika Gora", "Aleksandra Winkler", "Agata Maciejak", "Agata Leszczynska", "Ewa Gajda", "Janusz Kochanowski", "Grzegorz Opolski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050054.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Top_canonical_pathways_associated_with_acute_phase_of_STEMI_/208976", "title"=>"Top canonical pathways associated with acute phase of STEMI.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-21 02:29:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/538797"], "description"=>"<p>Differentially expressed genes common to both analyses: admission versus control and discharge versus control.</p>", "links"=>[], "tags"=>["genes", "discharge"], "article_id"=>209277, "categories"=>["Biological Sciences", "Hematology", "Immunology", "Physiology", "Molecular Biology", "Cell Biology", "Genetics"], "users"=>["Marek Kiliszek", "Beata Burzynska", "Marcin Michalak", "Monika Gora", "Aleksandra Winkler", "Agata Maciejak", "Agata Leszczynska", "Ewa Gajda", "Janusz Kochanowski", "Grzegorz Opolski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050054.t004", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differentially_expressed_genes_common_to_both_analyses_admission_versus_control_and_discharge_versus_control_/209277", "title"=>"Differentially expressed genes common to both analyses: admission versus control and discharge versus control.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-11-21 02:34:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/288561", "https://ndownloader.figshare.com/files/288576", "https://ndownloader.figshare.com/files/288585", "https://ndownloader.figshare.com/files/288608", "https://ndownloader.figshare.com/files/288622"], "description"=>"<div><h3>Background</h3><p>Despite a substantial progress in diagnosis and therapy, acute myocardial infarction (MI) is a major cause of mortality in the general population. A novel insight into the pathophysiology of myocardial infarction obtained by studying gene expression should help to discover novel biomarkers of MI and to suggest novel strategies of therapy. The aim of our study was to establish gene expression patterns in leukocytes from acute myocardial infarction patients.</p> <h3>Methods and Results</h3><p>Twenty-eight patients with ST-segment elevation myocardial infarction (STEMI) were included. The blood was collected on the 1<sup>st</sup> day of myocardial infarction, after 4–6 days, and after 6 months. Control group comprised 14 patients with stable coronary artery disease, without history of myocardial infarction. Gene expression analysis was performed with Affymetrix Human Gene 1.0 ST microarrays and GCS3000 TG system. Lists of genes showing altered expression levels (fold change >1.5, p<0.05) were submitted to Ingenuity Pathway Analysis. Gene lists from each group were examined for canonical pathways and molecular and cellular functions. Comparing acute phase of MI with the same patients after 6 months (stable phase) and with control group we found 24 genes with changed expression. In canonical analysis three pathways were highlighted: signaling of PPAR (peroxisome proliferator-activated receptor), IL-10 and IL-6 (interleukin 10 and 6).</p> <h3>Conclusions</h3><p>In the acute phase of STEMI, dozens of genes from several pathways linked with lipid/glucose metabolism, platelet function and atherosclerotic plaque stability show altered expression. Up-regulation of SOCS3 and FAM20 genes in the first days of myocardial infarction is observed in the vast majority of patients.</p> </div>", "links"=>[], "tags"=>["altered", "peripheral", "mononuclear", "cells", "patients", "acute", "myocardial", "infarction"], "article_id"=>116833, "categories"=>["Biological Sciences", "Hematology", "Immunology", "Physiology", "Molecular Biology", "Cell Biology", "Genetics"], "users"=>["Marek Kiliszek", "Beata Burzynska", "Marcin Michalak", "Monika Gora", "Aleksandra Winkler", "Agata Maciejak", "Agata Leszczynska", "Ewa Gajda", "Janusz Kochanowski", "Grzegorz Opolski"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0050054.s001", "https://dx.doi.org/10.1371/journal.pone.0050054.s002", "https://dx.doi.org/10.1371/journal.pone.0050054.s003", "https://dx.doi.org/10.1371/journal.pone.0050054.s004", "https://dx.doi.org/10.1371/journal.pone.0050054.s005"], "stats"=>{"downloads"=>50, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Altered_Gene_Expression_Pattern_in_Peripheral_Blood_Mononuclear_Cells_in_Patients_with_Acute_Myocardial_Infarction__/116833", "title"=>"Altered Gene Expression Pattern in Peripheral Blood Mononuclear Cells in Patients with Acute Myocardial Infarction", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-11-21 01:53:53"}

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Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[322, 550, 671, 773, 864, 955, 1048, 1135, 1223, 1308, 1387, 1465, 1534, 1602, 1673, 1744, 1813, 1885, 1955, 2026, 2093, 2160, 2228, 2290, 2349]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[333, 576, 707, 814, 908, 1004, 1104, 1197, 1280, 1370, 1449, 1531, 1603, 1673, 1742, 1817, 1886, 1954, 2025, 2098, 2171, 2234, 2304, 2365, 2431]}, {"subject_area"=>"/Medicine and health sciences/Cardiology", "average_usage"=>[262, 473, 578, 664, 746, 826, 913, 992, 1078, 1143, 1201, 1272, 1338, 1385, 1442, 1507, 1565, 1618, 1680, 1741, 1816, 1871, 1903, 1952, 2009]}, {"subject_area"=>"/Medicine and health sciences/Vascular medicine", "average_usage"=>[275, 494, 608, 705, 791, 880, 964, 1056, 1143, 1227, 1296, 1370, 1434, 1506, 1564, 1635, 1705, 1771, 1833, 1871, 1940, 1991, 2026, 2090, 2147]}]}
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