Evaluating a Parainfluenza Virus 5-Based Vaccine in a Host with Pre-Existing Immunity against Parainfluenza Virus 5
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{"title"=>"Evaluating a Parainfluenza Virus 5-Based Vaccine in a Host with Pre-Existing Immunity against Parainfluenza Virus 5", "type"=>"journal", "authors"=>[{"first_name"=>"Zhenhai", "last_name"=>"Chen", "scopus_author_id"=>"55616443900"}, {"first_name"=>"Pei", "last_name"=>"Xu", "scopus_author_id"=>"44961617000"}, {"first_name"=>"Gregory W.", "last_name"=>"Salyards", "scopus_author_id"=>"55263508800"}, {"first_name"=>"Stephen B.", "last_name"=>"Harvey", "scopus_author_id"=>"35237178500"}, {"first_name"=>"Balazs", "last_name"=>"Rada", "scopus_author_id"=>"7004008715"}, {"first_name"=>"Zhen F.", "last_name"=>"Fu", "scopus_author_id"=>"7403347700"}, {"first_name"=>"Biao", "last_name"=>"He", "scopus_author_id"=>"56388090000"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84869842290", "doi"=>"10.1371/journal.pone.0050144", "pui"=>"366105312", "pmid"=>"23185558", "scopus"=>"2-s2.0-84869842290", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic); 1932-6203 (Linking)"}, "id"=>"05ce16c1-8dc4-31d6-a33c-c0d68880ccda", "abstract"=>"Parainfluenza virus 5 (PIV5), formerly known as simian virus 5 (SV5), is a paramyxovirus often referred to as canine parainfluenza virus (CPI) in the veterinary field. PIV5 is thought to be a contributing factor to kennel cough. Kennel cough vaccines containing live PIV5 have been used in dogs for many decades. PIV5 is not known to cause any diseases in humans or other animals. PIV5 has been used as a vector for vaccine development for humans and animals. One critical question concerning the use of PIV5 as a vector is whether prior exposure to PIV5 would prevent the use of PIV5-based vaccines. In this work, we have examined immunogenicity of a recombinant PIV5 expressing hemagglutinin (HA) of influenza A virus subtype 3 (rPIV5-H3) in dogs that were immunized against PIV5. We found that vaccination of the dogs containing neutralizing antibodies against PIV5 with rPIV5-H3 generated immunity against influenza A virus, indicting that PIV5-based vaccine is immunogenic in dogs with prior exposure. Furthermore, we have examined exposure of PIV5 in human populations. We have detected neutralizing antibody (nAb) against PIV5 in 13 out of 45 human serum samples (about 29 percent). The nAb titers in humans were lower than that in vaccinated dogs, suggesting that nAb in humans is unlikely to prevent PIV5 from being an efficacious vector in humans.", "link"=>"http://www.mendeley.com/research/evaluating-parainfluenza-virus-5based-vaccine-host-preexisting-immunity-against-parainfluenza-virus", "reader_count"=>15, "reader_count_by_academic_status"=>{"Researcher"=>5, "Student > Ph. D. Student"=>6, "Student > Master"=>2, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Researcher"=>5, "Student > Ph. D. Student"=>6, "Student > Master"=>2, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Materials Science"=>1, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>1, "Psychology"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "group_count"=>4}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/540457"], "description"=>"<p>Eight dogs which had been vaccinated with live PIV5 were immunized with one dose of 8×10<sup>7</sup> PFU of rPIV5-H3 viruses in 1 mL or PBS via intranasal route. The dogs were divided into two groups: two dogs received PBS; The remaining six dogs received rPIV5-H3. Blood samples were collected at 0 and 21 days post infection for ELISA (A) and viral neutralization antibody assay (B). Data were presented as average value of duplicate wells. In the neutralization antibody assay, the white column indicates the PIV5 nAb titer is equal to or higher than 10.</p>", "links"=>[], "tags"=>["anti-piv5", "antibodies", "piv5-vaccinated"], "article_id"=>210946, "categories"=>["Virology", "Immunology"], "users"=>["Zhenhai Chen", "Pei Xu", "Gregory W. Salyards", "Stephen B. Harvey", "Balázs Rada", "Zhen F. Fu", "Biao He"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050144.g004", "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Titers_of_anti_PIV5_antibodies_in_the_PIV5_vaccinated_dogs_/210946", "title"=>"Titers of anti-PIV5 antibodies in the PIV5-vaccinated dogs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:04:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/540361"], "description"=>"<p>The dog blood samples were collected at 0 and 21 days post infection. 4 HAU of the influenza A virus (A/Udorn/72, H3N2 subtype) were mixed with serially diluted dog sera in 96-well round-bottom plates. The hemagglutination inhibition (HAI) titer was scored as the reciprocal of the highest dilution antiserum that completely inhibits hemagglutination. The graph shows the mean value of duplicate wells for each dog. The limit of detection of the HAI titer (10) is indicated.</p>", "links"=>[], "tags"=>["responses", "dogs", "inoculated"], "article_id"=>210851, "categories"=>["Virology", "Immunology"], "users"=>["Zhenhai Chen", "Pei Xu", "Gregory W. Salyards", "Stephen B. Harvey", "Balázs Rada", "Zhen F. Fu", "Biao He"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050144.g003", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immune_responses_in_the_8220_PIV5_na_239_ve_8221_dogs_inoculated_with_rPIV5_H3_/210851", "title"=>"Immune responses in the “PIV5 naïve” dogs inoculated with rPIV5-H3.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:04:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/540069"], "description"=>"<p>Eight PIV5 naïve dogs were immunized with one dose of 8×10<sup>7</sup> PFU of PIV5 or rPIV5-H3 viruses by intranasal route. The dogs were divided into two groups: PIV5-infected dogs and rPIV5-H3-infected dogs. Blood samples were collected at 0 and 21 days post infection for ELISA (A) and virus neutralization antibody (nAb) assay (B). The grey columns indicate that the PIV5 nAb titer is less than 10, the limit of detection in this assay. The black columns indicate that the nAb titer is equal to or higher than 10.</p>", "links"=>[], "tags"=>["anti-piv5", "antibodies", "dogs", "piv5"], "article_id"=>210549, "categories"=>["Virology", "Immunology"], "users"=>["Zhenhai Chen", "Pei Xu", "Gregory W. Salyards", "Stephen B. Harvey", "Balázs Rada", "Zhen F. Fu", "Biao He"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050144.g001", "stats"=>{"downloads"=>6, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Titers_of_anti_PIV5_antibodies_in_dogs_without_PIV5_exposure_/210549", "title"=>"Titers of anti-PIV5 antibodies in dogs without PIV5 exposure.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:02:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/540239"], "description"=>"<p>The nasal swabs of dogs were collected at 3 and 5 days post infection, and placed into a vial containing 0.5 mL of DMEM with 2% FBS. (A) Detection of virus with RT-PCR. (B) Detection of virus with plaque assay. Swab samples were examined by plaque assay on BHK21 cells. Two replicates for each serially diluted swab sample (1∶10<sup>0</sup> to 1∶10<sup>2</sup>) were used in the assay.</p>", "links"=>[], "tags"=>["piv5", "dogs"], "article_id"=>210729, "categories"=>["Virology", "Immunology"], "users"=>["Zhenhai Chen", "Pei Xu", "Gregory W. Salyards", "Stephen B. Harvey", "Balázs Rada", "Zhen F. Fu", "Biao He"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050144.g002", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Replication_of_PIV5_in_dogs_without_PIV5_exposure_/210729", "title"=>"Replication of PIV5 in dogs without PIV5 exposure.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:03:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/540576"], "description"=>"<p>The nasal swabs of dogs were collected at 3 and 5 dpi. Detections of virus were performed the same as in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050144#pone-0050144-g002\" target=\"_blank\">Fig. 2</a>. (A) RT-PCR and (B) Plaque assay.</p>", "links"=>[], "tags"=>["piv5", "dogs"], "article_id"=>211067, "categories"=>["Virology", "Immunology"], "users"=>["Zhenhai Chen", "Pei Xu", "Gregory W. Salyards", "Stephen B. Harvey", "Balázs Rada", "Zhen F. Fu", "Biao He"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050144.g005", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Replication_of_PIV5_in_dogs_with_prior_PIV5_vaccination_/211067", "title"=>"Replication of PIV5 in dogs with prior PIV5 vaccination.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:05:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/540667"], "description"=>"<p>The dog blood samples were collected at 0 and 21 dpi. Anti-PIV5 and HAI titers were determined using the same approach as in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050144#pone-0050144-g003\" target=\"_blank\">Fig. 3</a>.</p>", "links"=>[], "tags"=>["responses", "piv5-vaccinated", "dogs", "inoculated"], "article_id"=>211154, "categories"=>["Virology", "Immunology"], "users"=>["Zhenhai Chen", "Pei Xu", "Gregory W. Salyards", "Stephen B. Harvey", "Balázs Rada", "Zhen F. Fu", "Biao He"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050144.g006", "stats"=>{"downloads"=>1, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immune_responses_in_the_PIV5_vaccinated_dogs_inoculated_with_rPIV5_H3_/211154", "title"=>"Immune responses in the PIV5-vaccinated dogs inoculated with rPIV5-H3.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:05:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/540771"], "description"=>"<p>45 human serum samples were obtained from 18–50 year old healthy individuals. (A) Comparison of anti-PIV5 and anti-MuV antibody levels. ELISA was performed on plates coated with purified PIV5 or purified MuV with sera serially diluted. PIV5 or Mumps virus specific ELISA OD<sub>450</sub> values were shown at 320-fold dilution for each human serum sample. (B) Titers of neutralizing antibody against PIV5 in human sera. Data for the antibody titers were the average value of duplicate wells and presented for each human sample. The white column indicates that the PIV5 nAb titer is less than 10, the limit of detection. The black column indicates that the nAb titer is equal to or higher than 10.</p>", "links"=>[], "tags"=>["antibodies"], "article_id"=>211263, "categories"=>["Virology", "Immunology"], "users"=>["Zhenhai Chen", "Pei Xu", "Gregory W. Salyards", "Stephen B. Harvey", "Balázs Rada", "Zhen F. Fu", "Biao He"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050144.g007", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PIV5_antibodies_in_humans_/211263", "title"=>"PIV5 antibodies in humans.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 20:06:19"}

PMC Usage Stats | Further Information

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Relative Metric

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