Relationship between Circulating and Tissue microRNAs in a Murine Model of Breast Cancer
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{"title"=>"Relationship between Circulating and Tissue microRNAs in a Murine Model of Breast Cancer", "type"=>"journal", "authors"=>[{"first_name"=>"Peadar S.", "last_name"=>"Waters", "scopus_author_id"=>"36112480300"}, {"first_name"=>"Ailbhe M.", "last_name"=>"McDermott", "scopus_author_id"=>"45161586100"}, {"first_name"=>"Deirdre", "last_name"=>"Wall", "scopus_author_id"=>"55511955300"}, {"first_name"=>"Helen M.", "last_name"=>"Heneghan", "scopus_author_id"=>"24758826600"}, {"first_name"=>"Nicola", "last_name"=>"Miller", "scopus_author_id"=>"56612171300"}, {"first_name"=>"John", "last_name"=>"Newell", "scopus_author_id"=>"7202805692"}, {"first_name"=>"Michael J.", "last_name"=>"Kerin", "scopus_author_id"=>"26631163000"}, {"first_name"=>"Roisin M.", "last_name"=>"Dwyer", "scopus_author_id"=>"10145045200"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84870616787", "pui"=>"366207349", "doi"=>"10.1371/journal.pone.0050459", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84870616787", "pmid"=>"23226290"}, "id"=>"0766c23b-bbeb-30b5-ac15-662d396e0a7b", "abstract"=>"MiRNAs are key regulators of tumorigenesis that are aberrantly expressed in the circulation and tissue of patients with cancer. The aim of this study was to determine whether miRNA dysregulation in the circulation reflected similar changes in tumour tissue. Athymic nude mice (n = 20) received either a mammary fat pad (n = 8, MFP), or subcutaneous (n = 7, SC) injection of MDA-MB-231 cells. Controls received no tumour cells (n = 5). Tumour volume was monitored weekly and blood sampling performed at weeks 1, 3 and 6 following tumour induction (total n = 60). Animals were sacrificed at week 6 and tumour tissue (n = 15), lungs (n = 20) and enlarged lymph nodes (n = 3) harvested. MicroRNAs were extracted from all samples (n = 98) and relative expression quantified using RQ-PCR. MiR-221 expression was significantly increased in tumour compared to healthy tissue (p<0.001). MiR-10b expression was significantly higher in MFP compared to SC tumours (p<0.05), with the highest levels detected in diseased lymph nodes (p<0.05). MiR-10b was undetectable in the circulation, with no significant change in circulating miR-221 expression detected during disease progression. MiR-195 and miR-497 were significantly decreased in tumour tissue (p<0.05), and also in the circulation of animals 3 weeks following tumour induction (p<0.05). At both tissue and circulating level, a positive correlation was observed between miR-497 and miR-195 (r = 0.61, p<0.001; r = 0.41, p<0.01 respectively). This study highlights the distinct roles of miRNAs in circulation and tissue. It also implicates miRNAs in disease dissemination and progression, which may be important in systemic therapy and biomarker development.", "link"=>"http://www.mendeley.com/research/relationship-between-circulating-tissue-micrornas-murine-model-breast-cancer", "reader_count"=>24, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>5, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>5, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>14, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>14}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Spain"=>1}, "group_count"=>3}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/532530"], "description"=>"<p>Further significant positive correlations were observed between circulating <i>miR-195</i> and miR-497, circulating miR-195 and miR-221, and between <i>miR-497</i> and <i>miR-221</i>.</p>", "links"=>[], "tags"=>["relationships", "circulating"], "article_id"=>203021, "categories"=>["Cancer", "Cell Biology"], "users"=>["Peadar S. Waters", "Ailbhe M. McDermott", "Deirdre Wall", "Helen M. Heneghan", "Nicola Miller", "John Newell", "Michael J. Kerin", "Roisin M. Dwyer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050459.g005", "stats"=>{"downloads"=>4, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Investigation_of_relationships_between_circulating_miRNA_/203021", "title"=>"Investigation of relationships between circulating miRNA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-30 00:50:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/532256"], "description"=>"<p>(<b>A</b>) miR-10b expression. (<b>B</b>) miR-221 expression. (<b>C</b>) Positive correlation between miR-10b and miR-221 across all tissues. (<b>D</b>) MiR- 195 expression. (<b>E</b>) miR-497 expression. (<b>F</b>) Positive correlation between miR-195 and miR-497 expression across all tissues.</p>", "links"=>[], "tags"=>["mirnas", "tumour", "lymph", "nodes"], "article_id"=>202741, "categories"=>["Cancer", "Cell Biology"], "users"=>["Peadar S. Waters", "Ailbhe M. McDermott", "Deirdre Wall", "Helen M. Heneghan", "Nicola Miller", "John Newell", "Michael J. Kerin", "Roisin M. Dwyer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050459.g002", "stats"=>{"downloads"=>3, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relative_expression_of_MiRNAs_in_tumour_n_8202_8202_15_lymph_nodes_n_8202_8202_3_and_healthy_tissue_n_8202_8202_5_/202741", "title"=>"Relative expression of MiRNAs in tumour (n = 15), lymph nodes (n = 3) and healthy tissue (n = 5).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-30 00:45:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/532170"], "description"=>"<p>This study comprises of 20 athymic nude mice of which 15 were tumour bearing (MFP = 8 and SC = 7) and 5 were controls. Blood sampling was carried out from all animals at weeks 1, 3, and 6 as highlighted with red arrows. Tumour volume and weight measurements were undertaken at a weekly basis for the 6 week duration of the project. Animals were sacrificed at week 6 following tumour induction and all primary tumours (n = 15), lungs (n = 20) and lymph nodes (n = 3) were harvested for analysis and a terminal bleed via cardiac puncture was performed.</p>", "links"=>[], "tags"=>["vivo", "mirna"], "article_id"=>202662, "categories"=>["Cancer", "Cell Biology"], "users"=>["Peadar S. Waters", "Ailbhe M. McDermott", "Deirdre Wall", "Helen M. Heneghan", "Nicola Miller", "John Newell", "Michael J. Kerin", "Roisin M. Dwyer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050459.g001", "stats"=>{"downloads"=>2, "page_views"=>110, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_Vivo_miRNA_study_timeline_/202662", "title"=>"In Vivo miRNA study timeline.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-30 00:44:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/532353"], "description"=>"<p>At termination of this study, 6 weeks following tumour induction no significant difference was observed between circulating miR-221 (<b>A</b>), miR-195 (<b>B</b>) and miR-497 (<b>C</b>) in tumour bearing animals compared to healthy controls.</p>", "links"=>[], "tags"=>["mirna", "tumour", "bearing", "animals"], "article_id"=>202839, "categories"=>["Cancer", "Cell Biology"], "users"=>["Peadar S. Waters", "Ailbhe M. McDermott", "Deirdre Wall", "Helen M. Heneghan", "Nicola Miller", "John Newell", "Michael J. Kerin", "Roisin M. Dwyer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050459.g003", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Circulating_miRNA_expression_in_tumour_bearing_n_8202_8202_45_15_215_3_and_healthy_animals_n_8202_8202_15_5_215_3_/202839", "title"=>"Circulating miRNA expression in tumour bearing (n = 45, 15×3) and healthy animals (n = 15, 5×3).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-30 00:47:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/285933", "https://ndownloader.figshare.com/files/285970", "https://ndownloader.figshare.com/files/286015"], "description"=>"<div><p>MiRNAs are key regulators of tumorigenesis that are aberrantly expressed in the circulation and tissue of patients with cancer. The aim of this study was to determine whether miRNA dysregulation in the circulation reflected similar changes in tumour tissue. Athymic nude mice (n = 20) received either a mammary fat pad (n = 8, MFP), or subcutaneous (n = 7, SC) injection of MDA-MB-231 cells. Controls received no tumour cells (n = 5). Tumour volume was monitored weekly and blood sampling performed at weeks 1, 3 and 6 following tumour induction (total n = 60). Animals were sacrificed at week 6 and tumour tissue (n = 15), lungs (n = 20) and enlarged lymph nodes (n = 3) harvested. MicroRNAs were extracted from all samples (n = 98) and relative expression quantified using RQ-PCR. <em>MiR-221</em> expression was significantly increased in tumour compared to healthy tissue (p<0.001). <em>MiR-10b</em> expression was significantly higher in MFP compared to SC tumours (p<0.05), with the highest levels detected in diseased lymph nodes (p<0.05). <em>MiR-10b</em> was undetectable in the circulation, with no significant change in circulating <em>miR-221</em> expression detected during disease progression. <em>MiR-195</em> and <em>miR-497</em> were significantly decreased in tumour tissue (p<0.05), and also in the circulation of animals 3 weeks following tumour induction (p<0.05). At both tissue and circulating level, a positive correlation was observed between <em>miR-497</em> and <em>miR-195</em> (r = 0.61, p<0.001; r = 0.41, p<0.01 respectively). This study highlights the distinct roles of miRNAs in circulation and tissue. It also implicates miRNAs in disease dissemination and progression, which may be important in systemic therapy and biomarker development.</p> </div>", "links"=>[], "tags"=>["circulating", "micrornas", "murine", "cancer"], "article_id"=>116366, "categories"=>["Cancer", "Cell Biology"], "users"=>["Peadar S. Waters", "Ailbhe M. McDermott", "Deirdre Wall", "Helen M. Heneghan", "Nicola Miller", "John Newell", "Michael J. Kerin", "Roisin M. Dwyer"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0050459.s001", "https://dx.doi.org/10.1371/journal.pone.0050459.s002", "https://dx.doi.org/10.1371/journal.pone.0050459.s003"], "stats"=>{"downloads"=>4, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Relationship_between_Circulating_and_Tissue_microRNAs_in_a_Murine_Model_of_Breast_Cancer__/116366", "title"=>"Relationship between Circulating and Tissue microRNAs in a Murine Model of Breast Cancer", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-11-30 01:46:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/532447"], "description"=>"<p>Relative levels of circulating miRNAs were quantified 1, 3, and 6 weeks following tumour induction to investigate the relationship with disease progression (n = 20 at each time point, total n = 60) Circulating miR-221 was no significantly altered during the 6 week study (<b>A</b>)<b>.</b> Circulating <i>miR-195</i> and <i>miR-497</i> was significantly decreased at week 3 following tumour induction (<b>B, C</b>). <i>MiR-195</i> and <i>miR-497</i> expression was observed to increase again at week 6, however this was not significant.</p>", "links"=>[], "tags"=>["mirna", "tumour", "progression"], "article_id"=>202933, "categories"=>["Cancer", "Cell Biology"], "users"=>["Peadar S. Waters", "Ailbhe M. McDermott", "Deirdre Wall", "Helen M. Heneghan", "Nicola Miller", "John Newell", "Michael J. Kerin", "Roisin M. Dwyer"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050459.g004", "stats"=>{"downloads"=>8, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Circulating_miRNA_expression_during_tumour_progression_over_6_weeks_/202933", "title"=>"Circulating miRNA expression during tumour progression over 6 weeks.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-30 00:48:53"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[322, 550, 671, 773, 864, 955, 1048, 1135, 1223, 1308, 1387, 1465, 1534, 1602, 1673, 1744, 1813, 1885, 1955, 2026, 2093, 2160, 2228, 2290, 2349]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[312, 547, 668, 769, 861, 953, 1046, 1135, 1224, 1307, 1388, 1464, 1536, 1606, 1676, 1744, 1812, 1882, 1954, 2020, 2089, 2155, 2218, 2282, 2344]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[307, 529, 649, 751, 845, 936, 1025, 1113, 1197, 1284, 1360, 1432, 1501, 1570, 1632, 1697, 1765, 1834, 1904, 1972, 2041, 2107, 2170, 2231, 2292]}, {"subject_area"=>"/Medicine and health sciences/Hematology", "average_usage"=>[300, 532, 651, 749, 842, 929, 1022, 1106, 1192, 1267, 1351, 1423, 1489, 1553, 1631, 1694, 1764, 1835, 1899, 1964, 2027, 2087, 2159, 2228, 2280]}, {"subject_area"=>"/Medicine and health sciences/Oncology", "average_usage"=>[301, 551, 686, 790, 883, 972, 1069, 1162, 1250, 1341, 1426, 1503, 1571, 1634, 1701, 1779, 1848, 1919, 1986, 2052, 2114, 2183, 2253, 2301, 2367]}]}
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