Q-Elastography in the Presurgical Diagnosis of Thyroid Nodules with Indeterminate Cytology
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{"title"=>"Q-Elastography in the Presurgical Diagnosis of Thyroid Nodules with Indeterminate Cytology", "type"=>"journal", "authors"=>[{"first_name"=>"Vito", "last_name"=>"Cantisani", "scopus_author_id"=>"6603675758"}, {"first_name"=>"Salvatore", "last_name"=>"Ulisse", "scopus_author_id"=>"7004684082"}, {"first_name"=>"Eleonora", "last_name"=>"Guaitoli", "scopus_author_id"=>"39061348000"}, {"first_name"=>"Corrado", "last_name"=>"de Vito", "scopus_author_id"=>"24172674300"}, {"first_name"=>"Riccardo", "last_name"=>"Caruso", "scopus_author_id"=>"55166275200"}, {"first_name"=>"Renzo", "last_name"=>"Mocini", "scopus_author_id"=>"55511419500"}, {"first_name"=>"Vito", "last_name"=>"D'Andrea", "scopus_author_id"=>"25121507000"}, {"first_name"=>"Valeria", "last_name"=>"Ascoli", "scopus_author_id"=>"7006462301"}, {"first_name"=>"Alfredo", "last_name"=>"Antonaci", "scopus_author_id"=>"6701513445"}, {"first_name"=>"Carlo", "last_name"=>"Catalano", "scopus_author_id"=>"7103413151"}, {"first_name"=>"Francesco", "last_name"=>"Nardi", "scopus_author_id"=>"7006438478"}, {"first_name"=>"Adriano", "last_name"=>"Redler", "scopus_author_id"=>"6701629479"}, {"first_name"=>"Paolo", "last_name"=>"Ricci", "scopus_author_id"=>"35085415300"}, {"first_name"=>"Enrico", "last_name"=>"de Antoni", "scopus_author_id"=>"7005821269"}, {"first_name"=>"Salvatore", "last_name"=>"Sorrenti", "scopus_author_id"=>"6701466630"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"366195653", "doi"=>"10.1371/journal.pone.0050725", "sgr"=>"84870573042", "scopus"=>"2-s2.0-84870573042", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"23209819"}, "id"=>"4eb69c2e-8293-341b-8088-837c7ade598f", "abstract"=>"Quantitative ultrasound (US) elastography (Q-USE), able to evaluate tissue stiffness has been indicated as a new diagnostic tool to differentiate benign from malignant thyroid lesions. Aim of this prospective study, conducted at the Department of Surgical Sciences, of the \"Sapienza\" University of Rome, was to evaluate the diagnostic accuracy of Q-USE, compared with US parameters, in thyroid nodules with indeterminate cytology (Thy3).The case study included 140 nodules from 140 consecutive patients. Patient's thyroid nodules were evaluated by Q-USE, measuring the strain ratio (SR) of stiffness between nodular and surrounding normal thyroid tissue, and conventional US parameters prior fine-needle aspiration cytology. Those with Thy3 diagnosis were included in the study. Forty of the nodules analyzed harbored a malignant lesion. Q-USE demonstrated that malignant nodules have a significant higher stiffness with respect to benign one and an optimun SR cut-off value of 2.05 was individuated following ROC analysis. Univariate analysis showed that hypoechogenicity, irregular margins and SR >2.05 associated with malignancy, with an accuracy of 67.2%, 81,0% and 89.8%, respectively. Data were unaffected by nodule size or thyroiditis. These findings were confirmed in multivariate analysis demonstrating a significant association of the SR and the irregular margins with thyroid nodule's malignancy. In conclusion, we demonstrated the diagnostic utility of Q-USE in the differential diagnosis of thyroid nodules with indeterminate cytology that, if confirmed, could be of major clinical utility in patients' presurgical selection.", "link"=>"http://www.mendeley.com/research/qelastography-presurgical-diagnosis-thyroid-nodules-indeterminate-cytology", "reader_count"=>22, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Other"=>7, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Other"=>7, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>13, "Agricultural and Biological Sciences"=>3, "Neuroscience"=>1, "Immunology and Microbiology"=>1, "Biochemistry, Genetics and Molecular Biology"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Neuroscience"=>{"Neuroscience"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Italy"=>1, "France"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/535158"], "description"=>"<p>Comparison of the Receiver Operating Characteristic (ROC) curves of the strain ratio, irregular margin and hypoechogenicity/mixed nodules in the diagnosis of malignant Thy3 thyroid nodules.</p>", "links"=>[], "tags"=>["curves", "irregular", "nodules", "malignant", "thy3", "thyroid"], "article_id"=>205632, "categories"=>["Chemistry", "Cancer", "Cell Biology"], "users"=>["Vito Cantisani", "Salvatore Ulisse", "Eleonora Guaitoli", "Corrado De Vito", "Riccardo Caruso", "Renzo Mocini", "Vito D’Andrea", "Valeria Ascoli", "Alfredo Antonaci", "Carlo Catalano", "Francesco Nardi", "Adriano Redler", "Paolo Ricci", "Enrico De Antoni", "Salvatore Sorrenti"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050725.g002", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_the_Receiver_Operating_Characteristic_ROC_curves_of_the_strain_ratio_irregular_margin_and_hypoechogenicity_mixed_nodules_in_the_diagnosis_of_malignant_Thy3_thyroid_nodules_/205632", "title"=>"Comparison of the Receiver Operating Characteristic (ROC) curves of the strain ratio, irregular margin and hypoechogenicity/mixed nodules in the diagnosis of malignant Thy3 thyroid nodules.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 19:35:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/535047"], "description"=>"<p>Distribution of the strain ratio in thy3 benign and malignant thyroid nodules (A) and Receiver Operating Characteristic (ROC) analysis (B) used to identify the optimum cut-off value of the strain ratio to discriminate between benign and malignant Thy3 thyroid nodules.</p>", "links"=>[], "tags"=>["thy3", "benign", "malignant", "thyroid", "nodules", "optimum", "cut-off", "discriminate"], "article_id"=>205506, "categories"=>["Chemistry", "Cancer", "Cell Biology"], "users"=>["Vito Cantisani", "Salvatore Ulisse", "Eleonora Guaitoli", "Corrado De Vito", "Riccardo Caruso", "Renzo Mocini", "Vito D’Andrea", "Valeria Ascoli", "Alfredo Antonaci", "Carlo Catalano", "Francesco Nardi", "Adriano Redler", "Paolo Ricci", "Enrico De Antoni", "Salvatore Sorrenti"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050725.g001", "stats"=>{"downloads"=>2, "page_views"=>34, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_the_strain_ratio_in_thy3_benign_and_malignant_thyroid_nodules_A_and_Receiver_Operating_Characteristic_ROC_analysis_B_used_to_identify_the_optimum_cut_off_value_of_the_strain_ratio_to_discriminate_between_benign_and_malignant_Thy3_thyroid_/205506", "title"=>"Distribution of the strain ratio in thy3 benign and malignant thyroid nodules (A) and Receiver Operating Characteristic (ROC) analysis (B) used to identify the optimum cut-off value of the strain ratio to discriminate between benign and malignant Thy3 thyroid nodules.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 19:34:59"}
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Relative Metric

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