Functional Characterization of TLR4 +3725 G/C Polymorphism and Association with Protection against Overweight
Publication Date
December 11, 2012
Journal
PLOS ONE
Authors
Alberto Penas Steinhardt, Lucía Soledad Barcos, Fiorella Sabrina Belforte, Martha De Sereday, et al
Volume
7
Issue
12
Pages
e50992
DOI
https://dx.plos.org/10.1371/journal.pone.0050992
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0050992
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23239997
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519812
Europe PMC
http://europepmc.org/abstract/MED/23239997
Web of Science
000312290800033
Scopus
84871113198
Mendeley
http://www.mendeley.com/research/functional-characterization-tlr4-3725-gc-polymorphism-association-protection-against-overweight
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Mendeley | Further Information

{"title"=>"Functional Characterization of TLR4 +3725 G/C Polymorphism and Association with Protection against Overweight", "type"=>"journal", "authors"=>[{"first_name"=>"Alberto", "last_name"=>"Penas-Steinhardt", "scopus_author_id"=>"36097148400"}, {"first_name"=>"Lucía Soledad", "last_name"=>"Barcos", "scopus_author_id"=>"55523296500"}, {"first_name"=>"Fiorella Sabrina", "last_name"=>"Belforte", "scopus_author_id"=>"26422815700"}, {"first_name"=>"Martha", "last_name"=>"de Sereday", "scopus_author_id"=>"6603299015"}, {"first_name"=>"Jorge", "last_name"=>"Vilariño", "scopus_author_id"=>"12807179900"}, {"first_name"=>"Claudio Daniel", "last_name"=>"Gonzalez", "scopus_author_id"=>"7403372616"}, {"first_name"=>"María Teresa", "last_name"=>"Martínez-Larrad", "scopus_author_id"=>"6602791349"}, {"first_name"=>"Mariana Lorena", "last_name"=>"Tellechea", "scopus_author_id"=>"35094640800"}, {"first_name"=>"Manuel", "last_name"=>"Serrano-Ríos", "scopus_author_id"=>"55944007600"}, {"first_name"=>"Edgardo", "last_name"=>"Poskus", "scopus_author_id"=>"7004247399"}, {"first_name"=>"Gustavo Daniel", "last_name"=>"Frechtel", "scopus_author_id"=>"6602741278"}, {"first_name"=>"Federico Coluccio", "last_name"=>"Leskow", "scopus_author_id"=>"57032695200"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84871113198", "pmid"=>"23239997", "doi"=>"10.1371/journal.pone.0050992", "pui"=>"366273791", "isbn"=>"1932-6203", "sgr"=>"84871113198"}, "id"=>"1f409365-c1c9-32ec-9138-16f5f2a72614", "abstract"=>"Subclinical low-grade systemic inflammation has been associated with obesity, insulin resistance and metabolic syndrome (MS). Recent studies have highlighted the role of gut microbiota in these disorders. The toll-like receptor 4 (TLR4) plays a key role in the innate immune response activation. We studied two polymorphisms (+3725G/C and 11350G/C) in the 3' untranslated region (3'UTR) of the TLR4 gene that may alter its expression and their association with metabolic disorders related to systemic inflammation. We cloned the 3'UTR into a luciferase reporter system and compared wild-type 3'UTR (WT) and +3725C variant (MUT) constructs luciferase activities. MUT construct reduced the reporter gene activity by 30% compared to WT (P = 0.0001). To evaluate the association between these polymorphisms with biochemical and clinical overweight related variables, we conducted a population cross-sectional study in 966 men of Argentine general population. Considering smoking as a confounding variable that causes systemic inflammation, we studied these possible effects in both, smokers and nonsmokers. The 11350G/C polymorphism was not detected in our sample whereas the CC genotype of +3725 polymorphism was associated with lean subjects (p = 0.011) and higher Adiponectin levels (p = 0.021). Subjects without any NCEP/ATP III MS component were associated with this genotype as well (p = 0.001). These results were strengthened in nonsmokers, in which CC genotype was associated with lean subjects (p = 0.003) and compared with G carriers showed significantly lower BMI (25.53 vs. 28.60 kg/m2; p = 0.023) and waist circumference (89.27 vs. 97.51 cm; p = 0.025). None of these associations were found in smokers. These results showed that +3725C variant has a functional effect down-regulating gene expression and it could be considered as a predictive factor against overweight, particularly in nonsmokers. Considering the role of TLR4 in inflammation, these findings would suggest that the presence of +3725C variant could predict a lower prevalence of chronic metabolic disorders.", "link"=>"http://www.mendeley.com/research/functional-characterization-tlr4-3725-gc-polymorphism-association-protection-against-overweight", "reader_count"=>24, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>4, "Student > Master"=>6, "Student > Bachelor"=>6}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>5, "Student > Ph. D. Student"=>4, "Student > Master"=>6, "Student > Bachelor"=>6}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>13, "Neuroscience"=>1, "Psychology"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"Argentina"=>1, "United States"=>1, "Ukraine"=>2}, "group_count"=>4}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/527758"], "description"=>"<p>Scheme of TLR4 3′UTR, indicating the sequence variants studied and its regulatory regions.</p>", "links"=>[], "tags"=>["tlr4", "variants", "studied"], "article_id"=>198225, "categories"=>["Medicine", "Molecular Biology", "Genetics", "Immunology"], "users"=>["Alberto Penas-Steinhardt", "Lucía Soledad Barcos", "Fiorella Sabrina Belforte", "Martha de Sereday", "Jorge Vilariño", "Claudio Daniel Gonzalez", "Maria Teresa Martínez-Larrad", "Mariana Lorena Tellechea", "Manuel Serrano-Ríos", "Edgardo Poskus", "Gustavo Daniel Frechtel", "Federico Coluccio Leskow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0050992.g001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Scheme_of_TLR4_3_8242_UTR_indicating_the_sequence_variants_studied_and_its_regulatory_regions_/198225", "title"=>"Scheme of TLR4 3′UTR, indicating the sequence variants studied and its regulatory regions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 18:55:02"}

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  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
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  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
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  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
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  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
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  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
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Relative Metric

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