Metabolic Response to Klebsiella pneumoniae Infection in an Experimental Rat Model
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{"title"=>"Metabolic Response to Klebsiella pneumoniae Infection in an Experimental Rat Model", "type"=>"journal", "authors"=>[{"first_name"=>"Fangcong", "last_name"=>"Dong", "scopus_author_id"=>"55512849200"}, {"first_name"=>"Bin", "last_name"=>"Wang", "scopus_author_id"=>"57199070758"}, {"first_name"=>"Lulu", "last_name"=>"Zhang", "scopus_author_id"=>"55512895400"}, {"first_name"=>"Huiru", "last_name"=>"Tang", "scopus_author_id"=>"7403125119"}, {"first_name"=>"Jieshou", "last_name"=>"Li", "scopus_author_id"=>"38862109700"}, {"first_name"=>"Yulan", "last_name"=>"Wang", "scopus_author_id"=>"24336887400"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"366207377", "issn"=>"19326203", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0051060", "scopus"=>"2-s2.0-84870622344", "pmid"=>"23226457", "sgr"=>"84870622344"}, "id"=>"ea84d671-6ac6-30d7-a8f1-2d9a8ee8822b", "abstract"=>"Bacteremia, the presence of viable bacteria in the blood stream, is often associated with several clinical conditions. Bacteremia can lead to multiple organ failure if managed incorrectly, which makes providing suitable nutritional support vital for reducing bacteremia-associated mortality. In order to provide such information, we investigated the metabolic consequences of a Klebsiella pneumoniae (K. pneumoniae) infection in vivo by employing a combination of (1)H nuclear magnetic resonance spectroscopy and multivariate data analysis. K. pneumoniae was intravenously infused in rats; urine and plasma samples were collected at different time intervals. We found that K. pneumoniae-induced bacteremia stimulated glycolysis and the tricarboxylic acid cycle and also promoted oxidation of fatty acids and creatine phosphate to facilitate the energy-demanding host response. In addition, K. pneumoniae bacteremia also induced anti-endotoxin, anti-inflammatory and anti-oxidization responses in the host. Furthermore, bacteremia could cause a disturbance in the gut microbiotal functions as suggested by alterations in a range of amines and bacteria-host co-metabolites. Our results suggest that supplementation with glucose and a high-fat and choline-rich diet could ameliorate the burdens associated with bacteremia. Our research provides underlying pathological processes of bacteremia and a better understanding of the clinical and biochemical manifestations of bacteremia.", "link"=>"http://www.mendeley.com/research/metabolic-response-klebsiella-pneumoniae-infection-experimental-rat-model", "reader_count"=>16, "reader_count_by_academic_status"=>{"Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Other"=>3, "Student > Master"=>3, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Other"=>3, "Student > Master"=>3, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>10, "Medicine and Dentistry"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "reader_count_by_country"=>{"Argentina"=>1, "Japan"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/533391"], "description"=>"<p>Typical 500 MHz <sup>1</sup>H (CPMG) NMR spectra of plasma obtained from a non-infected SD rat (P<sub>A</sub>) and a rat infected with <i>K. pneumoniae</i> for 8 hours (P<sub>B</sub>). The region of δ 5.0–9.0 in the blood plasma spectra was vertically expanded 16 times compared with the region of δ 0.5–4.5; Representative 600 MHZ <sup>1</sup>H NMR spectra of urine samples obtained from a non-infected SD rat (U<sub>A</sub>) and a rat infected with <i>K. pneumoniae</i> for 8 hours (U<sub>B</sub>). The spectral region, δ 6.2–9.5, was vertically expanded 4 times compared with the region of δ 0.5–4.4. Key: 1,lipoprotein; 2,valine; 3,leucine; 4,isoleucine; 5,creatine; 6,<i>N</i>-acetyl glycoprotein; 7,<i>O</i>-acetyl glycoprotein; 8,alanine; 9,lactate; 10,acetoacetate; 11,α-glucose; 12,acetate; 13,pyruvate; 14,dihydrothymine; 15,threonine; 16,unsaturated fatty acid; 17,choline; 18,phosphorylcholine; 19,glycerophosphocholine; 20,lysine; 21,citrate; 22,<sub>D</sub>-3-hydroxybutyrate; 23,glutamine; 24,glutamate; 25,histidine; 26,phenylalanine; 27,tyrosine; 28,formate; 29,trimethylamine; 30,urea; 31,triglyceride; 32,arginine; 33,ω-3 fatty acid; 34,poly unsaturated fatty acid; 35,glucose and amino acids α-CH resonances; 36,2-oxoglutarate; 37,creatinine; 38,hippurate; 39,1-methylnicotimamide; 40,acetamide; 41,fumarate; 42,phenylacetylglycine; 43,cis-aconitate; 44,pantothenic acid; 45,succinate; 46,<i>N</i>-methylnicotinate; 47,malate; 48,indoxyl sulfate; 49,dimethylamine; 50,glycine; 51,isovalerate; 52,2-(4-hydroxyphenyl)propanoic acid; 53,2,3-dihydroxybutyrate; 54,4-cresol glucuronide; 55,dimethylglycine; 56,taurine; 57,hypotaurine; 58,4-deoxyerythronate; 59,trimethylamine <i>N</i>-oxide.</p>", "links"=>[], "tags"=>["nmr", "spectra", "plasma", "urine", "infected", "rats"], "article_id"=>203875, "categories"=>["Biochemistry", "Chemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Fangcong Dong", "Bin Wang", "Lulu Zhang", "Huiru Tang", "Jieshou Li", "Yulan Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051060.g001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_1_H_NMR_spectra_of_plasma_and_urine_from_control_and_K_pneumoniae_infected_rats_for_8_hours_/203875", "title"=>"<sup>1</sup>H NMR spectra of plasma and urine from control and <i>K. pneumoniae</i> infected rats for 8 hours.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-30 01:04:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/286973"], "description"=>"<div><p>Bacteremia, the presence of viable bacteria in the blood stream, is often associated with several clinical conditions. Bacteremia can lead to multiple organ failure if managed incorrectly, which makes providing suitable nutritional support vital for reducing bacteremia-associated mortality. In order to provide such information, we investigated the metabolic consequences of a <em>Klebsiella pneumoniae</em> (<em>K. pneumoniae</em>) infection <em>in vivo</em> by employing a combination of <sup>1</sup>H nuclear magnetic resonance spectroscopy and multivariate data analysis. <em>K. pneumoniae</em> was intravenously infused in rats; urine and plasma samples were collected at different time intervals. We found that <em>K. pneumoniae-</em>induced bacteremia stimulated glycolysis and the tricarboxylic acid cycle and also promoted oxidation of fatty acids and creatine phosphate to facilitate the energy-demanding host response. In addition, <em>K. pneumoniae</em> bacteremia also induced anti-endotoxin, anti-inflammatory and anti-oxidization responses in the host. Furthermore, bacteremia could cause a disturbance in the gut microbiotal functions as suggested by alterations in a range of amines and bacteria-host co-metabolites. Our results suggest that supplementation with glucose and a high-fat and choline-rich diet could ameliorate the burdens associated with bacteremia. Our research provides underlying pathological processes of bacteremia and a better understanding of the clinical and biochemical manifestations of bacteremia.</p> </div>", "links"=>[], "tags"=>["metabolic", "model"], "article_id"=>116549, "categories"=>["Cancer", "Biochemistry", "Chemistry", "Genetics", "Immunology"], "users"=>["Fangcong Dong", "Bin Wang", "Lulu Zhang", "Huiru Tang", "Jieshou Li", "Yulan Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051060", "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Metabolic_Response_to_Klebsiella_pneumoniae_Infection_in_an_Experimental_Rat_Model__/116549", "title"=>"Metabolic Response to <em>Klebsiella pneumoniae</em> Infection in an Experimental Rat Model", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-11-30 01:49:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/533869"], "description"=>"<p>The metabolites in red indicate the changes in plasma and those in blue indicate the changes in urine whereas those in black were not observed; the arrows pointing up and down denoted relative increase and decrease in the infected group compared with the controls.</p>", "links"=>[], "tags"=>["metabolites", "metabolic", "pathways"], "article_id"=>204358, "categories"=>["Biochemistry", "Chemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Fangcong Dong", "Bin Wang", "Lulu Zhang", "Huiru Tang", "Jieshou Li", "Yulan Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051060.g005", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_representation_of_the_metabolites_and_metabolic_pathways_in_K_pneumoniae_bacteremia_/204358", "title"=>"Schematic representation of the metabolites and metabolic pathways in <i>K. pneumoniae</i> bacteremia.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-30 01:12:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/534003"], "description"=>"a<p>Values are cumulative. One PLS component and one orthogonal component are calculated. The R<sup>2</sup>X value shows how much variation in the data set is explained by the model. The Q<sup>2</sup> value represents the predictability of the model.</p>b<p>All models have been validated using permutation tests (n = 200) and ANOVA of the cross-validated residuals (CV-ANOVA) tests. P-values are obtained from CV-ANOVA tests. The underlined values indicate valid models (p<0.05).</p>", "links"=>[], "tags"=>["cross-validation", "pair-wise", "nmr", "spectra", "plasma", "urine", "rats", "compared", "controls"], "article_id"=>204488, "categories"=>["Biochemistry", "Chemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Fangcong Dong", "Bin Wang", "Lulu Zhang", "Huiru Tang", "Jieshou Li", "Yulan Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051060.t002", "stats"=>{"downloads"=>8, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_O_PLS_DA_Cross_validation_Model_Summary_for_Pair_wise_Comparison_between_NMR_Spectra_of_Plasma_and_Urine_Obtained_from_K_pneumoniae_infected_Rats_Compared_to_Controls_on_Different_Time_Points_a_/204488", "title"=>"O-PLS-DA Cross-validation Model Summary for Pair-wise Comparison between NMR Spectra of Plasma and Urine Obtained from <i>K. pneumoniae-</i>infected Rats Compared to Controls on Different Time Points<sup>a</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-11-30 01:14:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/533760"], "description"=>"<p>(A) Cross validated O-PLS-DA scores (left hand side) and coefficient plots (right hand side) generated from NMR spectral data of urine of rats at 8 hours after <i>K. pneumoniae</i> infection (red dots), compared with those of non-infected (black squares). (B) a-f plots show metabolites changes in urine. C<sub>inf</sub> and C<sub>con</sub> stand for the averaged concentration in the infection and control group, respectively.</p>", "links"=>[], "tags"=>["urine", "spectra", "infected", "rats", "corresponding", "controls", "metabolite", "changes", "points"], "article_id"=>204233, "categories"=>["Biochemistry", "Chemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Fangcong Dong", "Bin Wang", "Lulu Zhang", "Huiru Tang", "Jieshou Li", "Yulan Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051060.g004", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_O_PLS_DA_comparison_between_urine_spectra_from_K_pneumoniae_infected_rats_and_corresponding_controls_and_metabolite_concentration_changes_relative_to_corresponding_controls_at_different_time_points_after_K_pneumoniae_infection_/204233", "title"=>"O-PLS-DA comparison between urine spectra from <i>K. pneumoniae</i> infected rats and corresponding controls and metabolite concentration changes relative to corresponding controls at different time points after <i>K. pneumoniae</i> infection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-30 01:10:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/533628"], "description"=>"<p>(A) Cross validated O-PLS-DA scores (left hand side) and coefficient plots (right hand side) generated from NMR spectral data of plasma of rats at 8 hours after <i>K. pneumoniae</i> infection (red dots), compared with those of non-infected (black squares). (B) a-c plots show metabolites changes in plasma. C<sub>inf</sub> and C<sub>con</sub> stand for the averaged concentration in the infection and control group, respectively.</p>", "links"=>[], "tags"=>["plasma", "spectra", "infected", "rats", "corresponding", "controls", "metabolite", "changes", "points"], "article_id"=>204110, "categories"=>["Biochemistry", "Chemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Fangcong Dong", "Bin Wang", "Lulu Zhang", "Huiru Tang", "Jieshou Li", "Yulan Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051060.g003", "stats"=>{"downloads"=>4, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_O_PLS_DA_comparison_between_plasma_spectra_from_K_pneumoniae_infected_rats_and_corresponding_controls_and_metabolite_concentration_changes_relative_to_corresponding_controls_at_different_time_points_after_K_pneumoniae_infection_/204110", "title"=>"O-PLS-DA comparison between plasma spectra from <i>K. pneumoniae</i> infected rats and corresponding controls and metabolite concentration changes relative to corresponding controls at different time points after <i>K. pneumoniae</i> infection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-30 01:08:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/533504"], "description"=>"<p>Time-dependent trajectories of plasma (A, R<sup>2</sup>X = 0.928, Q<sup>2</sup> = 0.918) and urinary (B, R<sup>2</sup>X = 0.789, Q<sup>2</sup> = 0.614) metabolic profiles of the control group (black squares) and the infection group (red squares) from hour 0 to day 14. Bars denote the standard deviations of each group.</p>", "links"=>[], "tags"=>["plasma", "urinary", "metabolic", "profiles", "infected"], "article_id"=>203993, "categories"=>["Biochemistry", "Chemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Fangcong Dong", "Bin Wang", "Lulu Zhang", "Huiru Tang", "Jieshou Li", "Yulan Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051060.g002", "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Trajectories_of_plasma_and_urinary_metabolic_profiles_of_the_control_group_and_the_infected_group_at_different_time_intervals_/203993", "title"=>"Trajectories of plasma and urinary metabolic profiles of the control group and the infected group at different time intervals.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-11-30 01:06:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/533959"], "description"=>"a<p>Bacterial counts data are represented as median (range); Procalcitonin, white blood cell count and C-reactive protein are represented as mean ± SD. *p<0.05, **p<0.01.</p>", "links"=>[], "tags"=>["c-reactive", "rats", "compared"], "article_id"=>204445, "categories"=>["Biochemistry", "Chemistry", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Fangcong Dong", "Bin Wang", "Lulu Zhang", "Huiru Tang", "Jieshou Li", "Yulan Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051060.t001", "stats"=>{"downloads"=>11, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bacterial_counts_procalcitonin_white_blood_cell_count_and_C_reactive_protein_in_blood_stream_obtained_from_K_pneumoniae_infected_rats_compared_to_controls_a_/204445", "title"=>"Bacterial counts, procalcitonin, white blood cell count and C-reactive protein in blood stream obtained from <i>K.</i><i>pneumoniae-</i>infected rats compared to controls<sup>a</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-11-30 01:14:05"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"6", "full-text"=>"1", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
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  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
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Relative Metric

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