Self-Rotation of Cells in an Irrotational AC E-Field in an Opto-Electrokinetics Chip
Publication Date
January 08, 2013
Journal
PLOS ONE
Authors
Long Ho Chau, Wenfeng Liang, Florence Wing Ki Cheung, Wing Keung Liu, et al
Volume
8
Issue
1
Pages
e51577
DOI
https://dx.plos.org/10.1371/journal.pone.0051577
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0051577
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/23320067
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540069
Europe PMC
http://europepmc.org/abstract/MED/23320067
Web of Science
000313429800009
Scopus
84872193631
Mendeley
http://www.mendeley.com/research/selfrotation-cells-irrotational-ac-efield-optoelectrokinetics-chip
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Mendeley | Further Information

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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/511337"], "description"=>"<p>Rotational speed of the lymphocytes in 0.2 M sucrose solution versus applied frequency from 40 kHz to 1 MHz at 20 Vpp.</p>", "links"=>[], "tags"=>["lymphocytes", "sucrose", "applied", "40", "khz", "mhz", "20"], "article_id"=>181824, "categories"=>["Physics", "Biophysics"], "users"=>["Long-Ho Chau", "Wenfeng Liang", "Florence Wing Ki Cheung", "Wing Keung Liu", "Wen Jung Li", "Shih-Chi Chen", "Gwo-Bin Lee"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051577.g009", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Rotational_speed_of_the_lymphocytes_in_0_2_M_sucrose_solution_versus_applied_frequency_from_40_kHz_to_1_MHz_at_20_Vpp_/181824", "title"=>"Rotational speed of the lymphocytes in 0.2 M sucrose solution versus applied frequency from 40 kHz to 1 MHz at 20 Vpp.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-08 00:30:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/511072"], "description"=>"<p>The cells in the dark-field region rotated toward the 30 µm spot image. Their <i>z</i>-axes were normal to the positive DEP force vectors. The axis of rotation was at the <i>x</i>-axis perpendicular to the E-field.</p>", "links"=>[], "tags"=>["rotation"], "article_id"=>181568, "categories"=>["Physics", "Biophysics"], "users"=>["Long-Ho Chau", "Wenfeng Liang", "Florence Wing Ki Cheung", "Wing Keung Liu", "Wen Jung Li", "Shih-Chi Chen", "Gwo-Bin Lee"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051577.g005", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Illustration_of_cell_rotation_in_an_OEK_/181568", "title"=>"Illustration of cell rotation in an OEK.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-08 00:26:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/511478"], "description"=>"<p>The response of white blood cell samples in the DEP field.</p>", "links"=>[], "tags"=>["samples", "dep"], "article_id"=>181971, "categories"=>["Physics", "Biophysics"], "users"=>["Long-Ho Chau", "Wenfeng Liang", "Florence Wing Ki Cheung", "Wing Keung Liu", "Wen Jung Li", "Shih-Chi Chen", "Gwo-Bin Lee"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051577.t001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_response_of_white_blood_cell_samples_in_the_DEP_field_/181971", "title"=>"The response of white blood cell samples in the DEP field.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-08 00:32:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/510986"], "description"=>"<p>Three optical images were projected onto an a-Si:H surface. A 10 µm diameter micro polystyrene bead acted as a control. (A) Peripheral WBCs experienced a negative DEP force at the applied frequency of 50 kHz and a voltage of 10 Vpp. They lay in the dark-field region and between the square and the ring image. (B) When the frequency was 200 kHz, 10 Vpp, a positive DEP force caused the cells to shift into the image. The polystyrene beads stayed in the same position in both cases because they only experienced a negative DEP force in 0.2 M sucrose solution.</p>", "links"=>[], "tags"=>["acting", "peripheral"], "article_id"=>181481, "categories"=>["Physics", "Biophysics"], "users"=>["Long-Ho Chau", "Wenfeng Liang", "Florence Wing Ki Cheung", "Wing Keung Liu", "Wen Jung Li", "Shih-Chi Chen", "Gwo-Bin Lee"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051577.g004", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_DEP_force_acting_on_the_peripheral_WBCs_/181481", "title"=>"DEP force acting on the peripheral WBCs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-08 00:24:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/511147"], "description"=>"<p>Time lapse for a melan-a cell completing one revolution with the applied frequency of 40 kHz at 6 Vpp as recorded by a CCD camera after grey-scale treatment. The similarity coefficients were 1 (A), 0.9973 (B), 0.9964 (C), 0.99656 (D), 0.9951(E) and 0.9963(F). Images were taken 0.155 seconds apart. The rotational speed was recorded as 65 rpm.</p>", "links"=>[], "tags"=>["biophysics", "physics"], "article_id"=>181639, "categories"=>["Physics", "Biophysics"], "users"=>["Long-Ho Chau", "Wenfeng Liang", "Florence Wing Ki Cheung", "Wing Keung Liu", "Wen Jung Li", "Shih-Chi Chen", "Gwo-Bin Lee"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051577.g006", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Rotation_of_melan_a_/181639", "title"=>"Rotation of melan-a.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-08 00:27:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/511438"], "description"=>"<p>The response of melan-a cells and macrophages to the DEP field.</p>", "links"=>[], "tags"=>["melan-a", "cells", "macrophages", "dep"], "article_id"=>181928, "categories"=>["Physics", "Biophysics"], "users"=>["Long-Ho Chau", "Wenfeng Liang", "Florence Wing Ki Cheung", "Wing Keung Liu", "Wen Jung Li", "Shih-Chi Chen", "Gwo-Bin Lee"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051577.t002", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_response_of_melan_a_cells_and_macrophages_to_the_DEP_field_/181928", "title"=>"The response of melan-a cells and macrophages to the DEP field.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-08 00:32:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/511403"], "description"=>"<p>Rotation behavior of white blood cell samples in the DEP field.</p>", "links"=>[], "tags"=>["samples", "dep"], "article_id"=>181896, "categories"=>["Physics", "Biophysics"], "users"=>["Long-Ho Chau", "Wenfeng Liang", "Florence Wing Ki Cheung", "Wing Keung Liu", "Wen Jung Li", "Shih-Chi Chen", "Gwo-Bin Lee"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051577.t003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Rotation_behavior_of_white_blood_cell_samples_in_the_DEP_field_/181896", "title"=>"Rotation behavior of white blood cell samples in the DEP field.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-08 00:31:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/510928"], "description"=>"<p>An illustration of the OEK used to manipulate biological cells. The patterned optical image is focused by a condenser lens and projected onto the hydrogenated amorphous silicon surface.</p>", "links"=>[], "tags"=>["opto-electrokinetics"], "article_id"=>181419, "categories"=>["Physics", "Biophysics"], "users"=>["Long-Ho Chau", "Wenfeng Liang", "Florence Wing Ki Cheung", "Wing Keung Liu", "Wen Jung Li", "Shih-Chi Chen", "Gwo-Bin Lee"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051577.g003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_opto_electrokinetics_device_OEK_/181419", "title"=>"The opto-electrokinetics device (OEK).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-08 00:23:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/278259", "https://ndownloader.figshare.com/files/278282", "https://ndownloader.figshare.com/files/278309", "https://ndownloader.figshare.com/files/278435"], "description"=>"<div><p>The use of optical dielectrophoresis (ODEP) to manipulate microparticles and biological cells has become increasingly popular due to its tremendous flexibility in providing reconfigurable electrode patterns and flow channels. ODEP enables the parallel and free manipulation of small particles on a photoconductive surface on which light is projected, thus eliminating the need for complex electrode design and fabrication processes. In this paper, we demonstrate that mouse cells comprising melan-a cells, RAW 267.4 macrophage cells, peripheral white blood cells and lymphocytes, can be manipulated in an opto-electrokinetics (OEK) device with appropriate DEP parameters. Our OEK device generates a non-rotating electric field and exerts a localized DEP force on optical electrodes. Hitherto, we are the first group to report that among all the cells investigated, melan-a cells, lymphocytes and white blood cells were found to undergo self-rotation in the device in the presence of a DEP force. The rotational speed of the cells depended on the voltage and frequency applied and the cells' distance from the optical center. We discuss a possible mechanism for explaining this new observation of induced self-rotation based on the physical properties of cells. We believe that this rotation phenomenon can be used to identify cell type and to elucidate the dielectric and physical properties of cells.</p> </div>", "links"=>[], "tags"=>["self-rotation", "cells", "irrotational", "ac", "e-field", "opto-electrokinetics", "chip"], "article_id"=>114858, "categories"=>["Physics", "Biophysics"], "users"=>["Long-Ho Chau", "Wenfeng Liang", "Florence Wing Ki Cheung", "Wing Keung Liu", "Wen Jung Li", "Shih-Chi Chen", "Gwo-Bin Lee"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0051577.s001", "https://dx.doi.org/10.1371/journal.pone.0051577.s002", "https://dx.doi.org/10.1371/journal.pone.0051577.s003", "https://dx.doi.org/10.1371/journal.pone.0051577.s004"], "stats"=>{"downloads"=>4, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Self_Rotation_of_Cells_in_an_Irrotational_AC_E_Field_in_an_Opto_Electrokinetics_Chip__/114858", "title"=>"Self-Rotation of Cells in an Irrotational AC E-Field in an Opto-Electrokinetics Chip", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-01-08 01:20:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/510790"], "description"=>"<p>A spherical particle with radius <i>R</i>, permittivity and conductivity, which is covered by a uniform layer of thickness , permittivity and conductivity , and surrounded by a solution of permittivity and conductivity .</p>", "links"=>[], "tags"=>["single-shell"], "article_id"=>181285, "categories"=>["Physics", "Biophysics"], "users"=>["Long-Ho Chau", "Wenfeng Liang", "Florence Wing Ki Cheung", "Wing Keung Liu", "Wen Jung Li", "Shih-Chi Chen", "Gwo-Bin Lee"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051577.g001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_single_shell_model_/181285", "title"=>"The single-shell model.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-08 00:21:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/510853"], "description"=>"<p>Experimental setup for manipulating cells with opto-electrokinetic device.</p>", "links"=>[], "tags"=>["odep"], "article_id"=>181343, "categories"=>["Physics", "Biophysics"], "users"=>["Long-Ho Chau", "Wenfeng Liang", "Florence Wing Ki Cheung", "Wing Keung Liu", "Wen Jung Li", "Shih-Chi Chen", "Gwo-Bin Lee"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051577.g002", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Illustration_of_an_ODEP_system_/181343", "title"=>"Illustration of an ODEP system.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-08 00:22:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/511220"], "description"=>"<p>Rotational speed of the melan-a and lymphocytes in 0.2 M sucrose solution versus applied voltage from 0 Vpp to 20 Vpp at 40 kHz.</p>", "links"=>[], "tags"=>["melan-a", "lymphocytes", "sucrose", "applied", "voltage", "vpp", "20", "40"], "article_id"=>181700, "categories"=>["Physics", "Biophysics"], "users"=>["Long-Ho Chau", "Wenfeng Liang", "Florence Wing Ki Cheung", "Wing Keung Liu", "Wen Jung Li", "Shih-Chi Chen", "Gwo-Bin Lee"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051577.g007", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Rotational_speed_of_the_melan_a_and_lymphocytes_in_0_2_M_sucrose_solution_versus_applied_voltage_from_0_Vpp_to_20_Vpp_at_40_kHz_/181700", "title"=>"Rotational speed of the melan-a and lymphocytes in 0.2 M sucrose solution versus applied voltage from 0 Vpp to 20 Vpp at 40 kHz.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-08 00:28:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/511277"], "description"=>"<p>Rotational speed of the melan-a in 0.2 M sucrose solution versus applied frequency from 40 kHz to 1 MHz at 20 Vpp.</p>", "links"=>[], "tags"=>["melan-a", "sucrose", "applied", "40", "khz", "mhz", "20"], "article_id"=>181759, "categories"=>["Physics", "Biophysics"], "users"=>["Long-Ho Chau", "Wenfeng Liang", "Florence Wing Ki Cheung", "Wing Keung Liu", "Wen Jung Li", "Shih-Chi Chen", "Gwo-Bin Lee"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051577.g008", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Rotational_speed_of_the_melan_a_in_0_2_M_sucrose_solution_versus_applied_frequency_from_40_kHz_to_1_MHz_at_20_Vpp_/181759", "title"=>"Rotational speed of the melan-a in 0.2 M sucrose solution versus applied frequency from 40 kHz to 1 MHz at 20 Vpp.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-08 00:29:19"}

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Relative Metric

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