Pilot Investigation of the Circadian Plasma Melatonin Rhythm across the Menstrual Cycle in a Small Group of Women with Premenstrual Dysphoric Disorder
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{"title"=>"Pilot Investigation of the Circadian Plasma Melatonin Rhythm across the Menstrual Cycle in a Small Group of Women with Premenstrual Dysphoric Disorder", "type"=>"journal", "authors"=>[{"first_name"=>"Ari", "last_name"=>"Shechter"}, {"first_name"=>"Paul", "last_name"=>"Lespérance"}, {"first_name"=>"N. M. K.", "last_name"=>"Ng Ying Kin"}, {"first_name"=>"Diane B.", "last_name"=>"Boivin"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0051929", "isbn"=>"1932-6203", "pmid"=>"23284821", "issn"=>"1932-6203"}, "id"=>"575ce009-a521-3d6d-92dd-0f806a86da83", "abstract"=>"Women with premenstrual dysphoric disorder (PMDD) experience mood deterioration and altered circadian rhythms during the luteal phase (LP) of their menstrual cycles. Disturbed circadian rhythms may be involved in the development of clinical mood states, though this relationship is not fully characterized in PMDD. We therefore conducted an extensive chronobiological characterization of the melatonin rhythm in a small group of PMDD women and female controls. In this pilot study, participants included five women with PMDD and five age-matched controls with no evidence of menstrual-related mood disorders. Participants underwent two 24-hour laboratory visits, during the follicular phase (FP) and LP of the menstrual cycle, consisting of intensive physiological monitoring under \"unmasked\", time-isolation conditions. Measures included visual analogue scale for mood, ovarian hormones, and 24-hour plasma melatonin. Mood significantly (P≤.03) worsened during LP in PMDD compared to FP and controls. Progesterone was significantly (P = .025) increased during LP compared to FP, with no between-group differences. Compared to controls, PMDD women had significantly (P<.05) decreased melatonin at circadian phases spanning the biological night during both menstrual phases and reduced amplitude of its circadian rhythm during LP. PMDD women also had reduced area under the curve of melatonin during LP compared to FP. PMDD women showed affected circadian melatonin rhythms, with reduced nocturnal secretion and amplitude during the symptomatic phase compared to controls. Despite our small sample size, these pilot findings support a role for disturbed circadian rhythms in affective disorders. Possible associations with disrupted serotonergic transmission are proposed.", "link"=>"http://www.mendeley.com/research/pilot-investigation-circadian-plasma-melatonin-rhythm-across-menstrual-cycle-small-group-women-preme-4", "reader_count"=>17, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Student > Bachelor"=>7}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Student > Bachelor"=>7}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>2, "Sports and Recreations"=>2, "Psychology"=>3, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Psychology"=>{"Psychology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Greece"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/522391"], "description"=>"<p>PMDD: premenstrual dysphoric disorder; FP: follicular phase; LP: luteal phase; DLMOn, dim light melatonin onset; DLMOff, dim light melatonin offset; AUC, area under the curve.</p><p>Values are mean ± SEM.</p>a<p>indicates different than controls at the level of P = .05 when LP values compared.</p>b<p>indicates different than PMDD FP at level of P = .03.</p>", "links"=>[], "tags"=>["melatonin", "controls", "pmdd"], "article_id"=>192882, "categories"=>["Chemistry", "Physiology", "Mental Health"], "users"=>["Ari Shechter", "Paul Lespérance", "N. M. K. Ng Ying Kin", "Diane B. Boivin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051929.t003", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Circadian_melatonin_profile_in_controls_and_PMDD_women_/192882", "title"=>"Circadian melatonin profile in controls and PMDD women.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 18:26:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/522324"], "description"=>"<p>PMDD: premenstrual dysphoric disorder; BMI: body mass index; FP: follicular phase; LP: luteal phase; VAS-core: mean score of visual analogue scale measures for depression, tension, affective lability and irritability values are mean ± SEM.</p>†<p>Participant characteristics were also included in a related manuscript <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0051929#pone.0051929-Shechter3\" target=\"_blank\">[26]</a>.</p>a<p>indicates PMDD late-LP value is significantly (P≤.03) different than PMDD FP value and pone.0051929.g003.tifcontrol values in both menstrual phases.</p>b<p>indicates LP values are significantly (P = .025) different than FP values.</p>", "links"=>[], "tags"=>["controls", "pmdd"], "article_id"=>192827, "categories"=>["Chemistry", "Physiology", "Mental Health"], "users"=>["Ari Shechter", "Paul Lespérance", "N. M. K. Ng Ying Kin", "Diane B. Boivin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051929.t001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_controls_and_PMDD_participants_8224_/192827", "title"=>"Characteristics of controls and PMDD participants<sup>†</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 18:26:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/522076"], "description"=>"<p>* indicates significant differences between controls and PMDD women (P<.05). Data are double-plotted for illustration purposes. Values are mean ± SEM.</p>", "links"=>[], "tags"=>["plasma", "melatonin", "follicular", "luteal", "phases", "pmdd", "women"], "article_id"=>192564, "categories"=>["Chemistry", "Physiology", "Mental Health"], "users"=>["Ari Shechter", "Paul Lespérance", "N. M. K. Ng Ying Kin", "Diane B. Boivin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051929.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Circadian_variation_of_plasma_melatonin_during_the_follicular_and_luteal_phases_in_PMDD_women_and_controls_/192564", "title"=>"Circadian variation of plasma melatonin during the follicular and luteal phases in PMDD women and controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 18:24:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/522235"], "description"=>"<p>* indicates significant differences between controls and PMDD women (P<.05). Data are double-plotted for illustration purposes. Values are mean ± SEM. <sup>†</sup> This figure presents FP data from the 5 control participants and 5 PMDD participants included in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0051929#pone-0051929-g001\" target=\"_blank\">Figure 1</a>, but the control group is supplemented by data from 3 other young healthy women who were studied under constant conditions in unrelated experiments. This larger group of 8 controls was compared to the 5 PMDD women of the current study during the FP in an attempt to increase sample size and further confirm results from our baseline group comparisons.</p>", "links"=>[], "tags"=>["plasma", "melatonin", "follicular", "pmdd", "women", "expanded"], "article_id"=>192727, "categories"=>["Chemistry", "Physiology", "Mental Health"], "users"=>["Ari Shechter", "Paul Lespérance", "N. M. K. Ng Ying Kin", "Diane B. Boivin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051929.g002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Circadian_variation_of_plasma_melatonin_during_the_follicular_phase_in_PMDD_women_and_an_expanded_group_of_controls_8224_/192727", "title"=>"Circadian variation of plasma melatonin during the follicular phase in PMDD women and an expanded group of controls.<sup>†</sup>", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 18:25:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/522363"], "description"=>"†<p>This table presents characteristics from the 5 control participants and 5 PMDD participants included in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0051929#pone-0051929-t001\" target=\"_blank\">Table 1</a>, but the control group is supplemented by demographics data from 3 other young healthy women who were studied under constant conditions in unrelated experiments. This larger group of 8 controls was compared to the 5 PMDD women of the current study during the FP in an attempt to increase sample size and further confirm results from our baseline group comparisons. Menstrual phase length, VAS-core scores, and progesterone and estradiol levels were not available for the 3 supplementary control participants. Values are mean ± SEM.</p>", "links"=>[], "tags"=>["expanded", "controls", "pmdd"], "article_id"=>192856, "categories"=>["Chemistry", "Physiology", "Mental Health"], "users"=>["Ari Shechter", "Paul Lespérance", "N. M. K. Ng Ying Kin", "Diane B. Boivin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051929.t002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_expanded_group_of_controls_and_PMDD_participants_8224_/192856", "title"=>"Characteristics of the expanded group of controls and PMDD participants<sup>†</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 18:26:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/522421"], "description"=>"<p>PMDD: premenstrual dysphoric disorder; FP: follicular phase; DLMOn: dim light melatonin onset; DLMOff: dim light melatonin offset; AUC: area under the curve values are mean ± SEM.</p>†<p>This table presents FP data from the 5 control participants and 5 PMDD participants included in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0051929#pone-0051929-t001\" target=\"_blank\">Table 1</a>, but the control group is supplemented by data from 3 other young healthy women who were studied under constant conditions in unrelated experiments. This larger group of 8 controls was compared to the 5 PMDD women of the current study during the FP in an attempt to increase sample size and further confirm results from our baseline group comparisons.</p>", "links"=>[], "tags"=>["melatonin", "follicular", "pmdd", "women", "expanded"], "article_id"=>192919, "categories"=>["Chemistry", "Physiology", "Mental Health"], "users"=>["Ari Shechter", "Paul Lespérance", "N. M. K. Ng Ying Kin", "Diane B. Boivin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0051929.t004", "stats"=>{"downloads"=>6, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Circadian_melatonin_profile_during_the_follicular_phase_in_PMDD_women_and_an_expanded_group_of_controls_8224_/192919", "title"=>"Circadian melatonin profile during the follicular phase in PMDD women and an expanded group of controls.<sup>†</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 18:26:36"}

PMC Usage Stats | Further Information

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Relative Metric

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