Canine Recombinant Adenovirus Vector Induces an Immunogenicity-Related Gene Expression Profile in Skin-Migrated CD11b+ -Type DCs
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{"title"=>"Canine Recombinant Adenovirus Vector Induces an Immunogenicity-Related Gene Expression Profile in Skin-Migrated CD11b+ -Type DCs", "type"=>"journal", "authors"=>[{"first_name"=>"Vanessa", "last_name"=>"Contreras", "scopus_author_id"=>"24334348100"}, {"first_name"=>"Céline", "last_name"=>"Urien", "scopus_author_id"=>"6507549664"}, {"first_name"=>"Luc", "last_name"=>"Jouneau", "scopus_author_id"=>"16836651100"}, {"first_name"=>"Mickael", "last_name"=>"Bourge", "scopus_author_id"=>"36011550000"}, {"first_name"=>"Coraline", "last_name"=>"Bouet-Cararo", "scopus_author_id"=>"36676919300"}, {"first_name"=>"Michel", "last_name"=>"Bonneau", "scopus_author_id"=>"7006854859"}, {"first_name"=>"Stephan", "last_name"=>"Zientara", "scopus_author_id"=>"7003285526"}, {"first_name"=>"Bernard", "last_name"=>"Klonjkowski", "scopus_author_id"=>"6603155515"}, {"first_name"=>"Isabelle", "last_name"=>"Schwartz-Cornil", "scopus_author_id"=>"6602578811"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"23300693", "doi"=>"10.1371/journal.pone.0052513", "pui"=>"366343731", "issn"=>"19326203", "sgr"=>"84871600279", "scopus"=>"2-s2.0-84871600279"}, "id"=>"70a97a2d-3e9a-3a2b-843c-339a0f28486c", "abstract"=>"Gene expression profiling of the blood cell response induced early after vaccination has previously been demonstrated to predict the immunogenicity of vaccines. In this study, we evaluated whether the analysis of the gene expression profile of skin-migrated dendritic cells (DCs) could be informative for the in vitro prediction of immunogenicity of vaccine, using canine adenovirus serotype 2 (CAV2) as vaccine vector. CAV2 has been shown to induce immunity to transgenes in several species including sheep and is an interesting alternative to human adenovirus-based vectors, based on the safety records of the parental strain in dogs and the lack of pre-existing immunity in non-host species. Skin-migrated DCs were collected from pseudo-afferent lymph in sheep. Both the CD11b(+) -type and CD103(+) -type skin-migrated DCs were transduced by CAV2. An analysis of the global gene response to CAV2 in the two skin DC subsets showed that the gene response in CD11b(+) -type DCs was far higher and broader than in the CD103(+) -type DCs. A newly released integrative analytic tool from Ingenuity systems revealed that the CAV2-modulated genes in the CD11b(+) -type DCs clustered in several activated immunogenicity-related functions, such as immune response, immune cell trafficking and inflammation. Thus gene profiling in skin-migrated DC in vitro indicates that the CD11b(+) DC type is more responsive to CAV2 than the CD103(+) DC type, and provides valuable information to help in evaluating and possibly improving viral vector vaccine effectiveness.", "link"=>"http://www.mendeley.com/research/canine-recombinant-adenovirus-vector-induces-immunogenicityrelated-gene-expression-profile-skinmigra", "reader_count"=>9, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>1, "Other"=>1, "Professor"=>1, "Student > Bachelor"=>1, "Student > Postgraduate"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>1, "Other"=>1, "Professor"=>1, "Student > Bachelor"=>1, "Student > Postgraduate"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Immunology and Microbiology"=>1, "Neuroscience"=>1, "Biochemistry, Genetics and Molecular Biology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Mexico"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/280724/Figure_S1.tif", "https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/280753/Figure_S2.tif", "https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/280803/Table_S1.doc", "https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/280943/Table_S2.doc"], "description"=>"<div><p>Gene expression profiling of the blood cell response induced early after vaccination has previously been demonstrated to predict the immunogenicity of vaccines. In this study, we evaluated whether the analysis of the gene expression profile of skin-migrated dendritic cells (DCs) could be informative for the <em>in vitro</em> prediction of immunogenicity of vaccine, using canine adenovirus serotype 2 (CAV2) as vaccine vector. CAV2 has been shown to induce immunity to transgenes in several species including sheep and is an interesting alternative to human adenovirus-based vectors, based on the safety records of the parental strain in dogs and the lack of pre-existing immunity in non-host species. Skin-migrated DCs were collected from pseudo-afferent lymph in sheep. Both the CD11b<sup>+</sup> -type and CD103<sup>+</sup> -type skin-migrated DCs were transduced by CAV2. An analysis of the global gene response to CAV2 in the two skin DC subsets showed that the gene response in CD11b<sup>+</sup> -type DCs was far higher and broader than in the CD103<sup>+</sup> -type DCs. A newly released integrative analytic tool from Ingenuity systems revealed that the CAV2-modulated genes in the CD11b<sup>+</sup> -type DCs clustered in several activated immunogenicity-related functions, such as immune response, immune cell trafficking and inflammation. Thus gene profiling in skin-migrated DC <em>in vitro</em> indicates that the CD11b<sup>+</sup> DC type is more responsive to CAV2 than the CD103<sup>+</sup> DC type, and provides valuable information to help in evaluating and possibly improving viral vector vaccine effectiveness.</p> </div>", "links"=>[], "tags"=>["canine", "recombinant", "adenovirus", "vector", "induces", "immunogenicity-related", "skin-migrated", "-type", "dcs"], "article_id"=>115354, "categories"=>["Molecular Biology", "Cancer", "Genetics", "Microbiology", "Immunology"], "users"=>["Vanessa Contreras", "Céline Urien", "Luc Jouneau", "Mickael Bourge", "Coraline Bouet-Cararo", "Michel Bonneau", "Stephan Zientara", "Bernard Klonjkowski", "Isabelle Schwartz-Cornil"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0052513"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/Canine_Recombinant_Adenovirus_Vector_Induces_an_Immunogenicity_Related_Gene_Expression_Profile_in_Skin_Migrated_CD11b_Type_DCs__/115354", "title"=>"Canine Recombinant Adenovirus Vector Induces an Immunogenicity-Related Gene Expression Profile in Skin-Migrated CD11b<sup>+</sup> -Type DCs", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-12-26 01:29:14"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/518719/Figure_1.tif"], "description"=>"<p>(A) LDL cells were cultured alone or infected for 36 hours with Cav-GFP R<sup>0</sup> (50 TCID<sub>50</sub>/ml). The percent of GFP<sup>+</sup> cells were detected within the CD1b<sup>+</sup> (red rectangle), the CD26<sup>+</sup> (CD103<sup>+</sup> -type, blue rectangle) and the CD26<sup>−</sup> (CD11b<sup>+</sup>-type, green rectangle) DCs. Representative FACS profiles are shown, including the isotype control (ISC) corresponding to the CD26 staining. (B) Six independent experiments described in (A) were performed with 2 different sheep (▪ #64 and •#80). Statistical significance (paired Student t-test) is indicated by * with p < 0.05.</p>", "links"=>[], "tags"=>["-type", "dcs", "transduced", "cav-gfp"], "article_id"=>189204, "categories"=>["Virology", "Molecular Biology", "Genetics", "Microbiology", "Immunology"], "users"=>["Vanessa Contreras", "Céline Urien", "Luc Jouneau", "Mickael Bourge", "Coraline Bouet-Cararo", "Michel Bonneau", "Stephan Zientara", "Bernard Klonjkowski", "Isabelle Schwartz-Cornil"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0052513.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_CD103_type_and_CD11b_type_DCs_are_transduced_by_Cav_GFP_R_0_/189204", "title"=>"CD103<sup>+</sup> -type and CD11b<sup>+</sup> -type DCs are transduced by Cav-GFP R<sup>0</sup>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-26 02:33:24"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/518795/Figure_2.tif"], "description"=>"<p>The expression value for each gene in mock and CAV2-activated CD103<sup>+</sup> and CD11b<sup>+</sup>-type DCs from 4 sheep (A: sheep #58; B: sheep #74, C: sheep #66, D: sheep #61) were used for the analysis. The expression values for the 4 first components (Dim 1, 2, 3, 4) of the principal component analysis were plotted. (A) The Dim 1 and dim 2 axes may be interpreted as the “animal” component representing 18.58 % and 16.28 % of the microarray data variance; CD11b<sup>+</sup> and CD103<sup>+</sup> stands for CD11b<sup>+</sup> and CD103<sup>+</sup> -type DCs, Mock stands for DCs cultured alone, CAV stands for Cav-null R0 treated DCs. (B) the Dim 3 may be interpreted as the “subset” component (12.71 % of the array data variance) and dim 4 represents the “CAV2 treatment” component (10.21 % of the array data variance).</p>", "links"=>[], "tags"=>["microarray", "dcs", "activated", "cav2"], "article_id"=>189281, "categories"=>["Virology", "Molecular Biology", "Genetics", "Microbiology", "Immunology"], "users"=>["Vanessa Contreras", "Céline Urien", "Luc Jouneau", "Mickael Bourge", "Coraline Bouet-Cararo", "Michel Bonneau", "Stephan Zientara", "Bernard Klonjkowski", "Isabelle Schwartz-Cornil"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0052513.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Principal_component_analysis_of_microarray_data_from_the_CD103_and_CD11b_type_DCs_activated_by_the_CAV2_vector_/189281", "title"=>"Principal component analysis of microarray data from the CD103<sup>+</sup> and CD11b<sup>+</sup>-type DCs activated by the CAV2 vector.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-26 02:34:41"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/518903/Figure_3.tif"], "description"=>"<p>(A)The mean fold induction of the selected genes up-regulated by Cav-null R<sup>0</sup> are represented in graded yellow to red color (from 1 to >3) for both CD103<sup>+</sup> and CD11b<sup>+</sup> -type DCs from 4 sheep. The represented genes were selected from the significantly induced genes in the CD11b<sup>+</sup> -type DC subset (222 genes, p<0.05, fold > 2) and they were ranked based on their fold induction in the CD11b<sup>+</sup> -type DC subset. The significantly activated genes in the CD103<sup>+</sup> subset (21 genes, p<0.05, fold > 2) are indicated by a star. (B) The mean fold reduction levels of the selected down-modulated genes by Cav-null R<sup>0</sup> are represented in graded yellow to blue color (from 1 to <0.2) for both CD103<sup>+</sup> and CD11b<sup>+</sup> -type DCs from 4 sheep. The represented genes were selected from the significantly reduced genes in the CD11b<sup>+</sup> -type DC subset (29 genes, p<0.05) and they were ranked based on their fold induction in the CD11b<sup>+</sup> -type DC subset. No gene expression was significantly reduced in the CD103<sup>+</sup> -type DC subset.</p>", "links"=>[], "tags"=>["cav2", "vector", "-type", "dc"], "article_id"=>189387, "categories"=>["Virology", "Molecular Biology", "Genetics", "Microbiology", "Immunology"], "users"=>["Vanessa Contreras", "Céline Urien", "Luc Jouneau", "Mickael Bourge", "Coraline Bouet-Cararo", "Michel Bonneau", "Stephan Zientara", "Bernard Klonjkowski", "Isabelle Schwartz-Cornil"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0052513.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Transcriptional_response_to_CAV2_vector_in_the_CD103_and_CD11b_type_DC_subsets_/189387", "title"=>"Transcriptional response to CAV2 vector in the CD103<sup>+</sup> and CD11b<sup>+</sup> -type DC subsets.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-26 02:36:27"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/518989/Figure_4.tif"], "description"=>"<p>A selection of genes was checked for CAV2-induced upregulation using qRT-PCR on cDNA from the CD103<sup>+</sup> and CD11b<sup>+</sup> -type DCs (4 different sheep were used in total, 3 per validated gene). Each gene detection was normalized with GAPDH expression and the relative gene expressions (log2(CTgene-CTGAPDH)) are reported. The gene names printed with regular font were selected as being up-regulated in the CD11b<sup>+</sup> type DC microarrays (p < 0.05 ANOVA followed by Benjamini-Hochberg FDR and > 2 fold), the gene names printed in italic are not represented by any probe on the ovine microarray, the underlined gene names were close to be selected by the variance analysis in the CD11b<sup>+</sup> -type DCs.</p>", "links"=>[], "tags"=>["induced", "cav2", "vector"], "article_id"=>189479, "categories"=>["Virology", "Molecular Biology", "Genetics", "Microbiology", "Immunology"], "users"=>["Vanessa Contreras", "Céline Urien", "Luc Jouneau", "Mickael Bourge", "Coraline Bouet-Cararo", "Michel Bonneau", "Stephan Zientara", "Bernard Klonjkowski", "Isabelle Schwartz-Cornil"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0052513.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Validation_of_gene_expression_induced_by_CAV2_vector_with_qRT_PCR_/189479", "title"=>"Validation of gene expression induced by CAV2 vector with qRT-PCR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-26 02:37:59"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/519173/Figure_5.tif"], "description"=>"<p>An antimicrobial gene network centered on IFN was generated by the Ingenuity Pathways Analysis on the selected genes dys-regulated by CAV2 vector in CD11b<sup>+</sup> -type DCs (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0052513#pone.0052513.s003\" target=\"_blank\">Table S1</a>, p < 0.05 and fold > 2, or p < 0.05 and folds confirmed by qRT-PCR). Molecule types are represented by symbols: diamonds (enzymes), triangles (kinase), square (cytokine), double circle (complex), oval (transcription regulator), circle (others).</p>", "links"=>[], "tags"=>["induced", "cav2", "vector", "-type"], "article_id"=>189664, "categories"=>["Virology", "Molecular Biology", "Genetics", "Microbiology", "Immunology"], "users"=>["Vanessa Contreras", "Céline Urien", "Luc Jouneau", "Mickael Bourge", "Coraline Bouet-Cararo", "Michel Bonneau", "Stephan Zientara", "Bernard Klonjkowski", "Isabelle Schwartz-Cornil"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0052513.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Antimicrobial_gene_network_induced_by_CAV2_vector_in_CD11b_type_DCs_/189664", "title"=>"Antimicrobial gene network induced by CAV2 vector in CD11b<sup>+</sup> -type DCs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-26 02:41:04"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/519279/Table_2.xls"], "description"=>"<p>Top canonical pathways induced by CAV2 vector in CD103<sup>+</sup> and CD11b<sup>+</sup> -type DCs.</p>", "links"=>[], "tags"=>["canonical", "pathways", "induced", "cav2", "vector", "-type"], "article_id"=>189769, "categories"=>["Virology", "Molecular Biology", "Genetics", "Microbiology", "Immunology"], "users"=>["Vanessa Contreras", "Céline Urien", "Luc Jouneau", "Mickael Bourge", "Coraline Bouet-Cararo", "Michel Bonneau", "Stephan Zientara", "Bernard Klonjkowski", "Isabelle Schwartz-Cornil"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0052513.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Top_canonical_pathways_induced_by_CAV2_vector_in_CD103_and_CD11b_type_DCs_/189769", "title"=>"Top canonical pathways induced by CAV2 vector in CD103<sup>+</sup> and CD11b<sup>+</sup> -type DCs.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-12-26 02:42:49"}
  • {"files"=>["https://s3-eu-west-1.amazonaws.com/pstorage-plos-3567654/519332/Table_1.xls"], "description"=>"*<p>the expression of the underlined molecules is down-modulated.</p>", "links"=>[], "tags"=>["functions", "activated", "cav2", "vector", "-type"], "article_id"=>189818, "categories"=>["Virology", "Molecular Biology", "Genetics", "Microbiology", "Immunology"], "users"=>["Vanessa Contreras", "Céline Urien", "Luc Jouneau", "Mickael Bourge", "Coraline Bouet-Cararo", "Michel Bonneau", "Stephan Zientara", "Bernard Klonjkowski", "Isabelle Schwartz-Cornil"], "doi"=>["http://dx.doi.org/10.1371/journal.pone.0052513.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"http://figshare.com/articles/_Biological_functions_that_are_predicted_to_be_activated_by_CAV2_vector_in_CD103_and_CD11b_type_DCs_/189818", "title"=>"Biological functions that are predicted to be activated by CAV2 vector in CD103<sup>+</sup> and CD11b<sup>+</sup> -type DCs.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-12-26 02:43:38"}

PMC Usage Stats | Further Information

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Relative Metric

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