Transcranial Low-Level Laser Therapy Improves Neurological Performance in Traumatic Brain Injury in Mice: Effect of Treatment Repetition Regimen
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{"title"=>"Transcranial Low-Level Laser Therapy Improves Neurological Performance in Traumatic Brain Injury in Mice: Effect of Treatment Repetition Regimen", "type"=>"journal", "authors"=>[{"first_name"=>"Weijun", "last_name"=>"Xuan", "scopus_author_id"=>"54392089800"}, {"first_name"=>"Fatma", "last_name"=>"Vatansever", "scopus_author_id"=>"55644113700"}, {"first_name"=>"Liyi", "last_name"=>"Huang", "scopus_author_id"=>"35198327600"}, {"first_name"=>"Qiuhe", "last_name"=>"Wu", "scopus_author_id"=>"57199303475"}, {"first_name"=>"Yi", "last_name"=>"Xuan", "scopus_author_id"=>"37119484800"}, {"first_name"=>"Tianhong", "last_name"=>"Dai", "scopus_author_id"=>"55147563800"}, {"first_name"=>"Takahiro", "last_name"=>"Ando", "scopus_author_id"=>"35089944200"}, {"first_name"=>"Tao", "last_name"=>"Xu", "scopus_author_id"=>"57199173450"}, {"first_name"=>"Ying Ying", "last_name"=>"Huang", "scopus_author_id"=>"57188637410"}, {"first_name"=>"Michael R.", "last_name"=>"Hamblin", "scopus_author_id"=>"7004296356"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84872153985", "issn"=>"19326203", "scopus"=>"2-s2.0-84872153985", "pmid"=>"23308226", "pui"=>"368086146", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0053454"}, "id"=>"2f582868-361b-3552-b503-19466f81bc0d", "abstract"=>"Low-level laser (light) therapy (LLLT) has been clinically applied around the world for a spectrum of disorders requiring healing, regeneration and prevention of tissue death. One area that is attracting growing interest in this scope is the use of transcranial LLLT to treat stroke and traumatic brain injury (TBI). We developed a mouse model of severe TBI induced by controlled cortical impact and explored the effect of different treatment schedules. Adult male BALB/c mice were divided into 3 broad groups (a) sham-TBI sham-treatment, (b) real-TBI sham-treatment, and (c) real-TBI active-treatment. Mice received active-treatment (transcranial LLLT by continuous wave 810 nm laser, 25 mW/cm(2), 18 J/cm(2), spot diameter 1 cm) while sham-treatment was immobilization only, delivered either as a single treatment at 4 hours post TBI, as 3 daily treatments commencing at 4 hours post TBI or as 14 daily treatments. Mice were sacrificed at 0, 4, 7, 14 and 28 days post-TBI for histology or histomorphometry, and injected with bromodeoxyuridine (BrdU) at days 21-27 to allow identification of proliferating cells. Mice with severe TBI treated with 1-laser Tx (and to a greater extent 3-laser Tx) had significant improvements in neurological severity score (NSS), and wire-grip and motion test (WGMT). However 14-laser Tx provided no benefit over TBI-sham control. Mice receiving 1- and 3-laser Tx had smaller lesion size at 28-days (although the size increased over 4 weeks in all TBI-groups) and less Fluoro-Jade staining for degenerating neurons (at 14 days) than in TBI control and 14-laser Tx groups. There were more BrdU-positive cells in the lesion in 1- and 3-laser groups suggesting LLLT may increase neurogenesis. Transcranial NIR laser may provide benefit in cases of acute TBI provided the optimum treatment regimen is employed.", "link"=>"http://www.mendeley.com/research/transcranial-lowlevel-laser-therapy-improves-neurological-performance-traumatic-brain-injury-mice-ef-3", "reader_count"=>52, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Researcher"=>15, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>8, "Other"=>8, "Student > Master"=>7, "Student > Bachelor"=>7, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Researcher"=>15, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>8, "Other"=>8, "Student > Master"=>7, "Student > Bachelor"=>7, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>3, "Nursing and Health Professions"=>3, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>12, "Medicine and Dentistry"=>17, "Neuroscience"=>4, "Arts and Humanities"=>2, "Sports and Recreations"=>2, "Physics and Astronomy"=>1, "Psychology"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>17}, "Neuroscience"=>{"Neuroscience"=>4}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>12}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>3}, "Arts and Humanities"=>{"Arts and Humanities"=>2}}, "reader_count_by_country"=>{"United States"=>6, "Australia"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/512359"], "description"=>"<p>Mean (n = 8–14) NSS scores measured over 4 weeks of mice in 9 groups consisting of sham TBI mice, sham control mice, 810-nm laser treated TBI mice (18 J/cm<sup>2</sup> delivered at 25 mW/cm<sup>2</sup>). (A) Mice and controls given 1 laser Tx or 1 sham Tx at 4 hours post TBI; (B) Mice and controls given 3 daily laser Tx or 3 sham Tx; (C) Mice and controls given 14 daily laser Tx or 14 sham Tx. * p<0.05; ** P<0.01; *** p<0.001. One way ANOVA. (D) Mean areas under curve of NSS time courses from mice in different groups. P values given were determined by one way ANOVA.</p>", "links"=>[], "tags"=>["scores"], "article_id"=>182828, "categories"=>["Neuroscience", "Mathematics", "Medicine", "Immunology"], "users"=>["Weijun Xuan", "Fatma Vatansever", "Liyi Huang", "Qiuhe Wu", "Yi Xuan", "Tianhong Dai", "Takahiro Ando", "Tao Xu", "Ying-Ying Huang", "Michael R. Hamblin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053454.g001", "stats"=>{"downloads"=>4, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_NSS_scores_of_the_mice_/182828", "title"=>"NSS scores of the mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 17:29:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/513105"], "description"=>"<p>Mice are awarded 1 point for each failure to complete a task.</p>", "links"=>[], "tags"=>["severity", "tbi"], "article_id"=>183587, "categories"=>["Neuroscience", "Mathematics", "Medicine", "Immunology"], "users"=>["Weijun Xuan", "Fatma Vatansever", "Liyi Huang", "Qiuhe Wu", "Yi Xuan", "Tianhong Dai", "Takahiro Ando", "Tao Xu", "Ying-Ying Huang", "Michael R. Hamblin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053454.t001", "stats"=>{"downloads"=>3, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Neurological_Severity_Score_NSS_for_TBI_Mice_/183587", "title"=>"Neurological Severity Score (NSS) for TBI Mice.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 17:34:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/513149"], "description"=>"<p>Mice are assessed the score for the best level they reach.</p>", "links"=>[], "tags"=>["tbi"], "article_id"=>183638, "categories"=>["Neuroscience", "Mathematics", "Medicine", "Immunology"], "users"=>["Weijun Xuan", "Fatma Vatansever", "Liyi Huang", "Qiuhe Wu", "Yi Xuan", "Tianhong Dai", "Takahiro Ando", "Tao Xu", "Ying-Ying Huang", "Michael R. Hamblin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053454.t002", "stats"=>{"downloads"=>4, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Wire_grip_and_motion_score_for_TBI_mice_/183638", "title"=>"Wire grip and motion score for TBI mice.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 17:34:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/512957"], "description"=>"<p>All sections were taken from mice sacrificed at 28 days post-TBI. Red is BrdU and blue is DAPI (control for equal numbers of cell nuclei). (A) Sham control mouse; (B) TBI sham untreated mouse. (C) TBI mouse treated with 1 laser Tx. (C) TBI mouse treated with 3 laser Tx (E) TBI mouse treated with 14 laser Tx (F) Mean (n = 6) red staining calculated with Image J from mice (n = 6) in the groups in panels A–E. *** P<0.001 vs TBI sham; # P<0.05 vs 1 laser Tx; <a href=\"mailto:@@\" target=\"_blank\">@@</a> P<0.01 vs 14 laser Tx. One way ANOVA.</p>", "links"=>[], "tags"=>["staining", "lesion", "areas"], "article_id"=>183435, "categories"=>["Neuroscience", "Mathematics", "Medicine", "Immunology"], "users"=>["Weijun Xuan", "Fatma Vatansever", "Liyi Huang", "Qiuhe Wu", "Yi Xuan", "Tianhong Dai", "Takahiro Ando", "Tao Xu", "Ying-Ying Huang", "Michael R. Hamblin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053454.g005", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_BrdU_staining_of_lesion_areas_in_brain_sections_/183435", "title"=>"BrdU staining of lesion areas in brain sections.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 17:33:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/512612"], "description"=>"<p>Example whole brain cross-sections taken from mice sacrificed at day 4 (A–D), day 7 (E–H), day 14 (I–L) and day 28 (M–P). Mice were taken from TBI sham Tx group (A, E, I, M); TBI 1 laser Tx group (B, F, J, N); TBI 3 laser Tx group (C, G, K, O); TBI 14 laser Tx group (D, H, L, P). (Q) Mean (n = 2–3) brain fractional lesion volumes calculated as described at 1, 2, and 4 weeks in brains of mice in 4 groups consisting of sham TBI mice, 810-nm laser treated TBI mice (18 J/cm<sup>2</sup> delivered at 25 mW/cm<sup>2</sup> given 1, 3 or 14 laser Tx. ** P<0.01; * p<0.05 vs TBI sham and TBI 14 laser Tx groups. One way ANOVA.</p>", "links"=>[], "tags"=>["lesion"], "article_id"=>183095, "categories"=>["Neuroscience", "Mathematics", "Medicine", "Immunology"], "users"=>["Weijun Xuan", "Fatma Vatansever", "Liyi Huang", "Qiuhe Wu", "Yi Xuan", "Tianhong Dai", "Takahiro Ando", "Tao Xu", "Ying-Ying Huang", "Michael R. Hamblin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053454.g003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Brain_lesion_size_in_the_mice_/183095", "title"=>"Brain lesion size in the mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 17:31:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/512478"], "description"=>"<p>Mean (n = 8–14) WGMT scores measured over 4 weeks, of mice in 9 groups consisting of sham TBI mice, sham control mice, 810-nm laser treated TBI mice (18 J/cm<sup>2</sup> delivered at 25 mW/cm<sup>2</sup>). (A) Mice and controls given 1 laser Tx or 1 sham Tx at 4 hours post TBI; (B) Mice and controls given 3 daily laser Tx or 3 sham Tx; (C) Mice and controls given 14 daily laser Tx or 14 sham Tx. (D) Mean areas under curve of WGMT time courses from mice in different groups. P values given were determined by one-way ANOVA.</p>", "links"=>[], "tags"=>["scores"], "article_id"=>182966, "categories"=>["Neuroscience", "Mathematics", "Medicine", "Immunology"], "users"=>["Weijun Xuan", "Fatma Vatansever", "Liyi Huang", "Qiuhe Wu", "Yi Xuan", "Tianhong Dai", "Takahiro Ando", "Tao Xu", "Ying-Ying Huang", "Michael R. Hamblin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053454.g002", "stats"=>{"downloads"=>1, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_WGMT_scores_of_the_mice_/182966", "title"=>"WGMT scores of the mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 17:30:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/512773"], "description"=>"<p>All sections were taken from mice sacrificed at 14 days post-TBI. Green is FJC and blue is DAPI )control for equal numbers of cell nuclei. (A) Sham-TBI control mouse; (B) real-TBI sham Tx mouse. (C) TBI mouse treated with 1 laser Tx. (C) TBI mouse treated with 3 laser Tx (E) TBI mouse treated with 14 laser Tx (F) Mean green staining calculated with Image J from mice (n = 2–3) in the groups in panels A–E. # P<0.05 vs TBI sham; * P<0.05 vs 14 laser Tx. One way ANOVA.</p>", "links"=>[], "tags"=>["jade", "staining", "lesion", "areas"], "article_id"=>183254, "categories"=>["Neuroscience", "Mathematics", "Medicine", "Immunology"], "users"=>["Weijun Xuan", "Fatma Vatansever", "Liyi Huang", "Qiuhe Wu", "Yi Xuan", "Tianhong Dai", "Takahiro Ando", "Tao Xu", "Ying-Ying Huang", "Michael R. Hamblin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053454.g004", "stats"=>{"downloads"=>7, "page_views"=>326, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fluoro_Jade_C_staining_of_lesion_areas_in_brain_sections_/183254", "title"=>"Fluoro Jade C staining of lesion areas in brain sections.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 17:32:13"}

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Relative Metric

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