Out-of-Hospital Cardiac Arrests and Outdoor Air Pollution Exposure in Copenhagen, Denmark
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{"title"=>"Out-of-Hospital Cardiac Arrests and Outdoor Air Pollution Exposure in Copenhagen, Denmark", "type"=>"journal", "authors"=>[{"first_name"=>"Janine", "last_name"=>"Wichmann", "scopus_author_id"=>"36027748800"}, {"first_name"=>"Fredrik", "last_name"=>"Folke", "scopus_author_id"=>"18633998900"}, {"first_name"=>"Christian", "last_name"=>"Torp-Pedersen", "scopus_author_id"=>"7007032846"}, {"first_name"=>"Freddy", "last_name"=>"Lippert", "scopus_author_id"=>"7004650443"}, {"first_name"=>"Matthias", "last_name"=>"Ketzel", "scopus_author_id"=>"17338655600"}, {"first_name"=>"Thomas", "last_name"=>"Ellermann", "scopus_author_id"=>"6603303125"}, {"first_name"=>"Steffen", "last_name"=>"Loft", "scopus_author_id"=>"7006963520"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84872345970", "pui"=>"368116167", "pmid"=>"23341975", "issn"=>"19326203", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0053684", "sgr"=>"84872345970"}, "id"=>"150ca743-785a-3cc0-bff2-7f63b8a34d61", "abstract"=>"Cardiovascular disease is the number one cause of death globally and air pollution can be a contributing cause. Acute myocardial infarction and cardiac arrest are frequent manifestations of coronary heart disease. The objectives of the study were to investigate the association between 4 657 out-of-hospital cardiac arrests (OHCA) and hourly and daily outdoor levels of PM(10), PM(2.5), coarse fraction of PM (PM(10-2.5)), ultrafine particle proxies, NO(x), NO(2), O(3) and CO in Copenhagen, Denmark, for the period 2000-2010. Susceptible groups by age and sex was also investigated. A case-crossover design was applied. None of the hourly lags of any of the pollutants were significantly associated with OHCA events. The strongest association with OHCA events was observed for the daily lag4 of PM(2.5), lag3 of PM(10), lag3 of PM(10-2.5), lag3 of NO(x) and lag4 of CO. An IQR increase of PM(2.5) and PM(10) was associated with a significant increase of 4% (95% CI: 0%; 9%) and 5% (95% CI: 1%; 9%) in OHCA events with 3 days lag, respectively. None of the other daily lags or other pollutants was significantly associated with OHCA events. Adjustment for O(3) slightly increased the association between OHCA and PM(2.5) and PM(10). No susceptible groups were identified.", "link"=>"http://www.mendeley.com/research/outofhospital-cardiac-arrests-outdoor-air-pollution-exposure-copenhagen-denmark-2", "reader_count"=>13, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>3, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>3, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Environmental Science"=>3, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>1, "Computer Science"=>1, "Earth and Planetary Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>3}}, "reader_count_by_country"=>{"Belgium"=>1, "Mexico"=>1}, "group_count"=>3}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/277160", "https://ndownloader.figshare.com/files/277524"], "description"=>"<div><p>Cardiovascular disease is the number one cause of death globally and air pollution can be a contributing cause. Acute myocardial infarction and cardiac arrest are frequent manifestations of coronary heart disease. The objectives of the study were to investigate the association between 4 657 out-of-hospital cardiac arrests (OHCA) and hourly and daily outdoor levels of PM<sub>10</sub>, PM<sub>2.5</sub>, coarse fraction of PM (PM<sub>10-2.5</sub>), ultrafine particle proxies, NO<sub>x</sub>, NO<sub>2</sub>, O<sub>3</sub> and CO in Copenhagen, Denmark, for the period 2000–2010. Susceptible groups by age and sex was also investigated. A case-crossover design was applied. None of the hourly lags of any of the pollutants were significantly associated with OHCA events. The strongest association with OHCA events was observed for the daily lag4 of PM<sub>2.5</sub>, lag3 of PM<sub>10</sub>, lag3 of PM<sub>10-2.5</sub>, lag3 of NO<sub>x</sub> and lag4 of CO. An IQR increase of PM<sub>2.5</sub> and PM<sub>10</sub> was associated with a significant increase of 4% (95% CI: 0%; 9%) and 5% (95% CI: 1%; 9%) in OHCA events with 3 days lag, respectively. None of the other daily lags or other pollutants was significantly associated with OHCA events. Adjustment for O<sub>3</sub> slightly increased the association between OHCA and PM<sub>2.5</sub> and PM<sub>10</sub>. No susceptible groups were identified.</p> </div>", "links"=>[], "tags"=>["out-of-hospital", "cardiac", "arrests", "denmark"], "article_id"=>114639, "categories"=>["Medicine", "Biotechnology"], "users"=>["Janine Wichmann", "Fredrik Folke", "Christian Torp-Pedersen", "Freddy Lippert", "Matthias Ketzel", "Thomas Ellermann", "Steffen Loft"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0053684.s001", "https://dx.doi.org/10.1371/journal.pone.0053684.s002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Out_of_Hospital_Cardiac_Arrests_and_Outdoor_Air_Pollution_Exposure_in_Copenhagen_Denmark__/114639", "title"=>"Out-of-Hospital Cardiac Arrests and Outdoor Air Pollution Exposure in Copenhagen, Denmark", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-01-14 01:17:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/507734"], "description"=>"a<p>Number of OHCA cases used in the models, which is less than 4657 due to missing exposure data.</p>", "links"=>[], "tags"=>["pollutants", "pollutant", "out-of-hospital", "cardiac", "arrests", "intervals", "inter-quartile", "lag0", "lag5", "4-day", "6-day", "cumulative", "january", "december"], "article_id"=>178202, "categories"=>["Medicine", "Biotechnology"], "users"=>["Janine Wichmann", "Fredrik Folke", "Christian Torp-Pedersen", "Freddy Lippert", "Matthias Ketzel", "Thomas Ellermann", "Steffen Loft"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0053684.t006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_air_pollutants_single_pollutant_models_and_out_of_hospital_cardiac_arrests_in_Copenhagen_expressed_as_percentage_increase_in_risk_and_95_confidence_intervals_per_inter_quartile_increase_in_daily_lag0_to_lag5_and_2_day_4_day_and_6_day_/178202", "title"=>"Association between air pollutants (single pollutant models) and out-of-hospital cardiac arrests in Copenhagen, expressed as percentage increase in risk (%) and 95% confidence intervals per inter-quartile increase in daily lag0 to lag5 and 2-day, 4-day and 6-day cumulative average (1 January 2000–31 December 2010).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-14 02:16:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/507783"], "description"=>"a<p>Number of OHCA cases used in the models, which is less than 4657 due to missing exposure data.</p>", "links"=>[], "tags"=>["pollutants", "pollutant", "out-of-hospital", "cardiac", "arrests", "copenhagen", "intervals", "inter-quartile", "lag3", "january", "december"], "article_id"=>178262, "categories"=>["Medicine", "Biotechnology"], "users"=>["Janine Wichmann", "Fredrik Folke", "Christian Torp-Pedersen", "Freddy Lippert", "Matthias Ketzel", "Thomas Ellermann", "Steffen Loft"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0053684.t007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_between_air_pollutants_single_pollutant_models_and_out_of_hospital_cardiac_arrests_in_Copenhagen_by_subgroups_expressed_as_percentage_increase_in_risk_and_95_confidence_intervals_per_inter_quartile_increase_in_daily_lag3_1_January_2000_8211_3/178262", "title"=>"Association between air pollutants (single pollutant models) and out-of-hospital cardiac arrests in Copenhagen by subgroups, expressed as percentage increase in risk (%) and 95% confidence intervals per inter-quartile increase in daily lag3 (1 January 2000–31 December 2010).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-14 02:17:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/507829"], "description"=>"a<p>p-value>0.05, otherwise p-value<0.05.</p><p>Top value is the Spearman correlation coefficient and the bottom value is the number of days. Of the 4018 days during the study period, 4657 OHCAs occurred on 2753 days.</p>", "links"=>[], "tags"=>["coefficients", "variables", "days", "out-of-hospital", "cardiac", "arrests", "occurred", "copenhagen", "january", "december"], "article_id"=>178312, "categories"=>["Medicine", "Biotechnology"], "users"=>["Janine Wichmann", "Fredrik Folke", "Christian Torp-Pedersen", "Freddy Lippert", "Matthias Ketzel", "Thomas Ellermann", "Steffen Loft"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0053684.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spearman_correlation_coefficients_between_exposure_variables_daily_lag0_on_days_that_out_of_hospital_cardiac_arrests_occurred_in_Copenhagen_1_January_2000_8211_31_December_2010_/178312", "title"=>"Spearman correlation coefficients between exposure variables (daily lag0) on days that out-of-hospital cardiac arrests occurred in Copenhagen (1 January 2000–31 December 2010).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-14 02:18:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/507879"], "description"=>"a<p>p-value>0.05. otherwise p-value<0.05.</p><p>Top value is the Spearman correlation coefficient and the bottom value is the number of hours. Of the 96432 hours (on 4018 days) during the study period, 4657 OHCAs occurred on 4556 hours (on 2753 days).</p>", "links"=>[], "tags"=>["coefficients", "variables", "days", "out-of-hospital", "cardiac", "arrests", "occurred", "copenhagen", "january", "december"], "article_id"=>178358, "categories"=>["Medicine", "Biotechnology"], "users"=>["Janine Wichmann", "Fredrik Folke", "Christian Torp-Pedersen", "Freddy Lippert", "Matthias Ketzel", "Thomas Ellermann", "Steffen Loft"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0053684.t005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spearman_correlation_coefficients_between_exposure_variables_hourly_lag0_on_days_that_out_of_hospital_cardiac_arrests_occurred_in_Copenhagen_1_January_2002_8211_31_December_2010_/178358", "title"=>"Spearman correlation coefficients between exposure variables (hourly lag0) on days that out-of-hospital cardiac arrests occurred in Copenhagen (1 January 2002–31 December 2010).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-14 02:19:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/507926"], "description"=>"<p>SD: Standard deviation.</p><p>IQR: Interquartile range.</p>a<p>Of the 4018 days during the study period, 4657 OHCAs occurred on 2753 days.</p>b<p>Differences between case days and control days are calculated by subtracting the average of the level on the associated control days from the case day. The average of these differences for the 4657 OHCA cases is then calculated.</p>", "links"=>[], "tags"=>["pollutant", "meteorological", "levels", "days", "out-of-hospital", "cardiac", "arrests", "occurred", "copenhagen", "january", "december"], "article_id"=>178410, "categories"=>["Medicine", "Biotechnology"], "users"=>["Janine Wichmann", "Fredrik Folke", "Christian Torp-Pedersen", "Freddy Lippert", "Matthias Ketzel", "Thomas Ellermann", "Steffen Loft"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0053684.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Descriptive_statistics_for_daily_air_pollutant_and_meteorological_levels_lag0_on_days_that_out_of_hospital_cardiac_arrests_occurred_in_Copenhagen_1_January_2000_8211_31_December_2010_/178410", "title"=>"Descriptive statistics for daily air pollutant and meteorological levels (lag0) on days that out-of-hospital cardiac arrests occurred in Copenhagen (1 January 2000–31 December 2010).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-14 02:20:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/507972"], "description"=>"<p>SD: Standard deviation.</p><p>IQR: Interquartile range.</p>a<p>Of the 96432 hours (on 4018 days) during the study period, 4657 OHCAs occurred on 4556 hours (on 2753 days).</p>b<p>Differences between case hours and control hours are calculated by subtracting the average of the level on the associated control hours from the case hour. The average of these differences for the 4657 OHCA cases is then calculated.</p>", "links"=>[], "tags"=>["hourly", "pollutant", "meteorological", "days", "out-of-hospital", "cardiac", "arrests", "occurred", "copenhagen", "january", "december"], "article_id"=>178454, "categories"=>["Medicine", "Biotechnology"], "users"=>["Janine Wichmann", "Fredrik Folke", "Christian Torp-Pedersen", "Freddy Lippert", "Matthias Ketzel", "Thomas Ellermann", "Steffen Loft"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0053684.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Descriptive_hourly_air_pollutant_and_meteorological_data_lag0_on_days_that_out_of_hospital_cardiac_arrests_occurred_in_Copenhagen_1_January_2000_8211_31_December_2010_/178454", "title"=>"Descriptive hourly air pollutant and meteorological data (lag0) on days that out-of-hospital cardiac arrests occurred in Copenhagen (1 January 2000–31 December 2010).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-14 02:20:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/508007"], "description"=>"<p>Characteristics of the out-of-hospital cardiac arrests in Copenhagen (1 January 2000–31 December 2010).</p>", "links"=>[], "tags"=>["out-of-hospital", "cardiac", "arrests", "copenhagen", "january", "december"], "article_id"=>178500, "categories"=>["Medicine", "Biotechnology"], "users"=>["Janine Wichmann", "Fredrik Folke", "Christian Torp-Pedersen", "Freddy Lippert", "Matthias Ketzel", "Thomas Ellermann", "Steffen Loft"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0053684.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_out_of_hospital_cardiac_arrests_in_Copenhagen_1_January_2000_8211_31_December_2010_/178500", "title"=>"Characteristics of the out-of-hospital cardiac arrests in Copenhagen (1 January 2000–31 December 2010).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-14 02:21:40"}

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Relative Metric

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