Associations between Aromatase CYP19 rs10046 Polymorphism and Breast Cancer Risk: From a Case-Control to a Meta-Analysis of 20,098 Subjects
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{"title"=>"Associations between Aromatase CYP19 rs10046 Polymorphism and Breast Cancer Risk: From a Case-Control to a Meta-Analysis of 20,098 Subjects", "type"=>"journal", "authors"=>[{"first_name"=>"Begoña", "last_name"=>"Pineda", "scopus_author_id"=>"24169178400"}, {"first_name"=>"Miguel Ángel", "last_name"=>"García-Pérez", "scopus_author_id"=>"7102174904"}, {"first_name"=>"Antonio", "last_name"=>"Cano", "scopus_author_id"=>"26038387000"}, {"first_name"=>"Ana", "last_name"=>"Lluch", "scopus_author_id"=>"24587394600"}, {"first_name"=>"Pilar", "last_name"=>"Eroles", "scopus_author_id"=>"6506194477"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"368133839", "pmid"=>"23342035", "doi"=>"10.1371/journal.pone.0053902", "scopus"=>"2-s2.0-84872451440", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203", "sgr"=>"84872451440"}, "id"=>"051567ce-20a0-3637-bce0-8beeee65d7f5", "abstract"=>"Lifetime exposure to estrogen is a factor that plays an important role in the pathogenesis and progression of breast cancer. Genetic variants in genes of the biosynthesis and metabolism of estrogen have been associated with breast cancer risk. Among them, the CYP19 gene encodes for aromatase, the enzyme that catalyzes the conversion of androgens to estrogens. The rs10046 polymorphism on the CYP19 gene has been related to levels of circulating estradiol and to the estradiol/testosterone ratio. To date, epidemiological studies of rs10046 have been performed in different populations with contradictory results. In the present study, we have conducted a case-control analysis (522 cases and 1221 controls) in a Spanish population. Furthermore, we have performed a meta-analysis including 20,098 subjects (7,998 cases and 12,100 controls) to summarize the data available for rs10046 and breast cancer risk. An odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association. The results of our case-control study show an association between the carriers of at least one C allele (dominant model) and breast cancer risk (OR = 1.29, 95% CI 1.01-1.66, p-value = 0.038). The meta-analysis shows no significant association with breast cancer risk in any of the genetic models tested. The analysis by ethnic subgroups also failed to produce associations. The evaluation of heterogeneity, influence analysis, and publication bias confirms the reliability of the analysis. We can conclude that the rs10046 polymorphism on CYP19 by itself does not constitute breast cancer risk. We cannot, however, reject the possibility that it could contribute (interact), together with other genetic variants, to modify the circulating levels of estradiol.", "link"=>"http://www.mendeley.com/research/associations-between-aromatase-cyp19-rs10046-polymorphism-breast-cancer-risk-casecontrol-metaanalysi", "reader_count"=>11, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>5, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Environmental Science"=>{"Environmental Science"=>1}}, "group_count"=>0}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/506107"], "description"=>"<p>Flow diagram of included/excluded studies.</p>", "links"=>[], "tags"=>["diagram"], "article_id"=>176624, "categories"=>["Cancer", "Genetics", "Biotechnology"], "users"=>["Begoña Pineda", "Miguel Ángel García-Pérez", "Antonio Cano", "Ana Lluch", "Pilar Eroles"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053902.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_diagram_of_included_excluded_studies_/176624", "title"=>"Flow diagram of included/excluded studies.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-16 01:50:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/506214"], "description"=>"<p>Meta-analysis of OR for rs10046 polymorphism associated with breast cancer (dominant model).</p>", "links"=>[], "tags"=>["rs10046", "polymorphism", "cancer"], "article_id"=>176733, "categories"=>["Cancer", "Genetics", "Biotechnology"], "users"=>["Begoña Pineda", "Miguel Ángel García-Pérez", "Antonio Cano", "Ana Lluch", "Pilar Eroles"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053902.g002", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Meta_analysis_of_OR_for_rs10046_polymorphism_associated_with_breast_cancer_dominant_model_/176733", "title"=>"Meta-analysis of OR for rs10046 polymorphism associated with breast cancer (dominant model).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-16 01:52:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/276823", "https://ndownloader.figshare.com/files/276852", "https://ndownloader.figshare.com/files/276896"], "description"=>"<div><p>Lifetime exposure to estrogen is a factor that plays an important role in the pathogenesis and progression of breast cancer. Genetic variants in genes of the biosynthesis and metabolism of estrogen have been associated with breast cancer risk. Among them, the <em>CYP19</em> gene encodes for aromatase, the enzyme that catalyzes the conversion of androgens to estrogens. The rs10046 polymorphism on the <em>CYP19</em> gene has been related to levels of circulating estradiol and to the estradiol/testosterone ratio. To date, epidemiological studies of rs10046 have been performed in different populations with contradictory results. In the present study, we have conducted a case-control analysis (522 cases and 1221 controls) in a Spanish population. Furthermore, we have performed a meta-analysis including 20,098 subjects (7,998 cases and 12,100 controls) to summarize the data available for rs10046 and breast cancer risk. An odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association. The results of our case-control study show an association between the carriers of at least one C allele (dominant model) and breast cancer risk (OR = 1.29, 95% CI 1.01–1.66, p-value = 0.038). The meta-analysis shows no significant association with breast cancer risk in any of the genetic models tested. The analysis by ethnic subgroups also failed to produce associations. The evaluation of heterogeneity, influence analysis, and publication bias confirms the reliability of the analysis. We can conclude that the rs10046 polymorphism on <em>CYP19</em> by itself does not constitute breast cancer risk. We cannot, however, reject the possibility that it could contribute (interact), together with other genetic variants, to modify the circulating levels of estradiol.</p> </div>", "links"=>[], "tags"=>["associations", "aromatase", "cyp19", "rs10046", "polymorphism", "cancer", "case-control", "meta-analysis", "subjects"], "article_id"=>114551, "categories"=>["Cancer", "Genetics", "Biotechnology"], "users"=>["Begoña Pineda", "Miguel Ángel García-Pérez", "Antonio Cano", "Ana Lluch", "Pilar Eroles"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0053902.s001", "https://dx.doi.org/10.1371/journal.pone.0053902.s002", "https://dx.doi.org/10.1371/journal.pone.0053902.s003"], "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Associations_between_Aromatase_CYP19_rs10046_Polymorphism_and_Breast_Cancer_Risk_From_a_Case_Control_to_a_Meta_Analysis_of_20_098_Subjects__/114551", "title"=>"Associations between Aromatase CYP19 rs10046 Polymorphism and Breast Cancer Risk: From a Case-Control to a Meta-Analysis of 20,098 Subjects", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-01-16 01:15:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/506578"], "description"=>"<p>Main characteristics of the meta-analysis papers and genotype distribution of rs10046.</p>", "links"=>[], "tags"=>["characteristics", "meta-analysis", "papers", "genotype"], "article_id"=>177093, "categories"=>["Cancer", "Genetics", "Biotechnology"], "users"=>["Begoña Pineda", "Miguel Ángel García-Pérez", "Antonio Cano", "Ana Lluch", "Pilar Eroles"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053902.t002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Main_characteristics_of_the_meta_analysis_papers_and_genotype_distribution_of_rs10046_/177093", "title"=>"Main characteristics of the meta-analysis papers and genotype distribution of rs10046.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-16 01:58:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/506504"], "description"=>"<p>Genotypic and allelic frequencies of rs10046 and breast cancer risk.</p>", "links"=>[], "tags"=>["allelic", "frequencies", "rs10046", "cancer"], "article_id"=>177023, "categories"=>["Cancer", "Genetics", "Biotechnology"], "users"=>["Begoña Pineda", "Miguel Ángel García-Pérez", "Antonio Cano", "Ana Lluch", "Pilar Eroles"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053902.t001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genotypic_and_allelic_frequencies_of_rs10046_and_breast_cancer_risk_/177023", "title"=>"Genotypic and allelic frequencies of rs10046 and breast cancer risk.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-16 01:57:03"}

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  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"19", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"15", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"5", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"17", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[266, 468, 593, 703, 804, 903, 993, 1084, 1171, 1256, 1339, 1422, 1492]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[284, 491, 620, 738, 843, 945, 1043, 1137, 1225, 1315, 1400, 1479, 1555]}, {"subject_area"=>"/Medicine and health sciences/Oncology", "average_usage"=>[249, 468, 599, 718, 820, 920, 1008, 1093, 1181, 1281, 1357, 1444, 1517]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[254, 431, 547, 651, 748, 842, 932, 1017, 1098, 1178, 1259, 1336, 1404]}, {"subject_area"=>"/Physical sciences/Mathematics", "average_usage"=>[259, 431, 541, 639, 727, 816, 898, 980, 1061, 1136, 1214, 1294, 1356]}]}
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Net::HTTPUnauthorized

Source
CrossRef
Time
2020-05-25 02:09:34 UTC
Target URL
http://doi.crossref.org/servlet/getForwardLinks?usr=plos&pwd=plos1&doi=10.1371%2Fjournal.pone.0053902
Trace

/app/models/concerns/networkable.rb:21:in `get_result'
/app/models/source.rb:165:in `get_data'
/app/models/retrieval_status.rb:47:in `perform_get_data'
/app/jobs/source_job.rb:52:in `block (2 levels) in perform'
/app/jobs/source_job.rb:51:in `block in perform'
/app/jobs/source_job.rb:35:in `each'
/app/jobs/source_job.rb:35:in `perform'