A Genome-Wide Methylation Study on Essential Hypertension in Young African American Males
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Mendeley | Further Information

{"title"=>"A Genome-Wide Methylation Study on Essential Hypertension in Young African American Males", "type"=>"journal", "authors"=>[{"first_name"=>"Xiaoling", "last_name"=>"Wang", "scopus_author_id"=>"35197136700"}, {"first_name"=>"Bonita", "last_name"=>"Falkner", "scopus_author_id"=>"55382762800"}, {"first_name"=>"Haidong", "last_name"=>"Zhu", "scopus_author_id"=>"55500592100"}, {"first_name"=>"Huidong", "last_name"=>"Shi", "scopus_author_id"=>"7402622746"}, {"first_name"=>"Shaoyong", "last_name"=>"Su", "scopus_author_id"=>"7402029786"}, {"first_name"=>"Xiaojing", "last_name"=>"Xu", "scopus_author_id"=>"56434722700"}, {"first_name"=>"Ashok Kumar", "last_name"=>"Sharma", "scopus_author_id"=>"55554061600"}, {"first_name"=>"Yanbin", "last_name"=>"Dong", "scopus_author_id"=>"7403390672"}, {"first_name"=>"Frank", "last_name"=>"Treiber", "scopus_author_id"=>"7005685862"}, {"first_name"=>"Bernard", "last_name"=>"Gutin", "scopus_author_id"=>"7006470769"}, {"first_name"=>"Gregory", "last_name"=>"Harshfield", "scopus_author_id"=>"7006663139"}, {"first_name"=>"Harold", "last_name"=>"Snieder", "scopus_author_id"=>"7006990967"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203", "pui"=>"368101384", "sgr"=>"84872221875", "doi"=>"10.1371/journal.pone.0053938", "scopus"=>"2-s2.0-84872221875", "pmid"=>"23325143"}, "id"=>"18bad80b-8e22-327b-8e79-3cb2c766e8e8", "abstract"=>"OBJECTIVE: There is emerging evidence from animal studies suggesting a key role for methylation in the pathogenesis of essential hypertension. However, to date, very few studies have investigated the role of methylation in the development of human hypertension, and none has taken a genome-wide approach. Based on the recent studies that highlight the involvement of inflammation in the development of hypertension, we hypothesize that changes in DNA methylation of leukocytes are involved in the pathogenesis of hypertension. METHOD & RESULTS: We conducted a genome-wide methylation analysis on 8 hypertensive cases and 8 normotensive age-matched controls aged 14-23 years and performed validation of the most significant CpG sites in 2 genes in an independent sample of 36 hypertensive cases and 60 normotensive controls aged 14-30 years. Validation of the CpG sites in the SULF1 gene was further conducted in a second replication sample of 36 hypertensive cases and 34 controls aged 15.8-40 years. A CpG site in the SULF1 gene showed higher methylation levels in cases than in healthy controls in the genome-wide step (p = 6.2x10(-5)), which was confirmed in the validation step (p = 0.011) for subjects </=30 years old but was not significant for subjects of all ages combined (p = 0.095). CONCLUSION: The identification of a difference in a blood leukocyte DNA methylation site between hypertensive cases and normotensive controls suggests that changes in DNA methylation may play an important role in the pathogenesis of hypertension. The age dependency of the effect further suggests complexity of epigenetic regulation in this age-related disease.", "link"=>"http://www.mendeley.com/research/genomewide-methylation-study-essential-hypertension-young-african-american-males", "reader_count"=>32, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Student > Doctoral Student"=>4, "Researcher"=>4, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Student > Master"=>5, "Student > Bachelor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Student > Doctoral Student"=>4, "Researcher"=>4, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Student > Master"=>5, "Student > Bachelor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>8, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>7, "Neuroscience"=>1, "Psychology"=>3, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Neuroscience"=>{"Neuroscience"=>1}, "Psychology"=>{"Psychology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Netherlands"=>1, "United States"=>2, "China"=>1, "United Kingdom"=>1, "Chile"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/509661"], "description"=>"a<p>Adjusted for age.</p>b<p>Adjusted for age and BMI.</p>", "links"=>[], "tags"=>["sulf1", "pa"], "article_id"=>180145, "categories"=>["Microbiology", "Genetics", "Biotechnology", "Immunology"], "users"=>["Xiaoling Wang", "Bonita Falkner", "Haidong Zhu", "Huidong Shi", "Shaoyong Su", "Xiaojing Xu", "Ashok Kumar Sharma", "Yanbin Dong", "Frank Treiber", "Bernard Gutin", "Gregory Harshfield", "Harold Snieder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053938.t006", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pyrosequencing_results_of_SULF1_gene_in_the_PA_cohort_/180145", "title"=>"Pyrosequencing results of SULF1 gene in the PA cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-10 00:02:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/509573"], "description"=>"a<p>Adjusted for age.</p>b<p>Adjusted for age and BMI.</p>", "links"=>[], "tags"=>["sulf1", "ga"], "article_id"=>180057, "categories"=>["Microbiology", "Genetics", "Biotechnology", "Immunology"], "users"=>["Xiaoling Wang", "Bonita Falkner", "Haidong Zhu", "Huidong Shi", "Shaoyong Su", "Xiaojing Xu", "Ashok Kumar Sharma", "Yanbin Dong", "Frank Treiber", "Bernard Gutin", "Gregory Harshfield", "Harold Snieder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053938.t004", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pyrosequencing_results_of_SULF1_gene_in_GA_cohort_/180057", "title"=>"Pyrosequencing results of SULF1 gene in GA cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-10 00:00:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/277959", "https://ndownloader.figshare.com/files/278000", "https://ndownloader.figshare.com/files/278049", "https://ndownloader.figshare.com/files/278082", "https://ndownloader.figshare.com/files/278127", "https://ndownloader.figshare.com/files/278174"], "description"=>"<div><h3>Objective</h3><p>There is emerging evidence from animal studies suggesting a key role for methylation in the pathogenesis of essential hypertension. However, to date, very few studies have investigated the role of methylation in the development of human hypertension, and none has taken a genome-wide approach. Based on the recent studies that highlight the involvement of inflammation in the development of hypertension, we hypothesize that changes in DNA methylation of leukocytes are involved in the pathogenesis of hypertension.</p> <h3>Method & Results</h3><p>We conducted a genome-wide methylation analysis on 8 hypertensive cases and 8 normotensive age-matched controls aged 14–23 years and performed validation of the most significant CpG sites in 2 genes in an independent sample of 36 hypertensive cases and 60 normotensive controls aged 14–30 years. Validation of the CpG sites in the <em>SULF1</em> gene was further conducted in a second replication sample of 36 hypertensive cases and 34 controls aged 15.8–40 years. A CpG site in the <em>SULF1</em> gene showed higher methylation levels in cases than in healthy controls in the genome-wide step (p = 6.2×10<sup>−5</sup>), which was confirmed in the validation step (p = 0.011) for subjects ≤30 years old but was not significant for subjects of all ages combined (p = 0.095).</p> <h3>Conclusion</h3><p>The identification of a difference in a blood leukocyte DNA methylation site between hypertensive cases and normotensive controls suggests that changes in DNA methylation may play an important role in the pathogenesis of hypertension. The age dependency of the effect further suggests complexity of epigenetic regulation in this age-related disease.</p> </div>", "links"=>[], "tags"=>["genome-wide", "methylation", "hypertension", "african", "american", "males"], "article_id"=>114810, "categories"=>["Microbiology", "Genetics", "Biotechnology", "Immunology"], "users"=>["Xiaoling Wang", "Bonita Falkner", "Haidong Zhu", "Huidong Shi", "Shaoyong Su", "Xiaojing Xu", "Ashok Kumar Sharma", "Yanbin Dong", "Frank Treiber", "Bernard Gutin", "Gregory Harshfield", "Harold Snieder"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0053938.s001", "https://dx.doi.org/10.1371/journal.pone.0053938.s002", "https://dx.doi.org/10.1371/journal.pone.0053938.s003", "https://dx.doi.org/10.1371/journal.pone.0053938.s004", "https://dx.doi.org/10.1371/journal.pone.0053938.s005", "https://dx.doi.org/10.1371/journal.pone.0053938.s006"], "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_Genome_Wide_Methylation_Study_on_Essential_Hypertension_in_Young_African_American_Males__/114810", "title"=>"A Genome-Wide Methylation Study on Essential Hypertension in Young African American Males", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-01-10 01:20:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/509702"], "description"=>"a<p>Adjusted for age.</p>b<p>Adjusted for age and BMI.</p>", "links"=>[], "tags"=>["-analysis", "cpg", "sites", "sulf1"], "article_id"=>180188, "categories"=>["Microbiology", "Genetics", "Biotechnology", "Immunology"], "users"=>["Xiaoling Wang", "Bonita Falkner", "Haidong Zhu", "Huidong Shi", "Shaoyong Su", "Xiaojing Xu", "Ashok Kumar Sharma", "Yanbin Dong", "Frank Treiber", "Bernard Gutin", "Gregory Harshfield", "Harold Snieder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053938.t007", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Meta_analysis_on_two_CpG_sites_in_the_SULF1_gene_/180188", "title"=>"Meta -analysis on two CpG sites in the SULF1 gene.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-10 00:03:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/509612"], "description"=>"<p>Means±SD.</p>", "links"=>[], "tags"=>["characteristics", "subjects", "pa", "cohort", "replication"], "article_id"=>180090, "categories"=>["Microbiology", "Genetics", "Biotechnology", "Immunology"], "users"=>["Xiaoling Wang", "Bonita Falkner", "Haidong Zhu", "Huidong Shi", "Shaoyong Su", "Xiaojing Xu", "Ashok Kumar Sharma", "Yanbin Dong", "Frank Treiber", "Bernard Gutin", "Gregory Harshfield", "Harold Snieder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053938.t005", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_General_characteristics_of_the_subjects_in_PA_cohort_2nd_replication_panel_/180090", "title"=>"General characteristics of the subjects in PA cohort (2nd replication panel).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-10 00:01:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/509804"], "description"=>"<p>TSS, transcription starting site.</p>", "links"=>[], "tags"=>["10", "differentially", "methylated", "cpg"], "article_id"=>180286, "categories"=>["Microbiology", "Genetics", "Biotechnology", "Immunology"], "users"=>["Xiaoling Wang", "Bonita Falkner", "Haidong Zhu", "Huidong Shi", "Shaoyong Su", "Xiaojing Xu", "Ashok Kumar Sharma", "Yanbin Dong", "Frank Treiber", "Bernard Gutin", "Gregory Harshfield", "Harold Snieder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0053938.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Top_10_differentially_methylated_CpG_sites_/180286", "title"=>"Top 10 differentially methylated CpG sites.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-01-10 00:04:46"}

PMC Usage Stats | Further Information

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Relative Metric

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