A Novel Protective MHC-I Haplotype Not Associated with Dominant Gag-Specific CD8+ T-Cell Responses in SIVmac239 Infection of Burmese Rhesus Macaques
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{"title"=>"A Novel Protective MHC-I Haplotype Not Associated with Dominant Gag-Specific CD8+ T-Cell Responses in SIVmac239 Infection of Burmese Rhesus Macaques", "type"=>"journal", "authors"=>[{"first_name"=>"Naofumi", "last_name"=>"Takahashi", "scopus_author_id"=>"55316697300"}, {"first_name"=>"Takushi", "last_name"=>"Nomura", "scopus_author_id"=>"36182534500"}, {"first_name"=>"Yusuke", "last_name"=>"Takahara", "scopus_author_id"=>"47461579200"}, {"first_name"=>"Hiroyuki", "last_name"=>"Yamamoto", "scopus_author_id"=>"55628546945"}, {"first_name"=>"Teiichiro", "last_name"=>"Shiino", "scopus_author_id"=>"35458860900"}, {"first_name"=>"Akiko", "last_name"=>"Takeda", "scopus_author_id"=>"56186855200"}, {"first_name"=>"Makoto", "last_name"=>"Inoue", "scopus_author_id"=>"36460982400"}, {"first_name"=>"Akihiro", "last_name"=>"Iida", "scopus_author_id"=>"7103375056"}, {"first_name"=>"Hiroto", "last_name"=>"Hara", "scopus_author_id"=>"24175608100"}, {"first_name"=>"Tsugumine", "last_name"=>"Shu", "scopus_author_id"=>"23098395600"}, {"first_name"=>"Mamoru", "last_name"=>"Hasegawa", "scopus_author_id"=>"7403099551"}, {"first_name"=>"Hiromi", "last_name"=>"Sakawaki", "scopus_author_id"=>"37114889300"}, {"first_name"=>"Tomoyuki", "last_name"=>"Miura", "scopus_author_id"=>"7402845043"}, {"first_name"=>"Tatsuhiko", "last_name"=>"Igarashi", "scopus_author_id"=>"7403250080"}, {"first_name"=>"Yoshio", "last_name"=>"Koyanagi", "scopus_author_id"=>"55514295600"}, {"first_name"=>"Taeko K.", "last_name"=>"Naruse", "scopus_author_id"=>"7102391140"}, {"first_name"=>"Akinori", "last_name"=>"Kimura", "scopus_author_id"=>"55556476300"}, {"first_name"=>"Tetsuro", "last_name"=>"Matano", "scopus_author_id"=>"7006088717"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"23342126", "sgr"=>"84872296070", "doi"=>"10.1371/journal.pone.0054300", "scopus"=>"2-s2.0-84872296070", "pui"=>"368116204", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203"}, "id"=>"0c9710b5-1403-39e0-8127-63260d0f616e", "abstract"=>"Several major histocompatibility complex class I (MHC-I) alleles are associated with lower viral loads and slower disease progression in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections. Immune-correlates analyses in these MHC-I-related HIV/SIV controllers would lead to elucidation of the mechanism for viral control. Viral control associated with some protective MHC-I alleles is attributed to CD8+ T-cell responses targeting Gag epitopes. We have been trying to know the mechanism of SIV control in multiple groups of Burmese rhesus macaques sharing MHC-I genotypes at the haplotype level. Here, we found a protective MHC-I haplotype, 90-010-Id (D), which is not associated with dominant Gag-specific CD8+ T-cell responses. Viral loads in five D+ animals became significantly lower than those in our previous cohorts after 6 months. Most D+ animals showed predominant Nef-specific but not Gag-specific CD8+ T-cell responses after SIV challenge. Further analyses suggested two Nef-epitope-specific CD8+ T-cell responses exerting strong suppressive pressure on SIV replication. Another set of five D+ animals that received a prophylactic vaccine using a Gag-expressing Sendai virus vector showed significantly reduced viral loads compared to unvaccinated D+ animals at 3 months, suggesting rapid SIV control by Gag-specific CD8+ T-cell responses in addition to Nef-specific ones. These results present a pattern of SIV control with involvement of non-Gag antigen-specific CD8+ T-cell responses.", "link"=>"http://www.mendeley.com/research/novel-protective-mhci-haplotype-not-associated-dominant-gagspecific-cd8-tcell-responses-sivmac239-in", "reader_count"=>15, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>6, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Japan"=>2, "France"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/508389"], "description"=>"<p>(A) Changes in plasma viral loads after challenge vaccinated macaques possessing MHC-I haplotype D. (B) Comparison of plasma viral loads at 3 months (left panel) and 6 months (right panel) between five unvaccinated D<sup>+</sup> and five vaccinated D<sup>+</sup> animals. Viral loads at 3 months in vaccinated animals were significantly lower than those in the unvaccinated (p = 0.0149 by t-test).</p>", "links"=>[], "tags"=>["viral", "loads", "sivmac239", "vaccinated"], "article_id"=>178855, "categories"=>["Virology", "Infectious Diseases", "Immunology"], "users"=>["Naofumi Takahashi", "Takushi Nomura", "Yusuke Takahara", "Hiroyuki Yamamoto", "Teiichiro Shiino", "Akiko Takeda", "Makoto Inoue", "Akihiro Iida", "Hiroto Hara", "Tsugumine Shu", "Mamoru Hasegawa", "Hiromi Sakawaki", "Tomoyuki Miura", "Tatsuhiko Igarashi", "Yoshio Koyanagi", "Taeko K. Naruse", "Akinori Kimura", "Tetsuro Matano"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054300.g005", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Plasma_viral_loads_after_SIVmac239_challenge_in_vaccinated_D_macaques_/178855", "title"=>"Plasma viral loads after SIVmac239 challenge in vaccinated D<sup>+</sup> macaques.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 17:08:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/508127"], "description"=>"<p>SIV Gag-specific CD8<sup>+</sup> T-cell responses in unvaccinated D<sup>+</sup> macaques at week 2 after SIVmac239 challenge.</p>", "links"=>[], "tags"=>["gag-specific", "t-cell", "responses", "unvaccinated", "macaques", "sivmac239"], "article_id"=>178598, "categories"=>["Virology", "Infectious Diseases", "Immunology"], "users"=>["Naofumi Takahashi", "Takushi Nomura", "Yusuke Takahara", "Hiroyuki Yamamoto", "Teiichiro Shiino", "Akiko Takeda", "Makoto Inoue", "Akihiro Iida", "Hiroto Hara", "Tsugumine Shu", "Mamoru Hasegawa", "Hiromi Sakawaki", "Tomoyuki Miura", "Tatsuhiko Igarashi", "Yoshio Koyanagi", "Taeko K. Naruse", "Akinori Kimura", "Tetsuro Matano"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054300.g002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SIV_Gag_specific_CD8_T_cell_responses_in_unvaccinated_D_macaques_at_week_2_after_SIVmac239_challenge_/178598", "title"=>"SIV Gag-specific CD8<sup>+</sup> T-cell responses in unvaccinated D<sup>+</sup> macaques at week 2 after SIVmac239 challenge.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 17:07:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/508196"], "description"=>"<p>Responses were measured by the detection of antigen-specific IFN-γ induction in PBMCs obtained at indicated time points after SIVmac239 challenge.</p>", "links"=>[], "tags"=>["antigen-specific", "t-cell", "responses", "unvaccinated"], "article_id"=>178670, "categories"=>["Virology", "Infectious Diseases", "Immunology"], "users"=>["Naofumi Takahashi", "Takushi Nomura", "Yusuke Takahara", "Hiroyuki Yamamoto", "Teiichiro Shiino", "Akiko Takeda", "Makoto Inoue", "Akihiro Iida", "Hiroto Hara", "Tsugumine Shu", "Mamoru Hasegawa", "Hiromi Sakawaki", "Tomoyuki Miura", "Tatsuhiko Igarashi", "Yoshio Koyanagi", "Taeko K. Naruse", "Akinori Kimura", "Tetsuro Matano"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054300.g003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SIV_antigen_specific_CD8_T_cell_responses_in_unvaccinated_D_macaques_/178670", "title"=>"SIV antigen-specific CD8<sup>+</sup> T-cell responses in unvaccinated D<sup>+</sup> macaques.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 17:07:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/508303"], "description"=>"<p>Nef<sub>35–49</sub>-specific (upper panels) and Nef<sub>115–129</sub>-specific (lower panels) CD8<sup>+</sup> T-cell responses were examined at indicated time points after SIVmac239 challenge.</p>", "links"=>[], "tags"=>["nef-specific", "t-cell", "responses", "macaques"], "article_id"=>178768, "categories"=>["Virology", "Infectious Diseases", "Immunology"], "users"=>["Naofumi Takahashi", "Takushi Nomura", "Yusuke Takahara", "Hiroyuki Yamamoto", "Teiichiro Shiino", "Akiko Takeda", "Makoto Inoue", "Akihiro Iida", "Hiroto Hara", "Tsugumine Shu", "Mamoru Hasegawa", "Hiromi Sakawaki", "Tomoyuki Miura", "Tatsuhiko Igarashi", "Yoshio Koyanagi", "Taeko K. Naruse", "Akinori Kimura", "Tetsuro Matano"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054300.g004", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SIV_Nef_specific_CD8_T_cell_responses_in_macaques_R05_006_R06_034_and_R_360_/178768", "title"=>"SIV Nef-specific CD8<sup>+</sup> T-cell responses in macaques R05-006, R06-034, and R-360.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 17:08:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/508556"], "description"=>"<p>Samples for this analysis were unavailable in macaque R01-009.</p>", "links"=>[], "tags"=>["antigen-specific", "t-cell", "responses", "vaccinated", "animals", "sivmac239"], "article_id"=>179022, "categories"=>["Virology", "Infectious Diseases", "Immunology"], "users"=>["Naofumi Takahashi", "Takushi Nomura", "Yusuke Takahara", "Hiroyuki Yamamoto", "Teiichiro Shiino", "Akiko Takeda", "Makoto Inoue", "Akihiro Iida", "Hiroto Hara", "Tsugumine Shu", "Mamoru Hasegawa", "Hiromi Sakawaki", "Tomoyuki Miura", "Tatsuhiko Igarashi", "Yoshio Koyanagi", "Taeko K. Naruse", "Akinori Kimura", "Tetsuro Matano"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054300.g007", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SIV_antigen_specific_CD8_T_cell_responses_in_vaccinated_D_animals_after_SIVmac239_challenge_/179022", "title"=>"SIV antigen-specific CD8<sup>+</sup> T-cell responses in vaccinated D<sup>+</sup> animals after SIVmac239 challenge.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 17:09:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/508032"], "description"=>"<p>Plasma viral loads (SIV <i>gag</i> RNA copies/ml plasma) were determined as described previously <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054300#pone.0054300-Matano2\" target=\"_blank\">[35]</a>. The lower limit of detection is approximately 4×10<sup>2</sup> copies/ml. (A) Changes in plasma viral loads after challenge in unvaccinated macaques possessing MHC-I haplotype D. (B) Changes in geometric means of plasma viral loads after challenge in five unvaccinated D<sup>+</sup> animals in the present study and twenty D<sup>−</sup> animals in our previous cohorts <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054300#pone.0054300-Nomura1\" target=\"_blank\">[21]</a>. Three of twenty D<sup>−</sup> animals were euthanized because of AIDS before 12 months, and we compared viral loads between D<sup>+</sup> and D<sup>−</sup> animals until 12 months. (C) Comparison of plasma viral loads at 3 months (left panel), 6 months (middle panel), and 9 months (right panel) between the unvaccinated D<sup>+</sup> and the D<sup>−</sup> animals. Viral loads at 6 months and 9 months in D<sup>+</sup> animals were significantly lower than those in the latter D<sup>−</sup> animals (p = 0.0360 at 6 months and p = 0.0135 at 9 months by t-test).</p>", "links"=>[], "tags"=>["viral", "loads", "sivmac239", "unvaccinated"], "article_id"=>178489, "categories"=>["Virology", "Infectious Diseases", "Immunology"], "users"=>["Naofumi Takahashi", "Takushi Nomura", "Yusuke Takahara", "Hiroyuki Yamamoto", "Teiichiro Shiino", "Akiko Takeda", "Makoto Inoue", "Akihiro Iida", "Hiroto Hara", "Tsugumine Shu", "Mamoru Hasegawa", "Hiromi Sakawaki", "Tomoyuki Miura", "Tatsuhiko Igarashi", "Yoshio Koyanagi", "Taeko K. Naruse", "Akinori Kimura", "Tetsuro Matano"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054300.g001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Plasma_viral_loads_after_SIVmac239_challenge_in_unvaccinated_macaques_/178489", "title"=>"Plasma viral loads after SIVmac239 challenge in unvaccinated macaques.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 17:06:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/508489"], "description"=>"<p>SIV Gag-specific CD8<sup>+</sup> T-cell responses in vaccinated D<sup>+</sup> macaques at week 2 after SIVmac239 challenge.</p>", "links"=>[], "tags"=>["gag-specific", "t-cell", "responses", "vaccinated", "macaques", "sivmac239"], "article_id"=>178954, "categories"=>["Virology", "Infectious Diseases", "Immunology"], "users"=>["Naofumi Takahashi", "Takushi Nomura", "Yusuke Takahara", "Hiroyuki Yamamoto", "Teiichiro Shiino", "Akiko Takeda", "Makoto Inoue", "Akihiro Iida", "Hiroto Hara", "Tsugumine Shu", "Mamoru Hasegawa", "Hiromi Sakawaki", "Tomoyuki Miura", "Tatsuhiko Igarashi", "Yoshio Koyanagi", "Taeko K. Naruse", "Akinori Kimura", "Tetsuro Matano"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054300.g006", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SIV_Gag_specific_CD8_T_cell_responses_in_vaccinated_D_macaques_at_week_2_after_SIVmac239_challenge_/178954", "title"=>"SIV Gag-specific CD8<sup>+</sup> T-cell responses in vaccinated D<sup>+</sup> macaques at week 2 after SIVmac239 challenge.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 17:09:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/508818"], "description"=>"<p>PBMCs obtained at week 31 from macaque R06-033 were stimulated by coculture with B-LCL pulsed with indicated concentrations of the wild-type Nef<sub>115–129</sub> peptide (open circles, 115–129, LAIDMSHFIKEKGGL) or the mutant Nef<sub>115–129</sub> peptide with a K126R alteration (closed triangles, 115–129.126R, LAIDMSHFIKERGGL).</p>", "links"=>[], "tags"=>["induction", "cells", "stimulation", "wild-type", "mutant"], "article_id"=>179287, "categories"=>["Virology", "Infectious Diseases", "Immunology"], "users"=>["Naofumi Takahashi", "Takushi Nomura", "Yusuke Takahara", "Hiroyuki Yamamoto", "Teiichiro Shiino", "Akiko Takeda", "Makoto Inoue", "Akihiro Iida", "Hiroto Hara", "Tsugumine Shu", "Mamoru Hasegawa", "Hiromi Sakawaki", "Tomoyuki Miura", "Tatsuhiko Igarashi", "Yoshio Koyanagi", "Taeko K. Naruse", "Akinori Kimura", "Tetsuro Matano"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054300.g010", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_IFN_induction_in_CD8_T_cells_after_stimulation_with_the_wild_type_or_the_mutant_peptide_/179287", "title"=>"IFN-γ induction in CD8<sup>+</sup> T cells after stimulation with the wild-type or the mutant peptide.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 17:10:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/508732"], "description"=>"<p>Amino acid substitutions are shown. Detection of similar levels of wild-type and mutant sequences at the residue is indicated by asterisks. Samples for this analysis were unavailable in macaque R01-009.</p>", "links"=>[], "tags"=>["non-synonymous", "mutations", "regions", "viral", "cdnas", "animals", "sivmac239"], "article_id"=>179205, "categories"=>["Virology", "Infectious Diseases", "Immunology"], "users"=>["Naofumi Takahashi", "Takushi Nomura", "Yusuke Takahara", "Hiroyuki Yamamoto", "Teiichiro Shiino", "Akiko Takeda", "Makoto Inoue", "Akihiro Iida", "Hiroto Hara", "Tsugumine Shu", "Mamoru Hasegawa", "Hiromi Sakawaki", "Tomoyuki Miura", "Tatsuhiko Igarashi", "Yoshio Koyanagi", "Taeko K. Naruse", "Akinori Kimura", "Tetsuro Matano"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054300.g009", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Predominant_non_synonymous_mutations_in_Nef_35_8211_49_coding_and_Nef_115_8211_129_coding_regions_of_viral_cDNAs_in_D_animals_after_SIVmac239_challenge_/179205", "title"=>"Predominant non-synonymous mutations in Nef<sub>35–49</sub>-coding and Nef<sub>115–129</sub>-coding regions of viral cDNAs in D<sup>+</sup> animals after SIVmac239 challenge.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 17:10:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/508652"], "description"=>"<p>Nef<sub>35–49</sub>-specific (upper panels) and Nef<sub>115–129</sub>-specific (lower panels) CD8<sup>+</sup> T-cell responses were examined at indicated time points after SIVmac239 challenge.</p>", "links"=>[], "tags"=>["nef-specific", "t-cell", "responses", "macaques"], "article_id"=>179123, "categories"=>["Virology", "Infectious Diseases", "Immunology"], "users"=>["Naofumi Takahashi", "Takushi Nomura", "Yusuke Takahara", "Hiroyuki Yamamoto", "Teiichiro Shiino", "Akiko Takeda", "Makoto Inoue", "Akihiro Iida", "Hiroto Hara", "Tsugumine Shu", "Mamoru Hasegawa", "Hiromi Sakawaki", "Tomoyuki Miura", "Tatsuhiko Igarashi", "Yoshio Koyanagi", "Taeko K. Naruse", "Akinori Kimura", "Tetsuro Matano"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054300.g008", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SIV_Nef_specific_CD8_T_cell_responses_in_macaques_R06_020_R06_033_R03_021_and_R03_016_/179123", "title"=>"SIV Nef-specific CD8<sup>+</sup> T-cell responses in macaques R06-020, R06-033, R03-021, and R03-016.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 17:10:06"}

PMC Usage Stats | Further Information

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Relative Metric

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