A Platform for the Remote Conduct of Gene-Environment Interaction Studies
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{"title"=>"A Platform for the Remote Conduct of Gene-Environment Interaction Studies", "type"=>"journal", "authors"=>[{"first_name"=>"John", "last_name"=>"Gallacher", "scopus_author_id"=>"7005198349"}, {"first_name"=>"Rory", "last_name"=>"Collins", "scopus_author_id"=>"7403350771"}, {"first_name"=>"Paul", "last_name"=>"Elliott", "scopus_author_id"=>"26643338400"}, {"first_name"=>"Stephen", "last_name"=>"Palmer", "scopus_author_id"=>"7402329336"}, {"first_name"=>"Paul", "last_name"=>"Burton", "scopus_author_id"=>"7202230787"}, {"first_name"=>"Clive", "last_name"=>"Mitchell", "scopus_author_id"=>"49861716500"}, {"first_name"=>"Gareth", "last_name"=>"John", "scopus_author_id"=>"35726848800"}, {"first_name"=>"Ronan", "last_name"=>"Lyons", "scopus_author_id"=>"55259733900"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203", "pmid"=>"23349852", "doi"=>"10.1371/journal.pone.0054331", "pui"=>"368150965", "issn"=>"19326203", "sgr"=>"84872538234", "scopus"=>"2-s2.0-84872538234"}, "id"=>"7b7974aa-d16b-3969-abd4-4b0f75e5d28c", "abstract"=>"BACKGROUND: Gene-environment interaction studies offer the prospect of robust causal inference through both gene identification and instrumental variable approaches. As such they are a major and much needed development. However, conducting these studies using traditional methods, which require direct participant contact, is resource intensive. The ability to conduct gene-environment interaction studies remotely would reduce costs and increase capacity. AIM: To develop a platform for the remote conduct of gene-environment interaction studies. METHODS: A random sample of 15,000 men and women aged 50+ years and living in Cardiff, South Wales, of whom 6,012 were estimated to have internet connectivity, were mailed inviting them to visit a web-site to join a study of successful ageing. Online consent was obtained for questionnaire completion, cognitive testing, re-contact, record linkage and genotyping. Cognitive testing was conducted using the Cardiff Cognitive Battery. Bio-sampling was randomised to blood spot, buccal cell or no request. RESULTS: A heterogeneous sample of 663 (4.5% of mailed sample and 11% of internet connected sample) men and women (47% female) aged 50-87 years (median=61 yrs) from diverse backgrounds (representing the full range of deprivation scores) was recruited. Bio-samples were donated by 70% of those agreeing to do so. Self report questionnaires and cognitive tests showed comparable distributions to those collected using face-to-face methods. Record linkage was achieved for 99.9% of participants. CONCLUSION: This study has demonstrated that remote methods are suitable for the conduct of gene-environment interaction studies. Up-scaling these methods provides the opportunity to increase capacity for large-scale gene-environment interaction studies.", "link"=>"http://www.mendeley.com/research/platform-remote-conduct-geneenvironment-interaction-studies", "reader_count"=>19, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Other"=>2, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>1, "Researcher"=>1, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Other"=>2, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>1, "Researcher"=>1, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>2, "Psychology"=>3, "Social Sciences"=>2, "Economics, Econometrics and Finance"=>1, "Neuroscience"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>3}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>1}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/505227"], "description"=>"<p>Participation process indicators.</p>", "links"=>[], "tags"=>["public health and epidemiology", "Mental health", "neurological disorders"], "article_id"=>175736, "categories"=>["Mental Health", "Biotechnology", "Neuroscience"], "users"=>["John Gallacher", "Rory Collins", "Paul Elliott", "Stephen Palmer", "Paul Burton", "Clive Mitchell", "Gareth John", "Ronan Lyons"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054331.g002", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Participation_process_indicators_/175736", "title"=>"Participation process indicators.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 16:51:43"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"5", "full-text"=>"2", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Computer and information sciences/Computer networks", "average_usage"=>[305, 611, 720, 852, 967, 1083, 1164, 1318, 1393, 1500, 1607, 1714, 1797]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[264, 460, 584, 692, 794, 887, 978, 1067, 1154, 1241, 1328, 1408, 1474]}, {"subject_area"=>"/Medicine and health sciences/Epidemiology", "average_usage"=>[263, 452, 568, 671, 758, 847, 921, 1023, 1101, 1187, 1264, 1340, 1394]}, {"subject_area"=>"/People and places/Geographical locations", "average_usage"=>[263, 456, 571, 673, 776, 866, 955, 1040, 1132, 1217, 1310, 1391, 1454]}, {"subject_area"=>"/Physical sciences/Mathematics", "average_usage"=>[259, 431, 541, 639, 727, 816, 898, 980, 1061, 1136, 1214, 1294, 1356]}]}
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