Photo(chemo)therapy Reduces Circulating Th17 Cells and Restores Circulating Regulatory T Cells in Psoriasis
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{"title"=>"Photo(chemo)therapy Reduces Circulating Th17 Cells and Restores Circulating Regulatory T Cells in Psoriasis", "type"=>"journal", "authors"=>[{"first_name"=>"Takuya", "last_name"=>"Furuhashi", "scopus_author_id"=>"35483723500"}, {"first_name"=>"Chiyo", "last_name"=>"Saito", "scopus_author_id"=>"24503684600"}, {"first_name"=>"Kan", "last_name"=>"Torii", "scopus_author_id"=>"32868162900"}, {"first_name"=>"Emi", "last_name"=>"Nishida", "scopus_author_id"=>"16181453300"}, {"first_name"=>"Sayuri", "last_name"=>"Yamazaki", "scopus_author_id"=>"7402012207"}, {"first_name"=>"Akimichi", "last_name"=>"Morita", "scopus_author_id"=>"7102118336"}], "year"=>2013, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"368187515", "doi"=>"10.1371/journal.pone.0054895", "sgr"=>"84872864622", "scopus"=>"2-s2.0-84872864622", "pmid"=>"23365685"}, "id"=>"2578eb85-8384-35da-acd4-ef318f46de09", "abstract"=>"BACKGROUND: Photo(chemo)therapy is widely used to treat psoriasis, the pathogenesis of which might be caused by an imbalance of Th17 cells/regulatory T cells (Treg). In the present study, we evaluated the effects of photo(chemo)therapy on the Th17/Treg balance and Treg function.\\n\\nMETHODS: Peripheral blood was obtained from psoriasis patients treated with bath-psoralen ultraviolet A (UVA, n = 50) or narrowband ultraviolet B (UVB, n = 18), and age-matched healthy volunteers (n = 20). CD3(+)CD4(+)IL-17A(+) or CD4(+)CD25(+)Foxp3(+)cells were analyzed to estimate Th17 or Treg number by fluorescence-activated cell sorting. Moreover, CD4(+) CD25(-) T cells from patients treated with PUVA(n = 14) were incubated in CFSE and activated with or without CD4(+) CD25(+)T cells, and the suppressive function of CD4(+) CD25(+)T cells were analyzed.\\n\\nRESULTS: Photo(chemo)therapy significantly reduced Th17 levels from 5.66 ± 3.15% to 2.96 ± 2.89% in patients with increased Th17 (Th17/CD4>3.01% [mean+SD of controls]). In contrast, photo(chemo)therapy significantly increased Treg levels from 2.77 ± 0.75 to 3.40 ± 1.88% in patients with less than 4.07% Treg level, defined as the mean of controls. Furthermore, while Treg suppressed the CD4(+)CD25(-) T cell proliferation to a greater extent in controls (Treg Functional Ratio 94.4 ± 4.28%) than in patients (70.3±25.1%), PUVA significantly increased Treg Functional Ratio to 88.1 ± 6.47%. Th17 levels in severe patients (>30 PASI) were significantly higher as compared to controls. Th17 levels that were left after treatment in the patients not achieving PASI 50 (3.78 ± 4.18%) were significantly higher than those in the patients achieving PASI 75 (1.83±1.87%). Treg levels in patients achieving PASI 90 (4.89 ± 1.70%) were significantly higher than those in the patients not achieving PASI 90 (3.90 ± 1.66%). Treg levels prior to treatment with Th17 high decreased group (5.16 ± 2.20%) was significantly higher than that with Th17 high increased group (3.33 ± 1.39%).\\n\\nCONCLUSION: These findings indicate that Treg is dysfunctional in psoriasis patients, and photochemotherapy restores those dysfunctional Treg. Photo(chemo)therapy resolved the Th17/Treg imbalance in patients with psoriasis.", "link"=>"http://www.mendeley.com/research/photochemotherapy-reduces-circulating-th17-cells-restores-circulating-regulatory-t-cells-psoriasis", "reader_count"=>26, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>7, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>3, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>7, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>3, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>4, "Medicine and Dentistry"=>14, "Agricultural and Biological Sciences"=>4, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Japan"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/501466"], "description"=>"<p>(<b>A</b>) Dot plots show percentages of Treg in patients and controls. Horizontal bar indicates mean value. (<b>B</b>) The correlations between Treg levels and the other parameters, such as PASI score, age, disease duration, number of treatments and Th17, Th22 levels were examined.</p>", "links"=>[], "tags"=>["treg", "levels", "patients"], "article_id"=>171985, "categories"=>["Developmental Biology", "Immunology"], "users"=>["Takuya Furuhashi", "Chiyo Saito", "Kan Torii", "Emi Nishida", "Sayuri Yamazaki", "Akimichi Morita"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054895.g001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Circulating_Treg_levels_in_patients_with_psoriasis_/171985", "title"=>"Circulating Treg levels in patients with psoriasis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-24 00:33:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/501819"], "description"=>"<p>(<b>A</b>) Dot plots show percentages of Th17 in patients and controls. Horizontal bar indicates mean value. Levels of Th17 greater than 3.01%, defined as the mean +1 SD of the control level, was analyzed. The higher levels of Th17 are shown, and those are restored to almost normal levels. *p<0.05. (<b>B</b>) Correlation coefficient between Th17 levels and PASI score, age, disease duration, the number of required treatment and Th22 levels.</p>", "links"=>[], "tags"=>["decreases", "circulating"], "article_id"=>172334, "categories"=>["Developmental Biology", "Immunology"], "users"=>["Takuya Furuhashi", "Chiyo Saito", "Kan Torii", "Emi Nishida", "Sayuri Yamazaki", "Akimichi Morita"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054895.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Photo_chemo_therapy_decreases_circulating_Th17_/172334", "title"=>"Photo(chemo)therapy decreases circulating Th17.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-24 00:38:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/478502", "https://ndownloader.figshare.com/files/478503", "https://ndownloader.figshare.com/files/478505", "https://ndownloader.figshare.com/files/478507"], "description"=>"<div><h3>Background</h3><p>Photo(chemo)therapy is widely used to treat psoriasis, the pathogenesis of which might be caused by an imbalance of Th17 cells/regulatory T cells (Treg). In the present study, we evaluated the effects of photo(chemo)therapy on the Th17/Treg balance and Treg function.</p> <h3>Methods</h3><p>Peripheral blood was obtained from psoriasis patients treated with bath-psoralen ultraviolet A (UVA, n = 50) or narrowband ultraviolet B (UVB, n = 18), and age-matched healthy volunteers (n = 20). CD3<sup>+</sup>CD4<sup>+</sup>IL-17A<sup>+</sup> or CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup>cells were analyzed to estimate Th17 or Treg number by fluorescence–activated cell sorting. Moreover, CD4<sup>+</sup> CD25<sup>−</sup> T cells from patients treated with PUVA(n = 14) were incubated in CFSE and activated with or without CD4<sup>+</sup> CD25<sup>+</sup>T cells, and the suppressive function of CD4<sup>+</sup> CD25<sup>+</sup>T cells were analyzed.</p> <h3>Results</h3><p>Photo(chemo)therapy significantly reduced Th17 levels from 5.66±3.15% to 2.96±2.89% in patients with increased Th17 (Th17/CD4>3.01% [mean+SD of controls]). In contrast, photo(chemo)therapy significantly increased Treg levels from 2.77±0.75 to 3.40±1.88% in patients with less than 4.07% Treg level, defined as the mean of controls. Furthermore, while Treg suppressed the CD4<sup>+</sup>CD25<sup>−</sup> T cell proliferation to a greater extent in controls (Treg Functional Ratio 94.4±4.28%) than in patients (70.3±25.1%), PUVA significantly increased Treg Functional Ratio to 88.1±6.47%. Th17 levels in severe patients (>30 PASI) were significantly higher as compared to controls. Th17 levels that were left after treatment in the patients not achieving PASI 50 (3.78±4.18%) were significantly higher than those in the patients achieving PASI 75 (1.83±1.87%). Treg levels in patients achieving PASI 90 (4.89±1.70%) were significantly higher than those in the patients not achieving PASI 90 (3.90±1.66%). Treg levels prior to treatment with Th17 high decreased group (5.16±2.20%) was significantly higher than that with Th17 high increased group (3.33±1.39%).</p> <h3>Conclusion</h3><p>These findings indicate that Treg is dysfunctional in psoriasis patients, and photochemotherapy restores those dysfunctional Treg. Photo(chemo)therapy resolved the Th17/Treg imbalance in patients with psoriasis.</p> </div>", "links"=>[], "tags"=>["reduces", "circulating", "th17", "cells", "restores", "psoriasis"], "article_id"=>154300, "categories"=>["Developmental Biology", "Immunology"], "users"=>["Takuya Furuhashi", "Chiyo Saito", "Kan Torii", "Emi Nishida", "Sayuri Yamazaki", "Akimichi Morita"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0054895.s001", "https://dx.doi.org/10.1371/journal.pone.0054895.s002", "https://dx.doi.org/10.1371/journal.pone.0054895.s003", "https://dx.doi.org/10.1371/journal.pone.0054895.s004"], "stats"=>{"downloads"=>9, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Photo_chemo_therapy_Reduces_Circulating_Th17_Cells_and_Restores_Circulating_Regulatory_T_Cells_in_Psoriasis__/154300", "title"=>"Photo(chemo)therapy Reduces Circulating Th17 Cells and Restores Circulating Regulatory T Cells in Psoriasis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-01-24 01:11:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/501564"], "description"=>"<p>Based on the PASI score, psoriasis lesions improved in all cases. Treg levels before and after photo(chemo)therapy in all patients and in the patients with less than 4.07% Treg, defined as the mean of controls, are shown. The results are presented as mean ± SD *p<0.05 and **p<0.01.</p>", "links"=>[], "tags"=>["increases", "circulating", "treg", "concomitant"], "article_id"=>172074, "categories"=>["Developmental Biology", "Immunology"], "users"=>["Takuya Furuhashi", "Chiyo Saito", "Kan Torii", "Emi Nishida", "Sayuri Yamazaki", "Akimichi Morita"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054895.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Photo_chemo_therapy_increases_circulating_Treg_population_concomitant_with_clinical_efficacy_/172074", "title"=>"Photo(chemo)therapy increases circulating Treg population concomitant with clinical efficacy.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-24 00:34:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/501941"], "description"=>"<p>(<b>A</b>) Psoriasis patients were grouped according to PASI score: 0≦PASI<10; 10≦PASI<20; 20≦PASI<30; 30≦PASI. Dot plots show the levels of Th17 or Treg in each group. Th17 levels in the patients with more than 30 PASI were significantly higher as compared to controls. Horizontal bar indicates mean value. (<b>B</b>) Psoriasis patients were grouped in each treatment group achieving 50%, 75% improvement PASI score from baseline (PASI 50, PASI 75). Dot plots show the levels of Th17 after treatment in each group and controls. Th17 levels after treatment in the patients not achieving PASI 50 were significantly higher than those in the patients achieving PASI 75. (<b>C</b>) Psoriasis patients were grouped according to the amount of decrease in Th17 levels by photo(chemo)therapy: Th17 high increased group n = 16, ΔTh17>1%; Th17 increased group n = 15, ΔTh17>0%; Th17 decreased group n = 24, ΔTh17<0%; Th17 high decreased group n = 13, ΔTh17<−1%. Dot plots show the levels of Treg prior to treatment in each group and controls. The levels of Treg prior to treatment with Th17 high decreased group; ΔTh17<−1% (5.16±2.20%) were significantly higher than that with Th17 high increased group; ΔTh17>1% (3.33±1.39%).</p>", "links"=>[], "tags"=>["higher", "poor-responder", "treg", "responder"], "article_id"=>172452, "categories"=>["Developmental Biology", "Immunology"], "users"=>["Takuya Furuhashi", "Chiyo Saito", "Kan Torii", "Emi Nishida", "Sayuri Yamazaki", "Akimichi Morita"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054895.g005", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Th17_level_is_higher_in_severe_and_poor_responder_patients_Treg_level_is_higher_in_responder_patients_/172452", "title"=>"Th17 level is higher in severe and poor-responder patients, Treg level is higher in responder patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-24 00:40:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/501674"], "description"=>"<p>(<b>A</b>) CD4<sup>+</sup>T cells were separated with magnetic beads as CD25<sup>+</sup>T cells or CD25<sup>−</sup> T cells. CD4<sup>+</sup> CD25<sup>−</sup> T cells were labeled with CFSE, and activated with anti-CD3, CD28 beads for 4 days, with or without CD4<sup>+</sup> CD25<sup>+</sup>T cells (Treg) (CD4<sup>+</sup> CD25<sup>−</sup> T cells : CD4<sup>+</sup> CD25<sup>+</sup>T cells = 2×10<sup>5</sup> : 1×10<sup>3</sup>). FACS data for a typical patient and control are presented. Cells were gated on CD4<sup>+</sup>T cells. Treg did not suppress CD4<sup>+</sup> CD25<sup>−</sup> T cell proliferation in patients (lower panels) as effectively as in controls (upper panels). The ability of Treg to suppress the proliferation was referred to as the Treg Functional Ratio, determined by comparing the rate of the proliferated CD4<sup>+</sup>CD25<sup>−</sup> T cells with and without CD4<sup>+</sup>CD25<sup>+</sup>T cells (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054895#pone.0054895.s001\" target=\"_blank\">Figure S1</a>). Summarized data of Treg Functional Ratio in the patients (n = 14) and in the age-matched controls (n = 11) are shown. *p<0.05 and **p<0.01. Horizontal bar indicates mean value. (<b>B</b>) Correlation coefficient between Treg Functional Ratio and PASI score, age or disease duration (n = 14). (<b>C</b>) A Treg functional assay was performed with PBMC in patients before and after photochemotherapy. Histograms of the proliferated CD4<sup>+</sup>CD25<sup>−</sup> T cells with CD4<sup>+</sup>CD25<sup>+</sup>T cells in three typical patients before and after treatment are shown. Summarized data of Treg Functional Ratio in the patients (n = 14) are shown. Treg Functional ratio in patients is restored to almost normal levels. *p<0.05.</p>", "links"=>[], "tags"=>["restores", "dysfunctional", "treg", "patients"], "article_id"=>172191, "categories"=>["Developmental Biology", "Immunology"], "users"=>["Takuya Furuhashi", "Chiyo Saito", "Kan Torii", "Emi Nishida", "Sayuri Yamazaki", "Akimichi Morita"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0054895.g003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Photo_chemo_therapy_restores_dysfunctional_Treg_in_patients_with_psoriasis_/172191", "title"=>"Photo(chemo)therapy restores dysfunctional Treg in patients with psoriasis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-01-24 00:36:31"}

PMC Usage Stats | Further Information

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Relative Metric

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